JP2012505151A5 - - Google Patents
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- Publication number
- JP2012505151A5 JP2012505151A5 JP2010528222A JP2010528222A JP2012505151A5 JP 2012505151 A5 JP2012505151 A5 JP 2012505151A5 JP 2010528222 A JP2010528222 A JP 2010528222A JP 2010528222 A JP2010528222 A JP 2010528222A JP 2012505151 A5 JP2012505151 A5 JP 2012505151A5
- Authority
- JP
- Japan
- Prior art keywords
- bmp
- polypeptide
- seq
- promoter
- canine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000008131 Bone Morphogenetic Protein 7 Human genes 0.000 claims 59
- 108010049870 Bone Morphogenetic Protein 7 Proteins 0.000 claims 59
- 238000000034 method Methods 0.000 claims 23
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 18
- 241000282465 Canis Species 0.000 claims 15
- 241000283073 Equus caballus Species 0.000 claims 10
- 230000000694 effects Effects 0.000 claims 10
- 239000012634 fragment Substances 0.000 claims 10
- 241000282324 Felis Species 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 241000701114 Canine adenovirus 2 Species 0.000 claims 4
- 241000701157 Canine mastadenovirus A Species 0.000 claims 4
- 241001135569 Human adenovirus 5 Species 0.000 claims 4
- 241000598171 Human adenovirus sp. Species 0.000 claims 4
- 229940125581 ImmunityBio COVID-19 vaccine Drugs 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 150000007523 nucleic acids Chemical group 0.000 claims 4
- 108010085238 Actins Proteins 0.000 claims 2
- 102100027211 Albumin Human genes 0.000 claims 2
- 108010088751 Albumins Proteins 0.000 claims 2
- 108060005980 Collagenase Proteins 0.000 claims 2
- 241000282326 Felis catus Species 0.000 claims 2
- 108091005904 Hemoglobin subunit beta Proteins 0.000 claims 2
- 108091005886 Hemoglobin subunit gamma Proteins 0.000 claims 2
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 2
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 2
- 108010059343 MM Form Creatine Kinase Proteins 0.000 claims 2
- 108090000157 Metallothionein Proteins 0.000 claims 2
- 101100165560 Mus musculus Bmp7 gene Proteins 0.000 claims 2
- 108010067372 Pancreatic elastase Proteins 0.000 claims 2
- 101001099217 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) Triosephosphate isomerase Proteins 0.000 claims 2
- 108010050122 alpha 1-Antitrypsin Proteins 0.000 claims 2
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 201000008482 osteoarthritis Diseases 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 210000002437 synoviocyte Anatomy 0.000 claims 2
- 241000701161 unidentified adenovirus Species 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/867,919 US7846428B2 (en) | 2007-10-05 | 2007-10-05 | Articular cartilage gene therapy with recombinant vector encoding BMP-7 |
| PCT/US2008/079090 WO2009046464A1 (en) | 2007-10-05 | 2008-10-07 | Articular cartilage gene therapy with recombinant vector encoding bmp-7 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012505151A JP2012505151A (ja) | 2012-03-01 |
| JP2012505151A5 true JP2012505151A5 (enExample) | 2012-04-12 |
Family
ID=40276182
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010528222A Pending JP2012505151A (ja) | 2007-10-05 | 2008-10-07 | Ｂｍｐ−７をコードする組換えベクターを用いる関節軟骨の遺伝子治療 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7846428B2 (enExample) |
| EP (1) | EP2205743B1 (enExample) |
| JP (1) | JP2012505151A (enExample) |
| CN (1) | CN102027114A (enExample) |
| BR (1) | BRPI0817753A8 (enExample) |
| CA (1) | CA2701215C (enExample) |
