JP2003261462A - Homeostasis-retaining composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a homeostasis-retaining composition enhancing performance for maintaining homeostasis in vivo to the external environment. <P>SOLUTION: The homeostasis-retaining composition contains a urine degenerate drug, an irrigative drug and a body-warming drug. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a composition for maintaining homeostasis that effectively acts to maintain homeostasis in a living body against an external environment, and a food using the composition.

In particular, the present invention relates to a composition for maintaining homeostasis that effectively maintains normal body temperature with respect to an external temperature environment, and a food product using the composition.

[0003]

2. Description of the Related Art In recent years, the natural environment has changed remarkably, such as extremely cold, warm winter, intense heat, cold summer, and the like, and the number of people who cannot cope with such a drastic change in environment is rapidly increasing. In particular, with the development of air conditioning and heating, the number of people suffering from obstacles due to excessive cooling of the living body, such as "cooling by cooling" and "cooling in winter", is accompanied by remarkable changes in the indoor and outdoor environments. Such a non-environmental change non-responsive disorder such as a disorder due to excessive cooling represented by "coldness" acts synergistically with autonomic imbalance due to excessive stress, and its intractability becomes remarkable. It is well known that sales of "disposable body warmers" and "warm underwear" are increasing with the increase in refractory coldness.

However, such a countermeasure does not solve the problem on the living body side, and is, so to speak, a symptomatic treatment. The only treatment for the living body has been to orally administer components such as ginger, which increase blood circulation. The administration of such a component that increases blood circulation promotes blood circulation, and thus may cause a phenomenon such as burning in a warm environment as well as in a cold environment. As for the countermeasures such as “coolness” due to the non-responsiveness to environmental changes, there is a side where it cannot be said that a mere blood circulation promotion measure is sufficient.

Therefore, by increasing the ability to respond to environmental changes,
Development of means capable of maintaining homeostasis in the living body in the external environment, for example, in both cold and warm environments, specifically, means for maintaining body temperature at normal temperature Development was desired.

On the other hand, it is not known at all that the combination of astringent drugs, water-use drugs, and anther drugs has the effect of enhancing the function of maintaining homeostasis, which is known in the classification of efficacy of Chinese herbal medicines. Further, there is no known example in which a composition comprising these combinations is actually used for the purpose of improving environmental friendliness.

[0007]

The present invention has been made from the above viewpoint, and it is an object of the present invention to provide a composition for maintaining homeostasis capable of enhancing the homeostasis of the whole living body.

[0008]

Means for Solving the Problems As a result of intensive studies to solve the above problems, the present inventor has found that a composition containing a solid astringent drug, a water remedy, and an anchocotic drug maintains homeostasis. The present invention has been completed and the present invention has been completed.

That is, the present invention is as follows. (1) A composition for maintaining homeostasis, which comprises a solid astringent drug, a water remedy, and an oncotic drug. (2) The composition for maintaining homeostasis according to (1), wherein the composition for maintaining homeostasis is a composition for oral administration. (3) The composition for maintaining homeostasis according to (1) or (2), wherein each of the solid astringent drug, the diuretic drug, and the hot-drug has an extract of crude drug. (4) The above-mentioned astringent medicines are Cornaceae Sanshuyu, Magnolia family Ginseng, Magnolia family Nangomishi, Rose family Ume, Shikunushi family Myrobalan, Nikuzuku family Nukuzuku, Poppy family poppy, pomegranate family pomegranate, water lily family lotus, lotus family lotus, Characteristically, it is an extract of a herbal medicine selected from Naniwaibara rose, Rhododendron strawberry, Nurude aura, Ginkgo biloba, and Ginkgo biloba,
The composition for maintaining homeostasis according to (3). (5) The above-mentioned water repellents include butterbur sprout, psyllidaceae chorei, sycamore, takusha, asteraceae, mugwort, ephemeridaceae, mokuboui, azalea family cambowi, gramineae, smeltaceae, oleaceae, moss family Tofu Shinso, Dianthus spp.
Polygonaceae, Willowaceae, Sekii, Psyllium, Psyllium, Mallow family Toki, Yamanoaceae Hikai, Leguminous calendula, Primrose family calendula, Convolvulaceae mungweed, Lamiaceae, Cornaceae, Leopardaceae, Leopardaceae, Gypsophila (3) characterized by being an extract of a crude drug selected
The composition for maintaining homeostasis according to 1. (6) The above-mentioned onion medicine is a buttercup family Karatikabuto, ginger family ginger, camphoraceae kei, citrus family goshuyu,
Homeostasis according to (3), which is an extract of a herbal medicine selected from Rutaceae Kahoksosho, Fusariumaceae Clove, Aceraceae fennel, Gingeraceae Ryokyo, Camphoraceae Sansoushi, Pepperidae Hihatu, Pepperidae. Maintenance composition. (7) The crude drug extract is characterized in that a solvent is removed from a polar solvent extract of a crude drug, (3) to
The composition for maintaining homeostasis according to any one of (6). (8) The composition for maintaining homeostasis is characterized in that it is applied to maintain homeostasis in a cold environment, (1)
~ The composition for maintaining homeostasis according to any one of (7). (9) The homeostatic composition according to any one of (1) to (8), wherein the homeostatic composition is used for food. (10) The composition for maintaining homeostasis according to any one of (1) to (9), wherein the composition for maintaining homeostasis is a tablet coated with an enteric coating agent. (11) The composition for maintaining homeostasis according to (10), wherein the enteric coating agent is selected from gelatin, zein and shellac. (12) The composition for maintaining homeostasis is a tablet coated with an enteric coating agent and a plasticizer, (1)
The composition for maintaining homeostasis according to 0) or (11). (13) The plasticizer is selected from triethyl citrate and monoglyceride caprate.
The composition for maintaining homeostasis according to (12).

