JP2011529964A5 - - Google Patents
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- Publication number
- JP2011529964A5 JP2011529964A5 JP2011522114A JP2011522114A JP2011529964A5 JP 2011529964 A5 JP2011529964 A5 JP 2011529964A5 JP 2011522114 A JP2011522114 A JP 2011522114A JP 2011522114 A JP2011522114 A JP 2011522114A JP 2011529964 A5 JP2011529964 A5 JP 2011529964A5
- Authority
- JP
- Japan
- Prior art keywords
- aryl
- alkyl
- alkynyl
- heteroaryl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims description 40
- -1 cycloalkenylalkyl Chemical group 0.000 claims description 33
- 125000000623 heterocyclic group Chemical group 0.000 claims description 31
- 125000000217 alkyl group Chemical group 0.000 claims description 23
- 125000003118 aryl group Chemical group 0.000 claims description 23
- 125000001072 heteroaryl group Chemical group 0.000 claims description 22
- 125000000304 alkynyl group Chemical group 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 20
- 239000011780 sodium chloride Substances 0.000 claims description 20
- 150000002148 esters Chemical class 0.000 claims description 19
- 239000008194 pharmaceutical composition Substances 0.000 claims description 19
- 239000012453 solvate Substances 0.000 claims description 19
- 125000003342 alkenyl group Chemical group 0.000 claims description 18
- 201000009910 diseases by infectious agent Diseases 0.000 claims description 16
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 14
- 125000005843 halogen group Chemical group 0.000 claims description 14
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- 230000000813 microbial Effects 0.000 claims description 12
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 10
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 9
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 8
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims description 8
- 235000010290 biphenyl Nutrition 0.000 claims description 6
- 239000004305 biphenyl Substances 0.000 claims description 6
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims description 6
- 125000001188 haloalkyl group Chemical group 0.000 claims description 6
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 6
- 125000004193 piperazinyl group Chemical group 0.000 claims description 6
- 125000003386 piperidinyl group Chemical group 0.000 claims description 6
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 6
- 239000004599 antimicrobial Substances 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 5
- 108010003026 EC 3.5.1.108 Proteins 0.000 claims description 4
- 125000005466 alkylenyl group Chemical group 0.000 claims description 4
- 125000001246 bromo group Chemical group Br* 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 229940079593 drugs Drugs 0.000 claims description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
- 125000004475 heteroaralkyl group Chemical group 0.000 claims description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 239000003112 inhibitor Substances 0.000 claims description 3
- 230000002401 inhibitory effect Effects 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- CWDWFSXUQODZGW-UHFFFAOYSA-N 5-thiazolyl Chemical group [C]1=CN=CS1 CWDWFSXUQODZGW-UHFFFAOYSA-N 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 claims description 2
- 206010060945 Bacterial infection Diseases 0.000 claims description 2
- 241000192125 Firmicutes Species 0.000 claims description 2
- 206010017533 Fungal infection Diseases 0.000 claims description 2
- 206010040490 Sexually transmitted disease Diseases 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 125000005025 alkynylaryl group Chemical group 0.000 claims description 2
- 102000004965 antibodies Human genes 0.000 claims description 2
- 108090001123 antibodies Proteins 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 125000004432 carbon atoms Chemical group C* 0.000 claims description 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 2
- 125000004966 cyanoalkyl group Chemical group 0.000 claims description 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims description 2
- 125000001153 fluoro group Chemical group F* 0.000 claims description 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims description 2
- 125000003106 haloaryl group Chemical group 0.000 claims description 2
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims description 2
- 125000005020 hydroxyalkenyl group Chemical group 0.000 claims description 2
- 230000001404 mediated Effects 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 2
- 125000002757 morpholinyl group Chemical group 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 125000004307 pyrazin-2-yl group Chemical group [H]C1=C([H])N=C(*)C([H])=N1 0.000 claims description 2
- 125000003373 pyrazinyl group Chemical group 0.000 claims description 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims description 2
- 125000004076 pyridyl group Chemical group 0.000 claims description 2
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 claims description 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 2
- 102000005962 receptors Human genes 0.000 claims description 2
