JP2012509300A - 色素コンジュゲートイメージング剤 - Google Patents

色素コンジュゲートイメージング剤 Download PDF

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Publication number
JP2012509300A
JP2012509300A JP2011536864A JP2011536864A JP2012509300A JP 2012509300 A JP2012509300 A JP 2012509300A JP 2011536864 A JP2011536864 A JP 2011536864A JP 2011536864 A JP2011536864 A JP 2011536864A JP 2012509300 A JP2012509300 A JP 2012509300A
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JP
Japan
Prior art keywords
group
btm
imaging agent
dye
imaging
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Pending
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JP2011536864A
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English (en)
Japanese (ja)
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JP2012509300A5 (https=
Inventor
ネアーン，ロバート・ジェームス・ドメット
ジャクソン，アレキサンダー
Original Assignee
ジーイー・ヘルスケア・アクスイェ・セルスカプ
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Application filed by ジーイー・ヘルスケア・アクスイェ・セルスカプ filed Critical ジーイー・ヘルスケア・アクスイェ・セルスカプ
Publication of JP2012509300A publication Critical patent/JP2012509300A/ja
Publication of JP2012509300A5 publication Critical patent/JP2012509300A5/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4842—Monitoring progression or stage of a disease

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2011536864A 2008-11-20 2009-11-19 色素コンジュゲートイメージング剤 Pending JP2012509300A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08169526.4 2008-11-20
EP08169526 2008-11-20
PCT/EP2009/065461 WO2010057944A1 (en) 2008-11-20 2009-11-19 Dye conjugate imaging agents

Publications (2)

Publication Number Publication Date
JP2012509300A true JP2012509300A (ja) 2012-04-19
JP2012509300A5 JP2012509300A5 (https=) 2012-06-07

Family

ID=40427489

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011536864A Pending JP2012509300A (ja) 2008-11-20 2009-11-19 色素コンジュゲートイメージング剤

Country Status (5)

Country Link
US (1) US20110280806A1 (https=)
EP (1) EP2373349A1 (https=)
JP (1) JP2012509300A (https=)
CN (1) CN102281904A (https=)
WO (1) WO2010057944A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR102743A1 (es) 2014-11-26 2017-03-22 Li Cor Inc Medios de contraste ir para imágenes por fluorescencia
CN108329255A (zh) * 2018-03-19 2018-07-27 华南理工大学 一种六氢咔唑酮衍生物的合成方法
US20200184558A1 (en) * 2018-12-05 2020-06-11 Abaxx Technologies Inc. System and computer method for trading a commodity with carry costs
US20240125773A1 (en) * 2021-02-05 2024-04-18 Beckman Coulter, Inc. Compositions and methods for preventing non-specific interactions between polymer dyes-antibody conjugates
CN115386081B (zh) * 2022-09-01 2023-07-28 武汉大学 一种原位热交联反应构筑二阶非线性光学聚合物材料的方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0625165A (ja) * 1992-03-16 1994-02-01 Minnesota Mining & Mfg Co <3M> ２−メチル−４，４ａ−ジヒドロ−３Ｈ−カルバゾリウム塩及びそれらから誘導される染料
JPH10510250A (ja) * 1994-12-07 1998-10-06 インスティトゥート・フュア・ディアゴノスティクフォルシュング・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング・アン・デル・フライエン・ウニヴェルジテート・ベルリン Ｎｉｒ光を利用したイン・ビボ診断のための方法
JP2001521530A (ja) * 1997-04-23 2001-11-06 インスティトゥート フュア ディアグノスティックフォルシュング ゲゼルシャフト ミット ベシュレンクテル ハフツング アン デア フライエン ウニヴェルジテート ベルリン 近赤外線を用いた診断法および治療のための酸不安定性で酵素的に分割可能な染料構造体
WO2005061456A1 (ja) * 2003-12-19 2005-07-07 Konica Minolta Medical & Graphic, Inc. 近赤外蛍光造影剤
JP2005220045A (ja) * 2004-02-04 2005-08-18 Konica Minolta Medical & Graphic Inc 蛍光造影剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1322710B2 (en) * 2000-09-29 2015-02-18 Life Technologies Corporation Modified carbocyanine dyes and their conjugates
JP5416970B2 (ja) * 2005-09-02 2014-02-12 ビセン メディカル， インコーポレイテッド ニコチン酸及びピコリン酸誘導近赤外線蛍光団
CN101100465A (zh) * 2007-06-12 2008-01-09 山东大学 阳离子咔唑类化合物及其作为双光子核酸荧光探针的应用

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0625165A (ja) * 1992-03-16 1994-02-01 Minnesota Mining & Mfg Co <3M> ２−メチル−４，４ａ−ジヒドロ−３Ｈ−カルバゾリウム塩及びそれらから誘導される染料
JPH10510250A (ja) * 1994-12-07 1998-10-06 インスティトゥート・フュア・ディアゴノスティクフォルシュング・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング・アン・デル・フライエン・ウニヴェルジテート・ベルリン Ｎｉｒ光を利用したイン・ビボ診断のための方法
JP2001521530A (ja) * 1997-04-23 2001-11-06 インスティトゥート フュア ディアグノスティックフォルシュング ゲゼルシャフト ミット ベシュレンクテル ハフツング アン デア フライエン ウニヴェルジテート ベルリン 近赤外線を用いた診断法および治療のための酸不安定性で酵素的に分割可能な染料構造体
WO2005061456A1 (ja) * 2003-12-19 2005-07-07 Konica Minolta Medical & Graphic, Inc. 近赤外蛍光造影剤
JP2005220045A (ja) * 2004-02-04 2005-08-18 Konica Minolta Medical & Graphic Inc 蛍光造影剤

Also Published As

Publication number Publication date
CN102281904A (zh) 2011-12-14
EP2373349A1 (en) 2011-10-12
US20110280806A1 (en) 2011-11-17
WO2010057944A9 (en) 2010-09-16
WO2010057944A1 (en) 2010-05-27

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