[0010]

BEST MODE FOR CARRYING OUT THE INVENTION The present invention will be described in detail below. <1> Composition for homeostasis maintenance of the present invention The composition for homeostasis maintenance of the present invention works effectively when maintaining homeostasis in the living body against the external environment, and functions of the living body for maintaining homeostasis. It has the effect of increasing. Specifically, it works to maintain normal body temperature even under external temperature changes and severe external temperature conditions. Therefore, the composition for maintaining homeostasis of the present invention can be used for improving the body temperature to recover the body temperature fluctuated by the external temperature or for preventing the body temperature fluctuation which prevents the fluctuation of the body temperature.

The combination of an astringent drug, a water remedy, and an onions has the action of enhancing homeostasis, as will be apparent from the following examples.

The homeostasis-maintaining composition of the present invention comprises a solid astringent drug, a water remedy, and a warming drug as active ingredients, and an effective amount for exhibiting this action and effect.

[0013] Here, the "solid astringency" is a term used for the purpose of preventing the metabolites such as perspiration and urine from leaking out without anxiety, and in the present invention, excess metabolite excretion as described above. Drugs used to prevent this are called "solid astringents."

Many of the solid astringents that can be used in the present invention contain tannin, and have quite strong astringent action, antibacterial action, hemostatic action, antitussive action, and tonic action. It is also effective against slipping.

Further, "liquor" is a term used for the purpose of promoting excretion of body fluids and secretion of body fluids. In the present invention, a drug used for the effects of evacuation, promotion of gastric secretion and diuresis is referred to as "diuresis". It is called a water remedy.

The diuretic which can be used in the present invention can be used for the purpose of fainting, promoting pleural effusion / ascites excretion, promoting gastric secretion, and diuresis. Effective in treating edema, bronchiectasis, chronic bronchitis, and chronic gastritis.

The term "onura" is a term used for the purpose of recovering energy metabolism deficiency due to chronic diseases or environmental temperature drop. In the present invention, it is a cardiotonic effect or an exercise central stimulation effect. Drugs that are used to activate energy metabolism are referred to as "unripe drugs".

The warming drug which can be used in the present invention has a cardiotonic action and a reflexive action to excite the vasomotor center. Also,
By promoting systemic and local vascular circulation, it is effective in improving shock conditions and analgesia. In addition, it has a stomachic effect, improves energy metabolism by enhancing the gastrointestinal digestive function, and at the same time, has an antibacterial effect and the effect of stopping vomiting and diarrhea.

In the present invention, the astringent drug, the water-use drug and the anthrax drug having the above-mentioned medicinal effects can be used. Specifically,
Judgment based on the criteria stipulated in the drug efficacy classification of Chinese herbal medicines described in clinical application of Chinese medicine (Kobe Chinese Medicine Research Association (translated by editor), published by Ito Denshaku Publishing Co., Ltd.) Astringents, water repellents and onions can be used.

In the present invention, it is preferable to use the crude drugs prescribed in the classification as the astringent drug, the water remedy drug and the anxiety drug, referring to the drug efficacy classification of the Chinese herbal drug.

