JP2012167060A - Oral composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an oral composition which can be continuously ingested in a safe way, and also has a high effect of improving excessive cold sensitivity.SOLUTION: The oral composition includes the extract of Indian long pepper and the extract of angelica in (1:0.01) to (1:0.5) by a (weight) ratio expressed in terms of dried products. In the oral composition, the (weight) ratio between the extract of Indian long pepper and the extract of angelica expressed in terms of dried products is (1:0.02) to (1:0.3). The agent for improving feeling of cold includes any one of the oral compositions as an active constituent. The agent for inhibiting a chilly feeling after a bath includes any one of the oral compositions as an active constituent. In the method for inhibiting a chilly feeling after a bath, any one of the oral compositions is ingested from a time before two hours of bath start to a time when bathing. The food and drink include any one of the oral compositions.

Description

  [Technical Field] The present invention relates to an oral composition having a thermal effect, in which a jade extract and shishido extract are contained in a specific blending ratio.

  It is said that the number of people complaining of coldness is increasing rapidly with the rapid change of living environment in recent years. This is thought to be due to the decrease in the body's ability to adapt to the season due to body temperature regulation, as a result of the penetration of the air-conditioning equipment that made the room temperature almost constant regardless of the season. In animals such as humans, information on the temperature originally received by the skin surface is transmitted to the brain, and homeostasis is maintained by adjusting body temperature based on the information. However, it has been pointed out that in rooms equipped with air conditioning facilities, this nerve function is reduced and information about temperature is not normally transmitted to the brain. On the other hand, because the temperature difference between the inside and outside of the room is large, as a result of continuing living with a sudden temperature change every time it enters and leaves the room, the function of the nerve transmission system to adapt to the temperature change also decreases, and the body It is said that there is a cold symptom due to abnormal thermoregulation at each site.

Regarding such coldness, it has been said that ginger is effective in ingesting food materials having vasodilatory action and body fat burning promoting action such as pepper and pepper. This is because a sense of warmth is imparted by the expansion of blood vessels and the burning of body fat. Among them, it is known that an extract of Piper longum which is a plant belonging to the genus Pepperaceae distributed in Southeast Asia can feel a thermal effect (cooling effect improving effect) by ingestion. For example, chilliness improver that contains Hihatsu extract as an active ingredient, Hibatsu extract, Ginkgo biloba leaves, safflower, ginger, chili, winter summer summer grass, plum meat, ginseng, garlic, viper, egg yolk oil, dokudami , Mugwort, field carrot, elephant sword, eel, toki, cucumber, cinnamon, nicke, kudzu, leek, leek, onion, carrot, sesame, seaweed, seaweed, pumpkin, burdock, radish, cabbage, red beans, grape, mandarin orange , An egg, chicken, beef, cheese, sanma, shrimp, vitamin B ₁ , vitamin E, ubiquinone and iron, one or more ingredients selected from the group consisting of iron or an extract thereof are disclosed (For example, refer to Patent Document 1). In addition, hihatsu has been reported to have a lipolysis promoting action (see, for example, Patent Document 2).

  On the other hand, Sicilian plant (Angelica pubescens Maxim.) (= Angelica polyclada Franc.) Is a medicinal plant that has long been used as a Chinese herbal medicine. It was clearly divided into food categories. Several health foods and methods for producing such health foods containing shisiudo or an extract thereof alone or in combination with other medicinal ingredients are also disclosed as active ingredients (see, for example, Patent Documents 3 to 5). .

Japanese Patent No. 4448266 Japanese Patent No. 3645608 Japanese Patent No. 4370196 JP 2008-303174 A JP 2009-118816 A

  The thermal effect when ingesting a baboon extract varies greatly depending on the person. For this reason, when blended with health foods such as supplements, it is necessary to contain a certain amount or more of the extract of a cherries in order to obtain a sufficient thermal effect by ingestion in an unspecified number of people. Become. However, when the content of the chickpea extract is increased to enhance the thermal effect, unpleasant hotness and irritation are also increased, which causes stomach discomfort and the like. As described above, the extract of Hibatsu is highly irritating and it is difficult to ingest a large amount continuously.

