JP2011528678A5 - - Google Patents
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- JP2011528678A5 JP2011528678A5 JP2011519085A JP2011519085A JP2011528678A5 JP 2011528678 A5 JP2011528678 A5 JP 2011528678A5 JP 2011519085 A JP2011519085 A JP 2011519085A JP 2011519085 A JP2011519085 A JP 2011519085A JP 2011528678 A5 JP2011528678 A5 JP 2011528678A5
- Authority
- JP
- Japan
- Prior art keywords
- pain
- peptide
- seq
- substituted
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 30
- 208000002193 Pain Diseases 0.000 claims 20
- 125000002723 alicyclic group Chemical group 0.000 claims 6
- 208000004550 Postoperative Pain Diseases 0.000 claims 5
- 125000002015 acyclic group Chemical group 0.000 claims 5
- 125000001931 aliphatic group Chemical group 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- -1 tert- butanoyl Chemical group 0.000 claims 4
- 201000004624 Dermatitis Diseases 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 208000004296 neuralgia Diseases 0.000 claims 3
- 208000004998 Abdominal Pain Diseases 0.000 claims 2
- 206010000087 Abdominal pain upper Diseases 0.000 claims 2
- 208000008035 Back Pain Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 206010040880 Skin irritation Diseases 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 208000021722 neuropathic pain Diseases 0.000 claims 2
- 239000003921 oil Substances 0.000 claims 2
- 239000002674 ointment Substances 0.000 claims 2
- 238000001126 phototherapy Methods 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 230000036556 skin irritation Effects 0.000 claims 2
- 231100000475 skin irritation Toxicity 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010003645 Atopy Diseases 0.000 claims 1
- 206010005063 Bladder pain Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 206010006002 Bone pain Diseases 0.000 claims 1
- 241000195940 Bryophyta Species 0.000 claims 1
- 206010006585 Bunion Diseases 0.000 claims 1
- 206010012442 Dermatitis contact Diseases 0.000 claims 1
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 1
- 206010013774 Dry eye Diseases 0.000 claims 1
- 206010015958 Eye pain Diseases 0.000 claims 1
- 206010016059 Facial pain Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 208000004454 Hyperalgesia Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 208000008930 Low Back Pain Diseases 0.000 claims 1
- 229920002774 Maltodextrin Polymers 0.000 claims 1
- 239000005913 Maltodextrin Substances 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 206010028391 Musculoskeletal Pain Diseases 0.000 claims 1
- 206010028836 Neck pain Diseases 0.000 claims 1
- 208000007920 Neurogenic Inflammation Diseases 0.000 claims 1
- 208000001715 Osteoblastoma Diseases 0.000 claims 1
- 208000000450 Pelvic Pain Diseases 0.000 claims 1
- 206010061339 Perineal pain Diseases 0.000 claims 1
- 208000004983 Phantom Limb Diseases 0.000 claims 1
- 206010056238 Phantom pain Diseases 0.000 claims 1
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims 1
- 208000008765 Sciatica Diseases 0.000 claims 1
- 206010039757 Scrotal pain Diseases 0.000 claims 1
- 206010040021 Sensory abnormalities Diseases 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 208000002847 Surgical Wound Diseases 0.000 claims 1
- 206010043269 Tension headache Diseases 0.000 claims 1
- 208000008548 Tension-Type Headache Diseases 0.000 claims 1
- 206010043345 Testicular pain Diseases 0.000 claims 1
- 206010044074 Torticollis Diseases 0.000 claims 1
- 206010062225 Urinary tract pain Diseases 0.000 claims 1
- 206010047095 Vascular pain Diseases 0.000 claims 1
- 206010069055 Vulvovaginal pain Diseases 0.000 claims 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 206010053552 allodynia Diseases 0.000 claims 1
- 229940035676 analgesics Drugs 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000003429 antifungal agent Substances 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 239000002249 anxiolytic agent Substances 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 239000000440 bentonite Substances 0.000 claims 1
