JP2012115275A5 - - Google Patents
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- JP2012115275A5 JP2012115275A5 JP2012012914A JP2012012914A JP2012115275A5 JP 2012115275 A5 JP2012115275 A5 JP 2012115275A5 JP 2012012914 A JP2012012914 A JP 2012012914A JP 2012012914 A JP2012012914 A JP 2012012914A JP 2012115275 A5 JP2012115275 A5 JP 2012115275A5
- Authority
- JP
- Japan
- Prior art keywords
- biological sample
- nucleotide sequence
- polypeptide
- tumor
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012472 biological sample Substances 0.000 claims 29
- 229920001184 polypeptide Polymers 0.000 claims 28
- 102000004196 processed proteins & peptides Human genes 0.000 claims 28
- 108090000765 processed proteins & peptides Proteins 0.000 claims 28
- 239000002773 nucleotide Substances 0.000 claims 24
- 125000003729 nucleotide group Chemical group 0.000 claims 24
- 210000001519 tissue Anatomy 0.000 claims 20
- 108020004707 nucleic acids Proteins 0.000 claims 19
- 102000039446 nucleic acids Human genes 0.000 claims 19
- 150000007523 nucleic acids Chemical class 0.000 claims 19
- 238000000034 method Methods 0.000 claims 18
- 125000003275 alpha amino acid group Chemical group 0.000 claims 16
- 108091026890 Coding region Proteins 0.000 claims 12
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 10
- 208000037841 lung tumor Diseases 0.000 claims 10
- 239000000523 sample Substances 0.000 claims 10
- 108020004414 DNA Proteins 0.000 claims 8
- 210000004072 lung Anatomy 0.000 claims 8
- 108091033319 polynucleotide Proteins 0.000 claims 8
- 102000040430 polynucleotide Human genes 0.000 claims 8
- 239000002157 polynucleotide Substances 0.000 claims 8
- 210000003734 kidney Anatomy 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 230000000295 complement effect Effects 0.000 claims 4
- 230000014509 gene expression Effects 0.000 claims 4
- 238000009396 hybridization Methods 0.000 claims 4
- 238000002493 microarray Methods 0.000 claims 4
- 210000004881 tumor cell Anatomy 0.000 claims 4
- 238000009007 Diagnostic Kit Methods 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 239000002299 complementary DNA Substances 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 230000002018 overexpression Effects 0.000 claims 2
- 208000013718 rectal benign neoplasm Diseases 0.000 claims 2
- 210000005084 renal tissue Anatomy 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 1
Applications Claiming Priority (30)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17209699P | 1999-12-23 | 1999-12-23 | |
| US60/172,096 | 1999-12-23 | ||
| USPCT/US99/31274 | 1999-12-30 | ||
| PCT/US1999/031274 WO2000053752A2 (en) | 1999-03-08 | 1999-12-30 | Promotion or inhibition of angiogenesis and cardiovascularization |
| US17548100P | 2000-01-11 | 2000-01-11 | |
| US60/175,481 | 2000-01-11 | ||
| USPCT/US00/04341 | 2000-02-18 | ||
| PCT/US2000/004341 WO2000053756A2 (en) | 1999-03-08 | 2000-02-18 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| PCT/US2000/005841 WO2000053758A2 (en) | 1999-03-08 | 2000-03-02 | Compositions and methods for the treatment of immune related diseases |
| USPCT/US00/05841 | 2000-03-02 | ||
| US19100700P | 2000-03-21 | 2000-03-21 | |
| US60/191,007 | 2000-03-21 | ||
| PCT/US2000/007532 WO2000070050A1 (en) | 1999-05-14 | 2000-03-21 | Compositions and methods for the treatment of immune related diseases |
| USPCT/US00/07532 | 2000-03-21 | ||