  In addition, as shown in Patent Document 1, although various food materials that can be used in combination with a hihatsu extract are known as active ingredients for obtaining an effect of improving cold disease, the thermal effect of the hihatsu extract can be obtained by using these in combination. It has not been investigated whether or not the odor is increased and whether or not stomach discomfort is reduced.

  An object of the present invention is to provide an oral composition that can be safely and continuously ingested and has a high thermal effect.

  As a result of diligent research to solve the above-mentioned problems, the present inventors have obtained a stronger thermal effect than the case of the chickpea extract alone by including the citrus extract in a specific blend ratio in the chickpea extract. The present invention has been completed.

That is, the present invention
(1) An oral composition characterized by containing a jade extract and shishido extract in a dry matter equivalent (weight) ratio of 1: 0.01 to 1: 0.5,
(2) The oral composition as described in (1) above, wherein the dry matter equivalent (weight) ratio of the Hibatsu extract and Shishiu extract is 1: 0.02 to 1: 0.3,
(3) A cooling property improving agent comprising the oral composition according to (1) or (2) as an active ingredient,
(4) A hot water cooling inhibitor comprising the oral composition according to (1) or (2) as an active ingredient,
(5) A method for suppressing the cooling of hot water, characterized in that the oral composition according to (1) or (2) is ingested 2 hours before the start of bathing to during bathing,
(6) A food or drink comprising the oral composition according to (1) or (2),
Is to provide.

  The oral composition of the present invention can obtain a sufficient thermal effect by ingestion and can be ingested safely and continuously. In addition, the intake of the chickpea extract required for obtaining a desired thermal effect can be reduced as compared with the case where the chickpea extract is taken alone. For this reason, by using the oral composition of the present invention, it is expected that a formulation design with reduced risk of occurrence of symptoms such as stomach discomfort can be realized.

In Example 1, it is the figure which showed the application situation obtained by performing an applied curved surface analysis about the compounding ratio and warmth effect of a Hihatsu extract and Shishido extract. In Example 2, it is the figure which showed the measurement result of the deep part body temperature (tympanic temperature) and the inner-arm sweating amount (moisture transpiration amount) of subjects A to C.

  In the present invention, the extract of hihatsu includes not only an extract obtained by using hihatsu as an extraction raw material but also a dilute solution and a concentrated solution of the extract. Moreover, the dried material which dried the extract with the well-known means is also contained. Similarly, the sicilian extract used in the present invention includes an extract obtained by using siucido as an extraction raw material, a diluted or concentrated solution of the extract, and a dried product of the extract. That is, the extract of cherries and shishido extract contained in the oral composition of the present invention may be liquid or dry powder.

The extract of the cherries used in the present invention is extracted from the ears, roots, stems, flowers, or mixed parts of the cherries.
On the other hand, the sicilian extract used in the present invention is an extract obtained using the rhizome part of sicilian as an extraction material.

  The tissue of baboon and shrimp used as the raw material for extraction may be one collected from a plant itself or may be dried. The drying method is not particularly limited as long as it is a method generally used when drying plants used as raw materials for herbal medicines and foods and drinks, and may be sun-dried or shade-dried, using a dryer. Also good. For example, it is possible to use, as the raw material for extraction, the collected spikelets of rhododendron or rhizome of shrimp as they are or after being shredded to an appropriate size and dried by sun drying or the like. Moreover, the extraction raw material may be shredded in advance before extraction or may be powdered. In addition, the extraction raw material may be subjected to pretreatment such as degreasing before extraction.

  The extraction method from the extraction raw material is not particularly limited, and examples thereof include a solvent extraction method using an extraction solvent and a supercritical extraction method.

