JP2011528372A5 - - Google Patents
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- JP2011528372A5 JP2011528372A5 JP2011518900A JP2011518900A JP2011528372A5 JP 2011528372 A5 JP2011528372 A5 JP 2011528372A5 JP 2011518900 A JP2011518900 A JP 2011518900A JP 2011518900 A JP2011518900 A JP 2011518900A JP 2011528372 A5 JP2011528372 A5 JP 2011528372A5
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- 150000001875 compounds Chemical class 0.000 claims description 50
- 239000008194 pharmaceutical composition Substances 0.000 claims description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 13
- 125000004122 cyclic group Chemical group 0.000 claims description 10
- 229910052736 halogen Inorganic materials 0.000 claims description 10
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 9
- 125000005843 halogen group Chemical group 0.000 claims description 9
- 239000003937 drug carrier Substances 0.000 claims description 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 8
- 208000035475 disorder Diseases 0.000 claims description 7
- 125000003545 alkoxy group Chemical group 0.000 claims description 6
- 125000004982 dihaloalkyl group Chemical group 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 6
- 208000010877 cognitive disease Diseases 0.000 claims description 5
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 5
- 201000000980 schizophrenia Diseases 0.000 claims description 5
- 208000032841 Bulimia Diseases 0.000 claims description 4
- 206010006550 Bulimia nervosa Diseases 0.000 claims description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
- 210000003169 central nervous system Anatomy 0.000 claims description 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 4
- 125000001188 haloalkyl group Chemical group 0.000 claims description 4
- 125000005842 heteroatom Chemical group 0.000 claims description 4
- 229910052739 hydrogen Chemical group 0.000 claims description 4
- 239000001257 hydrogen Chemical group 0.000 claims description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
- 230000004770 neurodegeneration Effects 0.000 claims description 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 239000001301 oxygen Chemical group 0.000 claims description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
- 125000004076 pyridyl group Chemical group 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 229920006395 saturated elastomer Polymers 0.000 claims description 4
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical group [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims description 4
- 229910052717 sulfur Chemical group 0.000 claims description 4
- 239000011593 sulfur Chemical group 0.000 claims description 4
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 4
- 125000004952 trihaloalkoxy group Chemical group 0.000 claims description 4
- 125000004385 trihaloalkyl group Chemical group 0.000 claims description 4
