JP2012127696A - 分析装置および分析方法 - Google Patents

分析装置および分析方法 Download PDF

Info

Publication number
JP2012127696A
JP2012127696A JP2010277335A JP2010277335A JP2012127696A JP 2012127696 A JP2012127696 A JP 2012127696A JP 2010277335 A JP2010277335 A JP 2010277335A JP 2010277335 A JP2010277335 A JP 2010277335A JP 2012127696 A JP2012127696 A JP 2012127696A
Authority
JP
Japan
Prior art keywords
substance
unit
detection
microchannels
detection unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010277335A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012127696A5 (enExample
Inventor
Yuichiro Shimizu
裕一郎 清水
Ikuo Nakano
郁雄 中野
Michinobu Saegusa
理伸 三枝
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sharp Corp
Original Assignee
Sharp Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sharp Corp filed Critical Sharp Corp
Priority to JP2010277335A priority Critical patent/JP2012127696A/ja
Priority to US13/993,282 priority patent/US20130260481A1/en
Priority to PCT/JP2011/076697 priority patent/WO2012081361A1/ja
Publication of JP2012127696A publication Critical patent/JP2012127696A/ja
Publication of JP2012127696A5 publication Critical patent/JP2012127696A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0694—Creating chemical gradients in a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/069—Absorbents; Gels to retain a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
JP2010277335A 2010-12-13 2010-12-13 分析装置および分析方法 Pending JP2012127696A (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2010277335A JP2012127696A (ja) 2010-12-13 2010-12-13 分析装置および分析方法
US13/993,282 US20130260481A1 (en) 2010-12-13 2011-11-18 Analysis device and analysis method
PCT/JP2011/076697 WO2012081361A1 (ja) 2010-12-13 2011-11-18 分析装置および分析方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2010277335A JP2012127696A (ja) 2010-12-13 2010-12-13 分析装置および分析方法

Publications (2)

Publication Number Publication Date
JP2012127696A true JP2012127696A (ja) 2012-07-05
JP2012127696A5 JP2012127696A5 (enExample) 2014-01-23

Family

ID=46244474

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010277335A Pending JP2012127696A (ja) 2010-12-13 2010-12-13 分析装置および分析方法

Country Status (3)

Country Link
US (1) US20130260481A1 (enExample)
JP (1) JP2012127696A (enExample)
WO (1) WO2012081361A1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015029979A1 (ja) * 2013-08-30 2015-03-05 国立大学法人東京大学 エキソソームの分析方法、エキソソーム分析チップ、及びエキソソーム分析装置
JP2017502262A (ja) * 2013-11-14 2017-01-19 ケンブリッジ・エンタープライズ・リミテッド 流体の分離および検出
KR101881203B1 (ko) * 2016-01-25 2018-08-17 고려대학교 산학협력단 혈소판 분석 장치
US10301682B2 (en) 2013-09-25 2019-05-28 The University Of Tokyo Fluidic device, exosome analysis method, biomolecule analysis method, and biomolecule detection method
JP2019120557A (ja) * 2017-12-28 2019-07-22 国立研究開発法人産業技術総合研究所 アッセイ装置

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10031100B2 (en) * 2013-03-13 2018-07-24 Robert Bosch Gmbh Generation of pH/temperature/ionic gradients on a lateral flow platform with multiple parallel lanes for modulating protein interactions
EP3163307B1 (en) 2014-06-30 2021-03-03 PHC Holdings Corporation Substrate for sample analysis, sample analysis device, sample analysis system, and method for removing liquid from liquid that contains magnetic particles
JP6588908B2 (ja) 2014-06-30 2019-10-09 Ｐｈｃホールディングス株式会社 試料分析用基板、試料分析装置、試料分析システムおよび試料分析システム用プログラム
US10539560B2 (en) 2014-06-30 2020-01-21 Phc Holdings Corporation Substrate for sample analysis, and sample analysis apparatus
US10520521B2 (en) 2014-06-30 2019-12-31 Phc Holdings Corporation Substrate for sample analysis, sample analysis device, sample analysis system, and program for sample analysis system
EP3232203B1 (en) 2014-12-12 2022-02-02 PHC Holdings Corporation Substrate for sample analysis, sample analysis device, sample analysis system, and program for sample analysis system
EP3276357B1 (en) * 2015-03-24 2021-01-20 The University of Tokyo Fluid device, system and method
JP6705502B2 (ja) * 2016-06-06 2020-06-03 株式会社ニコン 流体デバイス、システム、精製方法および検出方法
JP7111110B2 (ja) * 2017-12-11 2022-08-02 株式会社ニコン 流体デバイス
TWI691720B (zh) * 2019-01-18 2020-04-21 國立清華大學 生物感測器
US20230137689A1 (en) * 2019-08-23 2023-05-04 miDiagnostics NV Method for measuring analyte concentration