| PCT/US2000/015264 WO2000073452A2 (en) | 1999-06-02 | 2000-06-02 | Compositions and methods for the treatment of immune related diseases |
| USPCT/US00/15264 | 2000-06-02 | ||
| US21380700P | 2000-06-22 | 2000-06-22 | |
| US60/213,087 | 2000-06-22 | ||
| US64484800A | 2000-08-22 | 2000-08-22 | |
| US09/644,848 | 2000-08-22 | ||
| USPCT/US00/23328 | 2000-08-24 | ||
| PCT/US2000/023328 WO2001016318A2 (en) | 1999-09-01 | 2000-08-24 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US24283700P | 2000-10-24 | 2000-10-24 | |
| US60/242,837 | 2000-10-24 | ||
| USPCT/US00/30873 | 2000-11-10 | ||
| PCT/US2000/030873 WO2001040465A2 (en) | 1999-11-30 | 2000-11-10 | Compositions and methods for the treatment of immune related diseases |
| US25364600P | 2000-11-28 | 2000-11-28 | |
| US60/253,646 | 2000-11-28 | ||
| PCT/US2000/032678 WO2001040466A2 (en) | 1999-12-01 | 2000-12-01 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| USPCT/US00/32678 | 2000-12-01 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009023863A Division JP2009159968A (ja) | 1999-12-23 | 2009-02-04 | Ｉｌ−１７相同的ポリペプチドとその治療上の用途 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012063772A Division JP2012152218A (ja) | 1999-12-23 | 2012-03-21 | Ｉｌ−１７相同的ポリペプチドとその治療上の用途 |
| JP2014138440A Division JP2014239685A (ja) | 1999-12-23 | 2014-07-04 | Ｉｌ−１７相同的ポリペプチドとその治療上の用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012115275A JP2012115275A (ja) | 2012-06-21 |
| JP2012115275A5 true JP2012115275A5 (cg-RX-API-DMAC7.html) | 2013-03-28 |
Family
ID=40140243
Family Applications (10)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008109843A Expired - Fee Related JP5070117B2 (ja) | 1999-12-23 | 2008-04-21 | Ｉｌ−１７相同的ポリペプチドとその治療上の用途 |
| JP2009023863A Pending JP2009159968A (ja) | 1999-12-23 | 2009-02-04 | Ｉｌ−１７相同的ポリペプチドとその治療上の用途 |
| JP2009171169A Expired - Lifetime JP5258691B2 (ja) | 1999-12-23 | 2009-07-22 | Ｉｌ−１７相同的ポリペプチドとその治療上の用途 |
| JP2010152694A Pending JP2010266454A (ja) | 1999-12-23 | 2010-07-05 | Ｉｌ−１７相同的ポリペプチドとその治療上の用途 |
| JP2012012914A Pending JP2012115275A (ja) | 1999-12-23 | 2012-01-25 | Ｉｌ−１７相同的ポリペプチドとその治療上の用途 |
| JP2012063772A Pending JP2012152218A (ja) | 1999-12-23 | 2012-03-21 | Ｉｌ−１７相同的ポリペプチドとその治療上の用途 |
| JP2013038690A Withdrawn JP2013165712A (ja) | 1999-12-23 | 2013-02-28 | Ｉｌ−１７相同的ポリペプチドとその治療上の用途 |
| JP2014138440A Pending JP2014239685A (ja) | 1999-12-23 | 2014-07-04 | Ｉｌ−１７相同的ポリペプチドとその治療上の用途 |
| JP2014166220A Pending JP2015007091A (ja) | 1999-12-23 | 2014-08-18 | Ｉｌ−１７相同的ポリペプチドとその治療上の用途 |
| JP2014243369A Withdrawn JP2015077137A (ja) | 1999-12-23 | 2014-12-01 | Ｉｌ−１７相同的ポリペプチドとその治療上の用途 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008109843A Expired - Fee Related JP5070117B2 (ja) | 1999-12-23 | 2008-04-21 | Ｉｌ−１７相同的ポリペプチドとその治療上の用途 |
| JP2009023863A Pending JP2009159968A (ja) | 1999-12-23 | 2009-02-04 | Ｉｌ−１７相同的ポリペプチドとその治療上の用途 |
| JP2009171169A Expired - Lifetime JP5258691B2 (ja) | 1999-12-23 | 2009-07-22 | Ｉｌ−１７相同的ポリペプチドとその治療上の用途 |
| JP2010152694A Pending JP2010266454A (ja) | 1999-12-23 | 2010-07-05 | Ｉｌ−１７相同的ポリペプチドとその治療上の用途 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012063772A Pending JP2012152218A (ja) | 1999-12-23 | 2012-03-21 | Ｉｌ−１７相同的ポリペプチドとその治療上の用途 |
| JP2013038690A Withdrawn JP2013165712A (ja) | 1999-12-23 | 2013-02-28 | Ｉｌ−１７相同的ポリペプチドとその治療上の用途 |
| JP2014138440A Pending JP2014239685A (ja) | 1999-12-23 | 2014-07-04 | Ｉｌ−１７相同的ポリペプチドとその治療上の用途 |
| JP2014166220A Pending JP2015007091A (ja) | 1999-12-23 | 2014-08-18 | Ｉｌ−１７相同的ポリペプチドとその治療上の用途 |
