JP2012501646A5 - - Google Patents
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- Publication number
- JP2012501646A5 JP2012501646A5 JP2011526037A JP2011526037A JP2012501646A5 JP 2012501646 A5 JP2012501646 A5 JP 2012501646A5 JP 2011526037 A JP2011526037 A JP 2011526037A JP 2011526037 A JP2011526037 A JP 2011526037A JP 2012501646 A5 JP2012501646 A5 JP 2012501646A5
- Authority
- JP
- Japan
- Prior art keywords
- synaptic vesicle
- platform
- well
- electrode pairs
- vesicle cycling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000002504 synaptic vesicle Anatomy 0.000 claims 5
- 230000001351 cycling effect Effects 0.000 claims 4
- 230000001537 neural effect Effects 0.000 claims 2
- 210000002569 neuron Anatomy 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 1
- 230000005684 electric field Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9436108P | 2008-09-04 | 2008-09-04 | |
| US61/094,361 | 2008-09-04 | ||
| PCT/US2009/004932 WO2010027446A2 (en) | 2008-09-04 | 2009-08-31 | Synaptic vesicle cycling assays and systems |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015151623A Division JP6106225B2 (ja) | 2008-09-04 | 2015-07-31 | シナプス小胞サイクリングアッセイおよびシステム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012501646A JP2012501646A (ja) | 2012-01-26 |
| JP2012501646A5 true JP2012501646A5 (cg-RX-API-DMAC10.html) | 2012-10-18 |
| JP5789513B2 JP5789513B2 (ja) | 2015-10-07 |
Family
ID=41479300
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011526037A Expired - Fee Related JP5789513B2 (ja) | 2008-09-04 | 2009-08-31 | シナプス小胞サイクリングアッセイおよびシステム |
| JP2015151623A Expired - Fee Related JP6106225B2 (ja) | 2008-09-04 | 2015-07-31 | シナプス小胞サイクリングアッセイおよびシステム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015151623A Expired - Fee Related JP6106225B2 (ja) | 2008-09-04 | 2015-07-31 | シナプス小胞サイクリングアッセイおよびシステム |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20120053084A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2329275A2 (cg-RX-API-DMAC10.html) |
| JP (2) | JP5789513B2 (cg-RX-API-DMAC10.html) |
| KR (1) | KR20110073494A (cg-RX-API-DMAC10.html) |
| CN (1) | CN102203622A (cg-RX-API-DMAC10.html) |
| AU (2) | AU2009288657A1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2744804C (cg-RX-API-DMAC10.html) |
| WO (1) | WO2010027446A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011511665A (ja) * | 2008-02-04 | 2011-04-14 | バイエル・ヘルスケア・エルエルシー | 半導体を素材とする分析対象物センサー及び方法 |
| US9217155B2 (en) | 2008-05-28 | 2015-12-22 | University Of Massachusetts | Isolation of novel AAV'S and uses thereof |
| US8734809B2 (en) | 2009-05-28 | 2014-05-27 | University Of Massachusetts | AAV's and uses thereof |
| US9207237B2 (en) | 2010-08-23 | 2015-12-08 | President And Fellows Of Harvard College | Systems, methods, and workflows for optogenetics analysis |
| CA2838330C (en) | 2010-08-23 | 2021-01-26 | President And Fellows Of Harvard College | Optogenetic probes for measuring membrane potential |
| US9488637B2 (en) * | 2011-01-26 | 2016-11-08 | The Curators Of The University Of Missouri | Combination of single-cell electroporation and electrical recording using the same electrode |
| WO2012145624A2 (en) | 2011-04-21 | 2012-10-26 | University Of Massachusetts | Raav-based compositions and methods for treating alpha-1 anti-trypsin deficiencies |
| EP2798391A2 (en) * | 2011-11-23 | 2014-11-05 | President and Fellows of Harvard College | Systems and methods for imaging at high spatial and/or temporal precision |
| US9696275B2 (en) | 2012-10-12 | 2017-07-04 | The Curators Of The University Of Missouri | Addressable electrode arrays in multiple fluidic compartments and uses thereof |