  Examples of the extraction solvent used in the solvent extraction method include water, a hydrophilic solvent, and a mixture thereof. In the solvent extraction method, water used for the extraction solvent is not particularly limited, and examples thereof include tap water, distilled water, pure water, and ion exchange water. Examples of the hydrophilic solvent used as the extraction solvent in the solvent extraction method include lower alcohols having 1 to 5 carbon atoms such as methanol, ethanol, propyl alcohol, and isopropyl alcohol; lower aliphatic ketones such as acetone and methyl ethyl ketone; -Polyhydric alcohols having 2 to 5 carbon atoms such as butylene glycol, propylene glycol, isopropylene glycol, glycerin; tetrahydrofuran, acetonitrile, 1,4-dioxane, pyridine, dimethyl sulfoxide, N, N-dimethylformaldehyde, acetic acid, etc. be able to. It is preferable that the chickpea extract or shishido extract used in the present invention is extracted using water, a lower alcohol, a polyhydric alcohol, or a mixture thereof as an extraction solvent. In particular, it is more preferable that the extract of shishido used in the present invention is extracted using a mixed solvent of water and ethanol (hydrous ethanol) as an extraction solvent.

  When extracting by the solvent extraction method, the extraction raw material is immersed in the extraction solvent, the soluble components in the extraction raw material are eluted in the extraction solvent, and then the insoluble matter is removed by solid-liquid separation such as filtration. You can get things. Extraction conditions such as extraction temperature, extraction time, and pressure during extraction can be appropriately determined in consideration of the type of extraction raw material, the type of extraction solvent, the amount ratio of the extraction raw material and the solvent, and the like. Moreover, you may extract, stirring as needed.

  For example, when water is used as the extraction solvent when extracting the extract of cherries, a component having a thermal effect is extracted from the cherries by immersing the extraction raw material at 50 to 95 ° C. for about 1 to 4 hours. can do. Moreover, when hydrous ethanol is used as an extraction solvent, extraction conditions can be normally made into 40-80 degreeC for about 30 minutes-about 4 hours.

  For example, when water is used as an extraction solvent when extracting a shishido extract, the temperature of the water is preferably 50 to 100 ° C. In addition, when hydrous ethanol is used as an extraction solvent, 1 kg of sicil is impregnated with 10 L of hydrous alcohol (water: ethanol = 3: 7 (weight)) and left at room temperature for 1 day, and then hydrous alcohol containing siucido is added. By filtering, a sicilian extract can be obtained.

  In addition, a jade extract or shishido extract can also be obtained by a supercritical extraction method. The supercritical extraction method is an extraction method that uses a carbon dioxide fluid in a supercritical state at 31 ° C. and 7.4 MPa or more, and can extract effective components efficiently at a low temperature.

  The obtained cherries extract or shishido extract may be diluted and concentrated as necessary, or may be a dry powder. In addition, concentration and drying of the extract can be performed by conventional methods. For example, the extract can be concentrated by using a vacuum concentrator or heating to remove the solvent. Further, it can be made into a dry powder by vacuum drying or freeze drying.

  In addition, as long as the effects of the present invention such as the thermal effect are not impaired, rough purification treatment such as adsorbent treatment using an adsorbent such as activated carbon or high-pressure heating is performed on the obtained cherries extract or shisiudo extract. A sterilization treatment such as a treatment or a filtration treatment using a fine pore filter may be performed.

  In addition, in the present invention, a commercially available baboon extract or shishiudo extract may be used.

  The oral composition of the present invention is characterized in that it comprises a jade extract and a shishido extract so that the dry matter equivalent (weight) ratio is 1: 0.01 to 1: 0.5. The dry matter equivalent (by weight) ratio of the citrus extract and shishiudo extract contained in the oral composition of the present invention is preferably 1: 0.02 to 1: 0.3, and is 1: 0.14. It is particularly preferred. By blending the Citrus extract in the optimum amount ratio with the Citrus extract, a stronger thermal effect can be obtained than when the Citrus extract alone or the Citrus extract alone.

  It is the first time by the present inventors that the thermal effect of the extract of the cherries can be increased without increasing the side effects such as stomach discomfort by blending an appropriate amount of the citrus extract with the extract of the cherries. This is a finding.

  The composition for oral use of the present invention may be composed only of a jade extract and an extract of shishido, or may contain other components other than an extract of shihatsu and shishido. The other components that can be included in the oral composition of the present invention include the effect of heating by the extract of cherries and the effect of increasing the temperature effect of the extract of citrus (hereinafter, combined use effect of the extract of citrus). It is not particularly limited as long as it is not impaired. Examples of other components include a component having a thermal effect as described in Patent Document 1.

