JP2011529912A - 核酸送達システム用のナノ粒子組成物 - Google Patents

核酸送達システム用のナノ粒子組成物 Download PDF

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Publication number
JP2011529912A
JP2011529912A JP2011521353A JP2011521353A JP2011529912A JP 2011529912 A JP2011529912 A JP 2011529912A JP 2011521353 A JP2011521353 A JP 2011521353A JP 2011521353 A JP2011521353 A JP 2011521353A JP 2011529912 A JP2011529912 A JP 2011529912A
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nanoparticles
peg
nanoparticle
oligonucleotide
nanoparticle composition
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JP2011529912A5 (enExample
Inventor
ヅァオ,ホン
シー,リャンジュン
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エンゾン ファーマシューティカルズ,インコーポレーテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2011521353A 2008-07-31 2009-07-31 核酸送達システム用のナノ粒子組成物 Pending JP2011529912A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8528908P 2008-07-31 2008-07-31
US61/085,289 2008-07-31
PCT/US2009/052396 WO2010014895A2 (en) 2008-07-31 2009-07-31 Nanoparticle compositions for nucleic acids delivery system

Publications (2)

Publication Number Publication Date
JP2011529912A true JP2011529912A (ja) 2011-12-15
JP2011529912A5 JP2011529912A5 (enExample) 2012-07-26

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JP2011521353A Pending JP2011529912A (ja) 2008-07-31 2009-07-31 核酸送達システム用のナノ粒子組成物

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US (1) US20110111044A1 (enExample)
EP (1) EP2304026A4 (enExample)
JP (1) JP2011529912A (enExample)
CA (1) CA2731173A1 (enExample)
TW (1) TW201004658A (enExample)
WO (1) WO2010014895A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016511228A (ja) * 2013-01-03 2016-04-14 カウンスィル オブ サイエンティフィック アンド インダストリアル リサーチ マンノース受容体選択的リシニル化カチオン性両親媒性物質及びその調製方法
JP2016523564A (ja) * 2013-07-11 2016-08-12 モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. CRISPR関連タンパク質をコードする合成ポリヌクレオチドおよび合成sgRNAを含む組成物ならびに使用方法
JP2019535808A (ja) * 2016-10-17 2019-12-12 南京▲緑▼叶制▲薬▼有限公司 bcl−2を抑制するアンチセンスオリゴヌクレオチドの脂質ナノ粒子及びその調製方法
WO2024085149A1 (ja) * 2022-10-18 2024-04-25 第一三共株式会社 テイラー反応装置及びカプセル粒子の製造方法
JP2024521887A (ja) * 2021-06-01 2024-06-04 ナノベーション・セラピューティクス・インコーポレイテッド 脂質ナノ粒子を用いるdnaベクター送達