- 229910000278 bentonite Inorganic materials 0.000 claims 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 208000003295 carpal tunnel syndrome Diseases 0.000 claims 1
- 201000002866 cervical dystonia Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 208000010247 contact dermatitis Diseases 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- NZNMSOFKMUBTKW-UHFFFAOYSA-N cyclohexanecarboxylic acid Chemical compound OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 claims 1
- 125000003074 decanoyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(*)=O 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 230000001079 digestive effect Effects 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 210000000750 endocrine system Anatomy 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 210000004709 eyebrow Anatomy 0.000 claims 1
- 239000004744 fabric Substances 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 125000003104 hexanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000002669 linoleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 229940035034 maltodextrin Drugs 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000693 micelle Substances 0.000 claims 1
- 239000004530 micro-emulsion Substances 0.000 claims 1
- 239000003094 microcapsule Substances 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 239000004005 microsphere Substances 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 239000008267 milk Substances 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 235000011929 mousse Nutrition 0.000 claims 1
- 125000001419 myristoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000002088 nanocapsule Substances 0.000 claims 1
- 239000007908 nanoemulsion Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 239000002077 nanosphere Substances 0.000 claims 1
- 239000004745 nonwoven fabric Substances 0.000 claims 1
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 claims 1
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 claims 1
- 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229920000620 organic polymer Polymers 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000002304 perfume Substances 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 230000037307 sensitive skin Effects 0.000 claims 1
- 239000002453 shampoo Substances 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 201000009890 sinusitis Diseases 0.000 claims 1
- 239000000344 soap Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 239000000454 talc Substances 0.000 claims 1
- 229910052623 talc Inorganic materials 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 206010044652 trigeminal neuralgia Diseases 0.000 claims 1
- 208000009935 visceral pain Diseases 0.000 claims 1
- 210000003905 vulva Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200802210A ES2356883B1 (es) | 2008-07-24 | 2008-07-24 | Composición para el tratamiento del dolor y/o la inflamación. |
| ESP200802210 | 2008-07-24 | ||
| PCT/EP2009/005381 WO2010009892A2 (en) | 2008-07-24 | 2009-07-24 | Compositions for the treatment of pain and/or inflamation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011528678A JP2011528678A (ja) | 2011-11-24 |
| JP2011528678A5 true JP2011528678A5 (https=) | 2012-07-05 |
| JP5920916B2 JP5920916B2 (ja) | 2016-05-18 |
Family
ID=41462205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011519085A Active JP5920916B2 (ja) | 2008-07-24 | 2009-07-24 | 疼痛および／または炎症治療のための組成物 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US20110206752A1 (https=) |
| EP (1) | EP2318033B8 (https=) |
| JP (1) | JP5920916B2 (https=) |
| KR (1) | KR20110056491A (https=) |
| CN (1) | CN102164610B (https=) |
| AR (1) | AR072610A1 (https=) |
| AU (1) | AU2009273471C1 (https=) |
| BR (1) | BRPI0911743B1 (https=) |
| CA (1) | CA2731880C (https=) |
| CY (1) | CY1121125T1 (https=) |
| DK (1) | DK2318033T3 (https=) |
| ES (2) | ES2356883B1 (https=) |
| HR (1) | HRP20190059T1 (https=) |
