JP2012507994A5 - - Google Patents
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- Publication number
- JP2012507994A5 JP2012507994A5 JP2011535101A JP2011535101A JP2012507994A5 JP 2012507994 A5 JP2012507994 A5 JP 2012507994A5 JP 2011535101 A JP2011535101 A JP 2011535101A JP 2011535101 A JP2011535101 A JP 2011535101A JP 2012507994 A5 JP2012507994 A5 JP 2012507994A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- hla
- fusion polypeptide
- antigen
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims 25
- 102000004196 processed proteins & peptides Human genes 0.000 claims 25
- 108090000765 processed proteins & peptides Proteins 0.000 claims 25
- 230000004927 fusion Effects 0.000 claims 12
- 102100028967 HLA class I histocompatibility antigen, alpha chain G Human genes 0.000 claims 6
- 108010024164 HLA-G Antigens Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 108060003951 Immunoglobulin Proteins 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 102000018358 immunoglobulin Human genes 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 102100027314 Beta-2-microglobulin Human genes 0.000 claims 1
- 101000986079 Homo sapiens HLA class I histocompatibility antigen, alpha chain G Proteins 0.000 claims 1
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08168675.0 | 2008-11-07 | ||
| EP08168675A EP2184070A1 (en) | 2008-11-07 | 2008-11-07 | HLA-G proteins and pharmaceutical uses thereof |
| US11280408P | 2008-11-10 | 2008-11-10 | |
| US61/112,804 | 2008-11-10 | ||
| PCT/EP2009/064575 WO2010052228A1 (en) | 2008-11-07 | 2009-11-04 | Hla-g proteins and pharmaceutical uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012507994A JP2012507994A (ja) | 2012-04-05 |
| JP2012507994A5 true JP2012507994A5 (cg-RX-API-DMAC7.html) | 2012-12-06 |
Family
ID=40673439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011535101A Pending JP2012507994A (ja) | 2008-11-07 | 2009-11-04 | Ｈｌａ−ｇタンパク質及びその薬学的使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20110268737A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2184070A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2012507994A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2742517A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2352509T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2423993T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2352509E (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010052228A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010146094A1 (en) * | 2009-06-18 | 2010-12-23 | Hla-G Technologies | Hla-g alpha 1 multimers and pharmaceutical uses thereof |
| CA2764649C (en) * | 2009-06-25 | 2019-02-26 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Multimeric polypeptides of hla-g including alpha1-alpha3 monomers and pharmaceutical uses thereof |
| EA029560B1 (ru) * | 2012-01-12 | 2018-04-30 | Байоджен Эмэй Инк. | Применение химерного фактора свертывания крови для уменьшения ингибирующего иммунного ответа у субъекта |
| EP2880169B1 (en) | 2012-08-02 | 2017-05-17 | F. Hoffmann-La Roche AG | Method for producing monomeric and multimeric molecules and uses thereof |
| EP3640375A3 (en) | 2012-12-11 | 2020-07-29 | Albert Einstein College of Medicine | Methods for high throughput receptor/ligand identification |
| CA2936352A1 (en) * | 2014-01-21 | 2015-07-30 | Albert Einstein College Of Medicine, Inc. | Cellular platform for rapid and comprehensive t-cell immunomonitoring |
| JP6416480B2 (ja) * | 2014-01-29 | 2018-10-31 | 国立大学法人北海道大学 | 関節リウマチまたはその関連疾患の予防または治療剤 |
| US9765330B1 (en) | 2015-01-09 | 2017-09-19 | Nant Holdings Ip, Llc | Compositions and methods for reduction of allograft recognition and rejection |
| WO2017201131A1 (en) | 2016-05-18 | 2017-11-23 | Albert Einstein College Of Medicine, Inc. | Variant pd-l1 polypeptides, t-cell modulatory multimeric polypeptides, and methods of use thereof |
