BRPI0817753A8 - Terapia gênica de cartilagem articular com vetor recombinante codificando bmp-7 - Google Patents

Terapia gênica de cartilagem articular com vetor recombinante codificando bmp-7

Info

Publication number
BRPI0817753A8
BRPI0817753A8 BRPI0817753A BRPI0817753A BRPI0817753A8 BR PI0817753 A8 BRPI0817753 A8 BR PI0817753A8 BR PI0817753 A BRPI0817753 A BR PI0817753A BR PI0817753 A BRPI0817753 A BR PI0817753A BR PI0817753 A8 BRPI0817753 A8 BR PI0817753A8
Authority
BR
Brazil
Prior art keywords
gene therapy
vector encoding
articular cartilage
recombinant vector
encoding bmp
Prior art date
Application number
BRPI0817753A
Other languages
English (en)
Portuguese (pt)
Inventor
Bernard Fischer Laurent
Original Assignee
Merial Ltd
Merial Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Ltd, Merial Inc filed Critical Merial Ltd
Publication of BRPI0817753A2 publication Critical patent/BRPI0817753A2/pt
Publication of BRPI0817753A8 publication Critical patent/BRPI0817753A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/10—Animals modified by protein administration, for non-therapeutic purpose
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/102—Caprine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
BRPI0817753A 2007-10-05 2008-10-07 Terapia gênica de cartilagem articular com vetor recombinante codificando bmp-7 BRPI0817753A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/867,919 US7846428B2 (en) 2007-10-05 2007-10-05 Articular cartilage gene therapy with recombinant vector encoding BMP-7
PCT/US2008/079090 WO2009046464A1 (en) 2007-10-05 2008-10-07 Articular cartilage gene therapy with recombinant vector encoding bmp-7

Publications (2)

Publication Number Publication Date
BRPI0817753A2 BRPI0817753A2 (pt) 2015-03-24
BRPI0817753A8 true BRPI0817753A8 (pt) 2017-09-26

Family

ID=40276182

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0817753A BRPI0817753A8 (pt) 2007-10-05 2008-10-07 Terapia gênica de cartilagem articular com vetor recombinante codificando bmp-7

Country Status (7)

Country Link
US (1) US7846428B2 (enExample)
EP (1) EP2205743B1 (enExample)
JP (1) JP2012505151A (enExample)
CN (1) CN102027114A (enExample)
BR (1) BRPI0817753A8 (enExample)
CA (1) CA2701215C (enExample)
WO (1) WO2009046464A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2784861A1 (en) * 2009-12-21 2011-07-14 Pharmathene, Inc. Recombinant butyrylcholinesterases and truncates thereof
RU2516951C1 (ru) * 2013-03-01 2014-05-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Мордовский государственный университет им. Н.П. Огарёва" Способ профилактики посттравматического артроза коленного сустава
SI3021873T1 (sl) * 2013-07-18 2018-12-31 Xalud Therapeutics, Inc. Sestavek za zdravljenje vnetne sklepne bolezni
EP4786600A2 (en) * 2013-09-09 2026-08-05 FibroBiologics, Inc. Gene therapy for the regeneration of chondrocytes or cartilage type cells
MX381665B (es) 2016-01-13 2025-03-13 Genzyme Corp Star Vectores aav recombinantes que expresan genes osteoprotectores, que incluyen has2 y lubricina, de utilidad en el tratamiento de la osteoartritis y afecciones articulares relacionadas en mamiferos.
CN109310734B (zh) * 2016-04-13 2022-06-24 马斯特里赫特大学 骨关节炎的治疗或预防方法
CN110997708A (zh) 2017-04-27 2020-04-10 礼来公司 人bmp7蛋白的变体
CN109496152B (zh) * 2018-05-17 2021-06-18 广州蓝亮医药科技有限公司 癸氧喹酯组合物的肌肉内库存及其预防和治疗的方法
CN112168793A (zh) * 2020-10-26 2021-01-05 辰欣药业股份有限公司 一种盐酸氨溴索口腔崩解片及其制备方法
EP4333903A4 (en) * 2021-05-03 2025-03-19 North Carolina State University COMPOSITIONS AND METHODS RELATED TO THE TREATMENT OF OPHTHALMIC DISEASES IN HORSES

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US6159464A (en) * 1990-12-20 2000-12-12 University Of Pittsburgh Of The Commonwealth System Of Higher Education Viral vectors to inhibit leukocyte infiltration or cartilage degradation of joints
AU2002311777A1 (en) * 2001-04-17 2002-10-28 Genetix Pharmaceuticals, Inc. Method of treating arthritis using lentiviral vectors in gene therapy
US20040167088A1 (en) * 2003-02-25 2004-08-26 Genvec, Inc. Method of using adenoviral vectors with increased persistence in vivo
US20040223953A1 (en) * 2003-03-17 2004-11-11 Hsiang-Fu Kung Combined adeno-associated virus and adenovirus cocktail gene delivery system for high efficiency gene expression without eliciting immune response in immuno-competent subjects
WO2005007098A2 (en) * 2003-07-08 2005-01-27 New York University Nucleic acid therapy to enhance cartilage repair
EP1660663A4 (en) * 2003-08-12 2007-07-11 Brigham & Womens Hospital METHOD AND COMPOSITIONS FOR TISSUE REPAIR
EP1951751B1 (en) 2005-11-14 2017-11-01 Merial, Inc. Gene therapy for renal failure
ATE543833T1 (de) * 2005-12-22 2012-02-15 Janssen Biotech Inc Bmp-7-varianten-zusammensetzungen, verfahren und verwendungen

