JP2012504631A - 選択的プロトン共役葉酸トランスポーターおよび葉酸受容体、ならびにｇａｒｆｔアーゼインヒビター化合物、ならびにそれらの使用方法 - Google Patents
選択的プロトン共役葉酸トランスポーターおよび葉酸受容体、ならびにｇａｒｆｔアーゼインヒビター化合物、ならびにそれらの使用方法 Download PDFInfo
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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Landscapes
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- Nitrogen Condensed Heterocyclic Rings (AREA)
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| US12/242,988 | 2008-10-01 | ||
| US12/242,988 US8252804B2 (en) | 2008-10-01 | 2008-10-01 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same |
| PCT/US2009/058968 WO2010039792A1 (en) | 2008-10-01 | 2009-09-30 | Selective proton coupled folate transporter and folate receptor, and garftase inhibitor compounds and methods of using the same |
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| JP2014182217A Pending JP2014224159A (ja) | 2008-10-01 | 2014-09-08 | 選択的プロトン共役葉酸トランスポーターおよび葉酸受容体、ならびにｇａｒｆｔアーゼインヒビター化合物、ならびにそれらの使用方法 |
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| JP (2) | JP2012504631A (enExample) |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014224159A (ja) * | 2008-10-01 | 2014-12-04 | デュケイン ユニバーシティー オブ ザ ホリー スピリット | 選択的プロトン共役葉酸トランスポーターおよび葉酸受容体、ならびにｇａｒｆｔアーゼインヒビター化合物、ならびにそれらの使用方法 |
| JP2017537107A (ja) * | 2014-12-02 | 2017-12-14 | イーライ リリー アンド カンパニー | １−オキソ−１，２−ジヒドロイソキノリン−７−イル−（５−置換−チオフェン−２−イル）−スルホンアミド化合物、それらの化合物を含む製剤、がん治療におけるａｉｃａｒｆｔ阻害剤としてのそれらの使用 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110082158A1 (en) * | 2008-10-01 | 2011-04-07 | Aleem Gangjee | Selective proton coupled folate transporter and folate receptor, and garftase and/or other folate metabolizing enzymes inhibitor compounds and methods of using the same |
| US9481678B2 (en) * | 2015-02-09 | 2016-11-01 | Duquesne University Of The Holy Ghost | Substituted pyrrolo[2,3-D]dipyrimidines for selectively targeting tumor cells with FR-alpha and FR-beta type receptors |
| CN105111197B (zh) * | 2015-08-26 | 2021-05-04 | 上海鼎雅药物化学科技有限公司 | 雷替曲塞的合成方法 |
| WO2023086821A1 (en) * | 2021-11-11 | 2023-05-19 | Duquesne University Of The Holy Spirit | Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer |
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| JPH03173890A (ja) * | 1989-09-21 | 1991-07-29 | Takeda Chem Ind Ltd | ピロロ［２，３―ｄ］ピリミジン誘導体，その製造法，用途及び中間体 |
| US5248775A (en) * | 1989-12-11 | 1993-09-28 | The Trustees Of Princeton University | Pyrrolo(2,3-d)pyrimidines |
| JPH06172358A (ja) * | 1991-12-27 | 1994-06-21 | Takeda Chem Ind Ltd | 縮合ピリミジン誘導体、その製造法および用途 |
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| JP2000516961A (ja) * | 1996-08-30 | 2000-12-19 | イーライ・リリー・アンド・カンパニー | 非古典的ピロロ［２，３―ｄ］ピリミジン抗葉酸物質 |
| US20080045552A1 (en) * | 2006-06-28 | 2008-02-21 | Duquesne University Of The Holy Ghost | Methods of using selective chemotherapeutic agents for targeting tumor cells |
| WO2008027949A2 (en) * | 2006-09-01 | 2008-03-06 | Duquesne University Of The Holy Spirit | Thieno pyrimidine compounds |
| CN101195625A (zh) * | 2007-12-06 | 2008-06-11 | 上海交通大学 | 用于抗肿瘤药物抗叶酸剂及其盐和中间体 |
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2008
- 2008-10-01 US US12/242,988 patent/US8252804B2/en not_active Expired - Fee Related
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2009
