JP2012149096A - Anti-inflammatory preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an anti-inflammatory, anti-hepatopathy, anti-inflammatory intestinal syndrome, anti-functional enteropathy, anti-functional hepatopathy, anti-functional nephropathy or anti-diarrheal preparation characterized by containing the components of A, B and C, wherein A is cholic acid, scymnol or scymnol sulfate ester, B is soybean isoflavone or soybean isoflavone glycoside and C is curcumin.SOLUTION: This preparation is related to the anti-inflammatory, anti-hepatopathy, anti-inflammatory intestinal syndrome, anti-functional enteropathy, anti-functional hepatopathy, anti-functional nephropathy or anti-diarrheal preparation characterized by containing the components of A, B and C, wherein A is the cholic acid, scymnol or scymnol sulfate ester, B is the soybean isoflavone or soybean isoflavone glycoside and C is the curcumin.

Description

  The present invention relates to a novel anti-inflammatory agent, anti-hepatitis agent, anti-inflammatory bowel disease agent, anti-functional bowel disorder agent, anti-functional liver disorder agent, anti-functional kidney disorder agent, or anti-diarrheal agent.

The fulfillment of the will in the brain, that is, the fulfillment of energy, is governed by serotonin and noradrenaline, which are called brain hormones. Is activated by adrenaline.
Serotonin, noradrenaline, and adrenaline are called biological monoamines, and most monoamines that are secreted by oxidative degradation by the enzyme monoamine oxidase or reabsorbed into nerve tissue within a maximum of 3 hours lose their action. .
This is a clever human body mechanism to prevent fatigue because monoamines cause fatigue by acting for a long time.
By the way, Qi refers to all functions of the human body, but the functions are roughly divided into two types. One of them is the function of each organ, hormone secretion, blood vessels, etc., which is controlled by the autonomic nerve. The other is the function of brain thinking and voluntary muscles that move by commands issued by brain thinking.
It was pointed out early that the qi expressed by requisition and reasoning in Chinese medicine only refers to the function of the autonomic innervation of the former. The command to show how much of these functions is issued from the medulla at the bottom of the brain. Considering that the function of all autonomic innervation is activated rather than activating only a specific organ or organ with an adiabatic agent, the point of action of the adiabatic agent is not the organ or organ but the command source It is considered to be a medulla oblongata. In other words, the action of the aspirating drug is to promote the transmission of commands from the medulla and the enhancement of its transmission. I have found that ablative drugs are unevenly distributed in the organs of the body, but this is also one of the important actions of the medulla oblongata. This is achieved by constricting the blood vessels toward the brain and brain-regulated organs, and aiming to send more nutrients to the necessary parts as a side effect of the aerobic drugs.

JP 2000-103718 A Japanese Patent Laid-Open No. 5-51320 JP 2000-53573 A JP 2001-233768 A JP-T-2001-511117 Japanese Patent Laid-Open No. 11-2221048 JP-A-4-54139

Chugyaku Dictionary, Volume 2, Shogakukan Co., Ltd., 1998, first edition, third edition, p. 805-806, the section of "1628 cocody" Omura, Hashimoto, Sogo Plant, Yodogawa Shoten, 1936, p. 152-153 Yushiro Kimura, selection and medicinal properties of Japanese and Chinese medicines, Taniguchi Shoten Co., Ltd., 2000, 3rd printing, p. 228-234, “48 Carrots”

As you get older, anal prolapse and leg, lower back, and arm pain may occur, but it has been understood only because of the local blood circulation disorder or the resulting inflammation. The improvement of these medical conditions was insufficient with single use of a certain drug.
The cause of these disorders is due to inadequate transmission of brain commands to the local area, and blood circulation disorders and inflammation are troubles that occur because muscles cannot move normally due to incomplete transmission of brain commands.
For example, not all of the disorders in muscle are due to insufficient brain command transmission, but most of the disorders are thought to be due to insufficient brain command transmission. In particular, we found that muscle disorders such as low back pain and limb pain that occur with aging can be easily removed by improving brain command transmission by curcumin.
The present invention is based on this new medical theory, and has been developed as a medicine. Strong muscle action, anti-inflammatory action, anti-cerebral infarction action, anti-motor paralysis action, anti-asthma action, anti-sight loss action Another object of the present invention is to provide an extremely effective pharmaceutical agent having an anti-hepatitis action, an anti-inflammatory bowel disease action, an anti-functional bowel disorder action, and an anti-dementia action.

