JP2012502954A - 癌治療のための方法および組成物 - Google Patents

癌治療のための方法および組成物 Download PDF

Info

Publication number
JP2012502954A
JP2012502954A JP2011527326A JP2011527326A JP2012502954A JP 2012502954 A JP2012502954 A JP 2012502954A JP 2011527326 A JP2011527326 A JP 2011527326A JP 2011527326 A JP2011527326 A JP 2011527326A JP 2012502954 A JP2012502954 A JP 2012502954A
Authority
JP
Japan
Prior art keywords
acid ceramidase
inhibitor
cancer
chok
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011527326A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012502954A5 (enExample
Inventor
アナ、ラミレス、デ、モリナ
ルーデス、ガルシア、オロス
フアン、カルロス、ラカル、サンフアン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Traslational Cancer Drugs Pharma SL
Original Assignee
Traslational Cancer Drugs Pharma SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Traslational Cancer Drugs Pharma SL filed Critical Traslational Cancer Drugs Pharma SL
Publication of JP2012502954A publication Critical patent/JP2012502954A/ja
Publication of JP2012502954A5 publication Critical patent/JP2012502954A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5752—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the lungs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/978—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • G01N2333/98—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
JP2011527326A 2008-09-17 2009-09-17 癌治療のための方法および組成物 Pending JP2012502954A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08380270.2 2008-09-17
EP08380270 2008-09-17
PCT/EP2009/062078 WO2010031825A2 (en) 2008-09-17 2009-09-17 Methods and compositions for the treatment of cancer

Publications (2)

Publication Number Publication Date
JP2012502954A true JP2012502954A (ja) 2012-02-02
JP2012502954A5 JP2012502954A5 (enExample) 2012-10-25

Family

ID=40364454

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011527326A Pending JP2012502954A (ja) 2008-09-17 2009-09-17 癌治療のための方法および組成物

Country Status (15)

Country Link
US (4) US20100068302A1 (enExample)
EP (1) EP2340042B1 (enExample)
JP (1) JP2012502954A (enExample)
KR (1) KR20110067041A (enExample)
CN (1) CN102215872B (enExample)
AU (1) AU2009294618A1 (enExample)
BR (1) BRPI0919238A2 (enExample)
CA (1) CA2737551A1 (enExample)
DK (1) DK2340042T3 (enExample)
ES (1) ES2527361T3 (enExample)
MX (1) MX2011002956A (enExample)
PL (1) PL2340042T3 (enExample)
PT (1) PT2340042E (enExample)
RU (1) RU2011143520A (enExample)
WO (1) WO2010031825A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021083415A (ja) * 2019-11-29 2021-06-03 株式会社ダイセル エクソソーム産生促進剤