- 208000028017 Psychotic disease Diseases 0.000 claims description 3
- 206010027175 memory impairment Diseases 0.000 claims description 3
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 2
- TUVJCVZTAVSNKA-UHFFFAOYSA-N 5-(azepan-1-yl)-n-(5-pyridin-4-yl-1h-pyrazol-3-yl)pentanamide Chemical compound C1=C(C=2C=CN=CC=2)NN=C1NC(=O)CCCCN1CCCCCC1 TUVJCVZTAVSNKA-UHFFFAOYSA-N 0.000 claims description 2
- 208000024827 Alzheimer disease Diseases 0.000 claims description 2
- 208000019901 Anxiety disease Diseases 0.000 claims description 2
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims description 2
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims description 2
- 206010012289 Dementia Diseases 0.000 claims description 2
- 208000030814 Eating disease Diseases 0.000 claims description 2
- 208000019454 Feeding and Eating disease Diseases 0.000 claims description 2
- 208000018522 Gastrointestinal disease Diseases 0.000 claims description 2
- 208000023105 Huntington disease Diseases 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 208000019695 Migraine disease Diseases 0.000 claims description 2
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims description 2
- 208000002193 Pain Diseases 0.000 claims description 2
- 206010033664 Panic attack Diseases 0.000 claims description 2
- 208000018737 Parkinson disease Diseases 0.000 claims description 2
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims description 2
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims description 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims description 2
- 125000005153 alkyl sulfamoyl group Chemical group 0.000 claims description 2
- 125000002947 alkylene group Chemical group 0.000 claims description 2
- 208000022531 anorexia Diseases 0.000 claims description 2
- 230000036506 anxiety Effects 0.000 claims description 2
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims description 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 2
- 230000001713 cholinergic effect Effects 0.000 claims description 2
- 230000003920 cognitive function Effects 0.000 claims description 2
- 206010061428 decreased appetite Diseases 0.000 claims description 2
- 235000014632 disordered eating Nutrition 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 230000004064 dysfunction Effects 0.000 claims description 2
- 206010015037 epilepsy Diseases 0.000 claims description 2
- 125000001153 fluoro group Chemical group F* 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 230000001771 impaired effect Effects 0.000 claims description 2
- 125000000814 indol-3-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C([*])C2=C1[H] 0.000 claims description 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims description 2
- 206010027599 migraine Diseases 0.000 claims description 2
