JP2011527677A5 - - Google Patents

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Publication number
JP2011527677A5
JP2011527677A5 JP2011517461A JP2011517461A JP2011527677A5 JP 2011527677 A5 JP2011527677 A5 JP 2011527677A5 JP 2011517461 A JP2011517461 A JP 2011517461A JP 2011517461 A JP2011517461 A JP 2011517461A JP 2011527677 A5 JP2011527677 A5 JP 2011527677A5
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JP
Japan
Prior art keywords
alkyl
hydrogen
halogen
ring
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011517461A
Other languages
English (en)
Japanese (ja)
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JP2011527677A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/048394 external-priority patent/WO2010005783A1/en
Publication of JP2011527677A publication Critical patent/JP2011527677A/ja
Publication of JP2011527677A5 publication Critical patent/JP2011527677A5/ja
Pending legal-status Critical Current

Links

JP2011517461A 2008-07-08 2009-06-24 Ｎｈｅ−１阻害剤として有用なピロリジニル及びピペリジニル化合物 Pending JP2011527677A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7886708P 2008-07-08 2008-07-08
US61/078,867 2008-07-08
PCT/US2009/048394 WO2010005783A1 (en) 2008-07-08 2009-06-24 Pyrrolidinyl and piperidinyl compounds useful as nhe-1 inhibitors

Publications (2)

Publication Number Publication Date
JP2011527677A JP2011527677A (ja) 2011-11-04
JP2011527677A5 true JP2011527677A5 (enExample) 2012-08-09

Family

ID=41090284

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011517461A Pending JP2011527677A (ja) 2008-07-08 2009-06-24 Ｎｈｅ−１阻害剤として有用なピロリジニル及びピペリジニル化合物

Country Status (5)

Country Link
US (1) US20110118262A1 (enExample)
EP (1) EP2321274A1 (enExample)
JP (1) JP2011527677A (enExample)
CA (1) CA2730116A1 (enExample)
WO (1) WO2010005783A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ601483A (en) 2008-08-04 2013-10-25 Chdi Foundation Inc Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
CN102811620B (zh) 2010-01-25 2015-03-25 Chdi基金会股份有限公司 一些犬尿氨酸-3-单加氧酶抑制剂、药物组合物及其使用方法
WO2011103126A1 (en) * 2010-02-17 2011-08-25 Ampla Pharmaceuticals Inc. Treatment of metabolic syndrome with piperidine amides
AU2012300246A1 (en) 2011-08-30 2014-03-06 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
BR112014004741B1 (pt) 2011-08-30 2021-10-13 Chdi Foundation, Inc Entidade química, seu uso e composição farmacêutica compreendendo a mesma
WO2013157022A1 (en) 2012-04-20 2013-10-24 Advinus Therapeutics Limited Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof
FR3000065A1 (fr) * 2012-12-21 2014-06-27 Univ Lille Ii Droit & Sante Composes bicycliques ayant une activite potentialisatrice de l'activite d'un antibiotique actif contre les mycobacteries-composition et produit pharmaceutiques comprenant de tels composes
CN104098483A (zh) * 2013-04-12 2014-10-15 江苏英力科技发展有限公司 一种4-甲氧基-n,n-二甲基-1-萘甲酰胺制备方法
KR20160100329A (ko) 2013-12-20 2016-08-23 3-브이 바이오사이언시스, 인코포레이티드 지질 합성의 헤테로사이클릭 조절물질 및 이들의 조합물
AU2015289492B2 (en) 2014-07-17 2020-02-20 Chdi Foundation, Inc. Methods and compositions for treating HIV-related disorders
WO2016028971A1 (en) 2014-08-21 2016-02-25 Bristol-Myers Squibb Company Tied-back benzamide derivatives as potent rock inhibitors
EP3456716A4 (en) * 2016-05-09 2019-11-06 Nippon Soda Co., Ltd. RINGFUL AMID CONNECTION AND PESTICIDES
CN106905191B (zh) * 2017-03-05 2019-03-29 北京化工大学 一种含有羟肟酸基团的氮芥类化合物及其制备方法和用途
WO2019170543A1 (en) 2018-03-07 2019-09-12 Bayer Aktiengesellschaft Identification and use of erk5 inhibitors
EP3941916B1 (en) 2019-03-20 2025-10-01 Emory University Prostaglandin receptor ep2 antagonists, derivatives, and uses related thereto
CN113968804B (zh) * 2020-07-22 2022-12-02 中国农业大学 莫奈太尔砜的半抗原、人工抗原及其制备方法与应用
CN119923254A (zh) 2022-08-26 2025-05-02 米托迪治愈有限责任公司 具有钠氢反向转运物1抑制活性的治疗剂用于治疗和预防与慢性疲劳、筋疲力尽和/或劳累不耐受相关的疾病的用途