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006007560A2 (en) 2004-07-01 2006-01-19 University Of Pennsylvania Targeted protein replacement for the treatment of lysosomal storage disorders
WO2012051415A2 (en) * 2010-10-13 2012-04-19 Mount Sinai School Of Medicine Inhibitors of acid ceramidase and uses thereof in cancer and other disease treatment therapies
EP2468259A1 (en) * 2010-12-23 2012-06-27 Traslational Cancer Drugs Pharma, S.L. Pharmaceutical compositions of pyridinium and quinolinium derivatives
AU2012274156A1 (en) 2011-06-20 2014-01-23 Traslational Cancer Drugs Pharma, S.L. Method for predicting the clinical response to chemotherapy in a subject with cancer
US10350277B2 (en) 2011-09-07 2019-07-16 Icahn School Of Medicine At Mount Sinai Ceramidase and cell differentiation
ES2786128T3 (es) * 2012-06-01 2020-10-08 Icahn School Med Mount Sinai Niveles de ceramida en el tratamiento y prevención de infecciones
US20150182490A1 (en) 2012-06-26 2015-07-02 Del Mar Pharmaceuticals Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof
WO2014165216A1 (en) * 2013-03-12 2014-10-09 The Trustees Of The University Of Pennsylvania Diagnosing and treating cancer
JP6832158B2 (ja) 2013-03-14 2021-02-24 アイカーン スクール オブ メディシン アット マウント サイナイ 治療用酸性セラミダーゼ組成物ならびにそれを作製および使用する方法
CN105492011A (zh) 2013-04-08 2016-04-13 丹尼斯·M·布朗 不理想给药化学化合物的治疗增效
KR101537030B1 (ko) * 2013-08-23 2015-07-16 (주)바이오디펜스 천적동물의 눈을 포함한 홀로그램을 이용한 농작물 보호방법 및 그 보호기구
WO2015028662A1 (en) 2013-08-30 2015-03-05 Consejo Superior De Investigaciones Cientificas (Csic) Compositions and methods for characterization and amelioration of rheumatoid arthritis
WO2015138638A1 (en) 2014-03-11 2015-09-17 Theraly Pharmaceuticals, Inc. Long acting trail receptor agonists for treatment of autoimmune diseases
US11007251B2 (en) 2015-12-17 2021-05-18 The Johns Hopkins University Ameliorating systemic sclerosis with death receptor agonists
CN109195620B (zh) 2016-04-07 2022-06-28 约翰霍普金斯大学 用死亡受体激动剂治疗胰腺炎和疼痛的组合物和方法
CN107362370B (zh) * 2016-05-13 2022-07-26 国家纳米科学中心 一种基于金纳米簇联合NGF siRNA治疗胰腺癌的方法
CN109744199A (zh) * 2017-11-08 2019-05-14 南京艾莫瑞生物科技有限公司 一种肿瘤细胞异种移植斑马鱼模型、其构建方法及应用
WO2020163374A1 (en) * 2019-02-06 2020-08-13 The Regents Of The University Of California Methods for treating macrophage-mediated diseases, and methods of identifying agents useful therefore
US20220362254A1 (en) * 2019-08-22 2022-11-17 Thomas Jefferson University Methods for reprogramming cancer cells
CN114644626A (zh) * 2020-12-18 2022-06-21 南京施江医药科技有限公司 一种苯环类化合物及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998005644A1 (es) * 1996-08-02 1998-02-12 Universidad De Granada Nuevos compuestos con actividad selectiva antitumoral, antiviral, antiparasitaria y antifungica que bloquean la biosintesis de fosforilcolina mediante inhibicion selectiva de colina quinasa intracelular o su utilizacion como segundo mensajero en proliferacion celular
JP2007517837A (ja) * 2004-01-14 2007-07-05 コンセホ・スペリオール・デ・インベスティガシオネス・シエンティフィカス ピリジニウムおよびキノリニウム誘導体
JP2008535511A (ja) * 2005-04-13 2008-09-04 コンセホ スペリオール デ インベスティガシオネス シエンティフィカス 癌治療化合物のｉｎｖｉｔｒｏにおける同定方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830916A (en) * 1996-05-23 1998-11-03 Duke University Inhibitor of ceramidase
US6511676B1 (en) * 1999-11-05 2003-01-28 Teni Boulikas Therapy for human cancers using cisplatin and other drugs or genes encapsulated into liposomes
GB0121285D0 (en) * 2001-09-03 2001-10-24 Cancer Res Ventures Ltd Anti-cancer combinations
WO2005117916A1 (en) * 2004-06-03 2005-12-15 F. Hoffmann-La Roche Ag Treatment with cisplatin and an egfr-inhibitor
ES2277568B1 (es) * 2005-12-30 2008-04-01 Consejo Superior De Investigaciones Cientificas Derivados de triterpenoquinona y triterpenofenoles y su aplicacion para el tratamiento de tumores y enfermedades parasitarias.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998005644A1 (es) * 1996-08-02 1998-02-12 Universidad De Granada Nuevos compuestos con actividad selectiva antitumoral, antiviral, antiparasitaria y antifungica que bloquean la biosintesis de fosforilcolina mediante inhibicion selectiva de colina quinasa intracelular o su utilizacion como segundo mensajero en proliferacion celular
JP2007517837A (ja) * 2004-01-14 2007-07-05 コンセホ・スペリオール・デ・インベスティガシオネス・シエンティフィカス ピリジニウムおよびキノリニウム誘導体
JP2008535511A (ja) * 2005-04-13 2008-09-04 コンセホ スペリオール デ インベスティガシオネス シエンティフィカス 癌治療化合物のｉｎｖｉｔｒｏにおける同定方法