- IDQINVZEHVHNKA-UHFFFAOYSA-N n-[5-(1-ethylindol-3-yl)-1h-pyrazol-3-yl]-4-pyrrolidin-1-ylbutanamide Chemical compound C12=CC=CC=C2N(CC)C=C1C(=NN1)C=C1NC(=O)CCCN1CCCC1 IDQINVZEHVHNKA-UHFFFAOYSA-N 0.000 claims description 2
- HAOYPPBZLQMFRB-UHFFFAOYSA-N n-[5-(1h-indol-5-yl)-1h-pyrazol-3-yl]-5-piperidin-1-ylpentanamide Chemical compound C=1C(C=2C=C3C=CNC3=CC=2)=NNC=1NC(=O)CCCCN1CCCCC1 HAOYPPBZLQMFRB-UHFFFAOYSA-N 0.000 claims description 2
- ULVWYOLWRHJRGA-UHFFFAOYSA-N n-[5-(5-methylpyridin-3-yl)-1h-pyrazol-3-yl]-4-piperidin-1-ylbutanamide Chemical compound CC1=CN=CC(C=2NN=C(NC(=O)CCCN3CCCCC3)C=2)=C1 ULVWYOLWRHJRGA-UHFFFAOYSA-N 0.000 claims description 2
- PODSWXCZBZIQRU-UHFFFAOYSA-N n-[5-(6-methylpyridin-3-yl)-1h-pyrazol-3-yl]-4-piperidin-1-ylbutanamide Chemical compound C1=NC(C)=CC=C1C1=CC(NC(=O)CCCN2CCCCC2)=NN1 PODSWXCZBZIQRU-UHFFFAOYSA-N 0.000 claims description 2
- MUFOLRMJGLDINZ-UHFFFAOYSA-N n-[5-(furan-2-yl)-1h-pyrazol-3-yl]-5-piperidin-1-ylpentanamide Chemical compound C=1C(C=2OC=CC=2)=NNC=1NC(=O)CCCCN1CCCCC1 MUFOLRMJGLDINZ-UHFFFAOYSA-N 0.000 claims description 2
- 230000007514 neuronal growth Effects 0.000 claims description 2
- 208000019906 panic disease Diseases 0.000 claims description 2
- 125000003386 piperidinyl group Chemical group 0.000 claims description 2
- 208000020016 psychiatric disease Diseases 0.000 claims description 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 2
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 2
- 208000019116 sleep disease Diseases 0.000 claims description 2
- 208000020685 sleep-wake disease Diseases 0.000 claims description 2
- 230000000087 stabilizing effect Effects 0.000 claims description 2
- 201000009032 substance abuse Diseases 0.000 claims description 2
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 0 C*c1cc(-c2n[n]c(NC(CCC*3CCCCC3)=O)c2)cnc1 Chemical compound C*c1cc(-c2n[n]c(NC(CCC*3CCCCC3)=O)c2)cnc1 0.000 description 3
- XEWVWHPAIRHOCN-UHFFFAOYSA-N NC1=CC2C1=C2 Chemical compound NC1=CC2C1=C2 XEWVWHPAIRHOCN-UHFFFAOYSA-N 0.000 description 2
- 102000047725 alpha7 Nicotinic Acetylcholine Receptor Human genes 0.000 description 2
- 108700006085 alpha7 Nicotinic Acetylcholine Receptor Proteins 0.000 description 2
- RXDLNISRGKTTCU-UHFFFAOYSA-N CC(C)(C)c1ccc(-c2n[nH]c(NC(CCCN3CCCC3)=O)c2)[s]1 Chemical compound CC(C)(C)c1ccc(-c2n[nH]c(NC(CCCN3CCCC3)=O)c2)[s]1 RXDLNISRGKTTCU-UHFFFAOYSA-N 0.000 description 1
- MPCGNOSPLBENQI-CZCUMCSCSA-N CC(C)(C)c1ccc(C(/C=C(\N)/NC(CCCN2CCCCC2)=O)=N)[s]1 Chemical compound CC(C)(C)c1ccc(C(/C=C(\N)/NC(CCCN2CCCCC2)=O)=N)[s]1 MPCGNOSPLBENQI-CZCUMCSCSA-N 0.000 description 1
- AZDGONBLNUKYRG-UHFFFAOYSA-N CC(C)(CC(Nc([nH]nc1-c(cc2)cc3c2nccc3)c1F)=O)CN1CCCC1 Chemical compound CC(C)(CC(Nc([nH]nc1-c(cc2)cc3c2nccc3)c1F)=O)CN1CCCC1 AZDGONBLNUKYRG-UHFFFAOYSA-N 0.000 description 1
- MYNCUIQJVHNXGN-UHFFFAOYSA-N CC(C)(CC(Nc([nH]nc1-c2cc(F)cnc2)c1F)O)CN1CCCC1 Chemical compound CC(C)(CC(Nc([nH]nc1-c2cc(F)cnc2)c1F)O)CN1CCCC1 MYNCUIQJVHNXGN-UHFFFAOYSA-N 0.000 description 1