| WO (1) | WO2009046464A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011084145A2 (en) * | 2009-12-21 | 2011-07-14 | Pharmathene, Inc. | Recombinant butyrylcholinesterases and truncates thereof |
| RU2516951C1 (ru) * | 2013-03-01 | 2014-05-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Мордовский государственный университет им. Н.П. Огарёва" | Способ профилактики посттравматического артроза коленного сустава |
| HRP20181913T1 (hr) | 2013-07-18 | 2019-01-11 | Xalud Therapeutics, Inc. | Sastav za liječenje upale bolesti zglobova |
| WO2015035395A1 (en) * | 2013-09-09 | 2015-03-12 | Figene, Llc | Gene therapy for the regeneration of chondrocytes or cartilage type cells |
| RU2771490C2 (ru) | 2016-01-13 | 2022-05-05 | Мериал, Инк. | Рекомбинантные aav векторы, экспрессирующие остеопротективные гены, включая has2 и лубрицин, пригодные при лечении остеоартрита и сходных заболеваний суставов у млекопитающих |
| US10617739B2 (en) * | 2016-04-13 | 2020-04-14 | Universiteit Maastricht | Method for the treatment or prevention of osteoarthritis |
| AU2018258100B2 (en) * | 2017-04-27 | 2022-04-14 | Eli Lilly And Company | Variants of human BMP7 protein |
| US11246836B2 (en) * | 2018-05-17 | 2022-02-15 | Bluelight Pharmatech Co., Ltd. | Intramuscular depot of decoquinate compositions and method of prophylaxis and treatment thereof |
| CN112168793A (zh) * | 2020-10-26 | 2021-01-05 | 辰欣药业股份有限公司 | 一种盐酸氨溴索口腔崩解片及其制备方法 |
| US20240316219A1 (en) * | 2021-05-03 | 2024-09-26 | North Carolina State University | Compositions and methods related to the treatment of ocular diseases in equines |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5266683A (en) * | 1988-04-08 | 1993-11-30 | Stryker Corporation | Osteogenic proteins |
| US6159464A (en) * | 1990-12-20 | 2000-12-12 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Viral vectors to inhibit leukocyte infiltration or cartilage degradation of joints |
| WO2002083080A2 (en) * | 2001-04-17 | 2002-10-24 | Genetix Pharmaceuticals, Inc. | Method of treating arthritis using lentiviral vectors in gene therapy |
| US20040167088A1 (en) * | 2003-02-25 | 2004-08-26 | Genvec, Inc. | Method of using adenoviral vectors with increased persistence in vivo |
| WO2004083434A1 (en) * | 2003-03-17 | 2004-09-30 | The University Of Hong Kong | A combined adeno-associated virus and adenovirus cocktail gene delivery system for high effiency gene expression without eliciting immune response in immuno-competent subjects |
| WO2005007098A2 (en) * | 2003-07-08 | 2005-01-27 | New York University | Nucleic acid therapy to enhance cartilage repair |
| EP1660663A4 (en) * | 2003-08-12 | 2007-07-11 | Brigham & Womens Hospital | METHOD AND COMPOSITIONS FOR TISSUE REPAIR |
| EP1951751B1 (en) | 2005-11-14 | 2017-11-01 | Merial, Inc. | Gene therapy for renal failure |
| EP1978994B1 (en) * | 2005-12-22 | 2012-02-01 | Janssen Biotech, Inc. | Bmp-7 variant compositions, methods and uses |
-
2007
- 2007-10-05 US US11/867,919 patent/US7846428B2/en not_active Expired - Fee Related
-
2008
- 2008-10-07 BR BRPI0817753A patent/BRPI0817753A8/pt not_active Application Discontinuation
- 2008-10-07 JP JP2010528222A patent/JP2012505151A/ja active Pending
- 2008-10-07 WO PCT/US2008/079090 patent/WO2009046464A1/en not_active Ceased
- 2008-10-07 CA CA2701215A patent/CA2701215C/en not_active Expired - Fee Related
- 2008-10-07 CN CN2008801158299A patent/CN102027114A/zh active Pending
- 2008-10-07 EP EP08836475.7A patent/EP2205743B1/en active Active
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