JP2011530607A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011530607A5 JP2011530607A5 JP2011523078A JP2011523078A JP2011530607A5 JP 2011530607 A5 JP2011530607 A5 JP 2011530607A5 JP 2011523078 A JP2011523078 A JP 2011523078A JP 2011523078 A JP2011523078 A JP 2011523078A JP 2011530607 A5 JP2011530607 A5 JP 2011530607A5
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- phenyl
- substituted
- amino
- pyrimidylaminobenzamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 45
- -1 benzcycloalkyl Chemical group 0.000 claims 14
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims 13
- 125000004432 carbon atoms Chemical group C* 0.000 claims 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims 11
- 229910052757 nitrogen Inorganic materials 0.000 claims 10
- 125000000623 heterocyclic group Chemical group 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 150000002431 hydrogen Chemical class 0.000 claims 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000002619 bicyclic group Chemical group 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000002950 monocyclic group Chemical group 0.000 claims 6
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 6
- 125000004430 oxygen atoms Chemical group O* 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000003373 pyrazinyl group Chemical class 0.000 claims 6
- 125000000714 pyrimidinyl group Chemical class 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 125000004434 sulfur atoms Chemical group 0.000 claims 6
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000004423 acyloxy group Chemical group 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- HHZIURLSWUIHRB-UHFFFAOYSA-N Nilotinib Chemical compound C1=NC(C)=CN1C1=CC(NC(=O)C=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)=CC(C(F)(F)F)=C1 HHZIURLSWUIHRB-UHFFFAOYSA-N 0.000 claims 2
- 150000002829 nitrogen Chemical group 0.000 claims 2
- 125000005702 oxyalkylene group Chemical group 0.000 claims 2
- 102100014324 BMPR2 Human genes 0.000 claims 1
- 101700010052 BMPR2 Proteins 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000002308 endothelin receptor antagonist Substances 0.000 claims 1
- DKAGJZJALZXOOV-UHFFFAOYSA-N hydrate;hydrochloride Chemical compound O.Cl DKAGJZJALZXOOV-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000002590 phosphodiesterase V inhibitor Substances 0.000 claims 1
- 150000003814 prostanoids Chemical class 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8838208P | 2008-08-13 | 2008-08-13 | |
| US61/088,382 | 2008-08-13 | ||
| US16450109P | 2009-03-30 | 2009-03-30 | |
| US61/164,501 | 2009-03-30 | ||
| PCT/US2009/053358 WO2010019540A1 (en) | 2008-08-13 | 2009-08-11 | Treatment of pulmonary arterial hypertension |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011530607A JP2011530607A (ja) | 2011-12-22 |
| JP2011530607A5 true JP2011530607A5 (US07476746-20090113-C00133.png) | 2012-09-27 |
Family
ID=41137217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011523078A Pending JP2011530607A (ja) | 2008-08-13 | 2009-08-11 | 肺動脈高血圧の治療 |
Country Status (16)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3130908A1 (en) | 2009-06-30 | 2010-12-30 | Mallinckrodt Hospital Products IP Limited | Methods of treating term and near-term neonates having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension |
| AU2014205483B2 (en) | 2013-01-10 | 2017-11-30 | Gilead Sciences, Inc. | Non-selective kinase inhibitors |
| AU2014296032A1 (en) * | 2013-07-31 | 2016-03-17 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
| CN111743901B (zh) | 2013-10-11 | 2023-09-12 | 普尔莫凯恩股份有限公司 | 喷雾干燥制剂 |
| KR102543227B1 (ko) | 2016-10-27 | 2023-06-13 | 풀모킨 인코포레이티드 | 폐고혈압을 치료하기 위한 병용 요법 |
| US10953020B2 (en) | 2016-11-08 | 2021-03-23 | Reata Pharmaceuticals, Inc. | Methods of treating Alport syndrome using bardoxolone methyl or analogs thereof |
| US11464776B2 (en) | 2019-05-16 | 2022-10-11 | Aerovate Therapeutics, Inc. | Inhalable imatinib formulations, manufacture, and uses thereof |
| SG11202112719XA (en) | 2019-05-16 | 2021-12-30 | Aerovate Therapeutics Inc | Imatinib formulations, manufacture, and uses thereof |
| US20210154193A1 (en) * | 2019-11-25 | 2021-05-27 | PHPrecisionMed, LLC | Pharmaceutical compositions for the treatment of pulmonary hypertension |
| WO2022108939A1 (en) | 2020-11-17 | 2022-05-27 | United Therapeutics Corporation | Inhaled imatinib for pulmonary hypertension field |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5521184A (en) * | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| GB0215676D0 (en) * | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| AU2003272007A1 (en) * | 2002-10-25 | 2004-05-13 | The Administrators Of The Tulane Educational Fund | Use of n-5-4-(4-methylpiperaziomethyl)-benzoylamido!-2-methylphenyl!-4-(3-pyridyl)2-pyridine-amine for the treatment of pulmonary hypertension |