Specific examples of the astringent drug include Sanshuyu of the dogwood family, Asteraceae of the magnoliaceae family, Narcissus family of the magnolia family, Rosaceae family, Myrbalin family of mirobalan, Nikuzu family family of salmon, Poppy family of pomegranate, pomegranate family of lotus, lotus family of lotus and water lily. The herbal medicines include lotus family, rose family naniwaibara, rose family gosho strawberry, sumac family nurude, ginkgo family ginkgo, sycamore family sycamore.

Among the above, particularly preferable are herbal medicines of Ginkgo biloba.

Specific examples of the water repellents include succulent sycamore, syringaceae chorei, sycamore, takusha, asteraceae, mugwort, horse-tailed weeds, mokuboui, tsuzarafuji, kanboui, gramineae, swordweed, moss family , Rush family, deciduous family, dianthus family
Rhinoceros family Jifushi, Polygonaceae, Willowaceae, Sekii, Psyllium, Psyllium, Mallow family Toki, Yamanoyidae Hikai, Familiaceae calendula, Primrose family calendula, Convolvulaceae, Anemoneaceae, Meadowaceae, Pleurotus vulgaris Herbal medicines such as Gramineae can be mentioned.

Among the above, particularly preferable are herbal medicines of Artemisia genus Artemisia selected from Artemisia plants of the family Asteraceae.

[0025] Specific examples of an on-the-ground medicine include agaricaceae, agaricaceae, ginger, ginger, camphoraceae, citrus, goshuyu, citrus cabbage, ginger, ginkgo, ginger, ginger, butterbur, Herbal medicines such as Pepperaceae hihatu and Pepperaceae pepper are mentioned.

Among the above, particularly preferable one is a crude drug of Pepper genus Hihatu selected from the plants of the genus Pepper and the genus Pepper.

In the solid astringent drug, the water remedy drug and the anthrax drug of the present invention, it is more preferable to use a crude drug extract.

In the present invention, the extract means the plant itself, a processed product of the plant which has been processed by drying, shredding or crushing, an extract obtained by extracting the plant or the processed product with a solvent, Further, it means a solvent-removed product obtained by removing the solvent of the extract, or a purified fraction obtained by purifying the extract or the solvent-removed product by column chromatography or liquid-liquid extraction.

In the present invention, ginkgo biloba leaves are used as an astringent drug, the above-ground part of the Asteraceae mugwort is used as a water repellent, and the seeds of Pepperaceae Hihatu seeds are used as a warming drug. When used, a particularly good composition for maintaining homeostasis can be obtained. When these plant species are used, the above-mentioned medicinal effect of a solid astringent drug that contains tannin and has a considerably strong astringent action, antibacterial action, hemostatic action, antitussive action, tonic action and slipping effect, and , Excretion of pleural effusion / ascites, promotion of gastric secretion, diuresis are strong, and therapeutic effect on edema, bronchiectasis, chronic bronchitis, and chronic gastritis is excellent. This has the effect of stimulating the motor center, and by promoting systemic and local vascular circulation, it is possible to fully satisfy the medicinal effect of an anxiety drug, in which the effects of improving shock conditions and analgesia are prominent. .

In the present invention, the crude drug extract is particularly preferably the solvent extract of the crude drug from which the solvent has been removed.

In the present invention, when a solvent extract of a crude drug is obtained, the type of solvent used is preferably a polar solvent.

As such a polar solvent, for example, water,
Alcohols such as ethanol, methanol, 1,3-butanediol, propylene glycol, esters such as ethyl acetate and methyl formate, ketones such as acetone and methyl ethyl ketone, halogenated hydrocarbons such as chloroform and methylene chloride, acetonitrile, etc. Nitriles, ethers such as diethyl ether and tetrahydrofuran, and the like.

These solvents may be used alone or in combination of two or more.

Among these solvents, water and / or alcohols are more preferable. Particularly preferred is 50% ethanol.

The crude drug extract used in the present invention is obtained, for example, by the method described below.

1 to 10 times the amount of the solvent is added to the plant or its processed product, and the mixture is immersed for several days at room temperature and for several hours at temperatures near the boiling point. After that, the insoluble matter is removed by filtration or the like, and the solvent can be removed by concentration under reduced pressure or lyophilization, if necessary. Further, as a preferred method for producing an extract, there is a method in which each site of the plant is sufficiently dried, extracted with 50% ethanol, filtered, and concentrated under reduced pressure to remove the solvent.

In the present invention, the obtained extract may be freeze-dried and stored in some cases.

In the present invention, the number of each of the astringent drug, the water liquor and the anthotropic drug contained in the composition for maintaining homeostasis is
There is no particular limitation, and the astringent drug, the water remedy, and the anthracnace drug may be contained alone or in combination of two or more.