| HU (1) | HUE042083T2 (https=) |
| IL (1) | IL210810B (https=) |
| LT (1) | LT2318033T (https=) |
| MX (1) | MX2011000868A (https=) |
| PL (1) | PL2318033T3 (https=) |
| PT (1) | PT2318033T (https=) |
| RU (1) | RU2515054C2 (https=) |
| SG (1) | SG192548A1 (https=) |
| SI (1) | SI2318033T1 (https=) |
| TR (1) | TR201900542T4 (https=) |
| WO (1) | WO2010009892A2 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2961510A1 (fr) * | 2010-06-17 | 2011-12-23 | Oreal | Utilisation comme agent de traitement de la transpiration humaine ; nouveaux derives d'acide amine ; compositions les contenant |
| ES2385683B1 (es) * | 2010-10-18 | 2013-10-07 | Bcn Peptides, S.A. | Composiciones para el tratamiento del dolor y/o la inflamación. |
| DK3777876T3 (da) | 2011-10-28 | 2023-10-30 | Neostrata Company Inc | N-acyldipeptid-derivater og anvendelser deraf |
| WO2013070808A1 (en) | 2011-11-07 | 2013-05-16 | Feng Tian | Peptide-based compounds as inhibitors of neurotransmitter secretion |
| US9687669B2 (en) | 2011-11-09 | 2017-06-27 | John Stephan | Wearable light therapy apparatus |
| US20140349920A1 (en) * | 2012-01-03 | 2014-11-27 | Ruey J. Yu | N-acylpeptide derivatives and their uses |
| EP2649983A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis (II) |
| EP2836193B1 (en) | 2012-04-13 | 2018-01-31 | Lubrizol Advanced Materials, Inc. | Compounds which inhibit neuronal exocytosis (ii) |
| EP2649984A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis |
| EP2649985A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis (III) |
| DE102014007423A1 (de) * | 2014-05-22 | 2015-11-26 | Bitop Ag | Zusammensetzung zur Behandlung des Auges |
| RU2580280C2 (ru) * | 2014-07-08 | 2016-04-10 | Общество с ограниченной ответственностью "НИТРОЗДРАВ" | Композиция для местного применения для снижения или снятия болевого синдрома |
| GB201505527D0 (en) | 2015-03-31 | 2015-05-13 | Jmedtech Pte Ltd | Composition |
| US20190083809A1 (en) | 2016-07-27 | 2019-03-21 | Z2020, Llc | Componentry and devices for light therapy delivery and methods related thereto |
| US20200002377A1 (en) * | 2016-11-30 | 2020-01-02 | Lubrizol Advanced Materials, Inc. | Compounds useful for the treatment and/or care of the skin, hair, nails and/or mucous membranes |
| JP7100390B2 (ja) * | 2017-09-18 | 2022-07-13 | エニジェン カンパニー．，リミテッド． | 活性物質－ヘキサペプチド複合体、及びこれを含む化粧料組成物 |
| WO2019071245A1 (en) | 2017-10-06 | 2019-04-11 | Foundry Therapeutics, Inc. | IMPLANTABLE DEPOSITS FOR REGULATED RELEASE OF ANALGESICS TO TREAT POSTHOPERATIVE PAIN ASSOCIATED WITH ORTHOPEDIC SURGERY, AND RELATED DEVICES, SYSTEMS, AND METHODS |
| WO2019136490A1 (en) | 2018-01-08 | 2019-07-11 | Foundry Therapeutics, Inc. | Devices, systems, and methods for treating intraluminal cancer via controlled delivery of therapeutic agents |
| EP3793536A1 (en) | 2018-05-12 | 2021-03-24 | Foundry Therapeutics, Inc. | Implantable polymer depots for the controlled release of therapeutic agents |
| CN112165955A (zh) | 2018-05-21 | 2021-01-01 | 益普生生物制药有限公司 | 抑制骨癌引起的异常性疼痛 |
| WO2019238683A1 (en) | 2018-06-13 | 2019-12-19 | Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. S.P.A. | Peptides having inhibitory activity on neuronal exocytosis |
| US12303619B2 (en) | 2018-08-28 | 2025-05-20 | Foundry Therapeutics, Inc. | Polymer implants |
| BR112021018006A2 (pt) | 2019-03-14 | 2021-11-16 | Om Pharma Sa | Extratos bacterianos estáveis como farmacêuticos |
| JP7349052B2 (ja) | 2019-06-24 | 2023-09-22 | 湖南方升泰医薬科技有限公司 | 金属錯体の新規応用 |
| CN115583988B (zh) * | 2022-10-14 | 2023-08-18 | 深圳市维琪科技股份有限公司 | 合成肽及其组合物和用途 |
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| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US6974578B1 (en) * | 1993-12-28 | 2005-12-13 | Allergan, Inc. | Method for treating secretions and glands using botulinum toxin |
| PT1086702E (pt) * | 1994-05-09 | 2005-08-31 | William J Binder | Neurotoxinas pre-sinapticas para tratamento da dor de cabeca devida a enxaqueca |