  The composition for oral use of the present invention can be used as a warming sensation improver such as a cold symptom ameliorating agent and a hot water cooling inhibitor alone or by adding an appropriate auxiliary agent. These warming sensation improving agents may be health supplements such as supplements and energy drinks, health functional foods, and pharmaceuticals.

  The dosage form of the warming sensation improving agent containing the oral composition of the present invention is not particularly limited, and examples thereof include solid preparations such as tablets, powders, fine granules, granules, capsules, pills and the like. Alternatively, it may be a liquid agent such as a liquid agent, a suspension, a syrup, an emulsion, or a paste. For example, excipients, disintegrants, binders, lubricants, surfactants, alcohols, water, water-soluble polymers, sweeteners, flavoring agents that are commonly used in the art for the oral composition of the present invention , By appropriately adding a sour agent, a pharmaceutical carrier, etc., and by using conventional means, to produce a cold symptom improving agent, a hot water cooling inhibitor, etc. containing the oral composition of the present invention as an active ingredient Can do.

  If the content of the oral composition of the present invention in the warming sensation agent is an amount that exhibits the thermal effect of the extract of Hihitsu and the combined use effect of Shishido extract by ingesting the warming sensation agent, It is not particularly limited, and may be appropriately determined in consideration of the content of the cherries extract or shisi extract in the oral composition of the present invention, the dosage form of the warming sensation improver, the intake mode, and the like. it can. For example, the content of the oral composition of the present invention in the warming sensation improver as in Examples 1 and 2 can be 10 to 50% by weight, preferably 30% by weight.

  Moreover, the food-drinks from which a warm feeling improvement effect is acquired can be manufactured by adding the composition for oral use of this invention to a drink or foodstuff. A food or drink containing the oral composition of the present invention can be produced by a conventional method except that the oral composition of the present invention is used as a raw material. The oral composition of the present invention may be added to various foods, for example, processed meat foods such as ham and sausage, processed fish foods such as kamaboko and chikuwa, bread, confectionery, butter, powdered milk, fermented milk products, etc. It may be added to beverages such as water, fruit juice, milk and soft drinks. Content of the oral composition of this invention in food / beverage products is suitably determined in consideration of the kind of food / beverage products added. For example, in the case of 250 mL of food or drink, the oral composition of the present invention can be contained in an amount of 0.1 to 1% by weight, preferably 0.4% by weight.

  When the oral composition of the present invention is ingested alone or as an active ingredient of foods and drinks or pharmaceuticals, for example, the intake of the extract of Hihatsu is 10 to 150 mg, preferably 50 to 150 mg per day for an adult as a dry weight. Thus, the oral composition of the present invention can be contained in food or drink. The oral composition of the present invention may be taken orally in 1 to several times a day.

  The oral composition of the present invention has an effect of increasing body temperature and an effect of improving blood flow, as in the case of ingesting the chickpea extract alone or the ingestion of the shisiudo extract alone. For this reason, by ingesting the oral composition of the present invention and food and drink containing the composition, a warming effect is obtained, and coldness is improved.

  Furthermore, by ingesting the oral composition of the present invention before taking a bath, the rate of decrease in body temperature after taking a bath can be delayed, and hot water cooling can be suppressed. Although the reason why the oral composition of the present invention has an especially excellent effect of suppressing the cooling of hot water is not clear, the extract of Hihatsu acts on a heat-sensing receptor (TRPV) and increases heat production in the body through the sympathetic nerve. In addition, it is presumed that the blood in the peripheral blood vessels is effectively warmed by the heat of hot water due to the peripheral vasodilatory effect by the Hihatsu extract and the blood flow improving effect by the Shishiu extract.