In the composition for maintaining homeostasis according to the present invention, the mixing ratio of the astringent drug, the water-use drug and the anthotropic drug is 1: 0.
It is 1-10: 0.1-10 (weight ratio).

The method for administering the composition for maintaining homeostasis according to the present invention is not particularly limited and may be oral administration or parenteral administration.

The dosage form of the composition for maintaining homeostasis according to the present invention is not particularly limited, and oral dosage forms such as tablets, capsules, granules, fine granules and powders, injections and suppositories It may be a parenteral dosage form such as a drug.

However, in the present invention, in consideration of the convenience at the time of administration, it is more preferable that it is for oral administration, and particularly in the form of tablets.

Further, the composition for maintaining homeostasis of the present invention is preferably a tablet coated with an enteric coating agent. Here, as the enteric coating agent, gelatin, shellac which is a natural product of Lactobacillus secretion, zein which is a water-insoluble protein such as wheat and corn, and various lots of Eudragit (registered trademark) are preferably exemplified. Particularly, gelatin, shellac and zein are preferable.

Further, the composition for maintaining homeostasis of the present invention is more preferably a tablet coated with an enteric coating agent and a plasticizer. Here, as the plasticizer, polyhydric alcohols such as glycerin and propylene glycol, triesters of citric acid such as triethyl citrate, and low chain to medium chain fatty acid monoglycerides such as capric acid monoglyceride are preferably exemplified. . Among these, triethyl citrate and capric acid monoglyceride are particularly preferable.

When the enteric coating is applied as described above, a tablet that is not easily decomposed by gastric acid or the like and is excellent in absorption in the intestine can be obtained.
When a coating in which a plasticizer is added in addition to the enteric coating agent is applied, a good tablet having no crack in the coating can be obtained.

To form a tablet in which the composition for maintaining homeostasis of the present invention is coated with the above enteric coating agent, for example, the following method is used.

In a sugar-coated bread or the like, a tablet comprising the composition for maintaining homeostasis is sprayed with an enteric coating agent or an alcohol solution containing an enteric coating agent and a plasticizer under heating and stirring. It can be manufactured.

Here, the amount of the enteric coating agent is 3 to 300% by weight based on the weight of the tablet comprising the composition for maintaining homeostasis, and the amount of the plasticizer is 5 to 5% of that of the enteric coating agent. 20% by weight
Is preferred.

The composition for maintaining homeostasis of the present invention enhances the ability to respond to environmental changes and maintains homeostasis of the living body by maintaining body temperature at a normal temperature in both cold and warm environments. It works effectively to enhance the function to do. However,
The composition for maintaining homeostasis of the present invention is more effective when applied to the maintenance of homeostasis in a cold environment.

The composition for maintaining homeostasis of the present invention can be administered to other animals besides humans. <2> Oral pharmaceutical / food composition containing the homeostatic composition of the present invention The homeostatic composition of the present invention is blended with other optional components to provide an oral pharmaceutical composition or food. It can be used as a composition.

In the present invention, it is particularly preferable to apply the composition for maintaining homeostasis of the present invention to foods as various health foods and functional foods.

The food containing the composition for maintaining homeostasis according to the present invention can be used as a dietary supplement after illness or physical fatigue for environmental measures including a harsh personal environment. Recovery, fatigue recovery, shoulder stiffness / backache prevention,
For nutritional tonicity and anti-stress, it can be eaten and drink as a recovery and preventive measure when homeostasis is reduced and physical strength is reduced.

The above-mentioned other optional components are not particularly limited as long as they are components which are usually used as a medicine for an oral pharmaceutical composition and as a food for a food composition. Specifically, as an optional component, excipients such as sucrose and lactose, binders such as starch and gelatin, crystalline cellulose,
Disintegrators such as hydroxypropylmethylcellulose, sodium carboxymethylcellulose, calcium carboxymethylcellulose, surfactants such as soybean lecithin and sucrose fatty acid ester, lubricants such as magnesium stearate, talc and waxes, light anhydrous silicic acid, dry water Examples include glidants such as aluminum oxide gel, physiological saline, diluents such as glucose aqueous solution, flavoring agents, coloring agents, bactericides, preservatives, and fragrances.

The oral pharmaceutical / food composition of the present invention can be produced by treating the essential components consisting of an astringent drug, a water remedy and an anthotropic drug and optional components according to a conventional method.