| JP2014243369A Withdrawn JP2015077137A (ja) | 1999-12-23 | 2014-12-01 | Ｉｌ−１７相同的ポリペプチドとその治療上の用途 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1240325B1 (cg-RX-API-DMAC7.html) |
| JP (10) | JP5070117B2 (cg-RX-API-DMAC7.html) |
| AT (5) | ATE541931T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2590901A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2391374A1 (cg-RX-API-DMAC7.html) |
| CY (1) | CY1112334T1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1240325T3 (cg-RX-API-DMAC7.html) |
| ES (7) | ES2380958T3 (cg-RX-API-DMAC7.html) |
| PT (4) | PT1897947E (cg-RX-API-DMAC7.html) |
| WO (1) | WO2001046420A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6562578B1 (en) | 1999-01-11 | 2003-05-13 | Schering Corporation | IL-17-like cytokine binding compounds and antibodies |
| US7771719B1 (en) | 2000-01-11 | 2010-08-10 | Genentech, Inc. | Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to IL-17E |
| IL138930A0 (en) | 1998-05-15 | 2001-11-25 | Genentech Inc | Il-17 homologies polypeptides and therapeutic uses thereof |
| AU2001241816A1 (en) * | 2000-02-29 | 2001-09-12 | Zymogenetics Inc. | Methods for promoting production of myelin by schwann cells |
| US7718397B2 (en) | 2000-03-21 | 2010-05-18 | Genentech, Inc. | Nucleic acids encoding receptor for IL-17 homologous polypeptides and uses thereof |
| AU2001251655A1 (en) * | 2000-04-18 | 2001-10-30 | Schering Corporation | Cytokine uses; compositions; methods |
| AU2001274920A1 (en) * | 2000-05-24 | 2001-12-03 | Schering Corporation | Mammalian receptor proteins; related reagents and methods |
| US20030096969A1 (en) | 2000-06-02 | 2003-05-22 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| EP1332211A2 (en) * | 2000-07-26 | 2003-08-06 | ZymoGenetics, Inc. | Human cytokine receptor |
| EP1529843A3 (en) * | 2000-08-11 | 2005-06-08 | Eli Lilly & Company | Novel secreted proteins and their uses |
| DE60125563T2 (de) * | 2000-10-13 | 2007-10-04 | Eli Lilly And Co., Indianapolis | Verfahren zur verwendung eines humanen il-17 verwandten polypeptids zur behandlung von krankheiten |
| AU2002225714A1 (en) * | 2000-11-10 | 2002-05-21 | The Regents Of The University Of California | Il-17 receptor-like protein, uses thereof, and modulation of catabolic activity of il-17 cytokines on bone and cartilage |
| US20070160576A1 (en) | 2001-06-05 | 2007-07-12 | Genentech, Inc. | IL-17A/F heterologous polypeptides and therapeutic uses thereof |
| CA2675409A1 (en) * | 2001-10-19 | 2003-05-01 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of inflammatory bowel disorders |
| JP2006512903A (ja) * | 2002-09-11 | 2006-04-20 | ジェネンテック・インコーポレーテッド | 免疫関連疾患の治療のための新規組成物と方法 |
| WO2004047728A2 (en) * | 2002-11-26 | 2004-06-10 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| EP1599498A2 (en) * | 2003-03-03 | 2005-11-30 | Genentech, Inc. | Compositions and methods for the treatment of systemic lupus erythematosis |
| EP3594228A1 (en) * | 2003-07-08 | 2020-01-15 | Genentech, Inc. | Il-17a/f heterologous polypedtides and therapeutic uses thereof |
| WO2005051422A1 (en) | 2003-11-21 | 2005-06-09 | Celltech R & D Limited | Method for the treatment of multiple sclerosis by inhibiting il-17 activity |
| US20050287593A1 (en) | 2004-05-03 | 2005-12-29 | Schering Corporation | Use of cytokine expression to predict skin inflammation; methods of treatment |
| JP2007535930A (ja) | 2004-05-03 | 2007-12-13 | シェーリング コーポレイション | 皮膚の炎症を予測するためのｉｌ−１７発現の使用；処置方法 |