| GB0325031D0 (en) * | 2003-10-27 | 2003-12-03 | Novartis Ag | Organic compounds |
| KR20130100371A (ko) * | 2005-01-28 | 2013-09-10 | 노파르티스 아게 | Ｔｉｅ-2 키나제 활성의 조절에 반응하는 질환의 치료를 위한 피리미딜아미노벤즈아미드의 용도 |
| WO2006117185A1 (en) * | 2005-05-02 | 2006-11-09 | Novartis Ag | Pyrimidylaminobenzamide derivatives for hypereosinophilic syndrome |
| KR101498848B1 (ko) * | 2005-12-06 | 2015-03-05 | 노파르티스 아게 | 신경섬유종증의 치료를 위한 피리미딜아미노벤즈아미드 유도체 |
| EP2079729A1 (en) * | 2006-11-03 | 2009-07-22 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
-
2009
- 2009-08-11 NZ NZ590839A patent/NZ590839A/xx not_active IP Right Cessation
- 2009-08-11 CN CN2009801314677A patent/CN102123711A/zh active Pending
- 2009-08-11 WO PCT/US2009/053358 patent/WO2010019540A1/en active Application Filing
- 2009-08-11 CA CA2732789A patent/CA2732789A1/en not_active Abandoned
- 2009-08-11 MX MX2011001668A patent/MX2011001668A/es not_active Application Discontinuation
- 2009-08-11 EP EP09791358A patent/EP2315592A1/en not_active Withdrawn
- 2009-08-11 BR BRPI0917491A patent/BRPI0917491A2/pt not_active IP Right Cessation
- 2009-08-11 US US13/058,742 patent/US20110190313A1/en not_active Abandoned
- 2009-08-11 KR KR1020117005744A patent/KR20110053354A/ko not_active Application Discontinuation
- 2009-08-11 AU AU2009282104A patent/AU2009282104A1/en not_active Abandoned
- 2009-08-11 RU RU2011109078/04A patent/RU2011109078A/ru not_active Application Discontinuation
- 2009-08-11 JP JP2011523078A patent/JP2011530607A/ja active Pending
- 2009-08-12 TW TW098127172A patent/TW201010999A/zh unknown
-
2011
- 2011-01-27 IL IL210922A patent/IL210922A0/en unknown
- 2011-02-11 CL CL2011000295A patent/CL2011000295A1/es unknown
- 2011-03-07 MA MA33678A patent/MA32617B1/fr unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011530607A5 (US07476746-20090113-C00133.png) | ||
| USRE49556E1 (en) | Compounds and compositions as protein kinase inhibitors | |
| US11952386B2 (en) | N-azaspirocycloalkane substituted N-heteroaryl compounds and compositions for inhibiting the activity of SHP2 | |
| US10774065B2 (en) | 1-pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2 | |
| US9815813B2 (en) | 1-(triazin-3-yl/pyridazin-3-yl)-piper(-azine)idine derivatives and compositions therefor for inhibiting the activity of SHP2 | |
| RU2011109078A (ru) | Лечение легочной артериальной гипертензии | |
| RU2011137399A (ru) | Гетероциклическое производное | |
| RU2012124811A (ru) | СПОСОБ ЛЕЧЕНИЯ ПРОЛИФЕРАТИВНЫХ НАРУШЕНИЙ И ДРУГИХ ПАТОЛОГИЧЕСКИХ СОСТОЯНИЙ, ОПОСРЕДОВАННЫХ АКТИВНОСТЬЮ КИНАЗ Bcr-Abl, c-Kit, DDR1, DDR2, ИЛИ PDGF-R | |
| RU2012120901A (ru) | Способ лечения пролиферативных расстройств и других патологических состояний, опосредованных действием киназ bcr-abl, c-kit, ddr1, ddr2 или pdgf-r | |
| RU2007132255A (ru) | Применение пиримидиламинобензамидов для лечения заболеваний, чувствительных к модуляции активности киназы tie-2 | |
| JP2009537606A5 (US07476746-20090113-C00133.png) | ||
| RU2011105059A (ru) | Применение производных пиримидиламинобензамида для лечения фиброза | |
| EP2437745A1 (en) | Treatment of mammalian disorders mediated by alpha-carbonic anhydrase isoforms | |
| RU2007144530A (ru) | Применение производных пиримидиламинобензамида для лечения системного мастоцитоза | |
| RU2007147957A (ru) | Комбинация производных пиримидиламинобензамида и иматиниба для лечения или профилактики пролиферативных заболеваний | |
| CN113543784A (zh) | 用于治疗或预防癌症的喹啉衍生物 | |
| RU2007144522A (ru) | Производные пиримидиламинобензамида для лечения синдрома гиперэозинофилии | |
| JP2012519668A5 (US07476746-20090113-C00133.png) | ||
| JP2009501765A5 (US07476746-20090113-C00133.png) | ||
| RU2007135284A (ru) | Фармацевтические комбинации ингибиторов киназ bcr-abl и raf | |
| US20170035757A1 (en) | Method of Optimizing the treatment of Proliferative Diseases Mediated by the Tyrosine Kinase Receptor KIT with Imatinib | |
| JP2019530711A5 (US07476746-20090113-C00133.png) | ||
| RU2011140404A (ru) | Применение производных пиримидиламинобензамида для лечения нарушений, опосредованных киназой, содержащей мотив лейциновой "молнии" и стерильный альфа мотив (zak) | |
| JP5751568B2 (ja) | 悪性末梢神経鞘腫瘍の処置 | |
| AU2013201993B2 (en) | Method of optimizing the treatment of proliferative diseases mediated by the tyrosine kinase receptor KIT with imatinib |