The dosage form of the oral pharmaceutical / food composition of the present invention is not particularly limited, and the above-mentioned dosage forms can be applied.
Tablets are preferable in consideration of convenience at the time of administration. In that case, it is more preferable that the oral pharmaceutical / food composition containing the homeostatic composition of the present invention is coated with an enteric coating agent.

Here, the type of enteric coating agent, the type of plasticizer that can be used together with the enteric coating agent, and the method of coating the coating agent are as described above.

When coating an oral pharmaceutical or food composition, the amount of the enteric coating agent is 3 to 300% by weight based on the weight of the tablet comprising the composition for maintaining homeostasis and other optional ingredients.
Then, the amount of the plasticizer is preferably 5 to 20% by weight of the enteric coating agent.

The dose of the composition for maintaining homeostasis of the present invention in the composition for oral pharmaceuticals and foods is, for example, 0 if the composition for maintaining homeostasis is a dry extract.
01-100 mg / kg body weight / day, preferably 0.5
~ 50 mg / kg body weight / day.

[0059]

EXAMPLES The present invention will be described in more detail below with reference to examples. (Production Example 1) 500 g of dried mature fruits of the Magnolia family Nungomishi were heated and destilled with 5 L of hot water for 16 hours, then filtered to remove insoluble matter, and further concentrated under reduced pressure. Lyophilized. And the solid astringent medicine which consists of Nangomishi extract was obtained. (Production Example 2) Dried whole grass of Malvaceae 50
To 0 g, 5 L of hot water was heated and distilled for 16 hours, followed by filtration to remove insoluble matter, further concentrated under reduced pressure, and then freeze-dried. Then, a water remedy composed of Touki extract was obtained. (Production Example 3) To 500 g of dried whole grass of the Myrtaceae family, 5 L of hot water was heated and destilled for 16 hours,
Next, it is filtered to remove insoluble matter, and further concentrated under reduced pressure.
Then, it was freeze-dried. Then, a warming medicine made of Clove extract was obtained. (Production Example 4) 500 g of dried leaves of the Cornaceae Sanshuyu
5 L of 50% ethanol was added thereto, and the mixture was extracted at room temperature for 1 week, then filtered to remove insoluble matter, further concentrated under reduced pressure, and then freeze-dried. And, the solid astringent medicine which consists of Sanshuyu extract was obtained. (Production Example 5) 500 g of dried leaves of Ginkgo biloba
5 L of 50% ethanol was added thereto, and the mixture was extracted at room temperature for 1 week, then filtered to remove insoluble matter, further concentrated under reduced pressure, and then freeze-dried. Then, a solid astringent medicine made of ginkgo biloba extract was obtained. (Production Example 6) 5 L of 50% ethanol was added to 500 g of the dried aerial part of Chorioletaceae Chorei, extracted at room temperature for 1 week, then filtered to remove insoluble matter, and further concentrated under reduced pressure. Lyophilized. Then, a water remedy composed of Chorei extract was obtained. (Production Example 7) 500 g of dried above-ground wormwood mugwort
5 L of 50% ethanol was added thereto, and the mixture was extracted at room temperature for 1 week, then filtered to remove insoluble matter, further concentrated under reduced pressure, and then freeze-dried. Then, a water remedy consisting of mugwort extract was obtained. (Production Example 8) 500 g of dried seeds of Apiaceae fennel
5 L of 50% ethanol was added thereto, and the mixture was extracted at room temperature for 1 week, then filtered to remove insoluble matter, further concentrated under reduced pressure, and then freeze-dried. Then, an intimate medicine made of fennel extract was obtained. (Production Example 9) 500 g of dried seeds of Pepperceae
5 L of 50% ethanol was added thereto, and the mixture was extracted at room temperature for 1 week, then filtered to remove insoluble matter, further concentrated under reduced pressure, and then freeze-dried. Then, a hot-drinking medicine consisting of hihatsu extract was obtained.

[0060]

Example 1 In order to confirm the effect of maintaining homeostasis of the whole body, the effect of recovering the temperature of the back of the hand was examined. That is, we collected 40 volunteers of male subjects with an average age of 29.2 years old,
In a room kept at constant temperature and constant humidity (24 ° C., 50%), they were allowed to rest for 1 hour, and the temperature of the back of each person's hand was measured by thermography.

