JP2012139225A5 - - Google Patents
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- Publication number
- JP2012139225A5 JP2012139225A5 JP2012036971A JP2012036971A JP2012139225A5 JP 2012139225 A5 JP2012139225 A5 JP 2012139225A5 JP 2012036971 A JP2012036971 A JP 2012036971A JP 2012036971 A JP2012036971 A JP 2012036971A JP 2012139225 A5 JP2012139225 A5 JP 2012139225A5
- Authority
- JP
- Japan
- Prior art keywords
- yeast
- squalene
- process according
- oil
- water emulsion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 25
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 15
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 15
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 11
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 11
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 11
- 229940031439 squalene Drugs 0.000 claims 11
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 11
- 239000007764 o/w emulsion Substances 0.000 claims 10
- 241000282412 Homo Species 0.000 claims 7
- 230000002163 immunogen Effects 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000000839 emulsion Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 101710158485 3-hydroxy-3-methylglutaryl-coenzyme A reductase Proteins 0.000 claims 2
- VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical group NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- LOMPLISLGNPRKZ-UHFFFAOYSA-N 2-pentylsulfanyl-1,3-benzothiazol-6-amine Chemical compound C1=C(N)C=C2SC(SCCCCC)=NC2=C1 LOMPLISLGNPRKZ-UHFFFAOYSA-N 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108010059597 Lanosterol synthase Proteins 0.000 claims 1
- 241000235070 Saccharomyces Species 0.000 claims 1
- 102000005782 Squalene Monooxygenase Human genes 0.000 claims 1
- 108020003891 Squalene monooxygenase Proteins 0.000 claims 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims 1
- GNVMUORYQLCPJZ-UHFFFAOYSA-M Thiocarbamate Chemical compound NC([S-])=O GNVMUORYQLCPJZ-UHFFFAOYSA-M 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 210000000172 cytosol Anatomy 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 229940068968 polysorbate 80 Drugs 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 claims 1
- 229960003495 thiamine Drugs 0.000 claims 1
- 235000019157 thiamine Nutrition 0.000 claims 1
- 239000011721 thiamine Substances 0.000 claims 1
- BCEHBSKCWLPMDN-MGPLVRAMSA-N voriconazole Chemical compound C1([C@H](C)[C@](O)(CN2N=CN=C2)C=2C(=CC(F)=CC=2)F)=NC=NC=C1F BCEHBSKCWLPMDN-MGPLVRAMSA-N 0.000 claims 1
- 229960004740 voriconazole Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19048608P | 2008-08-28 | 2008-08-28 | |
| US61/190,486 | 2008-08-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011524473A Division JP4938911B2 (ja) | 2008-08-28 | 2009-08-28 | 高度に生産する酵母からのスクアレンの生産 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015000249A Division JP2015061546A (ja) | 2008-08-28 | 2015-01-05 | 高度に生産する酵母からのスクアレンの生産 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012139225A JP2012139225A (ja) | 2012-07-26 |
| JP2012139225A5 true JP2012139225A5 (enExample) | 2013-04-11 |
| JP5930766B2 JP5930766B2 (ja) | 2016-06-08 |