The invention of this application is
A. Cholic acid, simnol or simnol sulfate Soybean isoflavone or soybean isoflavone glycoside C.I. Anti-inflammatory agent, anti-hepatitis agent, anti-inflammatory bowel disease agent, anti-functional bowel disorder agent, anti-functional liver disorder agent, anti-functional kidney disorder characterized by containing A, B and C components of curcumin It relates to an agent or an antidiarrheal agent.
The present invention relates to an anti-hepatitis agent, an anti-inflammatory bowel disease agent, an anti-functional bowel disorder agent, an anti-functional liver disorder agent, an anti-functional kidney disorder agent, and an anti-diarrheal agent.
In the invention of the present application, the anti-inflammatory bowel disease agent includes a Crohn's disease agent, an anti-ulcerative colitis agent, and the like, and the anti-functional enteropathy agent includes an anti-irritable bowel syndrome agent.

The invention of this application relates to synergism by administering isoflavones, cholic acid or simnol, and pungent substances, bitter substances or sour substances, in particular, pungent substances, to reduce muscle weakness, inflammation, particularly arthritis such as arthritis and rheumatism. Antimuscular agent, anti-inflammatory agent or anti-cerebral infarction agent, anti-motor paralysis agent, anti-asthma agent, anti-vision loss agent, anti-hepatitis agent, anti-inflammatory bowel disease agent, anti-functional bowel disorder There is an excellent effect that an agent, an anti-functional heart disorder agent, an anti-functional liver disorder agent, an anti-functional kidney disorder agent, an anti-diarrheal agent, and an anti-dementia agent can be provided.
It is also effective for side effects caused by anticancer agents such as internal bleeding, diarrhea, heart, liver, kidney and other functional disorders. Therefore, these side effects can be suppressed by using together with an anticancer agent.

The invention of this application preferably contains a pungent substance, a bitter substance or a sour substance, but preferably contains isoflavones and isoflavone glycosides, and the isoflavones and isoflavone glycosides are contained in soybeans. Soy isoflavones and soy isoflavone glycosides are particularly preferred.
Moreover, when using isoflavone and an isoflavone glycoside, it is preferable to add cholic acid.

  The daily dose of isoflavone and isoflavone glycoside is preferably 1 to 500 mg, more preferably 5 to 200 mg, and particularly preferably 10 to 100 mg.

トウガラシのカプサイシン、

コショウのピペリン、

ショウガのジンゲロン、

ショウガの［６］−ショーガオール、

ショウガの［６］−ジンゲロール

であることが好ましく、クルクミンがとくに好ましい。
苦味物質は、スウェルチアマリン、ゲンチオピクリン、ロガニンが好ましい。
また、酸味物質は、クエン酸、乳酸が好ましい。 The pungent substance, bitter substance or sour substance of the present invention is preferably a pungent substance.
The pungent substance is turmeric curcumin,

Capsicum capsicum,

Pepperine with pepper,

Ginger gingeron,

Ginger [6]-Shogaol,

[6] -gingerol of ginger

And curcumin is particularly preferred.
The bitter substance is preferably swell thiamarin, gentiopicrin, or loganin.
The sour substance is preferably citric acid or lactic acid.

The daily dose of the pungent substance is preferably 1 to 1000 mg, more preferably 5 to 300 mg, and particularly preferably 10 to 70 mg.
The daily dose of these single uses is preferably 100 to 800 mg, particularly preferably 300 to 500 mg.
In addition, the daily dose when used in combination with a Chinese medicine preparation or Chinese medicine having a correcting effect such as Juzentaihoto is preferably 100 to 200 mg.

  The daily dose of cholic acid is preferably 1 to 1000 mg, more preferably 2 to 300 mg, and particularly preferably 10 to 100 mg.

  The daily dose of simnole and / or simnol ester is preferably 0.1 to 100 mg, more preferably 0.1 to 50 mg, and particularly preferably 0.3 to 10 mg.

As other ingredients, pharmaceuticals in general are used, and vitamins, antibiotics, anticancer agents, heme iron, prune extract, and crude drugs are used.
Preferred crude drugs are those that have a correcting effect, such as those that activate the functions of organs, glands and blood vessels that are governed by autonomic nerves, and those that aid digestion.