| EP1765865A2 (en) | 2004-06-10 | 2007-03-28 | ZymoGenetics, Inc. | Soluble zcytor14, anti-zcytor14 antibodies and binding partners and methods of using in inflammation |
| CA2579166A1 (en) * | 2004-09-21 | 2006-03-30 | Applied Research Systems Ars Holding N.V. | Use of il-17f for the treatment and/or prevention of neurologic diseases |
| WO2007019453A2 (en) * | 2005-08-04 | 2007-02-15 | Zymogenetics, Inc. | Treatment of wounds using il-17b |
| US20070249533A1 (en) | 2005-09-28 | 2007-10-25 | Levin Steven D | Il-17a and il-17f antagonists and methods of using the same |
| US7622116B2 (en) | 2006-02-10 | 2009-11-24 | Zymogenetics, Inc. | Method of treating inflammation using soluble IL-17RCX4 |
| CN101553501A (zh) | 2006-10-26 | 2009-10-07 | 诺沃-诺迪斯克有限公司 | Il-21变种 |
| EP2089050A2 (en) * | 2006-11-08 | 2009-08-19 | Zymogenetics, Inc. | Il- 17b for use in wound healing |
| MX2009010273A (es) | 2007-03-26 | 2009-10-12 | Zymogenetics Inc | Proteinas de fusion il-17ra/rc solubles y metodos relacionados. |
| AU2009245440C1 (en) | 2008-05-05 | 2013-03-14 | Novimmune Sa | Anti-IL-17A/IL-17F cross-reactive antibodies and methods of use thereof |
| US8790642B2 (en) | 2008-08-29 | 2014-07-29 | Genentech, Inc. | Cross-reactive and bispecific anti-IL-17A/F antibodies |
| US20120107267A1 (en) | 2009-03-11 | 2012-05-03 | Novo Nordisk A/S | Interleukin-21 variants having antagonistic binding to the il-21 receptor |
| PE20120628A1 (es) | 2009-04-01 | 2012-05-26 | Genentech Inc | Antagonistas de il-17a y/o il-17f |
| GB0905972D0 (en) * | 2009-04-06 | 2009-05-20 | Medical Res Council | Antibodies against IL-17BR |
| AU2010244142B2 (en) | 2009-05-05 | 2016-07-21 | Novimmune Sa | Anti-IL-17F antibodies and methods of use thereof |
| WO2010142551A2 (en) * | 2009-06-12 | 2010-12-16 | Ablynx N.V. | Single variable domain (vhh) antibodies to cytokines of the il-17 receptor family |
| JP2014506259A (ja) | 2011-01-17 | 2014-03-13 | ノヴォ ノルディスク アー／エス | Ｉｌ−２１リガンド |
| UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
| HRP20180776T1 (hr) | 2011-10-19 | 2018-08-10 | Morphosys Ag | Antagonisti il17c za liječenje upalnih poremećaja |
| JP6236948B2 (ja) * | 2013-07-17 | 2017-11-29 | 東ソー株式会社 | 抗体精製用溶出液および当該溶出液を用いた抗体精製方法 |
| KR20150050921A (ko) * | 2013-11-01 | 2015-05-11 | 현대중공업 주식회사 | 폐열 회수용 연관식 보일러 |
| CN107148283A (zh) | 2014-10-31 | 2017-09-08 | 豪夫迈·罗氏有限公司 | 抗il‑17a和il‑17f交叉反应性抗体变体、包含其的组合物及其制备和使用方法 |
| WO2016123329A2 (en) | 2015-01-28 | 2016-08-04 | Genentech, Inc. | Gene expression markers and treatment of multiple sclerosis |
Family Cites Families (15)
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| WO2000073452A2 (en) * | 1999-06-02 | 2000-12-07 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| AU696775B2 (en) * | 1995-03-23 | 1998-09-17 | Kirin-Amgen, Inc. | IL-17 receptor |
| WO2000053752A2 (en) * | 1999-03-08 | 2000-09-14 | Genentech, Inc. | Promotion or inhibition of angiogenesis and cardiovascularization |
| BR9809778A (pt) * | 1997-04-25 | 2000-06-20 | Zymogenetics Inc | Polinucleotìdeo isolado, vetor de expressão, peptìdeo ou polipetìdeo isolado, anticorpo, processo para produzir o mesmo, fragmentos de anticorpos, anticorpos de cadeia única ou anticorpos humanizados, e, anticorpo anti-idiotìpico. |
| WO1999003982A1 (en) * | 1997-07-16 | 1999-01-28 | Human Genome Sciences, Inc. | Interleukin-20 |
| US6482923B1 (en) * | 1997-09-17 | 2002-11-19 | Human Genome Sciences, Inc. | Interleukin 17-like receptor protein |