Also Published As

Publication number Publication date
US20090093427A1 (en) 2009-04-09
US7846428B2 (en) 2010-12-07
WO2009046464A1 (en) 2009-04-09
WO2009046464A8 (en) 2012-04-26
BRPI0817753A2 (pt) 2015-03-24
EP2205743A1 (en) 2010-07-14
JP2012505151A (ja) 2012-03-01
CN102027114A (zh) 2011-04-20
CA2701215A1 (en) 2009-04-09
CA2701215C (en) 2016-05-17
EP2205743B1 (en) 2017-07-19

Similar Documents

Publication Publication Date Title
WO2009046464A8 (en) Articular cartilage gene therapy with recombinant vector encoding bmp-7
JOP20190083A1 (ar) بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها
CY1123760T1 (el) Ανασυνδυασμενοι φορεις aav που εκφραζουν οστεοπροστατευτικα γονιδια, που περιλαμβανουν has2 και λουμπρικινη, χρησιμοι στην θεραπευτικη αγωγη οστεοαρθριτιδας και συναφων παθησεων των αρθρωσεων στα θηλαστικα
BR112017007765A2 (pt) composições de adenosina deaminase-2 (ada2), variantes do mesmo e métodos de usar o mesmo
BR112019005587A2 (pt) proteínas de ligação recombinantes e sua utilização
EA201171220A1 (ru) Мутанты fgf21 и их применение
BR112012013868A8 (pt) composição, proteína de fusão, polinucleotídeo, vetor ou constructo de gene, célula hospedeira , composição farmacêutica, método in vitro e uso de uma composição.
EA201170878A1 (ru) Полипептиды с ксиланазной активностью
BR112012029067A2 (pt) grupos-alvo de receptor do complemento 2 (cr2) melhorados.
MX387164B (es) Proteínas de fusión actriib-fc truncadas.
MX2009004243A (es) Nuevas proteinas h5, moleculas de acido nucleico y vectores que las codifican y su uso medicinal.
EP2550359A4 (en) VECTORS FOR THE CONDITIONAL EXPRESSION OF THERAPEUTIC PROTEINS, HOST CELLS WITH THESE VECTORS, AND USES THEREOF
BRPI0508068A (pt) moléculas de ácido nucléico isoladas, vetor compreendendo as mesmas, polipeptìdeos isolados e composições compreendendo os mesmos
BR112022010882A2 (pt) Oligômeros antissenso para tratamento de condições e doenças
WO2008061011A3 (en) Intra-vascular kidney gene therapy with plasmid encoding bmp-7
BRPI0906997A2 (pt) Proteína, uso da proteína combinante ou fragmento da mesma, método para induzir uma resposta imune em um individuo, método para tratar um paceinte, construção de ácido nicleico, vetor de ezpressão o ucélula hospedeira, vacina, anticorpo, e, composição farmaceutica
MX340231B (es) Enzimas fluidas incubadas y usos de las mismas.
BR112015011697A2 (pt) antibióticos macrocíclicos de amplo espectro
EP2898923A3 (en) Isoflavones for regulating sirtuin gene expression
BR112016011091A2 (pt) sequência de endolisina kz144 modificada
BRPI0515604A (pt) método para o tratamento de células de cáncer e método de tratamento de uma doença imune relacionada
EA201890856A1 (ru) Улучшенные транспортные молекулы модулярного антигена и их применение у животных
BRPI0923854A2 (pt) Métodos para tratar ou prevenir osteoartrite em um animal de estimação e uma condição degenerativa de articulação em um animal de estimação, para modular degradação enzimática de cartilagem articular em um animal de estimação, e para diminuir a liberação de glicosaminoglicano do tecido de cartilagem de um animal de estimação.
BRPI0506689A (pt) composições compreendendo memantina e polìmeros polianiÈnicos para administração ao olho
WO2010065536A3 (en) Recombinant bone marrow stromal antigen-2 in the treatment of autoimmune diseases

Legal Events

Date Code Title Description
B15I Others concerning applications: loss of priority

Free format text: PERDA DA PRIORIDADE US 11/867,919 DE 05/10/2007 REIVINDICADA NO PCT/US2008/079090, CONFORME AS DISPOSICOES PREVISTAS NA LEI 9.279 DE 14/05/1996 (LPI) ART. 16 7O, DECRETO NO. 635 DE 21/08/1992 E CONVENCAO DA UNIAO DE PARIS (REVISTA EM ESTOCOLMO 14/07/1967), ART. 4O, ALINEA C, ITEM 1. ESTA PERDA SE DEU PELO FATO DO BRASIL NAO ACEITAR RESTAURACAO DE PRIORIDADE (RESERVA DO BRASIL DE ACORDO COM A REGRA 49TER.1 ALINEA (G) E 49TER.2 ALINEA (H) DO REGULAMENTO DE EXECUCAO DO PCT), RESTAURACAO ESTA QUE FOI CONCEDIDA PELA OMPI, JA QUE O PRAZO PARA O DEPOSITO INTERNACIONAL COM REIVINDICACAO DE PRIORIDADE ULTRAPASSOU OS 12 MESES.

B25C Requirement related to requested transfer of rights

Owner name: MERIAL LIMITED (GB)

B25A Requested transfer of rights approved

Owner name: MERIAL, INC (US)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL