JP2012503478A5 - - Google Patents
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- Publication number
- JP2012503478A5 JP2012503478A5 JP2011528171A JP2011528171A JP2012503478A5 JP 2012503478 A5 JP2012503478 A5 JP 2012503478A5 JP 2011528171 A JP2011528171 A JP 2011528171A JP 2011528171 A JP2011528171 A JP 2011528171A JP 2012503478 A5 JP2012503478 A5 JP 2012503478A5
- Authority
- JP
- Japan
- Prior art keywords
- modified
- nucleic acid
- genetically engineered
- engineered strain
- polyketide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 230000001851 biosynthetic Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 150000003881 polyketide derivatives Chemical class 0.000 claims 2
- 229930001119 polyketides Natural products 0.000 claims 2
- OZAIFHULBGXAKX-UHFFFAOYSA-N precursor Substances N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 claims 2
- 101700008515 sfaA Proteins 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- LXZHHFFYSBIHSF-AYNMCBCYSA-N Sanglifehrin A Chemical compound N1C(=O)C(CC)CC(C)C21C(C)=CC(C)C(CC(O)C(C)CC\C=C\C=C(/C)C1OC(=O)C3CCCN(N3)C(=O)C(CC=3C=C(O)C=CC=3)NC(=O)C(C(C)C)NC(=O)C(CCC(C)=O)C(O)C(C)C(O)/C=C/C=C/C1)O2 LXZHHFFYSBIHSF-AYNMCBCYSA-N 0.000 claims 1
- 229920003013 deoxyribonucleic acid Polymers 0.000 claims 1
- 230000000977 initiatory Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001105 regulatory Effects 0.000 claims 1
Claims (5)
- 配列番号1の配列に基づいたハイブリッドポリケチド生成遺伝子クラスター核酸であって、sfaAが、さらに任意に、sfaB、J、M、N、P、Q、L、およびOから選択される1つ以上の他の開始単位もしくは前駆体生合成遺伝子が、欠失され、またはその活性を低下させるよう修飾され、またはその基質特異性を変化させるよう修飾もしくは置換されている、前記ハイブリッドポリケチド生成遺伝子クラスター核酸。
- 請求項１記載の核酸を1つ以上のプロモーターまたは他の調節エレメントとともに含むベクターであって、前記核酸がDNAである、前記ベクター。
- 請求項２記載のベクターを用いて形質転換された宿主細胞。
- サングリフェリンA産生株に基づいた遺伝子操作された株であって、sfaAが、さらに任意に、sfaB、J、M、N、P、Q、L、およびOから選択される1つ以上の他の開始単位または前駆体生合成遺伝子が、欠失され、またはその活性を低下させるよう修飾され、またはその基質特異性を変化させるよう修飾もしくは置換されている、前記遺伝子操作された株。
- 請求項３または４記載の形質転換された宿主細胞または遺伝子操作された株を培養することを含む、ポリケチドを製造する方法。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810200388.4 | 2008-09-24 | ||
| CN200810200388 | 2008-09-24 | ||
| PCT/CN2009/074178 WO2010034243A1 (en) | 2008-09-24 | 2009-09-24 | Novel gene cluster |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012503478A JP2012503478A (ja) | 2012-02-09 |
| JP2012503478A5 true JP2012503478A5 (ja) | 2012-11-08 |
| JP5789190B2 JP5789190B2 (ja) | 2015-10-07 |
Family
ID=42059282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011528171A Active JP5789190B2 (ja) | 2008-09-24 | 2009-09-24 | 新規の遺伝子クラスター |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8962329B2 (ja) |
| EP (1) | EP2342335B1 (ja) |
| JP (1) | JP5789190B2 (ja) |
| CN (1) | CN102224242B (ja) |
| ES (1) | ES2556211T3 (ja) |
| WO (1) | WO2010034243A1 (ja) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011098805A1 (en) | 2010-02-09 | 2011-08-18 | Biotica Technology Limited | Sanglifehrin based compounds |
| JP5894935B2 (ja) | 2010-02-09 | 2016-03-30 | ニューロヴィベ プハルマセウトイカル エービー | サングリフェリン系化合物 |
| WO2011098808A1 (en) | 2010-02-09 | 2011-08-18 | Biotica Technology Limited | Sanglifehrin based compounds |
| WO2012085553A1 (en) | 2010-12-20 | 2012-06-28 | Biotica Technology Limited | Sanglifehrin derivatives and methods for their production |
| US9428845B1 (en) | 2010-12-28 | 2016-08-30 | Warp Drive Bio, Inc. | Identifying new therapeutic agents |