| WO1999014240A1 (en) * | 1997-09-17 | 1999-03-25 | Human Genome Sciences, Inc. | Interleukin-17 receptor-like protein |
| AU2004799A (en) * | 1997-12-19 | 1999-07-12 | Millennium Biotherapeutics, Inc. | Novel embryo-derived interleukin related factor molecules and uses therefor |
| NZ507435A (en) * | 1998-03-10 | 2003-12-19 | Genentech Inc | Novel polypeptides and nucleic acids with homology to cornichon |
| IL138930A0 (en) * | 1998-05-15 | 2001-11-25 | Genentech Inc | Il-17 homologies polypeptides and therapeutic uses thereof |
| CA2361204A1 (en) * | 1999-01-11 | 2000-07-20 | Schering Corporation | Interleukin-17 related mammalian cytokines. polynucleotides encoding them. uses |
| AU3207000A (en) * | 1999-01-11 | 2000-08-01 | Schering Corporation | Interleukin-17 related mammalian cytokine (il-171). polynucleotides encoding them. uses |
| AU3632600A (en) * | 1999-05-14 | 2000-12-05 | Genentech Inc. | Compositions and methods for the treatment of immune related diseases |
| ES2286029T3 (es) * | 1999-07-07 | 2007-12-01 | Zymogenetics Inc | Receptor de citocina humano. |
| JP2003527104A (ja) * | 1999-12-23 | 2003-09-16 | ジェネンテック・インコーポレーテッド | Ｉｌ−１７相同的ポリペプチドとその治療上の用途 |
-
2000
- 2000-12-20 AT AT07016903T patent/ATE541931T1/de active
- 2000-12-20 AT AT07016900T patent/ATE519847T1/de active
- 2000-12-20 ES ES07016901T patent/ES2380958T3/es not_active Expired - Lifetime
- 2000-12-20 EP EP00989401A patent/EP1240325B1/en not_active Expired - Lifetime
- 2000-12-20 ES ES09009972.2T patent/ES2506665T3/es not_active Expired - Lifetime
- 2000-12-20 PT PT07016903T patent/PT1897947E/pt unknown
- 2000-12-20 ES ES00989401T patent/ES2333772T3/es not_active Expired - Lifetime
- 2000-12-20 PT PT07016900T patent/PT1897944E/pt unknown
- 2000-12-20 ES ES07016902T patent/ES2388748T3/es not_active Expired - Lifetime
- 2000-12-20 ES ES10009491.1T patent/ES2458349T3/es not_active Expired - Lifetime
- 2000-12-20 PT PT07016901T patent/PT1897945E/pt unknown
- 2000-12-20 ES ES07016899T patent/ES2379101T3/es not_active Expired - Lifetime
- 2000-12-20 WO PCT/US2000/034956 patent/WO2001046420A2/en not_active Ceased
- 2000-12-20 AT AT00989401T patent/ATE444361T1/de active
- 2000-12-20 AU AU25909/01A patent/AU2590901A/en not_active Abandoned
- 2000-12-20 ES ES07016903T patent/ES2380812T3/es not_active Expired - Lifetime
- 2000-12-20 PT PT00989401T patent/PT1240325E/pt unknown
- 2000-12-20 AT AT07016899T patent/ATE537258T1/de active
- 2000-12-20 CA CA002391374A patent/CA2391374A1/en not_active Withdrawn
- 2000-12-20 AT AT07016901T patent/ATE541930T1/de active
- 2000-12-20 DK DK00989401.5T patent/DK1240325T3/da active
-
2008
- 2008-04-21 JP JP2008109843A patent/JP5070117B2/ja not_active Expired - Fee Related
-
2009
- 2009-02-04 JP JP2009023863A patent/JP2009159968A/ja active Pending
- 2009-07-22 JP JP2009171169A patent/JP5258691B2/ja not_active Expired - Lifetime
-
2010
- 2010-07-05 JP JP2010152694A patent/JP2010266454A/ja active Pending
-
2011
- 2011-10-04 CY CY20111100948T patent/CY1112334T1/el unknown
-
2012
- 2012-01-25 JP JP2012012914A patent/JP2012115275A/ja active Pending
- 2012-03-21 JP JP2012063772A patent/JP2012152218A/ja active Pending
-
2013
- 2013-02-28 JP JP2013038690A patent/JP2013165712A/ja not_active Withdrawn
-
2014
- 2014-07-04 JP JP2014138440A patent/JP2014239685A/ja active Pending
- 2014-08-18 JP JP2014166220A patent/JP2015007091A/ja active Pending
- 2014-12-01 JP JP2014243369A patent/JP2015077137A/ja not_active Withdrawn