Family
ID=41625158
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011524473A Active JP4938911B2 (ja) | 2008-08-28 | 2009-08-28 | 高度に生産する酵母からのスクアレンの生産 |
| JP2012036971A Expired - Fee Related JP5930766B2 (ja) | 2008-08-28 | 2012-02-23 | 高度に生産する酵母からのスクアレンの生産 |
| JP2015000249A Pending JP2015061546A (ja) | 2008-08-28 | 2015-01-05 | 高度に生産する酵母からのスクアレンの生産 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011524473A Active JP4938911B2 (ja) | 2008-08-28 | 2009-08-28 | 高度に生産する酵母からのスクアレンの生産 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015000249A Pending JP2015061546A (ja) | 2008-08-28 | 2015-01-05 | 高度に生産する酵母からのスクアレンの生産 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US11236366B2 (enExample) |
| EP (2) | EP2369003B1 (enExample) |
| JP (3) | JP4938911B2 (enExample) |
| KR (1) | KR101443064B1 (enExample) |
| CN (1) | CN102257149B (enExample) |
| AT (1) | ATE513920T1 (enExample) |
| AU (1) | AU2009286426B2 (enExample) |
| BR (1) | BRPI0917716A2 (enExample) |
| CA (1) | CA2735404C (enExample) |
| CY (1) | CY1114687T1 (enExample) |
| DK (1) | DK2268823T3 (enExample) |
| EA (1) | EA028898B1 (enExample) |
| ES (2) | ES2761697T3 (enExample) |
| HR (1) | HRP20110671T1 (enExample) |
| IL (1) | IL211435A (enExample) |
| MX (1) | MX2011002279A (enExample) |
| NZ (1) | NZ591876A (enExample) |
| PL (1) | PL2268823T3 (enExample) |
| PT (1) | PT2268823E (enExample) |
| RS (1) | RS51999B (enExample) |
| SI (1) | SI2268823T1 (enExample) |
| SM (1) | SMT201100058B (enExample) |
| WO (1) | WO2010023551A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3260549A1 (en) | 2008-05-23 | 2017-12-27 | Nucelis LLC | Production of squalene using yeast |
| EP2292741A1 (en) * | 2009-08-26 | 2011-03-09 | OrganoBalance GmbH | Genetically modified organisms for the production of lipids |
| JP5978132B2 (ja) | 2009-11-23 | 2016-08-24 | ニューセリス インコーポレイテッド | 酵母を用いるスクアレン生成のための方法および組成物 |
| ES2453316T5 (es) | 2010-05-12 | 2017-07-18 | Novartis Ag | Procedimientos mejorados para preparar escualeno |
| CN102100260B (zh) * | 2010-12-03 | 2013-07-31 | 滨州学院 | 酵母油脂及其制备方法和应用 |
| CN102787140A (zh) | 2011-05-20 | 2012-11-21 | 罗盖特兄弟公司 | 从微藻制备与提取角鲨烯的工艺方法 |
| CN102787074B (zh) | 2011-05-20 | 2016-06-08 | 罗盖特兄弟公司 | 生产角鲨烯的微藻新菌株 |
| FR2975705B1 (fr) | 2011-05-27 | 2014-12-26 | Roquette Freres | Procede d'extraction du squalene a partir de microalgues |
| CA2866406A1 (en) | 2012-03-08 | 2013-09-12 | Novartis Ag | Adjuvanted formulations of booster vaccines |
| KR102192410B1 (ko) * | 2012-04-16 | 2020-12-17 | 로께뜨프레르 | 미세조류에 의해 생성된 스쿠알렌의 정련방법 |
| FR2989373B1 (fr) * | 2012-04-16 | 2016-05-06 | Roquette Freres | Procede de raffinage du squalene produit par microalgues |
| WO2014037472A1 (en) | 2012-09-06 | 2014-03-13 | Novartis Ag | Combination vaccines with serogroup b meningococcus and d/t/p |
| JP6440619B2 (ja) | 2012-10-12 | 2018-12-19 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 混合ワクチン用の架橋されていない無細胞百日咳抗原 |
| WO2014095771A1 (en) | 2012-12-18 | 2014-06-26 | Novartis Ag | Conjugates for protecting against diphtheria and/or tetanus |
| EP2971049B1 (en) | 2013-03-13 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Production of squalene and/or sterol from cell suspensions of fermented yeast |