  In order to sufficiently obtain the effect of suppressing the cooling of hot water after bathing, it is important that the active ingredient in the oral composition of the present invention taken in advance is absorbed into the body and exerts its action effect during bathing. The preferred intake time varies depending on the intake mode (form, composition, intake amount, etc.) of the oral composition of the present invention. For this reason, when the oral composition of the present invention is ingested in a mode that requires a relatively long time of absorption, such as a coating agent, it is ingested rather than being easily absorbed into the body, such as a liquid agent. It is preferable that the time from bathing to bathing is long. On the other hand, some liquids that can be absorbed quickly can be sufficiently effective even when ingested during bathing. Specifically, for example, the oral composition of the present invention is preferably taken between 2 hours before the start of bathing and during bathing, and taken between 2 hours before the start of bathing and 5 minutes before the start of bathing. More preferably.

  EXAMPLES Next, although an Example is shown and this invention is demonstrated further in detail, this invention is not limited to a following example.

[Example 1]
For 6 healthy women, the effects on warmth of five types of oral compositions with different contents of Hihatsu extract and Shishido extract were examined.
Specifically, we extract Hibatsu extract (Maruzen Pharmaceutical Co., Ltd.) and dried shishiudo extract (Ryu Fukuda Co., Ltd.) as shown in Table 1 (unit: mg), and take what is wrapped in oblate. A sample was used.
Subjects had lunch as usual at 12:00, and then refrained from eating snacks, caffeinated beverages, hot beverages, and cold beverages until the end of the study. After 2 hours or more after lunch, subjects took samples with water. The intake time is 0 minutes, and after 10, 30, 60, 90, 120 minutes, the subject feels the warmth of the whole body (VISUAL ANALOG SCALE: on the 10 cm line segment, the current feeling until it is hot because it is cold. ) And conducted a questionnaire on the parts that felt warm.
Each subject ingested one sample at a time and ingested all samples over 5 days.

  The results of VISUAL ANALOG SCALE were plotted against time and the area under the curve was calculated. The average value of the area under the curve with respect to the number of trials was used as the actual measurement of the effect of each blended sample. As a result, the effect on the warming effect when the subject ingested the sample (sample 1) consisting only of 100 mg of the chickpea extract (sample 1) and the sample (sample 2) consisting of only 150 mg of the chickpea extract is based on 150 mg of the Japanese radish and 100 mg of Shishido. And integrated as a relative value. Table 1 shows the relative value of the warming effect of each sample. In addition, by using response surface creation software (software name: DataNesia, manufactured by Yamatake Co., Ltd.) by multidimensional biharmonic spline interpolation, applied surface analysis was performed on the blending ratio and warmth effect of Hihatsu extract and Shishido extract. . FIG. 1 shows an applied aspect obtained by applied curved surface analysis.

  From the results of the applied surface analysis, the additional compounding amount of Shishido extract, which can enhance the warming effect of Hihitsu extract, was calculated to be 2.04 to 22.45 mg, and 150 mg of 100 mg Hihitsu extract. The amount was 2.04 to 44.89 mg based on the extract of Hihatsu. From these results, when the ratio of the ratio of the extract of Hibatsu to Shishido extract is 1: 0.01 to 1: 0.5 in terms of dry matter (weight), the ingestion of Hihatsu extract alone It is clear that the warm feeling effect of the Hihatsu extract can be enhanced. Moreover, from the applied curved surface analysis, it was calculated that the blending ratio capable of giving the maximum effect was 100 mg: 14 mg.

[Example 2]
For four healthy women, the effect of the oral composition containing the Japanese heron extract and shishiudo extract on the water cooling after bathing was examined.
The composition for oral use consists of 100 mg Hihatsu extract (Maruzen Pharmaceutical Co., Ltd.) and 14 mg dried dried sicildo (Fukuda Ryu Co., Ltd.), HF capsule (gelatin empty capsule; model number: # 1, manufacturer: Matsuya) The sample filled in was used as a test sample to be ingested. Moreover, it replaced with a jade extract and dried dried shrimp, and what filled 114 mg of dextrin into the HF capsule was made into the control sample.

