JP2009524830A - 骨構造をキャラクタライズするための拡散型磁気共鳴法 - Google Patents
骨構造をキャラクタライズするための拡散型磁気共鳴法 Download PDFInfo
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- JP2009524830A JP2009524830A JP2008552528A JP2008552528A JP2009524830A JP 2009524830 A JP2009524830 A JP 2009524830A JP 2008552528 A JP2008552528 A JP 2008552528A JP 2008552528 A JP2008552528 A JP 2008552528A JP 2009524830 A JP2009524830 A JP 2009524830A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/45—For evaluating or diagnosing the musculoskeletal system or teeth
- A61B5/4504—Bones
- A61B5/4509—Bone density determination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/45—For evaluating or diagnosing the musculoskeletal system or teeth
- A61B5/4504—Bones
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/561—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
- G01R33/5615—Echo train techniques involving acquiring plural, differently encoded, echo signals after one RF excitation, e.g. using gradient refocusing in echo planar imaging [EPI], RF refocusing in rapid acquisition with relaxation enhancement [RARE] or using both RF and gradient refocusing in gradient and spin echo imaging [GRASE]
- G01R33/5617—Echo train techniques involving acquiring plural, differently encoded, echo signals after one RF excitation, e.g. using gradient refocusing in echo planar imaging [EPI], RF refocusing in rapid acquisition with relaxation enhancement [RARE] or using both RF and gradient refocusing in gradient and spin echo imaging [GRASE] using RF refocusing, e.g. RARE
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/563—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution of moving material, e.g. flow contrast angiography
- G01R33/56341—Diffusion imaging
Abstract
【選択図】 図1
Description
Claims (18)
- 骨梁骨試料の強度を推定する方法であって、
磁気共鳴法を用いて骨梁骨試料の内部の分子拡散の効果を測定して測定データを与えることと、
少なくとも2回の拡散について測定を繰り返すことと、
測定されたデータから骨梁骨試料の構造に関するパラメータを導出することと、
前記パラメータから骨梁骨試料の強度を推定することと、を含む方法。 - 骨梁骨試料の骨体積分率を計算することを更に含み、前記骨梁骨試料の強度を推定することは、前記パラメータ及び前記骨体積分率に基づいて骨梁骨試料の強度を測定することを含む請求項1に記載の方法。
- 骨梁骨試料の骨ミネラル密度を計算することを更に含み、前記骨梁骨試料の強度を推定することは、前記パラメータ及び前記骨ミネラル密度に基づいて骨梁骨試料の強度を測定することを含む請求項1に記載の方法。
- 前記パラメータを導出することは、骨梁骨試料の表面/体積比を導出することを含む請求項1に記載の方法。
- 前記測定することは、骨梁骨試料にDDIF測定を行って測定されたDDIF減衰データを得ることを含む請求項1に記載の方法。
- 前記測定されたDDIF減衰データにラプラス変換を行ってDDIFスペクトルを得ることを更に含む請求項5に記載の方法。
- 前記測定することは、骨梁骨試料にPFG測定を行って測定されたADCデータを得ることを含む請求項1に記載の方法。
- 前記測定されたADCに近似を行って投影表面/体積比を得ることを更に含む請求項7に記載の方法。
- 前記測定することは、異なる方向に沿った磁場勾配を用いて骨梁骨試料にPFG測定を行うことを含む請求項1に記載の方法。
- 前記測定されたADCに近似を行って表面/体積テンソルを得ることを更に含む請求項9に記載の方法。
- 骨構造の指標を得る手順であって、
骨の試料内部の拡散を測定することと、
複数回の拡散について拡散の測定を繰り返すことと、
前記拡散測定に基づいて統計的情報を得ることと、
前記統計的情報から少なくとも1つの骨の性質を抽出して骨構造の指標を得ることとを含む手順。 - 前記少なくとも1つの骨の性質は骨の表面/体積比を含む請求項11に記載の手順。