| GB2518927A (en) * | 2013-05-21 | 2015-04-08 | Univ Swansea | The production of biomolecules using yeast |
| CN103849643A (zh) * | 2014-03-11 | 2014-06-11 | 北京理工大学 | 一种利用蛋白支架提高酿酒酵母中鲨烯的合成方法 |
| EP3130672B1 (en) * | 2014-04-09 | 2025-09-24 | Adeka Corporation | Mutant enzyme and production method for terpenoid using said mutant enzyme |
| EP3225691B1 (en) * | 2014-11-28 | 2020-10-28 | Ajinomoto Co., Inc. | Method for producing isoprenoid compound |
| EP3226904B1 (en) | 2014-12-02 | 2019-03-06 | Novartis AG | Manufacture of surfactant-containing compositions |
| CN104560731B (zh) * | 2014-12-26 | 2018-10-09 | 中国科学院青岛生物能源与过程研究所 | 一种高产角鲨烯的类酵母菌及其应用 |
| CN110373338B (zh) * | 2019-08-15 | 2021-09-28 | 宜昌东阳光生化制药有限公司 | 酿酒酵母及其用途 |
| CN111893049A (zh) * | 2020-06-30 | 2020-11-06 | 厦门大学 | 一种过表达角鲨烯合成酶基因的裂殖壶菌基因工程菌株及其构建方法和应用 |
| WO2025053947A1 (en) * | 2023-09-07 | 2025-03-13 | Avantor Performance Materials, Llc | Synthetic triterpenes composition, method of production and applications thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2017507C (en) | 1989-05-25 | 1996-11-12 | Gary Van Nest | Adjuvant formulation comprising a submicron oil droplet emulsion |
| US5460949A (en) * | 1990-11-15 | 1995-10-24 | Amoco Corporation | Method and composition for increasing the accumulation of squalene and specific sterols in yeast |
| JP2785084B2 (ja) | 1991-11-18 | 1998-08-13 | 三菱石油株式会社 | スクアレンを生産する酵母の作製法及び作製された新規酵母 |
| JPH06116171A (ja) | 1992-10-06 | 1994-04-26 | Nippon Fine Chem Co Ltd | 天然スクワレンの精製方法 |
| DE4316620A1 (de) | 1993-05-18 | 1994-11-24 | Mueller Extract Co Gmbh | Verfahren und Vorrichtung zur Herstellung von Squalen aus Olivenölrückständen |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| JPH10120548A (ja) | 1996-10-23 | 1998-05-12 | Shiseido Co Ltd | 肌荒れ防止剤 |
| US20040235088A1 (en) | 1997-09-30 | 2004-11-25 | Schering Aktiengesellschaft | Process for the production of ergosterol and its intermediate products using recombinant yeasts |
| DE19744212B4 (de) * | 1997-09-30 | 2006-01-19 | Schering Ag | Verfahren zur Herstellung von Ergosterol und dessen Zwischenprodukten mittels rekombinanter Hefen |
| DE10012370A1 (de) | 2000-03-14 | 2001-09-27 | Chiron Behring Gmbh & Co | Adjuvans für Vakzinen |
| US20020168389A1 (en) * | 2000-12-28 | 2002-11-14 | Prem Chandar | Stable skin conditioning compositions containing retinoid boosters |
| KR20060133994A (ko) * | 2003-12-12 | 2006-12-27 | 사노피 파스퇴르 리미티드 | 디프테리아 독소의 생산 방법 |
| US20060094104A1 (en) | 2004-10-29 | 2006-05-04 | Leopold Grillberger | Animal protein-free media for cultivation of cells |
| US20060286046A1 (en) | 2005-01-05 | 2006-12-21 | Haber C Andrew | Skin care compositions |
| DK1853623T3 (da) * | 2005-03-03 | 2013-07-15 | Allergan Inc | Dyreprodukt-frit system og fremgangsmåde til oprensning af et botulinumtoksin |
| US8703095B2 (en) | 2005-07-07 | 2014-04-22 | Sanofi Pasteur S.A. | Immuno-adjuvant emulsion |
| US7375188B2 (en) * | 2005-07-29 | 2008-05-20 | Mallinckrodt Baker, Inc. | Vegetarian protein a preparation and methods thereof |