| JP6346096B2 (ja) * | 2012-10-25 | 2018-06-20 | 浜松ホトニクス株式会社 | 細胞観察装置及び細胞観察方法 |
| WO2014065330A1 (ja) | 2012-10-25 | 2014-05-01 | 浜松ホトニクス株式会社 | 細胞観察装置、電気刺激装置、及び細胞観察方法 |
| JP6370544B2 (ja) * | 2013-11-11 | 2018-08-08 | 浜松ホトニクス株式会社 | 細胞観察装置及び細胞観察方法 |
| EP3095853B1 (en) | 2014-01-16 | 2019-01-30 | Hamamatsu Photonics K.K. | Cell observation device, electrostimulation device, and cell observation method |
| WO2015127128A2 (en) | 2014-02-19 | 2015-08-27 | University Of Massachusetts | Recombinant aavs having useful transcytosis properties |
| JP6756700B2 (ja) | 2014-03-18 | 2020-09-16 | ユニバーシティ オブ マサチューセッツ | 筋萎縮性側索硬化症を処置するためのrAAVベースの組成物および方法 |
| CA2946378A1 (en) | 2014-04-22 | 2015-10-29 | Q-State Biosciences, Inc. | Analysis of compounds for pain and sensory disorders |
| WO2015164786A1 (en) | 2014-04-25 | 2015-10-29 | University Of Massachusetts | Recombinant aav vectors useful for reducing immunity against transgene products |
| EP3158338B1 (en) | 2014-06-18 | 2020-03-11 | President and Fellows of Harvard College | Optogenetic probes for measuring membrane potential |
| WO2016033501A1 (en) | 2014-08-28 | 2016-03-03 | Robert John Petcavich | Method of fabricating cell arrays and uses thereof |
| US10370432B2 (en) | 2014-10-03 | 2019-08-06 | University Of Massachusetts | Heterologous targeting peptide grafted AAVS |
| WO2016054557A1 (en) | 2014-10-03 | 2016-04-07 | University Of Massachusetts | Novel high efficiency library-identified aav vectors |
| WO2016065001A1 (en) | 2014-10-21 | 2016-04-28 | University Of Massachusetts | Recombinant aav variants and uses thereof |
| WO2016115333A1 (en) | 2015-01-15 | 2016-07-21 | President And Fellows Of Harvard College | Optical selection of cells |
| EP3256170B1 (en) | 2015-02-13 | 2020-09-23 | University of Massachusetts | Compositions and methods for transient delivery of nucleases |
| US10048275B2 (en) | 2015-03-13 | 2018-08-14 | Q-State Biosciences, Inc. | Cardiotoxicity screening methods |
| EP3285788B1 (en) * | 2015-04-23 | 2024-12-18 | University of Massachusetts | Modulation of aav vector transgene expression |
| US11046955B2 (en) | 2015-04-24 | 2021-06-29 | University Of Massachusetts | Modified AAV constructs and uses thereof |
| US11248212B2 (en) | 2015-06-30 | 2022-02-15 | StemoniX Inc. | Surface energy directed cell self assembly |
| WO2017066663A1 (en) | 2015-10-15 | 2017-04-20 | Carromeu Cassiano | Method of manufacturing cells using a hollow fiber bioreactor |
| WO2017070516A1 (en) | 2015-10-22 | 2017-04-27 | University Of Massachusetts | Prostate-targeting adeno-associated virus serotype vectors |
| EP3364997B1 (en) | 2015-10-22 | 2024-01-17 | University of Massachusetts | Aspartoacylase gene therapy in the treatment of canavan disease |
| CA3011939A1 (en) | 2016-02-02 | 2017-08-10 | University Of Massachusetts | Method to enhance the efficiency of systemic aav gene delivery to the central nervous system |
| CA3012344A1 (en) | 2016-02-12 | 2017-08-17 | University Of Massachusetts | Anti-angiogenic mirna therapeutics for inhibiting corneal neovascularization |
| EP3225279B1 (en) * | 2016-03-31 | 2023-12-20 | Université de Rennes | Brain tissue stimulation apparatus and computer program |
| EP3440210A4 (en) | 2016-04-05 | 2019-11-27 | University of Massachusetts | COMPOSITIONS AND METHOD FOR SELECTIVELY INHIBITING THE EXPRESSION OF GRAINYHEAD LIKE PROTEIN |
| US11413356B2 (en) | 2016-04-15 | 2022-08-16 | University Of Massachusetts | Methods and compositions for treating metabolic imbalance |
| US11882815B2 (en) | 2016-06-15 | 2024-01-30 | University Of Massachusetts | Recombinant adeno-associated viruses for delivering gene editing molecules to embryonic cells |
