JP2012020996A5 - - Google Patents
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- Publication number
- JP2012020996A5 JP2012020996A5 JP2011149371A JP2011149371A JP2012020996A5 JP 2012020996 A5 JP2012020996 A5 JP 2012020996A5 JP 2011149371 A JP2011149371 A JP 2011149371A JP 2011149371 A JP2011149371 A JP 2011149371A JP 2012020996 A5 JP2012020996 A5 JP 2012020996A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- prolactin
- cell
- level
- glycine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 7
- 108010002519 Prolactin Receptors Proteins 0.000 claims 6
- 102100029000 Prolactin receptor Human genes 0.000 claims 6
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 5
- 239000004471 Glycine Substances 0.000 claims 5
- 101000687438 Homo sapiens Prolactin Proteins 0.000 claims 5
- 230000006907 apoptotic process Effects 0.000 claims 5
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 5
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 239000004475 Arginine Substances 0.000 claims 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 3
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 3
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000000328 estrogen antagonist Substances 0.000 claims 2
- 239000003183 carcinogenic agent Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000002464 receptor antagonist Substances 0.000 claims 1
- 229940044551 receptor antagonist Drugs 0.000 claims 1
- 229960001603 tamoxifen Drugs 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8512898P | 1998-05-12 | 1998-05-12 | |
| US60/085,128 | 1998-05-12 | ||
| US24604199A | 1999-02-05 | 1999-02-05 | |
| US09/246,041 | 1999-02-05 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000547993A Division JP5259896B2 (ja) | 1998-05-12 | 1999-05-11 | 増殖性疾患を治療するための抗プロラクチン剤の使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013127119A Division JP2013224309A (ja) | 1998-05-12 | 2013-06-18 | 増殖性疾患を治療するための抗プロラクチン剤の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012020996A JP2012020996A (ja) | 2012-02-02 |
| JP2012020996A5 true JP2012020996A5 (enExample) | 2012-09-13 |
| JP5453355B2 JP5453355B2 (ja) | 2014-03-26 |
Family
ID=26772335
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000547993A Expired - Lifetime JP5259896B2 (ja) | 1998-05-12 | 1999-05-11 | 増殖性疾患を治療するための抗プロラクチン剤の使用 |
| JP2010223963A Withdrawn JP2011079821A (ja) | 1998-05-12 | 2010-10-01 | 増殖性疾患を治療するための抗プロラクチン剤の使用 |
| JP2011149371A Expired - Lifetime JP5453355B2 (ja) | 1998-05-12 | 2011-07-05 | 増殖性疾患を治療するための抗プロラクチン剤の使用 |
| JP2013127119A Withdrawn JP2013224309A (ja) | 1998-05-12 | 2013-06-18 | 増殖性疾患を治療するための抗プロラクチン剤の使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000547993A Expired - Lifetime JP5259896B2 (ja) | 1998-05-12 | 1999-05-11 | 増殖性疾患を治療するための抗プロラクチン剤の使用 |
| JP2010223963A Withdrawn JP2011079821A (ja) | 1998-05-12 | 2010-10-01 | 増殖性疾患を治療するための抗プロラクチン剤の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013127119A Withdrawn JP2013224309A (ja) | 1998-05-12 | 2013-06-18 | 増殖性疾患を治療するための抗プロラクチン剤の使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7115556B2 (enExample) |
| EP (2) | EP1079851B1 (enExample) |
| JP (4) | JP5259896B2 (enExample) |
| AT (1) | ATE366114T1 (enExample) |
| AU (1) | AU3895299A (enExample) |
| CA (1) | CA2328520C (enExample) |
| DE (1) | DE69936451T2 (enExample) |
| DK (1) | DK1079851T3 (enExample) |
| ES (1) | ES2288777T3 (enExample) |
| PT (1) | PT1079851E (enExample) |
| WO (1) | WO1999058142A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001249372A1 (en) * | 2000-03-23 | 2001-10-03 | Greenville Hospital System | Bi-functional cancer treatment agents |
| ATE468104T1 (de) * | 2002-06-12 | 2010-06-15 | Oreal | Mit silikonpolymeren und organischen geliermitteln strukturierte pflege- und/oder- makeup-zusammensetzung in starrer form |
| US6995244B2 (en) | 2002-12-13 | 2006-02-07 | The Ohio State University | Antagonists for human prolactin |
| DK1667708T5 (da) | 2002-12-26 | 2012-11-12 | Mountain View Pharmaceuticals | Polyethylenglycolkonjugater af interferon-beta-1b med forøget biologisk styrke in vitro |