More than ten kinds of herbal medicines that activate the functions of organs, glands, and blood vessels controlled by autonomic nerves are known. For example, there are carrots, but some active ingredients of these herbal medicines including carrots are already clear. Has been.
Therefore, it is preferable to add these active ingredients. By further adding these active ingredients, the human body function activating effect can be exhibited.
Such herbal medicines include carrots, carrots, ginseng, talisins, western ginseng, jade, birch jutsu, sanyaku, licorice. Especially preferred are Taisu, Koui, Yellow spirit, and Yotsugin.

  In addition, it is particularly preferable to add hawthorn, Shinkiku, life comb, malt (Bakuga), cereal (Kokuga), chicken inner gold (Kainaikin), Aki (Agi), etc., which are herbal medicines that help digestion.

また、シムノール硫酸エステルナトリウム塩はつぎの構造式で表される。

Simnole and / or Simnol ester is contained in the bile of salmon.
Simnol is represented by the following structural formula:

Simnol sulfate sodium salt is represented by the following structural formula.

Another material used in the invention of this application is isoflavone and isoflavone glycoside.
The active ingredients for this purpose contained in soybeans are several isoflavone glycosides such as soybean in (Gaidin), glycitin (Glycitin), genistin (Gaistin) and the like, and their aglycones (Daizein), glycitein There are several isoflavones such as (Glycitein) and Genistein.
Soybean is a raw material for producing soybean oil, but the demand for soybean oil is large, and soybean meal, a by-product, is produced in large quantities at the same time. A part of soybean meal is used as a raw material for producing soybean protein as a raw material for food, but it is mainly used as fertilizer and feed, and its price is extremely low. Soybean isoflavone and soybean isoflavone glycosides can be produced with high purity and low cost from soybean meal that is close to industrial waste.

  In the invention of this application, inosinic acid is preferably added.

The invention of this application preferably adds odd fatty acids.
As the odd fatty acid, tridecanoic acid, pentadecanoic acid, heptadecanoic acid, and nonadecanoic acid are preferable, and pentadecanoic acid and heptadecanoic acid are particularly preferable.

The dosage form for administering the strong muscle agent and anti-inflammatory agent of the present invention is not particularly limited, but it is administered as an internal medicine such as a tablet, powder, solid, liquid, suppository, injection or the like.
In addition, excipients such as lactose and starch, vegetable oils, and others are used.

Hereinafter, the present invention will be described in detail.
The purity of the soy isoflavone and soy isoflavone glycoside used was 40%.
Moreover, the purity of cholic acid used other than a pure product is 90%.

Example 1
Powder
Curcumin 30mg
Simnole 1mg
Soy isoflavone 125mg
Lactose 800mg
Corn starch
Magnesium stearate 10mg
Total 2000mg
(1 bag 1g twice a day)
Similarly, powder was prepared using soy isoflavone glycosides instead of soy isoflavone.

Example 2
Granule curcumin 30mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Lactose 1500mg
Corn starch appropriate amount Magnesium stearate 10mg
Total 2000mg
(1 bag 1g twice a day)
Similarly, granules were produced using soy isoflavone glycosides instead of soy isoflavones.

Example 3
Tablet curcumin 30mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Crystalline cellulose appropriate amount lactose 140mg
Magnesium stearate 6mg
Talc 3mg
Total 1120mg
(1 tablet, 280 mg, 2 tablets, 2 times a day)
Similarly, tablets were made using soy isoflavone glycosides instead of soy isoflavones.

Example 4
Tablet curcumin 25mg
Simnole 1mg
Soy isoflavone 250mg
Carrot powder 2000mg
Lactose 886mg
Crystalline cellulose appropriate amount Carboxymethylcellulose calcium 320mg
Hydroxypropylcellulose 558mg
Carplex 30mg
Magnesium stearate 55mg
Total 5600mg
(1 tablet, 280 mg, 5 tablets, 2 times a day)
Similarly, tablets were made using soy isoflavone glycosides instead of soy isoflavones.

Example 5
Hard capsule curcumin 30mg
Simnole 1mg
Soy isoflavone 125mg
Lactose 218mg
Corn starch appropriate amount Magnesium stearate 6mg
Total 1150mg
(1 capsule / 4 capsules, 2 capsules once a day twice)
Similarly, hard capsules were produced using soy isoflavone glycosides instead of soy isoflavones.