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH055743A (ja) * 1991-01-31 1993-01-14 Wakunaga Pharmaceut Co Ltd 測定装置
JPH06341989A (ja) * 1993-06-02 1994-12-13 Teikoku Hormone Mfg Co Ltd 免疫化学的簡易半定量方法および装置
JP2005090972A (ja) * 2003-09-12 2005-04-07 Mitsubishi Motors Corp 眼球衝撃値計測装置
JP2006010529A (ja) * 2004-06-25 2006-01-12 Canon Inc 磁性粒子分離装置および分離方法
JP2006058280A (ja) * 2004-03-16 2006-03-02 Fuji Photo Film Co Ltd 分析チップ
JP2006121935A (ja) * 2004-10-27 2006-05-18 Konica Minolta Medical & Graphic Inc 前処理手段および廃液貯留部を有する生体物質検査用マイクロリアクタ
JP2006520461A (ja) * 2003-05-09 2006-09-07 カリパー・ライフ・サイエンシズ・インコーポレーテッド 自動サンプル分析
JP2007040814A (ja) * 2005-08-03 2007-02-15 Matsushita Electric Ind Co Ltd 吸光度測定用センサ及び吸光度測定方法
JP2008241698A (ja) * 2007-02-28 2008-10-09 Toray Ind Inc 免疫分析方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6613513B1 (en) * 1999-02-23 2003-09-02 Caliper Technologies Corp. Sequencing by incorporation
US20050112557A1 (en) * 2003-09-25 2005-05-26 Yongcheng Liu Mesoporous-chip based biosensor for rapid biological agent detection
EP1729130B1 (en) * 2004-03-18 2011-10-05 Nissui Pharmaceutical Co., Ltd. Method of preparing analytical device and kit
EP2285491A1 (en) * 2008-04-25 2011-02-23 Claros Diagnostics, Inc. Flow control in microfluidic systems
CA2758526A1 (en) * 2009-04-15 2010-10-21 Relia Diagnostic Systems, Inc. Diagnostic devices and related methods