Among the 40 persons, as Example 1, 5 persons include:
30 mg of Sanshyu extract, 30 mg of Chorei extract, 30 mg of fennel extract and 100 mL of water obtained in the above Production Examples 4, 6 and 8 were drunk. On the other hand, among 40 people, as Comparative Example 1, 5 people had 90 mg of Sanshyu extract and 100 mL of water as Comparative Example 2.
For 5 people, 90 mg Chorei extract and 100 mL water,
As Comparative Example 3, fennel extract 90 mg for 5 persons
And 100 mL of water as Comparative Example 4, for five people, 45 mg of Sanshyu extract, 45 mg of fennel extract and 1 part of water.
00 mL was set as Comparative Example 5, and five people had Sansuyu extract 45 mg, Chorei extract 45 mg and water 100 mL.
As Comparative Example 6, the chorei extract 45m for 5 people
g, fennel extract 45 mg, and water 100 mL were used as Control Example 1, and five people were asked to drink 100 mL of water alone.

Ten minutes later, the back of the subject's hand was put in a water tank at 24 ° C. for 2 minutes. After that, wipe off the water droplets, 2
After 0 minutes, the temperature of the back of each person's hand was measured by thermography, and the average value of the recovery rate of the temperature of the back of the hand was converted. The recovery rate is the temperature difference between the temperature of the back of the hand (a ° C) before applying it to the water tank and the temperature of the back of the hand (b ° C) after applying it to the water tank (2 minutes) x
And the temperature of the back of the hand (c ° C) 20 minutes after putting it in the water tank
And the temperature of the back of the hand (2 minutes) after putting it in the water tank (2 minutes)
The temperature difference of (° C.) was defined as y, and calculation was performed based on the following formula (I). The results are shown in Table 1.

[0063]

[Equation 1]

[0064]

[Table 1] In addition, the results of Table 1 are the average value of five people of the experimental results and Standed
Eerro Minimum (hereinafter also referred to as SEM) is shown.

As is clear from the results shown in Table 1, Example 1
The recovery rate of the temperature of the backs of the five hands is superior to that of the control group or the comparative example. From this, it can be seen that the combination of the three components of the astringent drug, the water remedy, and the anthracite improves the recovery rate of the temperature of the back of the hand and enhances the effect of maintaining homeostasis.

[0066]

[Example 2] In order to confirm the effect of maintaining homeostasis of the whole body, the effect of recovering the temperature of the back of the hand was examined. That is, we collected 40 volunteers of male subjects with an average age of 28.6 years,
In a room kept at constant temperature and constant humidity (24 ° C., 50%), they were allowed to rest for 1 hour, and the temperature of the back of each person's hand was measured by thermography.

Among the 40 persons, as Example 2, 5 persons include:
30 mg of ginkgo biloba extract, 30 mg of mugwort extract, 30 of hihatsu extract obtained in the above Production Examples 5, 7 and 9, respectively.
I had him drink mg and 100 mL of water. On the other hand, of 40 people, as Comparative Example 7, 5 people had 90 ginkgo biloba extract.
mg and water 100 mL, as Comparative Example 8, for 5 people, mugwort extract 90 mg and water 100 mL, and as Comparative Example 9, for 5 people, hihatsu extract 90 mg and water 100 mL.
As Comparative Example 10, ginkgo biloba extract 45
As comparative example 11, ginkgo biloba extract 45 mg, ginseng extract 45 mg, mugwort extract 45 mg and water 100 mL as comparative example 11, as comparative example 12, mugwort extract 45 mg, hihatsu extract 4 as comparative example 12.
5 mg and 100 mL of water were used as Control Example 2 for 5 persons.
I had him drink 100 mL of water only.

After 10 minutes, the back of the subject's hand was put in a water tank at 24 ° C. for 2 minutes. After that, wipe off the water droplets, 2
After 0 minutes, the temperature of the back of each person's hand was measured by thermography, and the average recovery rate of the temperature of the back of the hand was converted by the same method as in Example 1. The results are shown in Table 2.

[0069]

[Table 2] In addition, the result of Table 2 shows the average value and SEM of five persons of the experimental result.

As is clear from the results in Table 2, Example 2
The recovery rate of the temperature of the backs of the five hands is superior to that of the control group or the comparative example. From this, it can be seen that the combination of the three components of the astringent drug, the water remedy, and the anthracite improves the recovery rate of the temperature of the back of the hand and enhances the effect of maintaining homeostasis.

[0071]

Examples 3 to 5 According to the formulations shown in Table 3, foods containing the homeostatic composition of the present invention were produced. The ingredients shown in Table 3 were granulated by tumbling phase with 10 parts by weight of water and compressed into tablets to produce food products. In Table 3, the unit of numerical values is parts by weight (hereinafter, similarly, the unit of numerical values in each table is parts by weight).