Example 6
Soft capsule curcumin 25mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Cod liver oil 80mg
Tocopherol acetate 5mg
Carrot extract 200mg
Beeswax 55mg
Edible oil
Total 1200mg
(4 capsules per day)
Similarly, soft capsules were produced using soy isoflavone glycosides instead of soy isoflavones.

Example 7
Drink curcumin 30mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Ginseng extract 10mg
Giant extract 10mg
Royal Jelly 100mg
Thiamine nitrate 10mg
Riboflavin sodium phosphate 5mg
Pyridoxine hydrochloride 10mg
Anhydrous caffeine 50mg
Ethanol 1.2mL
Ethyl paraoxybenzoate 4mg
Purified water
Total 50 mL bottle Similarly, a drink was prepared using soy isoflavone glycoside instead of soy isoflavone.

Example 8
Vitamin preparation (hard capsule)
Curcumin 25mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Thiamine hydrochloride 25mg
Pyridoxine hydrochloride 10mg
Riboflavin 10mg
Cyanocobalamin 12mg
Nicotinamide 20mg
Calcium pantothenate 20mg
Ascorbic acid 60mg
L-cysteine 10m
Lactose 263mg
Magnesium stearate 6mg
Corn starch appropriate amount total 1150mg
(2 capsules, 2 times a day)
Similarly, hard capsules were produced using soy isoflavone glycosides instead of soy isoflavones.

Example 9
Injection curcumin 30mg
Simnol sulfate sodium salt 1mg
Pure soy isoflavone 20mg
Glucose 500mg
Make pH 7 with 10% sodium hydroxide for pH adjustment, add distilled water for injection to make a total volume of 5 mL, sterilize after ampules are sealed.
Similarly, an injection was prepared using soy isoflavone glycoside instead of soy isoflavone.

Example 10
Powder curcumin 30mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Lactose 2700mg
Corn starch appropriate amount light silicic acid anhydride 5mg
Magnesium stearate 10mg
Total 4000mg (1 packet 2g twice a day)
Similarly, powder was prepared using soy isoflavone instead of soy isoflavone glycoside.

Example 11
Granule curcumin 25mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Lactose 2700mg
Corn starch appropriate amount crystalline cellulose 300mg
Light anhydrous silicic acid 5mg
Magnesium stearate 10mg
Total 4000mg (1 packet 2g twice a day)
Similarly, granules were produced using soy isoflavones instead of soy isoflavone glycosides.

Example 12
Spherical granule curcumin 30mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Lactose 515mg
Corn starch 500mg
Crystalline cellulose 400mg
Total 2000mg (1 packet 1g twice a day)
Similarly, spherical granules were produced using soy isoflavone instead of soy isoflavone glycoside.

Example 13
Tablet curcumin 30mg
Cholic acid 140mg
Soy isoflavone glycoside 280mg
Lactose 4000mg
Carboxymethylcellulose calcium 320mg
Hydroxypropylcellulose 74mg
Crystalline cellulose appropriate amount Carplex 30mg
Magnesium stearate 10mg
Total 5484mg (1 tablet 280mg once 5 tablets twice a day)
Similarly, tablets were produced using soy isoflavones instead of soy isoflavone glycosides.

Example 14
Hard capsule curcumin 25mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Corn starch appropriate amount Magnesium stearate 9mg
Total 1153mg (1 capsule 4 capsules per day)
Similarly, hard capsules were produced using soy isoflavones instead of soy isoflavone glycosides.

Example 15
Soft capsule curcumin 30mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Beeswax 55mg
Edible oil appropriate amount total 1200mg (4 capsules per day)
Similarly, soft capsules were produced using soy isoflavones instead of soy isoflavone glycosides.

Example 16
Injection curcumin 25mg
Pure cholic acid 20mg
Pure soybean isoflavone glycoside 20mg
Glucose 1000mg
pH adjuster Sodium carbonate Add an appropriate amount of distilled water for injection to make a total volume of 5 ml.
Similarly, an injection was prepared using soy isoflavone instead of soy isoflavone glycoside.