| JO3063B1 (ar) | 2011-03-29 | 2017-03-15 | Neurovive Pharmaceutical Ab | مركب مبتكر وطرق لانتاجه |
| GB201118334D0 (en) | 2011-10-24 | 2011-12-07 | Biotica Tech Ltd | Novel dosage form |
| CN104263738A (zh) * | 2014-09-15 | 2015-01-07 | 武汉大学 | Fas ii抑制剂abx的生物合成基因簇 |
| US10533016B2 (en) | 2015-01-09 | 2020-01-14 | Revolution Medicines, Inc. | Compounds that participate in cooperative binding and uses thereof |
| TW201629069A (zh) | 2015-01-09 | 2016-08-16 | 霍普驅動生物科技股份有限公司 | 參與協同結合之化合物及其用途 |
| US9989535B2 (en) | 2015-10-01 | 2018-06-05 | Warp Drive Bio, Inc. | Methods and reagents for analyzing protein-protein interfaces |
| CN106916834B (zh) * | 2015-12-24 | 2022-08-05 | 武汉合生科技有限公司 | 化合物的生物合成基因簇及其应用 |
| EP4085933A3 (en) | 2016-04-12 | 2023-01-11 | Ginkgo Bioworks, Inc. | Compositions and methods for the production of compounds |
| AU2017350900A1 (en) | 2016-10-28 | 2019-06-13 | Ginkgo Bioworks, Inc. | Compositions and methods for the production of compounds |
| CN109943545B (zh) * | 2019-03-29 | 2021-08-03 | 浙江大学 | 一种酰基转移酶结构域定向改造合成化合物的方法 |
| TW202132316A (zh) | 2019-11-04 | 2021-09-01 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| WO2021091967A1 (en) | 2019-11-04 | 2021-05-14 | Revolution Medicines, Inc. | Ras inhibitors |
| KR20220109407A (ko) | 2019-11-04 | 2022-08-04 | 레볼루션 메디슨즈, 인크. | Ras 억제제 |
| CA3194067A1 (en) | 2020-09-15 | 2022-03-24 | Revolution Medicines, Inc. | Ras inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE206164T1 (de) * | 1993-09-20 | 2001-10-15 | Univ Leland Stanford Junior | Rekombinante herstellung von neuen polyketiden |
| AR006514A1 (es) * | 1995-07-04 | 1999-09-08 | Sandoz Ag | Un macrolido, sus usos, un proceso para producirlo, un aislado biologicamente puro capaz de producirlo, y una composicion farmaceutica quelo comprende |
| US6124453A (en) | 1995-07-04 | 2000-09-26 | Novartis Ag | Macrolides |
| SK182498A3 (en) | 1996-07-05 | 2000-05-16 | Biotica Tech Ltd | Erythromycins and process for their preparation |
| US6265202B1 (en) | 1998-06-26 | 2001-07-24 | Regents Of The University Of Minnesota | DNA encoding methymycin and pikromycin |
| GB9814622D0 (en) | 1998-07-06 | 1998-09-02 | Biotica Tech Ltd | Polyketides,their preparation,and materials for use therein |
| AU2001248588B2 (en) | 2000-04-13 | 2006-02-02 | Biotica Technology Limited | Hybrid glycosylated products and their production and use |
| ES2544624T3 (es) | 2002-07-16 | 2015-09-02 | Buck Institute For Research On Aging | Producción de policétidos |
| GB0230217D0 (en) | 2002-12-27 | 2003-02-05 | Biotica Tech Ltd | Borrelidin-producing polyketide synthase and its uses |
| GB0327720D0 (en) | 2003-11-28 | 2003-12-31 | Biotica Tech Ltd | Erythromycins and process for their preparation |
| GB0327721D0 (en) | 2003-11-28 | 2003-12-31 | Biotica Tech Ltd | Polyketides and their synthesis |
| AR054778A1 (es) | 2005-06-17 | 2007-07-18 | Novartis Ag | Uso de sangliferina en hcv |
-
2009
- 2009-09-24 WO PCT/CN2009/074178 patent/WO2010034243A1/en active Application Filing
- 2009-09-24 CN CN200980146616.7A patent/CN102224242B/zh active Active
- 2009-09-24 US US13/119,868 patent/US8962329B2/en active Active
- 2009-09-24 EP EP09815612.8A patent/EP2342335B1/en active Active
- 2009-09-24 JP JP2011528171A patent/JP5789190B2/ja active Active
- 2009-09-24 ES ES09815612.8T patent/ES2556211T3/es active Active
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