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
JPN5012001349; ＬＩＵ　ＸＩＡＮＧ: 'ＡＣＩＤ　ＣＥＲＡＭＩＤＡＳＥ　ＩＮＨＩＢＩＴＩＯＮ：　Ａ　ＮＯＶＥＬ　ＴＡＲＧＥＴ　ＦＯＲ　ＣＡＮＣＥＲ　ＴＨＥＲＡＰＹ' ＦＲＯＮＴＩＥＲＳ　ＩＮ　ＢＩＯＳＣＩＥＮＣＥ Ｖ１３, 20080101, Ｐ２２９３-２２９８ *
JPN5012001350; ＺＥＩＤＡＮ　Ｙ　Ｈ: 'ＭＯＬＥＣＵＬＡＲ　ＴＡＲＧＥＴＩＮＧ　ＯＦ　ＡＣＩＤ　ＣＥＲＡＭＩＤＡＳＥ：　ＩＭＰＬＩＣＡＴＩＯＮＳ　ＴＯ　ＣＡＮＣＥＲ　ＴＨＥＲＡＰＹ' ＣＵＲＲＥＮＴ　ＤＲＵＧ　ＴＡＲＧＥＴＳ Ｖ９　Ｎ８, 200808, Ｐ６５３-６６１, ＢＥＮＴＨＡＭ　ＳＣＩＥＮＣＥ　ＰＵＢＬＩＳＨＥＲ *
JPN6013064009; Ｎ．　Ｍｏｒｉ　ｅｔ　ａｌ．: Ｃａｎｃｅｒ　Ｒｅｓｅａｒｃｈ Ｖｏｌ．６７，　Ｎｏ．２３, 2007, ｐ．１１２８４-１１２９０ *
JPN6013064012; Ａ．　Ｍｏｒａｌｅｓ　ｅｔ　ａｌ．: Ｏｎｃｏｇｅｎｅ Ｖｏｌ．２６, 2007, ｐ．９０５-９１６ *
JPN6013064016; Ｓ．　Ｅｌｏｊｅｉｍｙ　ｅｔ　ａｌ．: Ｍｏｌｅｃｕｌａｒ　Ｔｈｅｒａｐｙ Ｖｏｌ．１５，　Ｎｏ．７, 2007 *
JPN6013064019; Ａ．　Ｆ．　Ｓａａｄ　ｅｔ　ａｌ．: Ｃａｎｃｅｒ　Ｂｉｏｌｏｇｙ　＆　Ｔｈｅｒａｐｙ Ｖｏｌ．６，　Ｎｏ．９, 2007, ｐ．１４５５-１４６０ *
JPN6013064023; 片岡之郎ら: 炎症と免疫 Ｖｏｌ．１４，　Ｎｏ．３, 2006 *
JPN6013064026; 矢那瀬紀子ら: 東京医科大学雑誌 Ｖｏｌ．６２，　Ｎｏ．１, 2004, ｐ．９-１７ *
JPN6014047435; Ｊ．　Ｍｅｄ．　Ｃｈｅｍ． ｖｏｌ．４６, 2003, ｐ．３７５４-３７５７ *
JPN6014047436; Ｃａｎｃｅｒ　Ｒｅｓｅａｒｃｈ ｖｏｌ．６１, 2001, ｐ．１２３３-１２４０ *
JPN6014047437; 今日の治療薬（２００３年版） , 2003, ｐ．１４１-１４４ *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021083415A (ja) * 2019-11-29 2021-06-03 株式会社ダイセル エクソソーム産生促進剤
JP7594358B2 (ja) 2019-11-29 2024-12-04 株式会社ダイセル エクソソーム産生促進剤