Example 17
Drink curcumin 30mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Ginseng extract 1500mg
Longan Extract 100mg
Garbage extract 300mg
Royal Jelly 150mg
Riboflavin sodium phosphate 10mg
Ethanol 1.2ml
Paraoxybenzoic acid 4mg
Purified water appropriate amount total 50ml
Similarly, a drink was prepared using soy isoflavone instead of soy isoflavone glycoside.

Example 18
Granule curcumin 25mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Thiamine hydrochloride 10mg
Pyridoxine hydrochloride 100mg
Hydroxocobalamin hydrochloride 1.027mg
Tocopherol acetate 100mg
Lactose 2700mg
Crystalline cellulose 300mg
Light anhydrous silicic acid 5mg
Magnesium stearate 10mg
Corn starch appropriate amount total 4000mg (1 sachet 2g twice a day)
Similarly, granules were produced using soy isoflavones instead of soy isoflavone glycosides.

Example 19
Capsule curcumin 30mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Vitamin A oil 4mg
Cholecalciferol 0.005mg
Tocopherol acetate 10mg
Vitamin C 600mg
Crystalline cellulose 250mg
Magnesium stearate 6mg
Corn starch appropriate amount total 1150mg
(1 capsule / 4 capsules, 2 capsules once a day twice)
Similarly, capsules were made using soy isoflavones instead of soy isoflavone glycosides.

Example 20
Capsule curcumin 25mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Cephalexin 375mg
Corn starch appropriate amount Magnesium stearate 6mg
Total 855mg (No.2 capsules / 3)
Similarly, capsules were made using soy isoflavones instead of soy isoflavone glycosides.

Example 21
Soft capsule curcumin 25mg
Simnol sulfate Na 1mg
Soy isoflavone 125mg
Cod liver oil 80mg
Tocopherol acetate 5mg
Heptadecanoic acid 30mg
Inosinic acid 100mg
Carrot extract 200mg
Beeswax 55mg
Edible oil
Total 1200mg
(4 capsules per day)
Similarly, soft capsules were produced using soy isoflavone glycosides instead of soy isoflavones.

Example 22
Soft capsule curcumin 30mg
Cholic acid 60mg
Soybean isoflavone glycoside 125mg
Heptadecanoic acid 30mg
Inosinic acid 100mg
Beeswax 55mg
Edible oil appropriate amount total 1200mg (4 capsules per day)
Similarly, soft capsules were produced using soy isoflavones instead of soy isoflavone glycosides.

Example 23
Powder
Simnole 1mg
Soy isoflavone 125mg
Lactose 800mg
Corn starch
Magnesium stearate 10mg
Total 2000mg (1 packet 1g twice a day)
Similarly, powder was prepared using soy isoflavone glycosides instead of soy isoflavone.

Example 24
Granules Simanol sulfate Na 1mg
Soy isoflavone 125mg
Lactose 1500mg
Corn starch appropriate amount Magnesium stearate 10mg
Total 2000mg (1 packet 1g twice a day)
Similarly, granules were produced using soy isoflavone glycosides instead of soy isoflavones.

Example 25
Tablet Simnol sulfate Na 1mg
Soy isoflavone 125mg
Crystalline cellulose appropriate amount lactose 140mg
Magnesium stearate 6mg
Talc 3mg
Total 1120mg
(1 tablet, 280 mg, 2 tablets, 2 times a day)
Similarly, tablets were made using soy isoflavone glycosides instead of soy isoflavones.

Example 26
Hard capsule simnole 1mg
Soy isoflavone 125mg
Lactose 218mg
Corn starch appropriate amount Magnesium stearate 6mg
Total 1150mg
(1 capsule / 4 capsules, 2 capsules once a day twice)
Similarly, hard capsules were produced using soy isoflavone glycosides instead of soy isoflavones.

Example 27
Soft capsule Simnol sulfate Na 1mg
Soy isoflavone 125mg
Cod liver oil 80mg
Tocopherol acetate 5mg
Carrot extract 200mg
Beeswax 55mg
Edible oil
Total 1200mg
(4 capsules per day)
Similarly, soft capsules were produced using soy isoflavone glycosides instead of soy isoflavones.