- 108020003175 receptors Proteins 0.000 claims description 2
- 125000000335 thiazolyl group Chemical group 0.000 claims description 2
- 125000001544 thienyl group Chemical group 0.000 claims description 2
- 125000004385 trihaloalkyl group Chemical group 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims 1
- 125000003003 spiro group Chemical group 0.000 claims 1
- 0 CC(C)(*(C(NO)O)NC(CCCN(CC*)C(C=C1)=CCC1=*(CC1)CCC1N1CCNCC1)=O)O Chemical compound CC(C)(*(C(NO)O)NC(CCCN(CC*)C(C=C1)=CCC1=*(CC1)CCC1N1CCNCC1)=O)O 0.000 description 3
- RTOGLJIVQSFYJY-UHFFFAOYSA-N C(CC1)CCN1C(CC1)C=CC1C#CC(CC1)C=CC1N1CCNCC1 Chemical compound C(CC1)CCN1C(CC1)C=CC1C#CC(CC1)C=CC1N1CCNCC1 RTOGLJIVQSFYJY-UHFFFAOYSA-N 0.000 description 1
- ZUGMNMDCFQYIBT-UHFFFAOYSA-N CC(C)(CNC(N(CC1)CCN1C(CC1)=CC=C1C1=CCCCC1)=O)C1CC1 Chemical compound CC(C)(CNC(N(CC1)CCN1C(CC1)=CC=C1C1=CCCCC1)=O)C1CC1 ZUGMNMDCFQYIBT-UHFFFAOYSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8598208P | 2008-08-04 | 2008-08-04 | |
US61/085,982 | 2008-08-04 | ||
PCT/US2009/051898 WO2010017060A1 (en) | 2008-08-04 | 2009-07-28 | Urea derivatives as antibacterial agents |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011529964A JP2011529964A (ja) | 2011-12-15 |
JP2011529964A5 true JP2011529964A5 (pt-PT) | 2012-08-30 |
Family
ID=41171285
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011522114A Pending JP2011529964A (ja) | 2008-08-04 | 2009-07-28 | 抗菌剤としての尿素誘導体 |
Country Status (6)
Country | Link |
---|---|
US (1) | US20110212080A1 (pt-PT) |
EP (1) | EP2315746A1 (pt-PT) |
JP (1) | JP2011529964A (pt-PT) |
AU (1) | AU2009279949A1 (pt-PT) |
CA (1) | CA2732045A1 (pt-PT) |
WO (1) | WO2010017060A1 (pt-PT) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5539864B2 (ja) | 2007-06-12 | 2014-07-02 | アカオゲン,インコーポレーテッド | 抗菌剤 |
CA2735929C (en) | 2008-09-19 | 2013-12-17 | Pfizer Inc. | Hydroxamic acid derivatives useful as antibacterial agents |
SI2512474T1 (sl) | 2009-12-16 | 2014-12-31 | Pfizer Inc. | N-vezani derivati hidroksamske kisline, uporabni kot protibakterijska sredstva |
DK2562155T3 (da) | 2010-04-20 | 2019-06-24 | Fujifilm Toyama Chemical Co Ltd | Hydroxaminsyrederivat |
US9738604B2 (en) | 2010-09-03 | 2017-08-22 | Duke University | Ethynylbenzene derivatives |
SG192766A1 (en) | 2011-03-07 | 2013-09-30 | Pfizer | Fluoro-pyridinone derivatives useful as antibacterial agents |
CN103717582B (zh) | 2011-04-08 | 2015-09-30 | 辉瑞大药厂 | 用作抗菌剂的异*唑衍生物 |
MX2013011432A (es) | 2011-04-08 | 2013-12-09 | Pfizer | Derivados de imidazol, pirazol, y triazol utiles como agentes antibacterianos. |
JP6006609B2 (ja) * | 2011-10-19 | 2016-10-12 | 大正製薬株式会社 | 新規なヒドロキサム酸誘導体を含有する医薬 |
WO2013170165A1 (en) | 2012-05-10 | 2013-11-14 | Achaogen, Inc. | Antibacterial agents |
WO2014165075A1 (en) | 2013-03-12 | 2014-10-09 | Achaogen, Inc. | Antibacterial agents |
ES2728336T3 (es) | 2013-03-15 | 2019-10-23 | Fujifilm Toyama Chemical Co Ltd | Nuevo derivado de ácido hidroxámico o sal del mismo |
WO2015024016A2 (en) | 2013-08-16 | 2015-02-19 | Duke University | 2-piperidinyl substituted n,3-dihydroxybutanamides |
WO2015024021A2 (en) | 2013-08-16 | 2015-02-19 | Duke University | Antibacterial compounds |
AU2014306451B2 (en) | 2013-08-16 | 2019-01-17 | Duke University | Substituted hydroxamic acid compounds |
US10149911B2 (en) | 2014-09-12 | 2018-12-11 | Toyama Chemical Co., Ltd. | Pharmaceutical composition containing hydroxamic acid derivative or salt thereof |
WO2016039432A1 (ja) | 2014-09-12 | 2016-03-17 | 富山化学工業株式会社 | 新規なヒドロキサム酸誘導体および抗菌性物質を組み合わせて使用する方法 |
US10118890B2 (en) | 2014-10-10 | 2018-11-06 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
WO2017223349A1 (en) | 2016-06-23 | 2017-12-28 | Achaogen, Inc. | Antibacterial agents |
SG11202007665RA (en) * | 2018-02-10 | 2020-09-29 | Kbp Biosciences Co Ltd | Compound acting as antibiotics |
CN115232130B (zh) * | 2021-04-22 | 2024-01-12 | 山东大学 | 一种apn和akt双靶点抑制剂及其制备方法和应用 |
CN117751113A (zh) * | 2021-08-05 | 2024-03-22 | 浙江海正药业股份有限公司 | 芳香乙炔类衍生物及其制备方法和用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5925659A (en) * | 1996-05-07 | 1999-07-20 | Merck & Co., Inc. | Antibacterial agents |
US6852752B2 (en) * | 1999-12-17 | 2005-02-08 | Vicuron Pharmaceuticals Inc. | Urea compounds, compositions and methods of use and preparation |
WO2002102791A1 (en) * | 2001-06-15 | 2002-12-27 | Vicuron Pharmaceuticals Inc. | Pyrrolidine bicyclic compounds |
MXPA05007394A (es) * | 2003-01-08 | 2005-09-12 | Chiron Corp | Agentes antibacterianos. |
MX2008015196A (es) * | 2006-05-31 | 2008-12-15 | Asubio Pharma Co Ltd | Compuesto de anillo de 7 miembros, proceso para producir el mismo, y su uso medico. |
-
2009
- 2009-07-28 US US13/057,505 patent/US20110212080A1/en not_active Abandoned
- 2009-07-28 WO PCT/US2009/051898 patent/WO2010017060A1/en active Application Filing
- 2009-07-28 CA CA2732045A patent/CA2732045A1/en not_active Abandoned
- 2009-07-28 EP EP09790866A patent/EP2315746A1/en not_active Withdrawn
- 2009-07-28 AU AU2009279949A patent/AU2009279949A1/en not_active Abandoned
- 2009-07-28 JP JP2011522114A patent/JP2011529964A/ja active Pending
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