| US10457940B2 (en) | 2016-09-22 | 2019-10-29 | University Of Massachusetts | AAV treatment of Huntington's disease |
| KR20190075964A (ko) | 2016-10-13 | 2019-07-01 | 유니버시티 오브 매사추세츠 | Aav 캡시드 설계 |
| AU2018264996A1 (en) | 2017-05-09 | 2019-12-05 | University Of Massachusetts | Methods of treating Amyotrophic Lateral Sclerosis (ALS) |
| CN118006607A (zh) | 2017-09-22 | 2024-05-10 | 马萨诸塞大学 | Sod1双表达载体及其用途 |
| WO2019200286A1 (en) | 2018-04-13 | 2019-10-17 | University Of Massachusetts | Bicistronic aav vectors encoding hexosaminidase alpha and beta-subunits and uses thereof |
| JP7065433B2 (ja) * | 2018-08-14 | 2022-05-12 | 日本電信電話株式会社 | 電極及びその製造方法、並びに積層体 |
| CA3115251A1 (en) | 2018-10-05 | 2020-04-09 | University Of Massachusetts | Raav vectors for the treatment of gm1 and gm2 gangliosidosis |
| IL325928A (en) * | 2019-07-16 | 2026-03-01 | Meso Scale Technologies Llc | Assay apparatuses, methods and reagents |
| EP4271789B1 (en) * | 2020-12-31 | 2026-08-12 | Quiver Holdings Inc. | Plate imager |
| CA3206828A1 (en) | 2020-12-31 | 2022-07-07 | Q-State Biosciences, Inc. | Calibrating and normalizing an imager for optogenetics |
| US12478971B2 (en) | 2020-12-31 | 2025-11-25 | Quiver Holdings Inc. | Optical plate controller and reader |
| JP7900889B2 (ja) | 2020-12-31 | 2026-08-05 | キュー-ステート バイオサイエンシーズ, インコーポレイテッド | 空間撮像およびビームホモジナイザを伴う顕微鏡 |
| JP2024516303A (ja) * | 2021-05-04 | 2024-04-12 | キュー-ステート バイオサイエンシーズ, インコーポレイテッド | 薬物フィンガプリンティング |
| EP4363832A4 (en) | 2021-06-30 | 2025-05-07 | Q-State Biosciences, Inc. | MULTIPLEX OPTICAL STIMULUS AND READOUT PROCESS |
| WO2023210585A1 (ja) * | 2022-04-25 | 2023-11-02 | 株式会社Jiksak Bioengineering | 標的化剤 |
| AU2024364213A1 (en) * | 2023-10-19 | 2026-05-14 | Jiksak Bioengineering, Inc. | Anti-synaptotagmin 2 antibody |
| WO2025089346A1 (ja) * | 2023-10-25 | 2025-05-01 | 株式会社Jiksak Bioengineering | 抗シナプトフィジン抗体 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002520615A (ja) | 1998-07-17 | 2002-07-09 | オーロラ バイオサイエンシズ コーポレーション | イオンチャンネルのための検出器およびスクリーニング装置 |
| US7399599B2 (en) * | 2000-07-10 | 2008-07-15 | Vertex Pharmaceuticals (San Diego) Llc | Ion channel assay methods |
| US7615356B2 (en) * | 2000-07-10 | 2009-11-10 | Vertex Pharmaceuticals (San Diego) Llc | Ion channel assay methods |
| WO2003006103A2 (en) | 2001-07-12 | 2003-01-23 | Merck & Co., Inc. | Electrical field stimulation of eukaryotic cells |
| US7221981B2 (en) * | 2002-03-28 | 2007-05-22 | Northstar Neuroscience, Inc. | Electrode geometries for efficient neural stimulation |
| US20070274923A1 (en) | 2005-01-11 | 2007-11-29 | Philippe Brulet | Non-invasive real-time in vivo bioluminescence imaging of local Ca2+ dynamics in living organisms |
-
2009
- 2009-08-31 CN CN2009801440769A patent/CN102203622A/zh active Pending
- 2009-08-31 KR KR1020117007795A patent/KR20110073494A/ko not_active Ceased
- 2009-08-31 WO PCT/US2009/004932 patent/WO2010027446A2/en not_active Ceased
- 2009-08-31 AU AU2009288657A patent/AU2009288657A1/en not_active Abandoned
- 2009-08-31 JP JP2011526037A patent/JP5789513B2/ja not_active Expired - Fee Related
- 2009-08-31 US US13/062,459 patent/US20120053084A1/en not_active Abandoned
- 2009-08-31 CA CA2744804A patent/CA2744804C/en not_active Expired - Fee Related
- 2009-08-31 EP EP09789240A patent/EP2329275A2/en not_active Withdrawn
-
2015
- 2015-07-31 JP JP2015151623A patent/JP6106225B2/ja not_active Expired - Fee Related
-
2016
- 2016-04-15 AU AU2016202387A patent/AU2016202387A1/en not_active Abandoned
-
2018
- 2018-01-11 US US15/868,200 patent/US20180136198A1/en not_active Abandoned
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