- 2009-09-30 JP JP2011530162A patent/JP2012504631A/ja not_active Withdrawn
- 2009-09-30 WO PCT/US2009/058968 patent/WO2010039792A1/en not_active Ceased
- 2009-09-30 EP EP09818418.7A patent/EP2348843B1/en not_active Not-in-force
- 2009-09-30 EP EP15187759.4A patent/EP2995199B1/en not_active Not-in-force
- 2009-09-30 CA CA2993404A patent/CA2993404C/en not_active Expired - Fee Related
- 2009-09-30 CA CA2739250A patent/CA2739250C/en not_active Expired - Fee Related
-
2012
- 2012-07-26 US US13/558,873 patent/US9511069B2/en not_active Expired - Fee Related
-
2014
- 2014-09-08 JP JP2014182217A patent/JP2014224159A/ja active Pending
-
2016
- 2016-11-03 US US15/342,359 patent/US10000498B2/en active Active
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2018
- 2018-06-06 US US16/000,954 patent/US10611767B2/en not_active Expired - Fee Related
-
2020
- 2020-02-26 US US16/801,943 patent/US11053252B2/en not_active Expired - Fee Related
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| JPH03173890A (ja) * | 1989-09-21 | 1991-07-29 | Takeda Chem Ind Ltd | ピロロ［２，３―ｄ］ピリミジン誘導体，その製造法，用途及び中間体 |
| US5028608A (en) * | 1989-12-11 | 1991-07-02 | The Trustees Of Princeton University | N-(6-Amino-(pyrrolo(2,3-d)pyrimidin-3-ylacyl) )-glutamic acid derivatives |
| US5248775A (en) * | 1989-12-11 | 1993-09-28 | The Trustees Of Princeton University | Pyrrolo(2,3-d)pyrimidines |
| JPH06172358A (ja) * | 1991-12-27 | 1994-06-21 | Takeda Chem Ind Ltd | 縮合ピリミジン誘導体、その製造法および用途 |
| JPH10503762A (ja) * | 1994-07-28 | 1998-04-07 | アグーロン ファーマシューティカルズ，インコーポレーテッド | 抗増殖剤およびｇａｒｆｔ阻害剤として有用な化合物 |
| JP2000516961A (ja) * | 1996-08-30 | 2000-12-19 | イーライ・リリー・アンド・カンパニー | 非古典的ピロロ［２，３―ｄ］ピリミジン抗葉酸物質 |
| US20080045552A1 (en) * | 2006-06-28 | 2008-02-21 | Duquesne University Of The Holy Ghost | Methods of using selective chemotherapeutic agents for targeting tumor cells |
| WO2008027949A2 (en) * | 2006-09-01 | 2008-03-06 | Duquesne University Of The Holy Spirit | Thieno pyrimidine compounds |
| CN101195625A (zh) * | 2007-12-06 | 2008-06-11 | 上海交通大学 | 用于抗肿瘤药物抗叶酸剂及其盐和中间体 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014224159A (ja) * | 2008-10-01 | 2014-12-04 | デュケイン ユニバーシティー オブ ザ ホリー スピリット | 選択的プロトン共役葉酸トランスポーターおよび葉酸受容体、ならびにｇａｒｆｔアーゼインヒビター化合物、ならびにそれらの使用方法 |
| JP2017537107A (ja) * | 2014-12-02 | 2017-12-14 | イーライ リリー アンド カンパニー | １−オキソ−１，２−ジヒドロイソキノリン−７−イル−（５−置換−チオフェン−２−イル）−スルホンアミド化合物、それらの化合物を含む製剤、がん治療におけるａｉｃａｒｆｔ阻害剤としてのそれらの使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010039792A1 (en) | 2010-04-08 |
| US10000498B2 (en) | 2018-06-19 |
| CA2993404C (en) | 2020-07-07 |
| EP2348843A4 (en) | 2012-08-08 |
| US20180346474A1 (en) | 2018-12-06 |
| CA2993404A1 (en) | 2010-04-08 |
| CA2739250C (en) | 2018-03-20 |
| US10611767B2 (en) | 2020-04-07 |
| US20200190097A1 (en) | 2020-06-18 |
| US20100081676A1 (en) | 2010-04-01 |
| US20120295926A1 (en) | 2012-11-22 |
| EP2348843A1 (en) | 2011-08-03 |
| CA2739250A1 (en) | 2010-04-08 |
| EP2995199A1 (en) | 2016-03-16 |
| EP2348843B1 (en) | 2015-11-11 |
| US20170114066A1 (en) | 2017-04-27 |
| JP2014224159A (ja) | 2014-12-04 |
| US8252804B2 (en) | 2012-08-28 |
| US11053252B2 (en) | 2021-07-06 |
| US9511069B2 (en) | 2016-12-06 |
| EP2995199B1 (en) | 2018-03-14 |
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