JP2012509666A5 - - Google Patents

Download PDF

Info

Publication number
JP2012509666A5
JP2012509666A5 JP2011537633A JP2011537633A JP2012509666A5 JP 2012509666 A5 JP2012509666 A5 JP 2012509666A5 JP 2011537633 A JP2011537633 A JP 2011537633A JP 2011537633 A JP2011537633 A JP 2011537633A JP 2012509666 A5 JP2012509666 A5 JP 2012509666A5
Authority
JP
Japan
Prior art keywords
cells
cell
hspc
population
support
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011537633A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012509666A (ja
JP5726744B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/065217 external-priority patent/WO2010059876A2/en
Publication of JP2012509666A publication Critical patent/JP2012509666A/ja
Publication of JP2012509666A5 publication Critical patent/JP2012509666A5/ja
Application granted granted Critical
Publication of JP5726744B2 publication Critical patent/JP5726744B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2011537633A 2008-11-21 2009-11-19 生体外におけるヒトｂリンパ球産生培養システム Active JP5726744B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19993208P 2008-11-21 2008-11-21
US61/199,932 2008-11-21
PCT/US2009/065217 WO2010059876A2 (en) 2008-11-21 2009-11-19 In vitro human b lymphopoiesis culture system

Publications (3)

Publication Number Publication Date
JP2012509666A JP2012509666A (ja) 2012-04-26
JP2012509666A5 true JP2012509666A5 (https=) 2013-01-10
JP5726744B2 JP5726744B2 (ja) 2015-06-03

Family

ID=42198808

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011537633A Active JP5726744B2 (ja) 2008-11-21 2009-11-19 生体外におけるヒトｂリンパ球産生培養システム

Country Status (4)

Country Link
US (1) US8133727B2 (https=)
EP (1) EP2358868B1 (https=)
JP (1) JP5726744B2 (https=)
WO (1) WO2010059876A2 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2786664C (en) 2010-01-08 2020-03-10 Immusoft Corporation Vectors and methods for transducing b cells
AU2013255511B2 (en) * 2012-05-04 2016-01-28 Pfizer Inc. Prostate-associated antigens and vaccine-based immunotherapy regimens
BR112015009933A2 (pt) * 2012-11-13 2017-12-12 Genentech Inc métodos de obtenção de uma população de plasmablastos, de enriquecimento de plasmablastos e de identificação de plasmablasto
PT2971039T (pt) 2013-03-14 2020-05-06 Immusoft Corp Métodos para diferenciação e transdução in vitro de células b de memória com vetores virais pseudotipados vsv-g
DK3234107T3 (da) 2014-12-19 2022-10-17 Immusoft Corp B-celler til in vivo-levering af terapeutiske midler
AU2016243052C1 (en) * 2015-04-03 2022-11-24 Dana-Farber Cancer Institute, Inc. Composition and methods of genome editing of B-cells
EP3510145A4 (en) 2016-09-06 2020-03-25 The Children's Medical Center Corporation IMMUNCELLS FROM INDUCED PLURIPOTENT STEM CELLS
MA46959A (fr) 2016-12-02 2019-10-09 Juno Therapeutics Inc Cellules b modifiées et compositions et méthodes associées
CN111936617A (zh) 2018-03-16 2020-11-13 益缪索夫特公司 经遗传工程化以分泌卵泡抑素的b细胞以及使用所述b细胞来治疗卵泡抑素相关的疾病、病况、病症及增强肌肉生长和力量的方法
CN109234232A (zh) * 2018-09-30 2019-01-18 杭州华安单抗生物技术有限公司 兔外周血b细胞的培养体系及培养方法、抗体的制备方法和应用
CA3216986A1 (en) * 2021-04-30 2022-11-03 Stemcell Technologies Canada Inc. Compositions and methods for differentiating and expanding b lineage cells
WO2025106856A1 (en) * 2023-11-15 2025-05-22 Immusoft Corporation Migratory modified differentiated b cells for cancer therapy
WO2025147573A2 (en) 2024-01-05 2025-07-10 Immusoft Corporation Glp-1 expressing modified b cells for the treatment of metabolic disease

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7939059B2 (en) * 2001-12-10 2011-05-10 California Institute Of Technology Method for the generation of antigen-specific lymphocytes
IL162111A0 (en) * 2001-12-22 2005-11-20 4Antibody Ag Method for the generation of generically modified vertebrate precursor lymphocytes and use thereof for the production of heterologo
EP2021460A4 (en) * 2006-05-11 2010-11-17 Univ Maryland Biotech Inst GENERAL METHOD FOR GENERATING IN VITRO HUMAN ANTIBODY RESPONSES

Similar Documents

Publication Publication Date Title
JP2012509666A5 (https=)
Wang et al. 3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells
Iriguchi et al. A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy
Zeng et al. Type 1 regulatory T cells: a new mechanism of peripheral immune tolerance
Spanholtz et al. High log-scale expansion of functional human natural killer cells from umbilical cord blood CD34-positive cells for adoptive cancer immunotherapy
Aqmasheh et al. Effects of mesenchymal stem cell derivatives on hematopoiesis and hematopoietic stem cells
Bagley et al. Extended culture of multipotent hematopoietic progenitors without cytokine augmentation in a novel three-dimensional device
US20100233130A1 (en) Method and Apparatus for Maintenance and Expansion of Hematopoietic Stem Cells From Mononuclear Cells
CN102329769A (zh) 一种获得造血干细胞的方法
JP2007536936A (ja) 幹細胞集団および使用方法
JP7171055B2 (ja) 多能性幹細胞からヘルパーｔ細胞を製造する方法
Edgar et al. Multi-objective optimization reveals time-and dose-dependent inflammatory cytokine-mediated regulation of human stem cell derived T-cell development
Zhu et al. Thymopentin enhances the generation of T-cell lineage derived from human embryonic stem cells in vitro
Shen et al. Single-cell transcriptome of early hematopoiesis guides arterial endothelial-enhanced functional T cell generation from human PSCs
CN118773133B (zh) 一种诱导性nk细胞及其制备方法和应用
Galić et al. Generation of T lineage cells from human embryonic stem cells in a feeder free system
Dorn et al. In vitro proliferation and differentiation of human CD34+ cells from peripheral blood into mature red blood cells with two different cell culture systems
Guo et al. Generation and clinical potential of functional T lymphocytes from gene-edited pluripotent stem cells
Chotinantakul et al. Wnt1 accelerates an ex vivo expansion of human cord blood CD34+ CD38− cells
Gaudeaux et al. T-Cell Progenitors as a new immunotherapy to bypass hurdles of allogeneic hematopoietic stem cell transplantation
Nakamori et al. Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors: a principal role for flt3 ligand in lymphopoiesis
EP4004194A1 (en) Low density cell culture
US20240218328A1 (en) Compositions and methods for differentiating and expanding b lineage cells
Kawano et al. Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors
Hanley et al. Improving clinical outcomes using adoptively transferred immune cells from umbilical cord blood