JP2012180361A5 - - Google Patents
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- Publication number
- JP2012180361A5 JP2012180361A5 JP2012104611A JP2012104611A JP2012180361A5 JP 2012180361 A5 JP2012180361 A5 JP 2012180361A5 JP 2012104611 A JP2012104611 A JP 2012104611A JP 2012104611 A JP2012104611 A JP 2012104611A JP 2012180361 A5 JP2012180361 A5 JP 2012180361A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound
- cycloalkyl
- virus
- therapeutic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 150000001875 compounds Chemical class 0.000 claims 8
- 241000124008 Mammalia Species 0.000 claims 6
- 241000700605 Viruses Species 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims 4
- -1 2-aminopurin-9-yl Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- HBOMLICNUCNMMY-UHFFFAOYSA-N 1-[4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound O=C1NC(=O)C(C)=CN1C1OC(CO)C(N=[N+]=[N-])C1 HBOMLICNUCNMMY-UHFFFAOYSA-N 0.000 claims 1
- BXZVVICBKDXVGW-NKWVEPMBSA-N Didanosine Chemical compound O1[C@H](CO)CC[C@@H]1N1C(NC=NC2=O)=C2N=C1 BXZVVICBKDXVGW-NKWVEPMBSA-N 0.000 claims 1
- 241000701024 Human betaherpesvirus 5 Species 0.000 claims 1
- 241000700584 Simplexvirus Species 0.000 claims 1
- WREGKURFCTUGRC-POYBYMJQSA-N Zalcitabine Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](CO)CC1 WREGKURFCTUGRC-POYBYMJQSA-N 0.000 claims 1
- 229960004150 aciclovir Drugs 0.000 claims 1
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960002963 ganciclovir Drugs 0.000 claims 1
- IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36449502P | 2002-03-15 | 2002-03-15 | |
| US60/364,495 | 2002-03-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004521423A Division JP5420135B2 (ja) | 2002-03-15 | 2003-03-13 | 抗ウイルス薬としての新規２−アミノ−９−［（２−ヒドロキシメチル）シクロプロピリデンメチル］プリン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012180361A JP2012180361A (ja) | 2012-09-20 |
| JP2012180361A5 true JP2012180361A5 (OSRAM) | 2013-11-07 |
Family
ID=30115469
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004521423A Expired - Fee Related JP5420135B2 (ja) | 2002-03-15 | 2003-03-13 | 抗ウイルス薬としての新規２−アミノ−９−［（２−ヒドロキシメチル）シクロプロピリデンメチル］プリン |
| JP2012104611A Ceased JP2012180361A (ja) | 2002-03-15 | 2012-05-01 | 抗ウイルス薬としての新規２−アミノ−９−［（２−ヒドロキシメチル）シクロプロピリデンメチル］プリン |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004521423A Expired - Fee Related JP5420135B2 (ja) | 2002-03-15 | 2003-03-13 | 抗ウイルス薬としての新規２−アミノ−９−［（２−ヒドロキシメチル）シクロプロピリデンメチル］プリン |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7183268B2 (OSRAM) |
| EP (1) | EP1490015B1 (OSRAM) |
| JP (2) | JP5420135B2 (OSRAM) |
| AT (1) | ATE443507T1 (OSRAM) |
| AU (1) | AU2003276824B8 (OSRAM) |
| CA (1) | CA2479037C (OSRAM) |
| DE (1) | DE60329375D1 (OSRAM) |
| WO (1) | WO2004006867A2 (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY141789A (en) * | 2001-01-19 | 2010-06-30 | Lg Chem Investment Ltd | Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same. |