- LKWAGWGTSPXSAU-UHFFFAOYSA-N CC(C)(CC1CCCC1)CC(Nc([nH]nc1-c(cn2)ccc2OCC2CN(CC(C)(C)CC(Nc([nH]nc3-c4cc(OC)cnc4)c3F)=O)CC2)c1F)=O Chemical compound CC(C)(CC1CCCC1)CC(Nc([nH]nc1-c(cn2)ccc2OCC2CN(CC(C)(C)CC(Nc([nH]nc3-c4cc(OC)cnc4)c3F)=O)CC2)c1F)=O LKWAGWGTSPXSAU-UHFFFAOYSA-N 0.000 description 1
- SXWRLSZSEFFVHE-UHFFFAOYSA-N CC(CCC(Nc1cc(-c2cnc(C(F)(F)F)c(C)c2)n[nH]1)=O)N(CC1)CC1c(c(C)c1)ncc1-c1n[nH]c(NC(CCCN2CCCC2)=O)c1 Chemical compound CC(CCC(Nc1cc(-c2cnc(C(F)(F)F)c(C)c2)n[nH]1)=O)N(CC1)CC1c(c(C)c1)ncc1-c1n[nH]c(NC(CCCN2CCCC2)=O)c1 SXWRLSZSEFFVHE-UHFFFAOYSA-N 0.000 description 1
- UOCQCKQAVHDNSY-UHFFFAOYSA-N CCCC(Nc([nH]nc1-c2cc(cccc3)c3nc2)c1F)=O Chemical compound CCCC(Nc([nH]nc1-c2cc(cccc3)c3nc2)c1F)=O UOCQCKQAVHDNSY-UHFFFAOYSA-N 0.000 description 1
- HLNRRPIYRBBHSQ-UHFFFAOYSA-N CCCN1CCCC1 Chemical compound CCCN1CCCC1 HLNRRPIYRBBHSQ-UHFFFAOYSA-N 0.000 description 1
- WTVULSSIYJTPKF-UHFFFAOYSA-N CC[n](ccc1c2)c1ccc2-c1n[nH]c(NC(CCCN2CCCC2)=O)c1 Chemical compound CC[n](ccc1c2)c1ccc2-c1n[nH]c(NC(CCCN2CCCC2)=O)c1 WTVULSSIYJTPKF-UHFFFAOYSA-N 0.000 description 1
- BLGGXPBHLUZEDW-UHFFFAOYSA-N CC[n]1c(cccc2)c2c(-c2n[nH]c(NC(CCCN3CCC(CC[n]4c5cc(-c6n[nH]c(NC(CCCN7CCCC7)=O)c6)ccc5cc4)CC3)=O)c2)c1 Chemical compound CC[n]1c(cccc2)c2c(-c2n[nH]c(NC(CCCN3CCC(CC[n]4c5cc(-c6n[nH]c(NC(CCCN7CCCC7)=O)c6)ccc5cc4)CC3)=O)c2)c1 BLGGXPBHLUZEDW-UHFFFAOYSA-N 0.000 description 1
- IEBQTOHHAVALDV-UHFFFAOYSA-N CC[n]1c2cc(-c3n[nH]c(NC(CCCN4CC(CC[n](ccc5c6)c5ccc6-c5n[nH]c(NC(CCCN6CCCCC6)=O)c5)CCC4)=O)c3)ccc2cc1 Chemical compound CC[n]1c2cc(-c3n[nH]c(NC(CCCN4CC(CC[n](ccc5c6)c5ccc6-c5n[nH]c(NC(CCCN6CCCCC6)=O)c5)CCC4)=O)c3)ccc2cc1 IEBQTOHHAVALDV-UHFFFAOYSA-N 0.000 description 1
- QDGLSADWFSXUBY-UHFFFAOYSA-N COc(cc1)ncc1-c1n[nH]c(NC(CCCC2CCCCCC2)=O)c1 Chemical compound COc(cc1)ncc1-c1n[nH]c(NC(CCCC2CCCCCC2)=O)c1 QDGLSADWFSXUBY-UHFFFAOYSA-N 0.000 description 1
- LQZCUVGTGAEKRA-LMUZMDBKSA-N C[C@@H]1N(CCCC(Nc2cc(-c(cc3)cc4c3nc(C3CN(CCCC(Nc5cc(-c6cnc(C)cc6)n[nH]5)=O)CC3)cc4)n[nH]2)=O)CCCC1 Chemical compound C[C@@H]1N(CCCC(Nc2cc(-c(cc3)cc4c3nc(C3CN(CCCC(Nc5cc(-c6cnc(C)cc6)n[nH]5)=O)CC3)cc4)n[nH]2)=O)CCCC1 LQZCUVGTGAEKRA-LMUZMDBKSA-N 0.000 description 1
- HOMQRFKEQCILAS-UHFFFAOYSA-N Cc(cc1)nc(cc2)c1cc2-c1n[nH]c(NC(CCCN2CCCC2)=O)c1 Chemical compound Cc(cc1)nc(cc2)c1cc2-c1n[nH]c(NC(CCCN2CCCC2)=O)c1 HOMQRFKEQCILAS-UHFFFAOYSA-N 0.000 description 1
- NJFKQPHGDREVOZ-UHFFFAOYSA-N Cc(nc(C(F)(F)F)cc1)c1-c1cc(NC(CCCN(CC2)CCC2c2ccc(cc(cc3)-c4n[nH]c(NC(CCCN5CCCC5)=O)c4)c3n2)=O)n[nH]1 Chemical compound Cc(nc(C(F)(F)F)cc1)c1-c1cc(NC(CCCN(CC2)CCC2c2ccc(cc(cc3)-c4n[nH]c(NC(CCCN5CCCC5)=O)c4)c3n2)=O)n[nH]1 NJFKQPHGDREVOZ-UHFFFAOYSA-N 0.000 description 1
- YZKPEZRDOHWTMW-WBDTVUNHSA-N N/C(/NC(CCCN1CCCCC1)=O)=C\C(c(cc1)c[n]2c1cnc2)=N Chemical compound N/C(/NC(CCCN1CCCCC1)=O)=C\C(c(cc1)c[n]2c1cnc2)=N YZKPEZRDOHWTMW-WBDTVUNHSA-N 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- VWQBSZXPQBSWMY-UHFFFAOYSA-N O=C(CCCN1CCCC1)Nc1cc(-c2cc(cccc3)c3nc2)n[nH]1 Chemical compound O=C(CCCN1CCCC1)Nc1cc(-c2cc(cccc3)c3nc2)n[nH]1 VWQBSZXPQBSWMY-UHFFFAOYSA-N 0.000 description 1
