JP2012110290A5 - - Google Patents

Info

Publication number

JP2012110290A5

JP2012110290A5 JP2010263148A JP2010263148A JP2012110290A5 JP 2012110290 A5 JP2012110290 A5 JP 2012110290A5 JP 2010263148 A JP2010263148 A JP 2010263148A JP 2010263148 A JP2010263148 A JP 2010263148A JP 2012110290 A5 JP2012110290 A5 JP 2012110290A5

Authority

JP

Japan

Prior art keywords

gene

kit

envelope

preparing

plasmid

Prior art date

2010-11-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 108090000623 proteins and genes Proteins 0.000 claims 17
• 238000000034 method Methods 0.000 claims 12
• 239000013612 plasmid Substances 0.000 claims 12
• 210000004027 cell Anatomy 0.000 claims 11
• 239000013603 viral vector Substances 0.000 claims 8
• 230000004927 fusion Effects 0.000 claims 7
• 101900083372 Rabies virus Glycoprotein Proteins 0.000 claims 6
• 239000013598 vector Substances 0.000 claims 6
• 241000700605 Viruses Species 0.000 claims 5
• 210000004556 brain Anatomy 0.000 claims 5
• 238000004806 packaging method and process Methods 0.000 claims 5
• 229920001184 polypeptide Polymers 0.000 claims 5
• 108090000765 processed proteins & peptides Proteins 0.000 claims 5
• 102000004196 processed proteins & peptides Human genes 0.000 claims 5
• 238000004519 manufacturing process Methods 0.000 claims 4
• 210000005036 nerve Anatomy 0.000 claims 4
• 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 3
• 241001465754 Metazoa Species 0.000 claims 3
• 238000001415 gene therapy Methods 0.000 claims 3
• 210000001577 neostriatum Anatomy 0.000 claims 3
• 210000002569 neuron Anatomy 0.000 claims 3
• 208000014644 Brain disease Diseases 0.000 claims 2
• 108090000288 Glycoproteins Proteins 0.000 claims 2
• 102000003886 Glycoproteins Human genes 0.000 claims 2
• 241000124008 Mammalia Species 0.000 claims 2
• 241000711975 Vesicular stomatitis virus Species 0.000 claims 2
• 210000004899 c-terminal region Anatomy 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 230000003834 intracellular effect Effects 0.000 claims 2
• 210000004897 n-terminal region Anatomy 0.000 claims 2
• 210000004940 nucleus Anatomy 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 102000007469 Actins Human genes 0.000 claims 1
• 108010085238 Actins Proteins 0.000 claims 1
• 241000271566 Aves Species 0.000 claims 1
• 208000019736 Cranial nerve disease Diseases 0.000 claims 1
• 241000701022 Cytomegalovirus Species 0.000 claims 1
• 208000018737 Parkinson disease Diseases 0.000 claims 1
• 241000288906 Primates Species 0.000 claims 1
• 201000002154 Pterygium Diseases 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 125000003275 alpha amino acid group Chemical group 0.000 claims 1
• 210000004727 amygdala Anatomy 0.000 claims 1
• 210000003050 axon Anatomy 0.000 claims 1
• 229910000389 calcium phosphate Inorganic materials 0.000 claims 1
• 239000001506 calcium phosphate Substances 0.000 claims 1
• 235000011010 calcium phosphates Nutrition 0.000 claims 1
• 210000000349 chromosome Anatomy 0.000 claims 1
• 239000012228 culture supernatant Substances 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 239000003623 enhancer Substances 0.000 claims 1
• 210000003016 hypothalamus Anatomy 0.000 claims 1
• 210000001073 mediodorsal thalamic nucleus Anatomy 0.000 claims 1
• 210000001009 nucleus accumben Anatomy 0.000 claims 1
• 210000002963 paraventricular hypothalamic nucleus Anatomy 0.000 claims 1
• 239000002245 particle Substances 0.000 claims 1
• 108700004029 pol Genes Proteins 0.000 claims 1
• 210000000976 primary motor cortex Anatomy 0.000 claims 1
• 230000007441 retrograde transport Effects 0.000 claims 1
• 210000004092 somatosensory cortex Anatomy 0.000 claims 1
• 210000003523 substantia nigra Anatomy 0.000 claims 1
• 238000001890 transfection Methods 0.000 claims 1
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 1
• 210000001030 ventral striatum Anatomy 0.000 claims 1