JP2012180363A - 皮膚を防護するためのカロチノイド組成物及び方法 - Google Patents
皮膚を防護するためのカロチノイド組成物及び方法 Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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Abstract
【解決手段】トマト抽出物などの天然ソースからのリコペンと、フィトエン、フィトフルエン又はこれらの組み合わせと、を含有し、天然ソースからのリコペンとフィトエン及びフィトフルエンとの組み合わせの重量比が1:1である組成物であり、更にビタミンEをビタミンE対フィトエン及びフィトフルエンとの組み合わせの重量比が1:1で含有する組成物。
【選択図】なし
Description
1.該組成物は、ある一定の高用量では健康上有害でありうる、プロビタミンAカロチノイドを含有しない。従って、本発明は先行技術で述べられている組成物よりも安全であり、健康上の危険性を有さない。
実施例全体を通じて使用するリコペンは、LycoRed(登録商標)による天然リコペンである。
リコペン 4.88mg
フィトエン 0.48mg
フィトフルエン 0.44mg
ビタミンE 1.81mg
製剤II:各々の清涼飲料ボトルは次のものを含有する:
リコペン 4.1mg
フィトエン 2.2mg
フィトフルエン 1.6mg
ビタミンE 3.8mg
製剤III:
リコペン 5.5mg
ビタミンE 2.0mg
3つの処置群は、次のリコペン補助食品を12週間摂取した:
a)第1群−Lyc−O−Mato(登録商標)ソフトゲルカプセル1)(1カプセルを1日2回)
b)第2群−Lyc−O−Guard(商標)飲料2)(250mlボトルを1日2回)
c)第3群−合成リコペン硬カプセル3)(1カプセルを1日2回)
1)カロチノイド分画は、天然リコペン、フィトエン、フィトフルエン及びトコフェロールを含有するトマト抽出物である。2)カロチノイド分画は、フィトエン、フィトフルエン及びトコフェロールを強化した、Lyc−O−Mato(登録商標)と同様のトマト抽出物である。3)カロチノイド分画は、合成リコペン及びトコフェロールを含有する。
Claims (27)
- 天然ソースからのリコペン、及びフィトエン及びフィトフルエンの中から選択される1又はそれ以上のカロチノイド又はそれらの混合物を含有する組成物の有効量を、防護を必要とする被験対象に投与することを含む、太陽からの紫外線(uv)によって引き起こされる損傷から皮膚を防護するための方法。
- 上記組成物がビタミンEをさらに含有する、請求項1に記載の方法。
- 天然ソースのリコペン6%から15%、及びフィトエン及びフィトフルエンの中から選択される1又はそれ以上のカロチノイド又はそれらの混合物0.3%から1.5%を含有するカロチノイド組成物1mgから10mgを投与する、請求項1に記載の方法。
- 上記組成物がビタミンE1.5%から2.5%を含有する、請求項3に記載の方法。
- 約5mgを投与する、請求項3に記載の方法。
- 約5mgを投与する、請求項4に記載の方法。
- 被験対象のカロチノイド血清レベルが0.3μMから1.5μMの範囲内のレベルに達する、請求項1から6のいずれかに記載の方法。
- 被験対象のカロチノイド血清レベルが約1.2μMのレベルに達する、請求項8に記載の方法。
- 投与が、カロチノイド組成物を含有するカプセル、ゲル−カプセル、ペレット剤、ソフトゲルカプセル又は錠剤の形態で行われる、請求項1から8のいずれかに記載の方法。
- 投与が、食品又は飲料による経口投与の形態で行われる、請求項1から8のいずれかに記載の方法。
- 投与を、紫外線への暴露の7日から30日前に開始する、請求項1から11のいずれかに記載の方法。
- 天然ソースのリコペン6%から15%、及びフィトエン及びフィトフルエンの中から選択される1又はそれ以上のカロチノイド又はそれらの混合物0.3%から1.5%を含有するカロチノイド組成物。
- ビタミンE1.5%から2.5%をさらに含有する、請求項12に記載の組成物。
- 天然リコペン約6%、フィトエン0.5%及びフィトフルエン0.5%を含有する、請求項12に記載の組成物。
- 天然リコペン約6%、フィトエン0.5%、フィトフルエン0.5%及びビタミンE2%を含有する、請求項13に記載の組成物。
- 天然リコペン5mgから15mg、及びフィトエン及び/又はフィトフルエンの中から選択される1又はそれ以上のカロチノイド又はそれらの混合物0.5mgから3.5mgを含有する経口投与形態。
- ビタミンE1.5mgから8mgをさらに含有する、請求項16に記載の経口投与形態。
- 天然リコペン5mg、フィトエン0.5mg、フィトフルエン0.45mg及びビタミンE1.8mgを含有する、請求項17に記載の経口投与形態。
- 医薬適合性の佐剤、賦形剤、担体、充填剤、安定剤又は添加物をさらに含有する、請求項16に記載の経口投与形態。
- 皮膚防護組成物の製剤中での、請求項12から15のいずれか一項に記載の組成物の使用。
- 皮膚防護剤としての、請求項12から15のいずれか一項に記載の組成物の使用。
- 紫外線によって引き起こされる損傷に対する皮膚の防護において使用するための、請求項12から15のいずか一項に記載の組成物。
- 請求項12から15のいずれか一項に記載の組成物を含有する食品及び飲料。
- 天然リコペン5mgから15mg、及びフィトエン及びフィトフルエンから成る群より選択される1又はそれ以上のカロチノイド0.5mgから3.5mgを含有する食品又は飲料。
- ビタミンE1.5mgから8mgをさらに含有する、請求項24に記載の食品又は飲料。
- 天然リコペン4.1mg、フィトエン2.2mg、フィトフルエン1.6mg及びビタミンE3.8mgを含有する、請求項25に記載の食品又は飲料。
- 請求項12から15のいずれか一項に記載の組成物を含有する、医薬適合性の経口投与形態。
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EP (1) | EP1443897B1 (ja) |
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DE10349983A1 (de) | 2003-10-24 | 2005-05-25 | Basf Ag | Verfahren zur Herstellung von Phytofluen |
US9579298B2 (en) | 2004-12-02 | 2017-02-28 | Piotr Chomczynski | Antioxidant dietary supplement compositions and methods for maintaining healthy skin |
IL176668A0 (en) * | 2006-07-02 | 2006-10-31 | Ibr Ltd | Colorless carotenoids for skin whitening |
US20080287508A1 (en) * | 2007-05-18 | 2008-11-20 | Intermune, Inc. | Altering pharmacokinetics of pirfenidone therapy |
FR2985064B1 (fr) * | 2011-12-23 | 2016-02-26 | Oreal | Procede pour delivrer un conseil cosmetique |
JP6012415B2 (ja) * | 2012-11-09 | 2016-10-25 | アサヒグループホールディングス株式会社 | 酒酔い軽減剤 |
CN103536506A (zh) * | 2013-10-15 | 2014-01-29 | 倪生标 | 一种防晒乳液 |
CN104188812A (zh) * | 2014-09-02 | 2014-12-10 | 青岛永通电梯工程有限公司 | 一种物理防晒霜 |
CN104323936A (zh) * | 2014-09-30 | 2015-02-04 | 青岛康和食品有限公司 | 一种防晒霜 |
CN108379563A (zh) * | 2018-05-14 | 2018-08-10 | 青岛琛蓝海洋生物工程有限公司 | 一种射线防护组合物及其制备方法 |
CN112789052A (zh) * | 2018-07-23 | 2021-05-11 | 乐康瑞德有限公司 | 用于保护皮肤免受紫外线辐射的番茄红素组合物和方法 |
US20220387344A1 (en) * | 2019-10-10 | 2022-12-08 | Lycored Ltd. | Compositions and methods for inhibiting collagen loss |
GB202109087D0 (en) | 2021-06-24 | 2021-08-11 | Norwegian Univ Sci & Tech Ntnu | Therapeutic methods and devices |
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Also Published As
Publication number | Publication date |
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US20050053559A1 (en) | 2005-03-10 |
RU2004114283A (ru) | 2005-03-20 |
PL209422B1 (pl) | 2011-08-31 |
RU2341252C2 (ru) | 2008-12-20 |
ES2641737T3 (es) | 2017-11-13 |
CN100391433C (zh) | 2008-06-04 |
CA2467056C (en) | 2014-11-04 |
CA2467056A1 (en) | 2003-05-22 |
WO2003041678A1 (en) | 2003-05-22 |
IL161704A0 (en) | 2004-09-27 |
US10420715B2 (en) | 2019-09-24 |
IL146496A0 (en) | 2002-07-25 |
KR20050043788A (ko) | 2005-05-11 |
IL161704A (en) | 2015-11-30 |
EP1443897B1 (en) | 2017-07-12 |
ZA200403529B (en) | 2005-01-12 |
AU2002363613B2 (en) | 2007-08-02 |
JP2005515179A (ja) | 2005-05-26 |
BR0214197A (pt) | 2004-08-31 |
CN1585629A (zh) | 2005-02-23 |
JP6125760B2 (ja) | 2017-05-10 |
US20090176872A1 (en) | 2009-07-09 |
NO20041803L (no) | 2004-08-06 |
PL368855A1 (en) | 2005-04-04 |
EP1443897A1 (en) | 2004-08-11 |
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