- PVGZAVBHVKFGHJ-UHFFFAOYSA-N O=C(CCCN1CCCCC1)NC(C1)NN=C1c1cncc([F]/[O]=C(/C=C2)\N(C(F)F)C=C2c2n[nH]c(NC(CCCN3CCCCC3)=O)c2)c1 Chemical compound O=C(CCCN1CCCCC1)NC(C1)NN=C1c1cncc([F]/[O]=C(/C=C2)\N(C(F)F)C=C2c2n[nH]c(NC(CCCN3CCCCC3)=O)c2)c1 PVGZAVBHVKFGHJ-UHFFFAOYSA-N 0.000 description 1
- CDZATIIGKUMVHU-UHFFFAOYSA-N O=C(CCCN1CCCCC1)Nc1cc(-c2c(cccc3)[n]3nc2)n[nH]1 Chemical compound O=C(CCCN1CCCCC1)Nc1cc(-c2c(cccc3)[n]3nc2)n[nH]1 CDZATIIGKUMVHU-UHFFFAOYSA-N 0.000 description 1
- AEYZDDZERKIIAB-UHFFFAOYSA-N O=C(CCCN1CCCCC1)Nc1n[nH]c(-c2cnc(C(F)(F)F)cc2)c1 Chemical compound O=C(CCCN1CCCCC1)Nc1n[nH]c(-c2cnc(C(F)(F)F)cc2)c1 AEYZDDZERKIIAB-UHFFFAOYSA-N 0.000 description 1
- 102000015296 acetylcholine-gated cation-selective channel activity proteins Human genes 0.000 description 1
- 108040006409 acetylcholine-gated cation-selective channel activity proteins Proteins 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000015654 memory Effects 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000003040 nociceptive effect Effects 0.000 description 1
- 239000004031 partial agonist Substances 0.000 description 1
- 208000012201 sexual and gender identity disease Diseases 0.000 description 1
- 208000015891 sexual disease Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8121108P | 2008-07-16 | 2008-07-16 | |
| US61/081,211 | 2008-07-16 | ||
| PCT/US2009/050797 WO2010009290A1 (en) | 2008-07-16 | 2009-07-16 | Alpha7 nicotinic acetylcholine receptor inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011528372A JP2011528372A (ja) | 2011-11-17 |
| JP2011528372A5 true JP2011528372A5 (https=) | 2012-07-19 |
Family
ID=41137861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011518900A Pending JP2011528372A (ja) | 2008-07-16 | 2009-07-16 | α７ニコチン性アセチルコリンレセプターインヒビター |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20100130474A1 (https=) |
| EP (1) | EP2323988A1 (https=) |
| JP (1) | JP2011528372A (https=) |
| AR (1) | AR072508A1 (https=) |
| CA (1) | CA2729606A1 (https=) |
| PA (1) | PA8836101A1 (https=) |
| TW (1) | TW201004941A (https=) |
| WO (1) | WO2010009290A1 (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200901974A (en) | 2007-01-16 | 2009-01-16 | Wyeth Corp | Compounds, compositions, and methods of making and using them |
| US8841329B2 (en) | 2008-09-11 | 2014-09-23 | Dignity Health | Nicotinic attenuation of CNS inflammation and autoimmunity |
| JP6155187B2 (ja) | 2010-03-30 | 2017-06-28 | ヴァーセオン コーポレイション | トロンビンの阻害剤としての多置換芳香族化合物 |
| EP2558458B1 (de) | 2010-04-16 | 2017-09-06 | Bayer Intellectual Property GmbH | Neue heterocyclische verbindungen als schädlingsbekämpfungsmittel |
| RU2576316C2 (ru) * | 2010-11-03 | 2016-02-27 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | Пестицидная композиция, способ контроля вредителей, способ контроля эндопаразитов, эктопаразитов или обоих и способ усиления жизнестойкости растений |
| JP6027128B2 (ja) | 2011-10-26 | 2016-11-16 | ダウ アグロサイエンシィズ エルエルシー | 有害生物防除組成物およびそれに関連した方法 |
| BR122014028247A2 (pt) * | 2012-04-27 | 2019-05-07 | Dow Agrosciences Llc | composições pesticidas, processo para controlar praga, uso de uma molécula, processo para aumentar a saúde, rendimento, vigor, qualidade ou tolerância de uma planta e processos para produção de compostos |
| US9282739B2 (en) | 2012-04-27 | 2016-03-15 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
| US9708288B2 (en) | 2012-04-27 | 2017-07-18 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
| US20150313884A1 (en) | 2013-01-15 | 2015-11-05 | Novartis Ag | Use of alpha 7 nicotinic acetylcholine receptor agonists |
| JP2016539092A (ja) | 2013-10-17 | 2016-12-15 | ダウ アグロサイエンシィズ エルエルシー | 有害生物防除性化合物の製造方法 |
| CA2925952A1 (en) | 2013-10-17 | 2015-04-23 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
| US9029554B1 (en) | 2013-10-17 | 2015-05-12 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
| MX2016004941A (es) | 2013-10-17 | 2016-06-28 | Dow Agrosciences Llc | Proceso para la preparacion de compuestos plaguicidas. |
| EP3057429A4 (en) | 2013-10-17 | 2017-08-09 | Dow AgroSciences LLC | Processes for the preparation of pesticidal compounds |
| CA2925953C (en) | 2013-10-17 | 2021-11-02 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
| CA2926095A1 (en) | 2013-10-17 | 2015-04-23 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
| RU2656894C2 (ru) | 2013-10-22 | 2018-06-07 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | Пестицидные композиции и соответствующие способы |
| US9801383B2 (en) | 2013-10-22 | 2017-10-31 | Dow Agrosciences Llc | Synergistic pesticidal compositions and related methods |
| US9282740B2 (en) | 2013-10-22 | 2016-03-15 | Dow Agrosciences Llc | Synergistic pesticidal compositions and related methods |
| MX2016005305A (es) | 2013-10-22 | 2017-03-01 | Dow Agrosciences Llc | Composiciones pesticidas sinergicas y metodos relacionados. |
| TW201517797A (zh) | 2013-10-22 | 2015-05-16 | Dow Agrosciences Llc | 協同性殺蟲組成物及相關方法（十一） |
| NZ719776A (en) | 2013-10-22 | 2017-06-30 | Dow Agrosciences Llc | Synergistic pesticidal compositions and related methods |
| AR098101A1 (es) | 2013-10-22 | 2016-05-04 | Dow Agrosciences Llc | Composiciones plaguicidas y métodos relacionados |
| KR20160074628A (ko) | 2013-10-22 | 2016-06-28 | 다우 아그로사이언시즈 엘엘씨 | 상승작용적 살충 조성물 및 관련 방법 |
| JP2016534073A (ja) | 2013-10-22 | 2016-11-04 | ダウ アグロサイエンシィズ エルエルシー | 相乗的有害生物防除組成物および関連する方法 |
| AR098100A1 (es) | 2013-10-22 | 2016-05-04 | Dow Agrosciences Llc | Composiciones plaguicidas y los métodos relacionados |
| AR098099A1 (es) | 2013-10-22 | 2016-05-04 | Dow Agrosciences Llc | Composiciones plaguicidas sinérgicas y los métodos relacionados |
| AU2014340424B2 (en) | 2013-10-22 | 2017-06-29 | Dow Agrosciences Llc | Pesticidal compositions and related methods |