[0072]

[Table 3] We asked 15 panelists, 1 group of workers working in a coal mine in Hokkaido, to eat the above food twice a day in the morning and evening for 3 months in winter, and evaluate the effect of enhancing the resistance to cold. It was

The evaluation criteria were as follows: score 2: remarkable improvement, score 1: clear improvement, score 0.5: slight improvement, score 0: no improvement. As a result, Example 3 was 0.91, Example 4 was 0.90, and Example 5 was 0.89.

As is clear from the results of Examples 3 to 5, it was found that the food containing the composition for maintaining homeostasis of the present invention has an effect of preventing sensitivity to cold and enhancing resistance to cold. It was It was confirmed that the food containing the composition for maintaining homeostasis of the present invention can be suitably used as a health food for preventing body temperature fluctuation under low temperature conditions in a cold environment.

[0075]

Examples 6 to 8 According to the formulations shown in Table 4, foods containing the homeostatic composition of the present invention were produced. The ingredients shown in Table 4 were tumbling-phase granulated together with 10 parts by weight of water and compressed into tablets to produce a food product.

[0076]

[Table 4] Using a group of 15 workers, one group of workers working in a coal mine in Hokkaido, asked them to eat the above food twice a day in the morning and evening during a winter work period of 3 months, and evaluate the effect of enhancing resistance to cold. It was The evaluation criteria are the same as in Examples 3 to 5 above. As a result, Example 6 is 0.94, and Example 7 is 0.94.
0, Example 8 was 0.92.

As is clear from the results of Examples 6 to 8, it was found that the food containing the composition for maintaining homeostasis of the present invention has the effects of preventing sensitivity to cold and enhancing resistance to cold. It was It was confirmed that the food containing the composition for maintaining homeostasis of the present invention can be suitably used as a health food for preventing body temperature fluctuation under low temperature conditions in a cold environment.

[0078]

Examples 9 to 11 According to the formulations shown in Table 5, foods containing the composition for maintaining homeostasis of the present invention were produced. The formulation components shown in Table 5 were solubilized with stirring to produce a food product as a drink formulation.

All of these foods showed excellent preventive and improving effects on coldness.

The food containing the composition for maintaining homeostasis according to the present invention can be preferably used as a health food for improving chills.

[0081]

[Table 5]

[0082]

Examples 12 to 14 According to the formulations shown in Table 6, foods containing the homeostatic composition of the present invention were produced. Table 6
The prescription components shown in (1) were stirred and solubilized to produce a drink formulation food product.

All of these foods showed excellent preventive and improving effects on coldness.

The food containing the composition for maintaining homeostasis according to the present invention can be suitably used as a health food for improving chills.

[0085]

[Table 6]

[0086]

Examples 15 to 17 According to the formulations shown in Table 7, foods containing the homeostatic composition of the present invention were produced. The prescription components were granulated by tumbling phase with 10 parts by weight of water and compressed to obtain a tablet-like composition for maintaining homeostasis. For this tablet
Tablets containing a homeostatic composition coated with an enteric coating agent were produced by spraying a 5% alcoholic solution of shellac with a mixed solution of triethyl citrate and capric acid monoglyceride as a plasticizer.

[0087]

[Table 7] All of these foods showed excellent preventive and improving effects on coldness.

It was confirmed that the tablet of the composition for maintaining homeostasis of the present invention, which was coated with the enteric coating agent containing the plasticizer, was a good tablet without cracks in the coating.

[0089]

Examples 18 to 20 According to the formulations shown in Table 8, foods containing the homeostatic composition of the present invention were produced. The prescription components were granulated by tumbling phase with 10 parts by weight of water and compressed to obtain a tablet-like composition for maintaining homeostasis. For this tablet
Tablets containing a homeostatic composition coated with an enteric coating agent were produced by spraying a 5% alcoholic solution of shellac with a mixed solution of triethyl citrate and capric acid monoglyceride as a plasticizer.

[0090]

[Table 8] All of these foods showed excellent preventive and improving effects on coldness.

It was confirmed that the tablet of the composition for maintaining homeostasis of the present invention, which was coated with the enteric coating agent containing the plasticizer, was a good tablet without cracks in the coating.

