JP2012501349A5 - - Google Patents

Info

Publication number

JP2012501349A5

JP2012501349A5 JP2011525264A JP2011525264A JP2012501349A5 JP 2012501349 A5 JP2012501349 A5 JP 2012501349A5 JP 2011525264 A JP2011525264 A JP 2011525264A JP 2011525264 A JP2011525264 A JP 2011525264A JP 2012501349 A5 JP2012501349 A5 JP 2012501349A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

oritavancin

dose

bacterial infection

pharmaceutically acceptable

Prior art date

2009-08-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 31
• 229960001607 oritavancin Drugs 0.000 claims 16
• VHFGEBVPHAGQPI-MYYQHNLBSA-N oritavancin Chemical compound O([C@@H]1C2=CC=C(C(=C2)Cl)OC=2C=C3C=C(C=2O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O[C@@H]2O[C@@H](C)[C@H](O)[C@@](C)(NCC=4C=CC(=CC=4)C=4C=CC(Cl)=CC=4)C2)OC2=CC=C(C=C2Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]2C(=O)N[C@@H]1C(N[C@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@@H](O)[C@H](C)O1 VHFGEBVPHAGQPI-MYYQHNLBSA-N 0.000 claims 16
• 108010006945 oritavancin Proteins 0.000 claims 16
• 208000035143 Bacterial infection Diseases 0.000 claims 15
• 208000022362 bacterial infectious disease Diseases 0.000 claims 15
• 150000003839 salts Chemical class 0.000 claims 8
• 241000191967 Staphylococcus aureus Species 0.000 claims 7
• 208000015181 infectious disease Diseases 0.000 claims 7
• 238000011282 treatment Methods 0.000 claims 6
• 241000194017 Streptococcus Species 0.000 claims 5
• 108010059993 Vancomycin Proteins 0.000 claims 5
• 239000003937 drug carrier Substances 0.000 claims 5
• 239000000546 pharmaceutical excipient Substances 0.000 claims 5
• 229960003165 vancomycin Drugs 0.000 claims 5
• MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims 5
• MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 claims 5
• 241000894006 Bacteria Species 0.000 claims 4
• 239000000203 mixture Substances 0.000 claims 3
• 230000002265 prevention Effects 0.000 claims 3
• RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims 2
• 230000002458 infectious effect Effects 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 229960003085 meticillin Drugs 0.000 claims 2
• 238000011321 prophylaxis Methods 0.000 claims 2
• 238000002560 therapeutic procedure Methods 0.000 claims 2
• 241000193738 Bacillus anthracis Species 0.000 claims 1
• 241000193163 Clostridioides difficile Species 0.000 claims 1
• 241000193403 Clostridium Species 0.000 claims 1
• 208000035473 Communicable disease Diseases 0.000 claims 1
• 241000194033 Enterococcus Species 0.000 claims 1
• 241000192125 Firmicutes Species 0.000 claims 1
• 241000191963 Staphylococcus epidermidis Species 0.000 claims 1
• 241000191984 Staphylococcus haemolyticus Species 0.000 claims 1
• 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
• 241000193996 Streptococcus pyogenes Species 0.000 claims 1
• 241000193990 Streptococcus sp. 'group B' Species 0.000 claims 1
• 241001468181 Streptococcus sp. 'group C' Species 0.000 claims 1
• 229940065181 bacillus anthracis Drugs 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 230000036470 plasma concentration Effects 0.000 claims 1
• 229940037649 staphylococcus haemolyticus Drugs 0.000 claims 1
• 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
• 238000001356 surgical procedure Methods 0.000 claims 1