CN102281904A - 染料缀合物成像剂 - Google Patents

染料缀合物成像剂 Download PDF

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Publication number
CN102281904A
CN102281904A CN2009801554191A CN200980155419A CN102281904A CN 102281904 A CN102281904 A CN 102281904A CN 2009801554191 A CN2009801554191 A CN 2009801554191A CN 200980155419 A CN200980155419 A CN 200980155419A CN 102281904 A CN102281904 A CN 102281904A
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CN
China
Prior art keywords
preparation
btm
group
independently
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801554191A
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English (en)
Chinese (zh)
Inventor
R·J·D·奈尔内
A·贾克森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
GE Healthcare AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare AS filed Critical GE Healthcare AS
Publication of CN102281904A publication Critical patent/CN102281904A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4842—Monitoring progression or stage of a disease

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
CN2009801554191A 2008-11-20 2009-11-19 染料缀合物成像剂 Pending CN102281904A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08169526.4 2008-11-20
EP08169526 2008-11-20
PCT/EP2009/065461 WO2010057944A1 (en) 2008-11-20 2009-11-19 Dye conjugate imaging agents

Publications (1)

Publication Number Publication Date
CN102281904A true CN102281904A (zh) 2011-12-14

Family

ID=40427489

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801554191A Pending CN102281904A (zh) 2008-11-20 2009-11-19 染料缀合物成像剂

Country Status (5)

Country Link
US (1) US20110280806A1 (https=)
EP (1) EP2373349A1 (https=)
JP (1) JP2012509300A (https=)
CN (1) CN102281904A (https=)
WO (1) WO2010057944A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108329255A (zh) * 2018-03-19 2018-07-27 华南理工大学 一种六氢咔唑酮衍生物的合成方法
CN115386081A (zh) * 2022-09-01 2022-11-25 武汉大学 一种原位热交联反应构筑二阶非线性光学聚合物材料的方法
CN117015711A (zh) * 2021-02-05 2023-11-07 贝克曼库尔特有限公司 用于阻止聚合物染料-抗体缀合物之间的非特异性相互作用的组合物和方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR102743A1 (es) 2014-11-26 2017-03-22 Li Cor Inc Medios de contraste ir para imágenes por fluorescencia
US20200184558A1 (en) * 2018-12-05 2020-06-11 Abaxx Technologies Inc. System and computer method for trading a commodity with carry costs

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5892056A (en) * 1992-03-16 1999-04-06 Imation Corp. Dyes derived from dihydro-carbazolium salts
US20050136007A1 (en) * 2003-12-19 2005-06-23 Nobuaki Kagawa Near-infrared fluorescent contrast medium
CN101100465A (zh) * 2007-06-12 2008-01-09 山东大学 阳离子咔唑类化合物及其作为双光子核酸荧光探针的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
DE19717904A1 (de) * 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
EP1322710B2 (en) * 2000-09-29 2015-02-18 Life Technologies Corporation Modified carbocyanine dyes and their conjugates
JP2005220045A (ja) * 2004-02-04 2005-08-18 Konica Minolta Medical & Graphic Inc 蛍光造影剤
JP5416970B2 (ja) * 2005-09-02 2014-02-12 ビセン メディカル， インコーポレイテッド ニコチン酸及びピコリン酸誘導近赤外線蛍光団

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5892056A (en) * 1992-03-16 1999-04-06 Imation Corp. Dyes derived from dihydro-carbazolium salts
US20050136007A1 (en) * 2003-12-19 2005-06-23 Nobuaki Kagawa Near-infrared fluorescent contrast medium
CN101100465A (zh) * 2007-06-12 2008-01-09 山东大学 阳离子咔唑类化合物及其作为双光子核酸荧光探针的应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
宋小磊 等: "近红外荧光散射断层成像的研究进展", 《国外医学生物医学工程分册》 *
陈宜张 等主编: "《生命科学中的单分子行为及细胞内实时检测》", 30 September 2005, 科学出版社 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108329255A (zh) * 2018-03-19 2018-07-27 华南理工大学 一种六氢咔唑酮衍生物的合成方法
CN117015711A (zh) * 2021-02-05 2023-11-07 贝克曼库尔特有限公司 用于阻止聚合物染料-抗体缀合物之间的非特异性相互作用的组合物和方法
CN115386081A (zh) * 2022-09-01 2022-11-25 武汉大学 一种原位热交联反应构筑二阶非线性光学聚合物材料的方法
CN115386081B (zh) * 2022-09-01 2023-07-28 武汉大学 一种原位热交联反应构筑二阶非线性光学聚合物材料的方法

Also Published As

Publication number Publication date
EP2373349A1 (en) 2011-10-12
US20110280806A1 (en) 2011-11-17
WO2010057944A9 (en) 2010-09-16
WO2010057944A1 (en) 2010-05-27
JP2012509300A (ja) 2012-04-19

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