| EP3060044A4 (en) | 2013-10-22 | 2017-04-05 | Dow AgroSciences LLC | Synergistic pesticidal compositions and related methods |
| US9295260B2 (en) | 2013-10-22 | 2016-03-29 | Dow Agrosciences Llc | Pesticidal compositions and related methods |
| NZ719952A (en) | 2013-10-22 | 2017-05-26 | Dow Agrosciences Llc | Pesticidal compositions and related methods |
| JP2016535026A (ja) | 2013-10-22 | 2016-11-10 | ダウ アグロサイエンシィズ エルエルシー | 相乗的有害生物防除組成物および関連する方法 |
| US9788545B2 (en) | 2013-10-22 | 2017-10-17 | Dow Agrosciences Llc | Synergistic pesticidal compositions and related methods |
| AU2015261775B2 (en) | 2014-05-23 | 2019-07-11 | Active Biotech Ab | Novel compounds useful as S100-inhibitors |
| MX2014006541A (es) * | 2014-05-30 | 2015-11-30 | Univ Autonoma Del Estado De Morelos | Sintesis de analogos y-aminoacidos y productos obtenidos. |
| US9249122B1 (en) | 2014-07-31 | 2016-02-02 | Dow Agrosciences Llc | Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine |
| BR112017000293A2 (pt) | 2014-07-31 | 2017-10-31 | Dow Agrosciences Llc | processo para a preparação de 3-(3-cloro-1h-pirazol-1-il)piridina |
| JP2017523168A (ja) | 2014-07-31 | 2017-08-17 | ダウ アグロサイエンシィズ エルエルシー | ３−（３−クロロ−１ｈ−ピラゾール−１−イル）ピリジンの製造方法 |
| JP2017525703A (ja) | 2014-08-19 | 2017-09-07 | ダウ アグロサイエンシィズ エルエルシー | ３−（３−クロロ−１ｈ−ピラゾール−１−イル）ピリジンの調製方法 |
| AR098113A1 (es) | 2014-09-12 | 2016-05-04 | Dow Agrosciences Llc | Proceso para la preparación de 3-(3-cloro-1h-pirazol-1-il)piridina |
| CN107405333A (zh) | 2015-02-27 | 2017-11-28 | 维颂公司 | 作为丝氨酸蛋白酶抑制剂的被取代的吡唑化合物 |
| JP2020503336A (ja) | 2016-12-29 | 2020-01-30 | ダウ アグロサイエンシィズ エルエルシー | 殺有害生物化合物の調製方法 |
| CN110325036B (zh) | 2016-12-29 | 2021-10-26 | 美国陶氏益农公司 | 用于制备杀虫化合物的方法 |
| CN112480005B (zh) * | 2017-11-08 | 2022-08-19 | 北京嘉林药业股份有限公司 | 化合物及其治疗癌症的用途 |
| CN109134406A (zh) * | 2018-08-02 | 2019-01-04 | 丽珠集团新北江制药股份有限公司 | 一种布瓦西坦中间体及布瓦西坦的合成方法 |
| TW202334117A (zh) | 2020-08-24 | 2023-09-01 | 美商達薩瑪治療公司 | Ｓａｒｍ１之抑制劑 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1991528A2 (en) * | 2006-01-18 | 2008-11-19 | Siena Biotech S.p.A. | Modulators of alpha7 nicotinic acetylcholine receptors and therapeutic uses thereof |
| TW200901974A (en) * | 2007-01-16 | 2009-01-16 | Wyeth Corp | Compounds, compositions, and methods of making and using them |
-
2009
- 2009-06-30 TW TW098122040A patent/TW201004941A/zh unknown
- 2009-07-14 AR ARP090102661A patent/AR072508A1/es not_active Application Discontinuation
- 2009-07-16 JP JP2011518900A patent/JP2011528372A/ja active Pending
- 2009-07-16 CA CA2729606A patent/CA2729606A1/en not_active Abandoned
- 2009-07-16 EP EP09790514A patent/EP2323988A1/en not_active Withdrawn
- 2009-07-16 US US12/503,997 patent/US20100130474A1/en not_active Abandoned
- 2009-07-16 PA PA20098836101A patent/PA8836101A1/es unknown
- 2009-07-16 WO PCT/US2009/050797 patent/WO2010009290A1/en not_active Ceased
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