| AU2003267947B2 (en) * | 2002-03-15 | 2008-11-13 | The Regents Of The University Of Michigan | 2,2-bis(hydroxymethyl)cyclopropylidenemethyl - purines and -pyrimidines as antiviral agents |
| JP3991223B2 (ja) * | 2003-02-13 | 2007-10-17 | 信越化学工業株式会社 | 新規スルホニルジアゾメタン化合物、光酸発生剤、並びにそれを用いたレジスト材料及びパターン形成方法 |
| EA008596B1 (ru) | 2003-04-29 | 2007-06-29 | Пфайзер Инк. | 5,7-ДИАМИНОПИРАЗОЛО[4,3-d]ПИРИМИДИНЫ, ПОЛЕЗНЫЕ ПРИ ЛЕЧЕНИИ ГИПЕРТЕНЗИИ |
| US7572799B2 (en) | 2003-11-24 | 2009-08-11 | Pfizer Inc | Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors |
| CA2552279C (en) * | 2003-12-02 | 2014-07-15 | The Ohio State University Research Foundation | Zn2+-chelating motif-tethered short -chain fatty acids as a novel class of histone deacetylase inhibitors |
| JP2007532526A (ja) | 2004-04-07 | 2007-11-15 | ファイザー・インク | ピラゾロ［４，３−ｄ］ピリミジン類 |
| WO2009048752A2 (en) | 2007-10-09 | 2009-04-16 | Dow Agrosciences Llc | Insecticidal substituted azinyl derivatives |
| JP5437254B2 (ja) | 2007-10-09 | 2014-03-12 | ダウ アグロサイエンシィズ エルエルシー | 殺虫性（１，３，５）−トリアジニルフェニルヒドラゾン |
| US8058279B2 (en) | 2007-10-09 | 2011-11-15 | Dow Agrosciences Llc | Insecticidal pyrimidinyl aryl hyrdrazones |
| SG11201901633WA (en) * | 2016-08-29 | 2019-03-28 | Hoffmann La Roche | 7-substituted sulfonimidoylpurinone compounds for the treatment and prophylaxis of virus infection |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8815265D0 (en) * | 1988-06-27 | 1988-08-03 | Wellcome Found | Therapeutic nucleosides |
| PT95516A (pt) * | 1989-10-06 | 1991-08-14 | Wellcome Found | Processo para a preparacao de derivados de 2',3'-didesoxi nucleosidos 6-substituidos |
| WO1998030563A1 (en) * | 1997-01-08 | 1998-07-16 | The Regents Of The University Of Michigan | 2-hydroxymethylcyclopropyli- denemethylpurines and -pyrimidines as antiviral agents |
| US6352991B1 (en) * | 1997-01-08 | 2002-03-05 | Wayne State University | 2-hydroxymethylcyclopropylidenemethylpurines and -pyrimidines as antiviral agents |
| AU2003267947B2 (en) * | 2002-03-15 | 2008-11-13 | The Regents Of The University Of Michigan | 2,2-bis(hydroxymethyl)cyclopropylidenemethyl - purines and -pyrimidines as antiviral agents |
-
2003
- 2003-03-13 DE DE60329375T patent/DE60329375D1/de not_active Expired - Lifetime
- 2003-03-13 CA CA2479037A patent/CA2479037C/en not_active Expired - Fee Related
- 2003-03-13 WO PCT/US2003/007909 patent/WO2004006867A2/en not_active Ceased
- 2003-03-13 AT AT03764294T patent/ATE443507T1/de not_active IP Right Cessation
- 2003-03-13 AU AU2003276824A patent/AU2003276824B8/en not_active Ceased
- 2003-03-13 EP EP03764294A patent/EP1490015B1/en not_active Expired - Lifetime
- 2003-03-13 JP JP2004521423A patent/JP5420135B2/ja not_active Expired - Fee Related
-
2004
- 2004-09-15 US US10/942,314 patent/US7183268B2/en not_active Expired - Fee Related
-
2007
- 2007-02-15 US US11/707,248 patent/US9174990B2/en not_active Expired - Fee Related
-
2012
- 2012-05-01 JP JP2012104611A patent/JP2012180361A/ja not_active Ceased
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