- 前記拡散を測定することは、骨の内部磁場中での減衰による拡散を測定することを含む請求項11に記載の手順。
- 前記拡散を測定することは、PFGを用いて拡散を測定することを含む請求項11に記載の手順。
- 骨の構造的性質のマップを得るための手順であって、
骨の試料内部の拡散重み付けされた画像を測定することと、
複数回の拡散について拡散重み付けされた画像を繰り返すことと、
前記拡散測定に基づいて統計的情報を得ることと、
前記統計的情報から少なくとも1つの骨の性質を抽出して各ボクセルについて骨構造の指標を得ることと、
骨試料全体について前記骨の性質のマップを得ることとを含む手順。 - 前記拡散重み付けされた画像を測定することは、PFGパルスシーケンス、次いでイメージングシーケンスを用いて拡散を測定することを含む請求項15に記載の手順。
- 前記拡散重み付けされた画像を測定することは、DDIFパルスシーケンス、次いでイメージングシーケンスを用いて拡散を測定することを含む請求項15に記載の手順。
- 骨中の特定のボクセルにおける構造的性質を得るための手順であって、
骨の試料内部で体積選択MRI法を用いて拡散重み付けされたシグナルを測定することと、
複数回の拡散について拡散重み付けされたシグナルを繰り返すことと、
前記拡散測定に基づいて統計的情報を得ることと、
前記統計的情報から少なくとも1つの骨の性質を抽出して前記ボクセルについて骨構造の指標を得ることとを含む手順。
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EP (1) | EP1976430A2 (ja) |
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Cited By (5)
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JP2010071839A (ja) * | 2008-09-19 | 2010-04-02 | Jeol Ltd | Nmr測定方法 |
JP2015518408A (ja) * | 2012-05-04 | 2015-07-02 | セェーアール ディベロップメント アクチエボラグCr Development Ab | Mriのパルス・シーケンス方法 |
JP2017507698A (ja) * | 2014-02-10 | 2017-03-23 | シーアール ディベロップメント アーベー | サンプルにおける等方性拡散及び/又は異方性拡散を定量化するための方法 |
JP2019534087A (ja) * | 2016-11-09 | 2019-11-28 | シーアール ディベロップメント アーベー | サンプルに拡散強調磁気共鳴測定を実行する方法 |
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WO2011103689A1 (en) * | 2010-02-25 | 2011-09-01 | Ao Technology Ag | Method for designing and/or optimizing a surgical device |
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JP2010071839A (ja) * | 2008-09-19 | 2010-04-02 | Jeol Ltd | Nmr測定方法 |
JP2015518408A (ja) * | 2012-05-04 | 2015-07-02 | セェーアール ディベロップメント アクチエボラグCr Development Ab | Mriのパルス・シーケンス方法 |
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JP2017507698A (ja) * | 2014-02-10 | 2017-03-23 | シーアール ディベロップメント アーベー | サンプルにおける等方性拡散及び/又は異方性拡散を定量化するための方法 |
US11112476B2 (en) | 2015-12-29 | 2021-09-07 | Cr Development Ab | Method of extracting information about a sample by nuclear magnetic resonance measurements |
JP2019534087A (ja) * | 2016-11-09 | 2019-11-28 | シーアール ディベロップメント アーベー | サンプルに拡散強調磁気共鳴測定を実行する方法 |
JP2019534086A (ja) * | 2016-11-09 | 2019-11-28 | シーアール ディベロップメント アーベー | サンプルに拡散強調磁気共鳴測定を実行する方法 |
JP7057355B2 (ja) | 2016-11-09 | 2022-04-19 | シーアール ディベロップメント アーベー | サンプルに拡散強調磁気共鳴測定を実行する方法 |
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IL192992A0 (en) | 2009-02-11 |
WO2007087494A2 (en) | 2007-08-02 |
US7894891B2 (en) | 2011-02-22 |
US20110105886A1 (en) | 2011-05-05 |
JP2012130759A (ja) | 2012-07-12 |
US8473046B2 (en) | 2013-06-25 |
IL217728A (en) | 2015-02-26 |
EP1976430A2 (en) | 2008-10-08 |
IL217728A0 (en) | 2012-03-29 |
WO2007087494A3 (en) | 2008-01-31 |
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IL192992A (en) | 2012-07-31 |
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