Also Published As

Publication number Publication date
RU2011143520A (ru) 2013-05-10
EP2340042B1 (en) 2014-07-23
HK1159498A1 (en) 2012-08-03
DK2340042T3 (da) 2014-10-27
EP2340042A2 (en) 2011-07-06
US20150297576A1 (en) 2015-10-22
PL2340042T3 (pl) 2015-01-30
WO2010031825A3 (en) 2010-08-19
KR20110067041A (ko) 2011-06-20
BRPI0919238A2 (pt) 2019-09-24
CA2737551A1 (en) 2010-03-25
CN102215872B (zh) 2015-06-10
WO2010031825A2 (en) 2010-03-25
MX2011002956A (es) 2011-08-03
AU2009294618A2 (en) 2011-04-14
PT2340042E (pt) 2014-11-27
US20110256241A1 (en) 2011-10-20
CN102215872A (zh) 2011-10-12
US20120040021A1 (en) 2012-02-16
AU2009294618A1 (en) 2010-03-25
ES2527361T3 (es) 2015-01-22
US20100068302A1 (en) 2010-03-18

Similar Documents

Publication Publication Date Title
CN102215872B (zh) 用于治疗癌症的方法和组合物
Gandhirajan et al. Small molecule inhibitors of Wnt/β-catenin/lef-1 signaling induces apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo
EP3004396B1 (en) Compositions for the treatment of cancer
JP5919593B2 (ja) 併用療法
US20140030259A1 (en) Methods of treating fgfr3 related conditions
Vermi et al. Ligand-dependent activation of EGFR in follicular dendritic cells sarcoma is sustained by local production of cognate ligands
US20210353721A1 (en) Methods and compositions relating to inhibiting cardiovascular calcification via annexin a1
US20200216906A1 (en) Methods and compositions relating to the diagnosis and treatment of cancer
JP2022028749A (ja) 腫瘍の診断および治療におけるＡｋｔ２の使用
Gao et al. DysUFMylation reprograms immunosuppressive neutrophils to potentiate anti-PD-1 therapy in hepatocellular carcinoma
Yao et al. Novel c-Myc G4 stabilizer EP12 promotes myeloma cytotoxicity by disturbing NF-κB signaling
CA2633715A1 (en) Translational dysfunction based therapeutics
US20250179502A1 (en) Targeting neuropilin 2 (nrp2) in lethal prostate cancer
JP7825883B2 (ja) 膵臓がん及び胆管がんの治療のための医薬用組成物
HK1159498B (en) Methods and compositions for the treatment of cancer
JP2008230977A (ja) ニチジンを成分とする抗癌剤、および該抗癌剤の感受性増強剤
WO2023192969A1 (en) Method for treating clonal hematopoietic blood disorders
Class et al. Patent application title: METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER Inventors: Johnathan R. Whetstine (Winchester, MA, US)
WO2013148202A1 (en) Novel compositions and methods for preventing or treating cancer metastasis
WO2013126368A1 (en) Methods, assays, and systems relating to sakt
WO2005103255A1 (en) Formylpeptide receptor (fpr) as a target for anti-malignant glioma therapy
Class et al. Patent application title: TRANSLATIONAL DYSFUNCTION BASED THERAPEUTICS Inventors: Gordon A. Jamieson, Jr.(Arlington, MA, US) Katherine LB Borden (St. Laurent, CA) Biljana Culjkovic (Montreal, CA) Alex Kentsis (New York, NY, US) Assignees: Translational Therapeutics, Inc.

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120906

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20120906

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140107

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140407

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140414

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140502

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140513

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140609

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140616

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140707

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20141111

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150206

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150511

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20150804