First, the subject was allowed to rest indoors (room temperature 24 ° C. ± 2, humidity 55% ± 15%) for 20 minutes, and then deep body temperature (tympanic temperature), inner arm sweating amount (moisture transpiration), and body surface temperature. Initial values were measured. The deep body temperature was measured using an OMRON ear-type thermometer (product name: Ken-on-kun Mimi, model number: MC-510, manufacturer: OMRON Healthcare Co., Ltd.). The amount of perspiration was measured using Vapometer (model number: SML4001, manufacturer: Keystone Scientific Co., Ltd.). The body surface temperature was measured using an infrared thermography (model number: TH7102MV, manufacturer: NEC Avio Infrared Technology Co., Ltd.). Moreover, indoor temperature and humidity were measured with the digital thermo-hygrometer (model number: TT-538, manufacturer: Tanita Co., Ltd.), and were adjusted in the desired range. After the measurement, the subject was allowed to ingest the sample with water and rested for another 20 minutes.
After 20 minutes from the sample ingestion, bathing in hot water at 40 to 41 ° C. for 15 minutes was performed. The hot water temperature is measured using a waterproof digital thermometer (model number: SK-1250MC3α, manufacturer: Sato Keiki Seisakusho Co., Ltd.), and is a multi-purpose heating & thermal insulation heater (product name: Taro Boishi, model number: SCH-901). , Manufactured by: Kumagaya Denko Co., Ltd.). The time at the start of bathing was 0 minute, and the deep body temperature was measured at 5, 10, and 15 minutes. Immediately after bathing, the body was rested for 70 minutes, and the deep body temperature, the amount of sweating, the feeling of warmth, and the body surface temperature were measured over time.
Each subject first took a test sample and a control sample to conduct a test, and after taking a rest period, took the remaining sample and conducted the test.

  FIG. 2 shows the deep body temperature (tympanic temperature) and the inner sweating amount (moisture transpiration amount) of subjects A to C. In FIG. 2, “0 minute” is the bathing start time. As a result, in subjects A to C, when the test sample was ingested from the sample ingestion until about 20 minutes after the start of bathing, the deep body temperature tended to be slightly higher than when the control sample was ingested. It was. Moreover, the tendency for the amount of sweating inside the arm after bathing to increase in the subjects A to C when the test sample was ingested was greater than when the control sample was ingested. The reason why the amount of sweat increased due to the intake of the test sample is thought to be that the body temperature was felt to have increased. That is, from these results, it is clear that the sense of warmth is enhanced by ingesting an oral composition containing an extract of baboon and shishido extract at an optimum blending ratio.

  Further, for the body surface temperature of the face, decollete, left hand, and right hand, the measurement results at the time point 10 minutes after the bathing of the subject A are shown in Table 2, and the measurement results at the time point 15 minutes after the bathing of the subject B are in Table 3. Table 4 shows the measurement results of the subject C after 20 minutes of bathing. In Tables 2 to 4, “Active” is the result when the test sample is ingested, and “Placebo” is the result when the control sample is ingested. In addition, the average temperature of the body surface of each site | part is an average value per pixel in each site | part measured by thermography. Moreover, by Student-t-test, the result when a test sample was ingested was compared with the result when a control sample was ingested. As a result, in all subjects, the tendency that the average temperature of the body surface was higher when the test sample was ingested than when the control sample was ingested was observed. The difference was statistically significant.

  Since the oral composition of the present invention is a composition that can be safely and continuously ingested and has a high thermal effect, it is particularly useful in the field of the production of functional foods and pharmaceuticals for the improvement of cold symptoms and prevention of cold cooling. It can be used.

Claims (6)

  An oral composition characterized by containing a jade extract and shishido extract in a dry matter equivalent (weight) ratio of 1: 0.01 to 1: 0.5.   The oral composition according to claim 1, wherein a dry matter equivalent (weight) ratio of the jade extract and shisiudo extract is 1: 0.02 to 1: 0.3.   A cooling property improving agent comprising the oral composition according to claim 1 or 2 as an active ingredient.   A hot water cooling inhibitor comprising the oral composition according to claim 1 or 2 as an active ingredient.   A method for suppressing cooling of hot water, comprising ingesting the oral composition according to claim 1 or 2 between 2 hours before the start of bathing and during bathing.   A food or drink comprising the oral composition according to claim 1 or 2.