[0092]

Industrial Applicability According to the present invention, it is possible to provide a composition for maintaining homeostasis capable of enhancing the function of maintaining homeostasis in the living body with respect to the external environment, and a food using the composition. . In particular, the homeostasis-maintaining composition of the present invention works effectively for maintaining normal body temperature against the external temperature environment, and thus the food containing the homeostasis-maintaining composition of the present invention recovers body temperature. It can be effectively used as a health food for preventing body temperature fluctuation.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 35/84 A61K 35/84 A 47/14 47/14 47/42 47/42 47/46 47/46 A61P 25/02 103 A61P 25/02 103 43/00 43/00 F term (reference) 4B018 MD48 MD61 MD84 ME14 MF01 4C076 AA45 BB05 CC01 CC26 CC40 DD46L DD47L EE41J EE42J EE57J FF25 FF29 4C084 AA02 AA35 CA13 MA13 MAA24 MA13 MA37 MA41 MA43 MA52 MA55 MA60 MA66 NA14 ZA082 ZA241 ZA362 ZA372 ZA532 ZA592 ZA612 ZA622 ZA632 ZA692 ZA832 ZB211 ZB352 4C088 AA04 AB02 AB04 AB12 AB13 AB16 AB19 AB21 AB72 AB65 AB81 AB62 AB35 AB36 AB38 AB39 AB35 AB36 AB38 AB39 AB35 AB36 AB38 AB39 AB35 AB36 AB38 AB39 AB35 AB36 AB38 AB39 AB35 AB84 BA07 BA08 CA04 CA11 MA07 MA17 MA22 MA23 MA31 MA35 MA36 MA37 MA41 MA52 MA55 MA60 MA66 NA14 ZA08 ZA24 ZA36 ZA37 ZA51 ZA53 ZA59 ZA61 ZA62 ZA63 ZA69 ZA83 Z B21 ZB35 ZC21

Claims (13)

[Claims] 1. A composition for maintaining homeostasis, which comprises an astringent drug, a diuretic and an oncotic drug. 2. The composition for maintaining homeostasis according to claim 1, wherein the composition for maintaining homeostasis is a composition for oral administration. 3. The composition for maintaining homeostasis according to claim 1, wherein each of the solid astringent drug, the diuretic drug, and the hot-drug has a crude drug extract. 4. The solid astringent drug is Sanshuyu, Cornaceae, Magnoliaceae, Paramecium, Magnoliaceae, Plumaceae, Rumeaceae, Rhinoceros, Myrobalan, Pomegranate, Pomegranate, Poppy, Pomegranate, Pomegranate, Lotus, Lotus. The composition for maintaining homeostasis according to claim 3, which is an extract of a herbal medicine selected from lotus, Naniwaibara rose, Rhododendron strawberry, Nurude aura, Ginkgo biloba, and Ginkgo biloba. 5. The above-mentioned water repellents are succulent sycamore, syringaceae chorei, sycamore, takusha, asteraceae, mugwort, horse-tailed weeds, mokuboui, azalea family cambowi, gramineae, moss family, moss family, moss family, moss family. Lizardaceae, Caryophyllaceae, Echinacea japonica, Diptera, Diptera, Polygonumaceae, Willowaceae, Sekii, Psyllium, Psyllium, Mallow, Toad, Yamanoiaceae, Pea, Calendula, Primrose, Calendula,
4. The composition for maintaining homeostasis according to claim 3, which is an extract of a herbal medicine selected from Convolvulaceae, Dermatophagoides sinensis, Lamiaceae, Lentilaceae, Vineaceae, Azuki Bean, Hanpenrei, and Gramineae corn. 6. The above-mentioned onion medicine is a buttercup, agaricaceae, ginger, ginger, camphoraceae, citrus fruit, goshuyu, citrus cabbage salmon, phyllaceae clove, celeryaceae fennel, ginger ryekyo, camphoraceae sansoushi, pepper. The composition for maintaining homeostasis according to claim 3, which is an extract of a herbal medicine selected from the family Hihatu and pepper. 7. The crude drug extract is characterized in that a solvent is removed from a polar solvent extract of a crude drug.
The composition for maintaining homeostasis according to any one of claims 3 to 6. 8. The homeostatic maintenance according to any one of claims 1 to 7, wherein the homeostatic maintenance composition is applied to homeostatic maintenance in a cold environment. Composition. 9. The composition for maintaining homeostasis according to claim 1, wherein the composition for maintaining homeostasis is used for foods. 10. The composition for maintaining homeostasis according to claim 1, wherein the composition is a tablet coated with an enteric coating agent.
10. The composition for maintaining homeostasis according to any one of items 1 to 9. 11. The composition for maintaining homeostasis according to claim 10, wherein the enteric coating agent is selected from gelatin, zein and shellac. 12. The homeostatic composition according to claim 10, wherein the homeostatic composition is a tablet coated with an enteric coating agent and a plasticizer. 13. The plasticizer is triethyl citrate,
The composition for maintaining homeostasis according to claim 12, wherein the composition is selected from capric acid monoglyceride.