| KR101321732B1 (ko) | 2005-08-02 | 2013-10-29 | 노바티스 백신즈 앤드 다이아그노스틱스 에스.알.엘. | 오일-함유 보조제 및 계면활성제-함유 항원 사이의 간섭감소 |
| JP4210674B2 (ja) | 2005-08-31 | 2009-01-21 | 全国農業協同組合連合会 | マイコプラズマ・ガリセプティカム培養用培地 |
| FR2896162B1 (fr) | 2006-01-13 | 2008-02-15 | Sanofi Pasteur Sa | Emulsion huile dans eau thermoreversible |
| JP5053557B2 (ja) * | 2006-03-24 | 2012-10-17 | 株式会社 資生堂 | 白濁状水中油型乳化化粧料の製造方法 |
| DK2468300T3 (da) * | 2006-09-26 | 2018-01-29 | Infectious Disease Res Inst | Vaccinesammensætning indeholdende syntetisk adjuvant |
| WO2008130372A2 (en) | 2006-09-28 | 2008-10-30 | Microbia, Inc. | Production of sterols in oleaginous yeast and fungi |
| HRP20130023T1 (hr) | 2006-10-12 | 2013-02-28 | Glaxosmithkline Biologicals S.A. | Cjepivo koje sadrži emulziju ulje u vodi kao adjuvans |
| GB0622282D0 (en) * | 2006-11-08 | 2006-12-20 | Novartis Ag | Quality control methods |
| US8092813B1 (en) * | 2007-12-28 | 2012-01-10 | Novartis Ag | Polychlorinated biphenyls and squalene-containing adjuvants |
| EP3260549A1 (en) * | 2008-05-23 | 2017-12-27 | Nucelis LLC | Production of squalene using yeast |
| EP2292741A1 (en) | 2009-08-26 | 2011-03-09 | OrganoBalance GmbH | Genetically modified organisms for the production of lipids |
-
2009
- 2009-08-28 EA EA201170381A patent/EA028898B1/ru not_active IP Right Cessation
- 2009-08-28 HR HR20110671T patent/HRP20110671T1/hr unknown
- 2009-08-28 NZ NZ591876A patent/NZ591876A/xx not_active IP Right Cessation
- 2009-08-28 ES ES11170769T patent/ES2761697T3/es active Active
- 2009-08-28 EP EP11170769.1A patent/EP2369003B1/en active Active
- 2009-08-28 PT PT09786243T patent/PT2268823E/pt unknown
- 2009-08-28 MX MX2011002279A patent/MX2011002279A/es active IP Right Grant
- 2009-08-28 AT AT09786243T patent/ATE513920T1/de active
- 2009-08-28 ES ES09786243T patent/ES2366941T3/es active Active
- 2009-08-28 IL IL211435A patent/IL211435A/en active IP Right Grant
- 2009-08-28 KR KR1020117007019A patent/KR101443064B1/ko active Active
- 2009-08-28 RS RS20110410A patent/RS51999B/sr unknown
- 2009-08-28 US US13/061,505 patent/US11236366B2/en active Active
- 2009-08-28 WO PCT/IB2009/006825 patent/WO2010023551A2/en not_active Ceased
- 2009-08-28 DK DK09786243.7T patent/DK2268823T3/da active
- 2009-08-28 EP EP09786243A patent/EP2268823B1/en active Active
- 2009-08-28 JP JP2011524473A patent/JP4938911B2/ja active Active
- 2009-08-28 CA CA2735404A patent/CA2735404C/en active Active
- 2009-08-28 CN CN2009801391118A patent/CN102257149B/zh active Active
- 2009-08-28 AU AU2009286426A patent/AU2009286426B2/en active Active
- 2009-08-28 BR BRPI0917716A patent/BRPI0917716A2/pt not_active Application Discontinuation
- 2009-08-28 PL PL09786243T patent/PL2268823T3/pl unknown
- 2009-08-28 SI SI200930070T patent/SI2268823T1/sl unknown
-
2011
- 2011-09-15 CY CY20111100893T patent/CY1114687T1/el unknown
- 2011-11-17 SM SM201100058T patent/SMT201100058B/it unknown
-
2012
- 2012-02-23 JP JP2012036971A patent/JP5930766B2/ja not_active Expired - Fee Related
-
2015
- 2015-01-05 JP JP2015000249A patent/JP2015061546A/ja active Pending
-
2021
- 2021-12-20 US US17/555,867 patent/US20220177928A1/en not_active Abandoned
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