JP2012130759A - 骨構造をキャラクタライズするための拡散型磁気共鳴法の手順 - Google Patents
骨構造をキャラクタライズするための拡散型磁気共鳴法の手順 Download PDFInfo
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Abstract
【解決手段】インビトロまたはインビボの核磁気共鳴及び/または磁気共鳴画像により骨試料内部の分子拡散の効果を測定することによって骨梁の構造に関するパラメータを導出する。分子拡散の効果を測定にはDDIF(Decay from diffusion inthe internal field(内部磁場中での拡散による減衰))および/またはパルス磁場勾配(PFG)法を利用する。本手順は、骨梁骨の構造の完全な高解像度画像を必要とすることなく骨梁骨についてトポロジカルな情報を与える非侵襲的な検査法であって、臨床での使用に適合したものである。
【選択図】図7
Description
Claims (8)
- 骨構造の指標を得る手順であって、
骨の試料内部の拡散を測定することと、
複数回の拡散について拡散の測定を繰り返すことと、
前記拡散測定に基づいて統計的情報を得ることと、
前記統計的情報から少なくとも1つの骨の性質を抽出して骨構造の指標を得ることとを含む手順。 - 前記少なくとも1つの骨の性質は骨の表面/体積比を含む請求項1に記載の手順。
- 前記拡散を測定することは、骨の内部磁場中での減衰による拡散を測定することを含む請求項1に記載の手順。
- 前記拡散を測定することは、PFGを用いて拡散を測定することを含む請求項1に記載の手順。
- 骨の構造的性質のマップを得るための手順であって、
骨の試料内部の拡散重み付けされた画像を測定することと、
複数回の拡散について拡散重み付けされた画像を繰り返すことと、
前記拡散測定に基づいて統計的情報を得ることと、
前記統計的情報から少なくとも1つの骨の性質を抽出して各ボクセルについて骨構造の指標を得ることと、
骨試料全体について前記骨の性質のマップを得ることとを含む手順。 - 前記拡散重み付けされた画像を測定することは、PFGパルスシーケンス、次いでイメージングシーケンスを用いて拡散を測定することを含む請求項5に記載の手順。
- 前記拡散重み付けされた画像を測定することは、DDIFパルスシーケンス、次いでイメージングシーケンスを用いて拡散を測定することを含む請求項5に記載の手順。
- 骨中の特定のボクセルにおける構造的性質を得るための手順であって、
骨の試料内部で体積選択MRI法を用いて拡散重み付けされたシグナルを測定することと、
複数回の拡散について拡散重み付けされたシグナルを繰り返すことと、
前記拡散測定に基づいて統計的情報を得ることと、
前記統計的情報から少なくとも1つの骨の性質を抽出して前記ボクセルについて骨構造の指標を得ることとを含む手順。
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CN103353462A (zh) * | 2013-06-17 | 2013-10-16 | 中国石油大学(华东) | 一种基于核磁共振成像的岩石非均质性定量评价方法 |
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US7894891B2 (en) * | 2006-01-24 | 2011-02-22 | Schlumberger Technology Corporation | Diffusion-based magnetic resonance methods for characterizing bone structure |
US8704515B2 (en) * | 2008-08-11 | 2014-04-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Magnetic resonance specimen evaluation using multiple pulsed field gradient sequences with a wavenumber magnitude local minimum and restricted compartment estimation |
JP5364954B2 (ja) * | 2008-09-19 | 2013-12-11 | 株式会社 Jeol Resonance | Nmr測定方法 |
US9097778B2 (en) * | 2009-03-30 | 2015-08-04 | Hitachi, Ltd. | Magnetic resonance device with diffusion gradient phase variation positionally corrected |
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JP5611882B2 (ja) * | 2010-05-31 | 2014-10-22 | 株式会社東芝 | 磁気共鳴イメージング装置 |
EP2585845A1 (en) | 2010-06-24 | 2013-05-01 | Ramot at Tel Aviv University Ltd. | Magnetic resonance analysis using a plurality of pairs of bipolar gradient pulses |
JP5925529B2 (ja) * | 2011-03-31 | 2016-05-25 | 株式会社東芝 | 磁気共鳴イメージング装置 |
US9404986B2 (en) * | 2011-05-06 | 2016-08-02 | The Regents Of The University Of California | Measuring biological tissue parameters using diffusion magnetic resonance imaging |
US20140184224A1 (en) * | 2011-08-10 | 2014-07-03 | Ramot At Tel-Aviv University Ltd. | Magnetic resonance method for analyzing pore size distribution |
US9245069B2 (en) * | 2012-02-03 | 2016-01-26 | The Regents Of The University Of California | Methods for calculating bone fracture load |
SE537065C2 (sv) | 2012-05-04 | 2014-12-23 | Cr Dev Ab | Pulssekvensförfarande för MRI |
CN103479356B (zh) * | 2012-06-14 | 2015-07-29 | 西门子(深圳)磁共振有限公司 | 一种扩散张量磁共振成像方法 |
US10228335B2 (en) | 2013-01-03 | 2019-03-12 | Schlumberger Technology Corporation | Method for nuclear magnetic resonance diffusion measurements |
US9541513B2 (en) | 2013-01-03 | 2017-01-10 | Schlumberger Technology Corporation | Method for nuclear magnetic resonance diffusion measurements |
US9678185B2 (en) | 2013-03-15 | 2017-06-13 | Pepsico, Inc. | Method and apparatus for measuring physico-chemical properties using a nuclear magnetic resonance spectrometer |
AU2015214638B2 (en) * | 2014-02-10 | 2019-07-11 | Random Walk Imaging Ab | Method for quantifying isotropic diffusion and/or anisotropic diffusion in a sample |
US10031255B2 (en) * | 2014-03-24 | 2018-07-24 | Schlumberger Technology Corporation | Multi-dimensional nuclear magnetic resonance methods for characterizing fluids |
SE1551719A1 (sv) | 2015-12-29 | 2016-12-20 | Cr Dev Ab | Method of extracting information about a sample by nuclear magnetic resonance measurements |
KR102620599B1 (ko) * | 2016-11-09 | 2024-01-02 | 랜덤 워크 이미징 에이비 | 샘플에 대해 확산 가중 자기 공명 측정을 수행하는 방법 |
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CN103353462B (zh) * | 2013-06-17 | 2015-12-09 | 中国石油大学(华东) | 一种基于核磁共振成像的岩石非均质性定量评价方法 |
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IL192992A (en) | 2012-07-31 |
JP5443531B2 (ja) | 2014-03-19 |
US20070238969A1 (en) | 2007-10-11 |
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IL217728A (en) | 2015-02-26 |
EP1976430A2 (en) | 2008-10-08 |
IL192992A0 (en) | 2009-02-11 |
US20110105886A1 (en) | 2011-05-05 |
WO2007087494A2 (en) | 2007-08-02 |
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US7894891B2 (en) | 2011-02-22 |
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