| US8754031B2 (en) | 2004-03-08 | 2014-06-17 | Oncolix, Inc. | Use of prolactin receptor antagonists in combination with an agent that inactivates the HER2/neu signaling pathway |
| US7507716B2 (en) * | 2005-07-06 | 2009-03-24 | Board Of Regents, The University Of Texas System | Method for treating pain with prolactin antagonists |
| WO2008028684A2 (en) * | 2006-09-08 | 2008-03-13 | Novo Nordisk A/S | Peptides with high affinity for the prolactin receptor |
| EP2129793A1 (en) | 2007-03-20 | 2009-12-09 | Institut National De La Sante Et De La Recherche Medicale | Constitutively active mutants of the prolactin receptor |
| US20100249029A1 (en) * | 2007-07-05 | 2010-09-30 | Novo Nordisk A/S | Peptides with high affinity for the prolactin receptor |
| US20110129873A1 (en) * | 2008-04-30 | 2011-06-02 | Monsanto Technology Llc | Recombinant DNA Vectors for Expression of Human Prolactin Antagonists |
| US8648046B2 (en) * | 2009-02-26 | 2014-02-11 | Oncolix, Inc. | Compositions and methods for visualizing and eliminating cancer stem cells |
| US8754035B2 (en) | 2009-02-26 | 2014-06-17 | Oncolix, Inc. | Compositions and methods for visualizing and eliminating cancer stem cells |
| US8759289B2 (en) * | 2010-02-03 | 2014-06-24 | Orbis Health Solutions Llc | Method for sensitizing cancer stem cells to cancer therapy |
| TWI641620B (zh) | 2013-08-21 | 2018-11-21 | 再生元醫藥公司 | 抗－ｐｒｌｒ抗體及其用途 |
| US9545451B2 (en) | 2013-08-21 | 2017-01-17 | Regeneron Pharmaceuticals, Inc. | Anti-PRLR antibodies and methods for killing PRLR-expressing cells |
| JP7174699B2 (ja) | 2016-11-29 | 2022-11-17 | レゲネロン ファーマシューティカルス，インコーポレーテッド | Ｐｒｌｒ陽性乳癌の治療方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4833516A (en) * | 1987-08-03 | 1989-05-23 | International Business Machines Corporation | High density memory cell structure having a vertical trench transistor self-aligned with a vertical trench capacitor and fabrication methods therefor |
| US5350836A (en) | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| US6429186B1 (en) * | 1991-05-10 | 2002-08-06 | Genentech, Inc. | Ligand antagonists for treatment of breast cancer |
| WO1992021029A1 (en) | 1991-05-10 | 1992-11-26 | Genentech, Inc. | Selecting ligand agonists and antagonists |
| US5590656A (en) * | 1992-09-15 | 1997-01-07 | The Ohio State University Research Foundation | Application of peptide/cell receptor kinetics utilizing radiolabeled somatostatin congeners in the in situ, in vivo detection and differentiation of neoplastic tissue |
| DE4231297A1 (de) * | 1992-09-18 | 1994-03-24 | Basf Ag | Verfahren zur Herstellung von 3-(2'-Oxyethyl)-dihydro-2-(3H)furanonen |
| DE69431041T2 (de) | 1993-02-19 | 2003-02-06 | Genentech, Inc. | Ligand Antagonisten zur Behandlung von Brustkrebs |
| KR100293867B1 (ko) * | 1994-04-06 | 2001-09-17 | 니뽄 신야쿠 가부시키가이샤 | 아미노스틸바졸유도체및의약 |
| DE19718721C2 (de) * | 1997-05-02 | 1999-10-07 | Siemens Ag | DRAM-Zellenanordnung und Verfahren zu deren Herstellung |
-
1999
- 1999-05-11 WO PCT/US1999/010232 patent/WO1999058142A1/en not_active Ceased
- 1999-05-11 EP EP99921843A patent/EP1079851B1/en not_active Revoked
- 1999-05-11 EP EP10010603A patent/EP2316467A1/en not_active Withdrawn
- 1999-05-11 PT PT99921843T patent/PT1079851E/pt unknown
- 1999-05-11 JP JP2000547993A patent/JP5259896B2/ja not_active Expired - Lifetime
- 1999-05-11 AU AU38952/99A patent/AU3895299A/en not_active Abandoned
- 1999-05-11 DE DE69936451T patent/DE69936451T2/de not_active Expired - Lifetime
- 1999-05-11 ES ES99921843T patent/ES2288777T3/es not_active Expired - Lifetime
- 1999-05-11 AT AT99921843T patent/ATE366114T1/de active
- 1999-05-11 CA CA2328520A patent/CA2328520C/en not_active Expired - Lifetime
- 1999-05-11 DK DK99921843T patent/DK1079851T3/da active
-
2002
- 2002-05-08 US US10/140,293 patent/US7115556B2/en not_active Expired - Lifetime
-
2006
- 2006-08-04 US US11/498,962 patent/US20070060520A1/en not_active Abandoned
-
2010
- 2010-10-01 JP JP2010223963A patent/JP2011079821A/ja not_active Withdrawn
-
2011
- 2011-07-05 JP JP2011149371A patent/JP5453355B2/ja not_active Expired - Lifetime
-
2013
- 2013-06-18 JP JP2013127119A patent/JP2013224309A/ja not_active Withdrawn
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