CA2701215C - Articular cartilage gene therapy with recombinant vector encoding bmp-7 - Google Patents
Articular cartilage gene therapy with recombinant vector encoding bmp-7 Download PDFInfo
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- CA2701215C CA2701215C CA2701215A CA2701215A CA2701215C CA 2701215 C CA2701215 C CA 2701215C CA 2701215 A CA2701215 A CA 2701215A CA 2701215 A CA2701215 A CA 2701215A CA 2701215 C CA2701215 C CA 2701215C
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/10—Animals modified by protein administration, for non-therapeutic purpose
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/102—Caprine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
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- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/867,919 | 2007-10-05 | ||
| US11/867,919 US7846428B2 (en) | 2007-10-05 | 2007-10-05 | Articular cartilage gene therapy with recombinant vector encoding BMP-7 |
| PCT/US2008/079090 WO2009046464A1 (en) | 2007-10-05 | 2008-10-07 | Articular cartilage gene therapy with recombinant vector encoding bmp-7 |
Publications (2)
| Publication Number | Publication Date |
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| CA2701215A1 CA2701215A1 (en) | 2009-04-09 |
| CA2701215C true CA2701215C (en) | 2016-05-17 |
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| Application Number | Title | Priority Date | Filing Date |
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| CA2701215A Expired - Fee Related CA2701215C (en) | 2007-10-05 | 2008-10-07 | Articular cartilage gene therapy with recombinant vector encoding bmp-7 |
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| Country | Link |
|---|---|
| US (1) | US7846428B2 (enExample) |
| EP (1) | EP2205743B1 (enExample) |
| JP (1) | JP2012505151A (enExample) |
| CN (1) | CN102027114A (enExample) |
| BR (1) | BRPI0817753A8 (enExample) |
| CA (1) | CA2701215C (enExample) |
| WO (1) | WO2009046464A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2784861A1 (en) * | 2009-12-21 | 2011-07-14 | Pharmathene, Inc. | Recombinant butyrylcholinesterases and truncates thereof |
| RU2516951C1 (ru) * | 2013-03-01 | 2014-05-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Мордовский государственный университет им. Н.П. Огарёва" | Способ профилактики посттравматического артроза коленного сустава |
| SI3021873T1 (sl) * | 2013-07-18 | 2018-12-31 | Xalud Therapeutics, Inc. | Sestavek za zdravljenje vnetne sklepne bolezni |
| EP4786600A2 (en) * | 2013-09-09 | 2026-08-05 | FibroBiologics, Inc. | Gene therapy for the regeneration of chondrocytes or cartilage type cells |
| MX381665B (es) | 2016-01-13 | 2025-03-13 | Genzyme Corp Star | Vectores aav recombinantes que expresan genes osteoprotectores, que incluyen has2 y lubricina, de utilidad en el tratamiento de la osteoartritis y afecciones articulares relacionadas en mamiferos. |
| CN109310734B (zh) * | 2016-04-13 | 2022-06-24 | 马斯特里赫特大学 | 骨关节炎的治疗或预防方法 |
| CN110997708A (zh) | 2017-04-27 | 2020-04-10 | 礼来公司 | 人bmp7蛋白的变体 |
| CN109496152B (zh) * | 2018-05-17 | 2021-06-18 | 广州蓝亮医药科技有限公司 | 癸氧喹酯组合物的肌肉内库存及其预防和治疗的方法 |
| CN112168793A (zh) * | 2020-10-26 | 2021-01-05 | 辰欣药业股份有限公司 | 一种盐酸氨溴索口腔崩解片及其制备方法 |
| EP4333903A4 (en) * | 2021-05-03 | 2025-03-19 | North Carolina State University | COMPOSITIONS AND METHODS RELATED TO THE TREATMENT OF OPHTHALMIC DISEASES IN HORSES |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5266683A (en) * | 1988-04-08 | 1993-11-30 | Stryker Corporation | Osteogenic proteins |
| US6159464A (en) * | 1990-12-20 | 2000-12-12 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Viral vectors to inhibit leukocyte infiltration or cartilage degradation of joints |
| AU2002311777A1 (en) * | 2001-04-17 | 2002-10-28 | Genetix Pharmaceuticals, Inc. | Method of treating arthritis using lentiviral vectors in gene therapy |
| US20040167088A1 (en) * | 2003-02-25 | 2004-08-26 | Genvec, Inc. | Method of using adenoviral vectors with increased persistence in vivo |
| US20040223953A1 (en) * | 2003-03-17 | 2004-11-11 | Hsiang-Fu Kung | Combined adeno-associated virus and adenovirus cocktail gene delivery system for high efficiency gene expression without eliciting immune response in immuno-competent subjects |
| WO2005007098A2 (en) * | 2003-07-08 | 2005-01-27 | New York University | Nucleic acid therapy to enhance cartilage repair |
| EP1660663A4 (en) * | 2003-08-12 | 2007-07-11 | Brigham & Womens Hospital | METHOD AND COMPOSITIONS FOR TISSUE REPAIR |
| EP1951751B1 (en) | 2005-11-14 | 2017-11-01 | Merial, Inc. | Gene therapy for renal failure |
| ATE543833T1 (de) * | 2005-12-22 | 2012-02-15 | Janssen Biotech Inc | Bmp-7-varianten-zusammensetzungen, verfahren und verwendungen |
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2008
- 2008-10-07 CN CN2008801158299A patent/CN102027114A/zh active Pending
- 2008-10-07 WO PCT/US2008/079090 patent/WO2009046464A1/en not_active Ceased
- 2008-10-07 CA CA2701215A patent/CA2701215C/en not_active Expired - Fee Related
- 2008-10-07 JP JP2010528222A patent/JP2012505151A/ja active Pending
- 2008-10-07 BR BRPI0817753A patent/BRPI0817753A8/pt not_active Application Discontinuation
- 2008-10-07 EP EP08836475.7A patent/EP2205743B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0817753A8 (pt) | 2017-09-26 |
| US20090093427A1 (en) | 2009-04-09 |
| US7846428B2 (en) | 2010-12-07 |
| WO2009046464A1 (en) | 2009-04-09 |
| WO2009046464A8 (en) | 2012-04-26 |
| BRPI0817753A2 (pt) | 2015-03-24 |
| EP2205743A1 (en) | 2010-07-14 |
| JP2012505151A (ja) | 2012-03-01 |
| CN102027114A (zh) | 2011-04-20 |
| CA2701215A1 (en) | 2009-04-09 |
| EP2205743B1 (en) | 2017-07-19 |
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| MKLA | Lapsed |
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