| US6169074B1 (en) * | 1996-03-18 | 2001-01-02 | The Regents Of The University Of California | Peptide inhibitors of neurotransmitter secretion by neuronal cells |
| ES2160485B1 (es) * | 1999-04-23 | 2002-05-16 | Lipotec Sa | Peptidos inhibidores de la exocitosis neuronal, composiciones cosmeticas y farmaceuticas que los contienen. |
| US6113915A (en) * | 1999-10-12 | 2000-09-05 | Allergan Sales, Inc. | Methods for treating pain |
| US6500436B2 (en) * | 2000-01-19 | 2002-12-31 | Allergan, Inc. | Clostridial toxin derivatives and methods for treating pain |
| US6641820B1 (en) * | 2000-01-19 | 2003-11-04 | Allergan, Inc. | Clostridial toxin derivatives and methods to treat pain |
| US6464986B1 (en) * | 2000-04-14 | 2002-10-15 | Allegan Sales, Inc. | Method for treating pain by peripheral administration of a neurotoxin |
| US6565870B1 (en) * | 2000-04-28 | 2003-05-20 | Allergan, Inc. | Methods for treating bone tumors |
| US6423319B1 (en) * | 2000-10-04 | 2002-07-23 | Allergan Sales, Inc. | Methods for treating muscle injuries |
| GB0111146D0 (en) * | 2001-05-04 | 2001-06-27 | Imp College Innovations Ltd | Methods |
| US7255866B2 (en) * | 2001-09-17 | 2007-08-14 | Allergan, Inc. | Botulinum toxin therapy for fibromyalgia |
| US6623742B2 (en) * | 2001-09-17 | 2003-09-23 | Allergan, Inc. | Methods for treating fibromyalgia |
| US7071167B2 (en) * | 2002-11-13 | 2006-07-04 | L'oreal | Use of a combination of components with an inhibitory synergistic effect on calcium channels to prevent or treat wrinkles and fine lines |
| US6838434B2 (en) * | 2003-05-02 | 2005-01-04 | Allergan, Inc. | Methods for treating sinus headache |
| GB2416122A (en) * | 2004-07-12 | 2006-01-18 | Ipsen Ltd | Botulinum neurotoxin composition |
| CN101160318A (zh) * | 2005-03-03 | 2008-04-09 | 雷文斯治疗公司 | 用于局部施用和经皮肤递送寡肽的组合物和方法 |
| WO2007071448A2 (en) * | 2005-12-23 | 2007-06-28 | Partnership & Corp. Technology Transfer | Synthetic peptides for use as inhibitors of neurotransmitter secretion and as inducers of muscle relaxation |
| GB0602992D0 (en) * | 2006-02-15 | 2006-03-29 | Morvus Technology Ltd | Methods, genes and proteins |
| FR2902341B1 (fr) * | 2006-06-16 | 2011-02-25 | Scras | Utilisation therapeutique simultanee, separee ou etalee dans le temps d'au moins une neurotoxine botulique, et d'au moins un derive opiace |
| ES2322882B1 (es) * | 2006-10-25 | 2010-04-22 | Lipotec Sa | Peptidos inhibidores de la exocitosis neuronal. |
| KR20090041066A (ko) * | 2007-10-23 | 2009-04-28 | 성균관대학교산학협력단 | 신경전달물질 배출을 조절하는 합성 펩타이드 |
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2008
- 2008-07-24 ES ES200802210A patent/ES2356883B1/es active Active
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2009
- 2009-07-24 JP JP2011519085A patent/JP5920916B2/ja active Active
- 2009-07-24 MX MX2011000868A patent/MX2011000868A/es active IP Right Grant
- 2009-07-24 BR BRPI0911743-1A patent/BRPI0911743B1/pt active IP Right Grant
- 2009-07-24 EP EP09777419.4A patent/EP2318033B8/en active Active
- 2009-07-24 RU RU2011105280/04A patent/RU2515054C2/ru active
- 2009-07-24 KR KR1020117004108A patent/KR20110056491A/ko not_active Ceased
- 2009-07-24 HR HRP20190059TT patent/HRP20190059T1/hr unknown
- 2009-07-24 AU AU2009273471A patent/AU2009273471C1/en active Active
- 2009-07-24 AR ARP090102843A patent/AR072610A1/es unknown
- 2009-07-24 CN CN200980137382.XA patent/CN102164610B/zh active Active
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- 2009-07-24 WO PCT/EP2009/005381 patent/WO2010009892A2/en not_active Ceased
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- 2009-07-24 DK DK09777419.4T patent/DK2318033T3/en active
- 2009-07-24 LT LTEP09777419.4T patent/LT2318033T/lt unknown
- 2009-07-24 HU HUE09777419A patent/HUE042083T2/hu unknown
- 2009-07-24 SG SG2013055900A patent/SG192548A1/en unknown
- 2009-07-24 PT PT09777419T patent/PT2318033T/pt unknown
- 2009-07-24 TR TR2019/00542T patent/TR201900542T4/tr unknown
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2018
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