Example 28
Drink agent Simnol sulfate Na 1mg
Soy isoflavone 125mg
Ginseng extract 10mg
Giant extract 10mg
Royal Jelly 100mg
Thiamine nitrate 10mg
Riboflavin sodium phosphate 5mg
Pyridoxine hydrochloride 10mg
Anhydrous caffeine 50mg
Ethanol 1.2mL
Ethyl paraoxybenzoate 4mg
Purified water
Total 50 mL bottle Similarly, a drink was prepared using soy isoflavone glycoside instead of soy isoflavone.

Example 29
Injection Shimonol sulfate sodium salt 1mg
Pure soy isoflavone 20mg
Glucose 500mg
Make pH 7 with 10% sodium hydroxide for pH adjustment, add distilled water for injection to make a total volume of 5 mL, sterilize after ampules are sealed.
Similarly, an injection was prepared using soy isoflavone glycoside instead of soy isoflavone.

  Although no studies have been conducted on the effects of curcumin, zingerone, and shogaol on promoting adrenergic secretion, animal experiments using sputum showed a marked increase in blood glucose concentration, confirming the existence of adrenergic stimulating action. It was.

The tablet of Example 4 was taken once a day.
This makes it possible for a 83-year-old man who has become unintentionally walking and prolapsed with age to become able to easily walk normally and to become aware of the action of the anal sphincter by detaching from the anal prolapse and making a one-month trial. It was clearly improved, and a 63-year-old man who had difficulty walking on the stairs could easily walk on the stairs. The tablet of Example 13 had the same effect.
If these results are a simple pharmacological effect of improving local muscle activity, the information should be included in the results of curcumin use in Europe, the United States, and Okinawa. This is due to abnormal transmission of brain commands issued as a result of brain thinking to the local area.
In Western medicine, anal prolapse, leg, lower back, and arm pain have been understood only as a result of circulatory disturbance in the local area or the resulting inflammation, but simanol, isoflavone, and cholic acid are powerful enough to remove the vascular disturbance. Since the improvement of these disease states was insufficient with regular use alone, the cause of these disorders was due to insufficient transmission of brain commands to the local area. It can be understood that this is a trouble that occurs because muscles cannot move normally due to incomplete transmission of commands.
In addition, when they were taken by patients aged between 60 and 75 years old who complained of muscular disorders such as back pain, limb pain and anal prolapse, which occurred with aging, those symptoms improved.
Not all of the muscle disorders are due to insufficient brain command transmission, but most of the disorders are poor brain command transmission.
The combined use of isoflavones, cholic acid, simnol, curcumin, etc. has the effect of improving brain activity, so it can also eliminate muscle disorders, and it will be good news for the elderly to rejuvenate both spirit and physical strength. In addition, this prescription is very effective for arthritis such as rheumatism, and exerts great power especially for its prevention.
Curcumin is easy to obtain because high-purity curcumin is commercially available.