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH055743A (ja) * 1991-01-31 1993-01-14 Wakunaga Pharmaceut Co Ltd 測定装置
JPH06341989A (ja) * 1993-06-02 1994-12-13 Teikoku Hormone Mfg Co Ltd 免疫化学的簡易半定量方法および装置
JP2006520461A (ja) * 2003-05-09 2006-09-07 カリパー・ライフ・サイエンシズ・インコーポレーテッド 自動サンプル分析
JP2005090972A (ja) * 2003-09-12 2005-04-07 Mitsubishi Motors Corp 眼球衝撃値計測装置
JP2006058280A (ja) * 2004-03-16 2006-03-02 Fuji Photo Film Co Ltd 分析チップ
JP2006010529A (ja) * 2004-06-25 2006-01-12 Canon Inc 磁性粒子分離装置および分離方法
JP2006121935A (ja) * 2004-10-27 2006-05-18 Konica Minolta Medical & Graphic Inc 前処理手段および廃液貯留部を有する生体物質検査用マイクロリアクタ
JP2007040814A (ja) * 2005-08-03 2007-02-15 Matsushita Electric Ind Co Ltd 吸光度測定用センサ及び吸光度測定方法
JP2008241698A (ja) * 2007-02-28 2008-10-09 Toray Ind Inc 免疫分析方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
XINGYU JIANG: "A Miniaturized, Parallel, Serially Diluted Immunoassay for Analyzing Multiple Antigens", J. AM. CHEM. SOC., vol. 125, JPN6014054971, 2003, pages 5294 - 5295, ISSN: 0002979135 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015029979A1 (ja) * 2013-08-30 2015-03-05 国立大学法人東京大学 エキソソームの分析方法、エキソソーム分析チップ、及びエキソソーム分析装置
US10301682B2 (en) 2013-09-25 2019-05-28 The University Of Tokyo Fluidic device, exosome analysis method, biomolecule analysis method, and biomolecule detection method
JP2017502262A (ja) * 2013-11-14 2017-01-19 ケンブリッジ・エンタープライズ・リミテッド 流体の分離および検出
JP2021099359A (ja) * 2013-11-14 2021-07-01 ケンブリッジ・エンタープライズ・リミテッド 流体の分離および検出
JP7015109B2 (ja) 2013-11-14 2022-02-02 ケンブリッジ・エンタープライズ・リミテッド 流体の分離および検出
KR101881203B1 (ko) * 2016-01-25 2018-08-17 고려대학교 산학협력단 혈소판 분석 장치
JP2019120557A (ja) * 2017-12-28 2019-07-22 国立研究開発法人産業技術総合研究所 アッセイ装置

Also Published As

Publication number Publication date
US20130260481A1 (en) 2013-10-03
WO2012081361A1 (ja) 2012-06-21

Similar Documents

Publication Publication Date Title
JP2012127696A (ja) 分析装置および分析方法
EP2028475B1 (en) Chip for optical analysis
JP6016168B2 (ja) アッセイ装置及び読み取り装置
Jiang et al. Microfluidic whole-blood immunoassays
CN102016584B (zh) 生物传感器
RU2538652C2 (ru) Способ анализа и аналитическое устройство
JP2003114229A (ja) マイクロチャネルチップ，マイクロチャネルチップを使用した測定装置及び測定方法
CN111013677B (zh) 微流控芯片、检测装置以及检测方法
US20080014575A1 (en) Rapid Microfluidic Assay for Quantitative Measurement of Interactions Among One or More Analytes
Lin et al. Urine analysis in microfluidic devices
KR20170118042A (ko) 성형에 의해 제조되는 유체 시스템을 비롯한, 항온 처리 채널을 포함하는 유체 시스템
JP2010032505A (ja) 目的物質の検出方法、それに用いる検出試薬およびその用途
US20210055284A1 (en) Microchip immunoassay device having precise incubation time control and signal scaling and related methods
WO2009136476A1 (ja) バイオセンサの製造方法およびバイオセンサ
WO2003025547A1 (en) Method and device for screening analytes using surface plasmon resonance
JP2003075444A (ja) 測定対象物の測定用チップ，測定対象物の測定装置及び測定対象物の測定方法
JP2011220768A (ja) 分析装置および分析方法
JP2002122597A (ja) 測定対象物の測定用チップ，測定対象物の測定装置及び測定対象物の測定方法
US8563328B2 (en) Fiber-optic biosensor and biosensing methods
KR101787791B1 (ko) 시료 중의 분석 대상 물질을 측정하기 위한 검사 기구 및 그것을 사용한 분석 대상 물질의 측정 방법
JP2013113690A (ja) 分析素子、分析装置、および分析方法
US20090162944A1 (en) Method of Measuring Biomolecular Reaction at Ultrahigh Speed
WO2016035197A1 (ja) 電気化学免疫センサ用カートリッジ及びそれを用いた測定装置
JP2004077387A (ja) タンパク質検出方法及びタンパク質検出装置
RU2776889C1 (ru) Способ количественного определения селективно связанных белков-маркеров заболеваний в планарных ячейках биочипа и устройство для его осуществления

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20131204

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20131204

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150113

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20150602