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
DK0589336T3 (da) * 1992-09-22 1997-06-16 Hoechst Ag Benzylguanidiner, fremgangsmåde til deres fremstilling samt deres anvendelse som antiarytmetika
US5665739A (en) * 1992-12-15 1997-09-09 Hoechst Aktiengesellschaft Substituted benzoylguanidines, process and their preparation, their use as pharmaceutical or diagnostic, and pharmaceutical containing them
DE4430861A1 (de) * 1994-08-31 1996-03-07 Merck Patent Gmbh Heterocyclyl-benzoylguanidine
DE19601303A1 (de) * 1996-01-16 1997-07-17 Boehringer Ingelheim Kg Neuartige Benzoylguanidin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln
DE19621482A1 (de) * 1996-05-29 1997-12-04 Hoechst Ag Substituierte 1-Naphthoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US6323207B1 (en) * 1998-09-22 2001-11-27 Boehringer Ingelheim Pharma Kg Benzoylguanidine derivatives
DE19843489B4 (de) * 1998-09-22 2006-12-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Benzoylguanidin-Abkömmlinge mit vorteilhaften Eigenschaften, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln, sowie diese enthaltende pharmazeutische Zubereitung
DE60036568T2 (de) * 1999-11-10 2008-06-26 Sanofi-Aventis Deutschland Gmbh N-acylpyrrolidin-2-ylalkylbenzamidin-derivate als inhibitoren von factor xa
US20020045613A1 (en) * 2000-04-27 2002-04-18 Heinz Pauls 1-aroyl-piperidinyl benzamidines
DE10106970A1 (de) * 2001-02-15 2002-08-29 Boehringer Ingelheim Pharma Neues Benzoylguanidinsalz
US6730678B2 (en) * 2001-02-15 2004-05-04 Boehringer Ingelheim Pharma Kg Benzoylguanidine salt and hydrates thereof
US20040097583A1 (en) * 2002-02-14 2004-05-20 Hans-Jochen Lang Use of inhibitors of the sodium/hydrogen exchanger for the treatment of thrombotic and inflammatory disorders
US20030220383A1 (en) * 2002-02-14 2003-11-27 Aventis Pharma Deutschland Gmbh Use of inhibitors of the sodium-dependent chloride/bicarbonate exchanger for the treatment of thrombotic and inflammatory disorders
DE10353204A1 (de) * 2003-11-13 2005-06-16 Aventis Pharma Deutschland Gmbh Verfahren zur Herstellung von 4-Pentafluorsulfanyl-benzoylguanidinen
JP2007526324A (ja) * 2004-03-02 2007-09-13 スミスクライン・ビーチャム・コーポレイション Ａｋｔ活性のある阻害剤
DE102004054847A1 (de) * 2004-11-13 2006-05-24 Sanofi-Aventis Deutschland Gmbh Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
MX2007009946A (es) * 2005-02-16 2007-09-26 Schering Corp Piperazin-piperidinas sustituidas con piridilo y fenilo con actividad antagonista de cxcr3.
US7781437B2 (en) * 2005-10-11 2010-08-24 Schering Corporation Substituted heterocyclic compounds with CXCR3 antagonist activity

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