| BR112018073606A2 (pt) | 2016-05-18 | 2019-02-26 | Cue Biopharma, Inc. | polipeptídeos multiméricos moduladores de células t e métodos de uso dos mesmos |
| BR112018074847A2 (pt) | 2016-06-03 | 2019-03-26 | Invectys | anticorpos específicos anti hla-g |
| WO2017218714A1 (en) * | 2016-06-14 | 2017-12-21 | Regents Of The University Of Minnesota | Genetically modified cells, tissues, and organs for treating disease |
| CA3044838A1 (en) | 2016-12-02 | 2018-06-07 | Bioverativ Therapeutics Inc. | Methods of inducing immune tolerance to clotting factors |
| WO2018119114A1 (en) | 2016-12-22 | 2018-06-28 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| US11851471B2 (en) | 2017-01-09 | 2023-12-26 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| EP3596118B1 (en) | 2017-03-15 | 2024-08-21 | Cue Biopharma, Inc. | Combination of multimeric fusion polypeptides and immune checkpoint inhibitor for treating hpv-associated cancer |
| EP3737689A4 (en) | 2018-01-09 | 2021-12-01 | Cue Biopharma, Inc. | MULTIMERIC T CELL-MODULATING POLYPEPTIDES AND METHOD OF USING THEREOF |
| JP2021080171A (ja) * | 2018-03-13 | 2021-05-27 | 国立大学法人北海道大学 | 改変タンパク質、医薬品、炎症性疾患の予防又は治療剤及び改変タンパク質の製造方法 |
| AU2021272895A1 (en) | 2020-05-12 | 2022-09-22 | Cue Biopharma, Inc. | Multimeric T-cell modulatory polypeptides and methods of use thereof |
| EP4211149A4 (en) | 2020-09-09 | 2024-10-09 | Cue Biopharma, Inc. | MULTIMERIC POLYPEPTIDES MODULATING MHC CLASS II T CELLS FOR THE TREATMENT OF TYPE 1 DIABETES MELLITUS (T1D) AND METHODS OF USE THEREOF |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2717498B1 (fr) | 1994-03-18 | 1996-05-03 | Commissariat Energie Atomique | Transcrits du gène de CMH de classe I HLA-G et leurs applications. |
| ES2224603T3 (es) | 1998-02-20 | 2005-03-01 | Commissariat A L'energie Atomique | Procedimiento de seleccion de tumores que expresan hla-g sensibles a un tratamiento anticanceroso y sus aplicaciones. |
| FR2794977B1 (fr) | 1999-06-18 | 2003-10-31 | Commissariat Energie Atomique | Utilisation de compositions contenant des formes solubles d'hla-g dans le traitement de pathologies inflammatoires de la peau, et leur procede d'obtention |
| FR2810047B1 (fr) | 2000-06-13 | 2004-04-02 | Commissariat Energie Atomique | Nouvelle isoforme d'hla-g et ses applications |
| CA2551916C (en) * | 2003-12-31 | 2014-04-29 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Fc-erythropoietin fusion protein with improved pharmacokinetics |
| US20050281822A1 (en) * | 2004-06-18 | 2005-12-22 | Cedarbaum Jesse M | Method of administering and using VEGF inhibitors for the treatment of malignant pleural effusion |
| WO2007011044A1 (ja) | 2005-07-15 | 2007-01-25 | Kyushu University, National University Corporation | ジスルフィド結合型hla-g二量体を含む医薬組成物及びジスルフィド結合型hla-g二量体の製造方法 |
| WO2007091078A2 (en) | 2006-02-10 | 2007-08-16 | Axordia Limited | Polypeptide conjugate comprising hla-g and uses thereof, stem cells transfected with hla-g |
| JP2009537145A (ja) * | 2006-05-15 | 2009-10-29 | バイラル ロジック システムズ テクノロジー コーポレーション | 免疫学的疾患および障害を治療するためのｃｄ４７と関連した組成物および方法 |
-
2008
- 2008-11-07 EP EP08168675A patent/EP2184070A1/en not_active Withdrawn
-
2009
- 2009-11-04 DK DK09747827.5T patent/DK2352509T3/da active
- 2009-11-04 JP JP2011535101A patent/JP2012507994A/ja active Pending
- 2009-11-04 CA CA2742517A patent/CA2742517A1/en not_active Abandoned
- 2009-11-04 ES ES09747827T patent/ES2423993T3/es active Active
- 2009-11-04 EP EP09747827.5A patent/EP2352509B1/en not_active Not-in-force
- 2009-11-04 US US13/127,788 patent/US20110268737A1/en not_active Abandoned
- 2009-11-04 PT PT97478275T patent/PT2352509E/pt unknown
- 2009-11-04 WO PCT/EP2009/064575 patent/WO2010052228A1/en not_active Ceased