CN102224135A - 用作皮质儿茶酚胺能神经传递调节剂的新3-苯基-氮杂环丁烷衍生物 - Google Patents

用作皮质儿茶酚胺能神经传递调节剂的新3-苯基-氮杂环丁烷衍生物 Download PDF

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Publication number
CN102224135A
CN102224135A CN2009801464443A CN200980146444A CN102224135A CN 102224135 A CN102224135 A CN 102224135A CN 2009801464443 A CN2009801464443 A CN 2009801464443A CN 200980146444 A CN200980146444 A CN 200980146444A CN 102224135 A CN102224135 A CN 102224135A
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phenyl
steric isomer
mixture
obstacle
oxide compound
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Chinese (zh)
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C·索内松
L·斯万松
F·彼德森
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NSAB Filial af Neurosearch Sweden AB
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NSAB Filial af Neurosearch Sweden AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2009801464443A 2008-11-24 2009-11-24 用作皮质儿茶酚胺能神经传递调节剂的新3-苯基-氮杂环丁烷衍生物 Pending CN102224135A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA200801656 2008-11-24
DKPA200801656 2008-11-24
US11781808P 2008-11-25 2008-11-25
US61/117,818 2008-11-25
PCT/EP2009/065675 WO2010058017A1 (en) 2008-11-24 2009-11-24 Novel 3-phenyl-azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission

Publications (1)

Publication Number Publication Date
CN102224135A true CN102224135A (zh) 2011-10-19

Family

ID=41649970

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801464443A Pending CN102224135A (zh) 2008-11-24 2009-11-24 用作皮质儿茶酚胺能神经传递调节剂的新3-苯基-氮杂环丁烷衍生物

Country Status (8)

Country Link
US (1) US8586572B2 (https=)
EP (1) EP2367785B1 (https=)
JP (1) JP5621087B2 (https=)
CN (1) CN102224135A (https=)
AU (1) AU2009317155A1 (https=)
CA (1) CA2744307A1 (https=)
MX (1) MX2011005034A (https=)
WO (1) WO2010058017A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107646031A (zh) * 2015-05-20 2018-01-30 综合研究实验室瑞典股份公司 用作皮质儿茶酚胺能神经传递调节剂的新型氮杂环丁烷衍生物
CN109963834A (zh) * 2016-11-18 2019-07-02 综合研究实验室瑞典股份公司 可用作皮质儿茶酚胺能神经传递调节剂的新型氮杂环丁烷衍生物

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2367787B1 (en) 2008-11-24 2013-01-09 NSAB, Filial af NeuroSearch Sweden AB, Sverige 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1236078A (en) * 1968-07-04 1971-06-16 Beecham Group Ltd Substituted azetidinols
GB1266587A (https=) * 1968-06-28 1972-03-15
WO2003037271A2 (en) * 2001-10-30 2003-05-08 Millennium Pharmaceuticals,Inc. Compounds, pharmaceutical compositions and methods of use therefor
WO2005026153A1 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinazoline-2, 4-diones as antibacterial agents
CN1902169A (zh) * 2003-11-10 2007-01-24 迈克罗比亚公司 4－联芳基－1－苯基氮杂环丁烷－2－酮
WO2007140200A2 (en) * 2006-05-25 2007-12-06 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine hcv ns5b inhibitors

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US3481920A (en) 1965-10-22 1969-12-02 Lilly Co Eli Azetidinones
US3668196A (en) 1965-10-22 1972-06-06 Lilly Co Eli 3-azetidinols
US3822252A (en) 1968-06-28 1974-07-02 Schering Corp 3-azetidinols
US3494964A (en) 1969-01-13 1970-02-10 Lilly Co Eli Alpha-halo-alpha-amino ketones
AU2178099A (en) * 1998-01-23 1999-08-09 Vernalis Research Limited Azetidinecarboxamide derivatives for treating cns disorders
GB9917384D0 (en) * 1999-07-23 1999-09-22 Cerebrus Ltd Chemical compounds-III
WO2005026146A1 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Azetidinyl quinolones as antibacterial agents
SE0401465D0 (sv) 2004-06-08 2004-06-08 Carlsson A Research Ab New substituted piperdines as modulators of dopamine neurotransmission
EP1893593A1 (en) 2005-06-15 2008-03-05 Pfizer Limited 3-phenylazetidine derivatives as dopamine agonists
AU2008258599B2 (en) 2007-06-05 2013-06-13 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission
JP2010529080A (ja) 2007-06-05 2010-08-26 エヌエスエイビー、フィリアル アヴ ノイロサーチ スウェーデン エービー、スヴェーリエ 皮質カテコールアミン作動性神経伝達の調節因子としての新規な二置換フェニルピロリジン
EP2367786B1 (en) 2008-11-24 2013-01-09 NSAB, Filial af NeuroSearch Sweden AB, Sverige Novel 1 -alkyl- 3 -hydroxy- 3 -phenylazetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
EP2367787B1 (en) 2008-11-24 2013-01-09 NSAB, Filial af NeuroSearch Sweden AB, Sverige 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1266587A (https=) * 1968-06-28 1972-03-15
GB1236078A (en) * 1968-07-04 1971-06-16 Beecham Group Ltd Substituted azetidinols
WO2003037271A2 (en) * 2001-10-30 2003-05-08 Millennium Pharmaceuticals,Inc. Compounds, pharmaceutical compositions and methods of use therefor
WO2005026153A1 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinazoline-2, 4-diones as antibacterial agents
CN1902169A (zh) * 2003-11-10 2007-01-24 迈克罗比亚公司 4－联芳基－1－苯基氮杂环丁烷－2－酮
WO2007140200A2 (en) * 2006-05-25 2007-12-06 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine hcv ns5b inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JANE BROWN，等: "New functionalised silicas for highly selective cation exchange SPE purification in medicinal chemistry", 《TETRAHEDRON LETTERS》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107646031A (zh) * 2015-05-20 2018-01-30 综合研究实验室瑞典股份公司 用作皮质儿茶酚胺能神经传递调节剂的新型氮杂环丁烷衍生物
CN107646031B (zh) * 2015-05-20 2020-11-17 综合研究实验室瑞典股份公司 用作皮质儿茶酚胺能神经传递调节剂的氮杂环丁烷衍生物
CN109963834A (zh) * 2016-11-18 2019-07-02 综合研究实验室瑞典股份公司 可用作皮质儿茶酚胺能神经传递调节剂的新型氮杂环丁烷衍生物
CN109963834B (zh) * 2016-11-18 2023-04-14 综合研究实验室瑞典股份公司 可用作皮质儿茶酚胺能神经传递调节剂的新型氮杂环丁烷衍生物

Also Published As

Publication number Publication date
AU2009317155A1 (en) 2010-05-27
EP2367785B1 (en) 2014-10-15
JP2012509860A (ja) 2012-04-26
US8586572B2 (en) 2013-11-19
CA2744307A1 (en) 2010-05-27
WO2010058017A1 (en) 2010-05-27
JP5621087B2 (ja) 2014-11-05
EP2367785A1 (en) 2011-09-28
MX2011005034A (es) 2011-06-16
US20110281835A1 (en) 2011-11-17

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