76-year-old and 83-year-olds were dosed once daily by using capsaicin 30 mg instead of curcumin in Example 1.
After several days, the effect was dramatic, and after one week it was effective against muscle weakness, arthritis and rheumatism.
Similarly, there were the following effects.
When given to a 74-year-old woman, the back pain was cured in 6 weeks. When given to a 39-year-old woman, the headache was cured in 6 weeks. When administered to a 56-year-old woman, rheumatoid arthritis was cured in a week. When administered to a 70-year-old woman, joint pain and bone pain were cured in 2 weeks. When administered to a 59-year-old woman for 6 weeks, the stiff neck was cured.
Capsaicin has a strong taste.
The capsule of Example 6 was taken once a day. The following effects were obtained by this administration.
A 39-year-old woman complaining of chilliness, headache, and loss of sight cured all symptoms after taking it for 6 weeks. A 71-year-old man with cerebral infarction sequelae and left-handed movement disorder improved after taking it for 8 weeks. A 73-year-old woman with cerebral infarction sequelae and left-sided motor paralysis was improved by taking it for 8 weeks. A 71-year-old male with sequelae of cerebral infarction and senile dementia was cured by taking it for 9 weeks. A 53-year-old woman with arrhythmia was significantly improved by taking it for 1 year. A 43-year-old woman with paroxysmal positional change dizziness took 6 weeks to improve. A 64-year-old woman with asthma improved after taking it for 4 weeks.
A 25-year-old man with irritable colitis was cured in 4 weeks. A 32-year-old man with irritable colitis improved in 4 weeks. A 66-year-old man with gastric ulcer and diarrhea was cured in 2 weeks. A 66-year-old woman with diarrhea was cured in 4 weeks. A 29-year-old woman with ulcerative colitis was cured in a week. A 42-year-old woman with diarrhea and chilliness was cured in 8 weeks. A man with diarrhea and constipation was cured. A 36 year old man with Crohn's disease was cured in 3 weeks. Hepatitis was cured by a 48-year-old man taking it for 2 weeks. A 48-year-old woman with chronic nephritis significantly improved after taking it for 6 weeks. It was improved by taking it for 16 weeks by a 64-year-old hypothyroid woman. A 74-year-old low-back and abdominal pain-forgetful woman improved after taking it for 6 weeks. A 39-year-old woman who was cold and easily tired improved after taking it for 6 weeks. A 54-year-old woman with chronic fatigue syndrome improved after taking it for 17 weeks. A 47-year-old man with chronic fatigue improved after taking it for 4 weeks. A 41-year-old woman with chronic fatigue improved after taking it for 6 weeks. A 71-year-old woman with tinnitus fatigue improved after taking it for 9 weeks. A 43-year-old woman with paroxysmal positional change dizziness took 6 weeks to improve. A 71-year-old woman with dizziness and tinnitus improved in 6 weeks. A 50-year-old man complaining of dullness and lethargy improved after taking it for 16 weeks. A 75-year-old woman with lung cancer, senile dementia, and an atomic bomb survivor took it for 4 weeks, and the side effects of drugs on lung cancer and the atomic bomb survivor were improved. A 34-year-old woman with lung cancer and brain tumor improved significantly after taking it for 4 weeks. A 51-year-old woman with breast cancer and lymphoma significantly improved after taking it for 2 weeks. A 36-year-old woman who complained of lethargy and lack of physical strength improved after taking it for 12 weeks. A 71-year-old man with senile dementia was cured by taking for 9 weeks. A 75-year-old woman with senile dementia improved in 4 weeks. A speckled 60-year-old woman was cured in 12 weeks. A 46-year-old woman with climacteric anemia and epilepsy improved markedly after taking it for 8 weeks.

  The present invention provides a new anti-inflammatory agent, anti-hepatitis agent, anti-inflammatory bowel disease agent, anti-functional bowel disorder agent, anti-functional liver disorder agent, anti-functional kidney disorder agent, or anti-diarrheal agent About.

Claims (5)

A. Cholic acid, simnol or simnol sulfate Soybean isoflavone or soybean isoflavone glycoside C.I. Anti-inflammatory agent, anti-hepatitis agent, anti-inflammatory bowel disease agent, anti-functional bowel disorder agent, anti-functional liver disorder agent, anti-functional kidney disorder characterized by containing A, B and C components of curcumin Agent or antidiarrheal agent. An anti-inflammatory agent, an anti-hepatitis agent, an anti-inflammatory bowel disease agent, an anti-functional bowel disorder agent, an anti-functional liver disorder agent, an anti-functional kidney disorder agent according to claim 1, characterized in that a vitamin agent is added. Or anti-diarrhea. Carrot, Carrot, Ginseng, Tai-jinjin, Western ginseng, Yellow ginseng, Japanese white birch, Sanyaku, Licorice, Licorice, Ganoderma, Kosei, Yotsuin, Hawthorn, Shinkiku, Life Kushi, Malt (Bakuga), Grain (Kokuga), Chicken inner gold (Kainaikin), Aki (Agi) The anti-inflammatory agent, anti-hepatitis agent, anti-inflammatory bowel disease agent, anti-functional bowel disorder agent, anti-functional liver disorder agent, anti-function according to claim 1 or 2, Sexual kidney disorder or antidiarrheal agent. An anti-inflammatory agent, an anti-hepatitis agent, an anti-inflammatory bowel disease agent, an anti-functional bowel disorder agent, an anti-functional liver disorder agent, an anti-inflammatory agent according to any one of claims 1 to 3, wherein inosinic acid is added. Functional nephropathy or antidiarrheal agent. An anti-inflammatory agent, an anti-hepatitis agent, an anti-inflammatory bowel disease agent, an anti-functional bowel disorder agent, an anti-functional liver disorder agent, an anti-inflammatory agent according to any one of claims 1 to 4, wherein heptadecanoic acid is added. Functional nephropathy or antidiarrheal agent.