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WO2011103528A2 (en) * 2010-02-22 2011-08-25 Opko Curna Llc Treatment of pyrroline-5-carboxylate reductase 1 (pycr1) related diseases by inhibition of natural antisense transcript to pycr1
JP2013524811A (ja) * 2010-04-20 2013-06-20 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド ナノザイム、ナノザイムの製造方法、およびナノザイムの使用方法
JP6194248B2 (ja) 2010-10-28 2017-09-06 パシラ ファーマシューティカルズ インコーポレーテッド 非ステロイド性抗炎症薬の徐放性処方物
CA2831613A1 (en) 2011-03-31 2012-10-04 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
US8709466B2 (en) 2011-03-31 2014-04-29 International Business Machines Corporation Cationic polymers for antimicrobial applications and delivery of bioactive materials
WO2013143555A1 (en) 2012-03-26 2013-10-03 Biontech Ag Rna formulation for immunotherapy
EP2915300A1 (en) * 2012-11-02 2015-09-09 Telefonaktiebolaget L M Ericsson (Publ) Network node, user node and methods for channel estimation
EP4279610A3 (en) 2013-03-15 2024-01-03 ModernaTX, Inc. Ribonucleic acid purification
WO2014144767A1 (en) 2013-03-15 2014-09-18 Moderna Therapeutics, Inc. Ion exchange purification of mrna
US10077439B2 (en) 2013-03-15 2018-09-18 Modernatx, Inc. Removal of DNA fragments in mRNA production process
WO2015023715A1 (en) 2013-08-14 2015-02-19 The University Of Florida Research Foundation, Inc. Nanozymes, methods of making nanozymes, and methods of using nanozymes
EP3052511A4 (en) 2013-10-02 2017-05-31 Moderna Therapeutics, Inc. Polynucleotide molecules and uses thereof
US10286086B2 (en) 2014-06-19 2019-05-14 Modernatx, Inc. Alternative nucleic acid molecules and uses thereof
AU2015289656A1 (en) 2014-07-16 2017-02-16 Modernatx, Inc. Circular polynucleotides
EP4101930A1 (en) 2015-09-17 2022-12-14 ModernaTX, Inc. Polynucleotides containing a stabilizing tail region
WO2017049286A1 (en) 2015-09-17 2017-03-23 Moderna Therapeutics, Inc. Polynucleotides containing a morpholino linker
CN109983013A (zh) 2016-11-18 2019-07-05 帕西拉制药有限公司 美洛昔康锌复合物微粒多囊脂质体制剂及其制备方法
CA3071968A1 (en) 2017-08-04 2019-02-07 Kyowa Kirin Co., Ltd. Nucleic acid-containing lipid nanoparticle
CN111971066B (zh) * 2018-01-18 2025-03-11 伊泽阿恩埃免疫疗法股份有限公司 脂质纳米颗粒
US20210261964A1 (en) * 2018-07-19 2021-08-26 The Research Foundation For Microbial Diseases Of Osaka University LIPID PARTICLE CONTAINING A-TYPE CpG OLIGODEOXYNUCLEOTIDE
DK3864163T3 (da) 2018-10-09 2024-05-06 Univ British Columbia Sammensætninger og systemer omfattende transfektionskompetente vesikler fri for organiske opløsningsmidler og rengøringsmidler og fremgangsmåder forbundet dermed
CN109549934B (zh) * 2018-12-25 2021-03-09 上海交通大学 一种多糖基脂质纳米粒子的制备方法
TWI851090B (zh) * 2022-03-17 2024-08-01 國立成功大學 雙股寡去氧核苷酸、包含該雙股寡去氧核苷酸的組合物及其用途
EP4248949B1 (en) 2022-03-21 2024-08-28 R.G.C.C. Holdings AG Liposomal compositions
KR20240157096A (ko) 2022-03-23 2024-10-31 나노베이션 테라퓨틱스 인크. 고 스테롤-함유 지질 나노입자
US12011507B2 (en) 2022-04-01 2024-06-18 Nanovation Therapeutics Inc. MRNA delivery composition
CN121568686A (zh) * 2023-07-24 2026-02-24 北京生命科学研究所 用于皮肤疾病局部治疗的脂质纳米颗粒组合物

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016511228A (ja) * 2013-01-03 2016-04-14 カウンスィル オブ サイエンティフィック アンド インダストリアル リサーチ マンノース受容体選択的リシニル化カチオン性両親媒性物質及びその調製方法
JP2016523564A (ja) * 2013-07-11 2016-08-12 モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. CRISPR関連タンパク質をコードする合成ポリヌクレオチドおよび合成sgRNAを含む組成物ならびに使用方法
JP7019233B2 (ja) 2013-07-11 2022-02-15 モデルナティエックス インコーポレイテッド CRISPR関連タンパク質をコードする合成ポリヌクレオチドおよび合成sgRNAを含む組成物ならびに使用方法
JP2022115896A (ja) * 2013-07-11 2022-08-09 モデルナティエックス インコーポレイテッド CRISPR関連タンパク質をコードする合成ポリヌクレオチドおよび合成sgRNAを含む組成物ならびに使用方法
JP7225456B2 (ja) 2013-07-11 2023-02-20 モデルナティエックス インコーポレイテッド CRISPR関連タンパク質をコードする合成ポリヌクレオチドおよび合成sgRNAを含む組成物ならびに使用方法
JP2019535808A (ja) * 2016-10-17 2019-12-12 南京▲緑▼叶制▲薬▼有限公司 bcl−2を抑制するアンチセンスオリゴヌクレオチドの脂質ナノ粒子及びその調製方法
JP2024521887A (ja) * 2021-06-01 2024-06-04 ナノベーション・セラピューティクス・インコーポレイテッド 脂質ナノ粒子を用いるdnaベクター送達
WO2024085149A1 (ja) * 2022-10-18 2024-04-25 第一三共株式会社 テイラー反応装置及びカプセル粒子の製造方法
JPWO2024085149A1 (enExample) * 2022-10-18 2024-04-25
JP7557915B2 (ja) 2022-10-18 2024-09-30 株式会社チップトン テイラー反応装置及びカプセル粒子の製造方法

Also Published As

Publication number Publication date
WO2010014895A2 (en) 2010-02-04
US20110111044A1 (en) 2011-05-12
CA2731173A1 (en) 2010-02-04
EP2304026A4 (en) 2013-12-18
TW201004658A (en) 2010-02-01
WO2010014895A3 (en) 2010-05-27
EP2304026A2 (en) 2011-04-06

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