JP2011527677A5 - - Google Patents

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Publication number
JP2011527677A5
JP2011527677A5 JP2011517461A JP2011517461A JP2011527677A5 JP 2011527677 A5 JP2011527677 A5 JP 2011527677A5 JP 2011517461 A JP2011517461 A JP 2011517461A JP 2011517461 A JP2011517461 A JP 2011517461A JP 2011527677 A5 JP2011527677 A5 JP 2011527677A5
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JP
Japan
Prior art keywords
alkyl
hydrogen
halogen
ring
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011517461A
Other languages
English (en)
Japanese (ja)
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JP2011527677A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/048394 external-priority patent/WO2010005783A1/en
Publication of JP2011527677A publication Critical patent/JP2011527677A/ja
Publication of JP2011527677A5 publication Critical patent/JP2011527677A5/ja
Pending legal-status Critical Current

Links

JP2011517461A 2008-07-08 2009-06-24 Ｎｈｅ−１阻害剤として有用なピロリジニル及びピペリジニル化合物 Pending JP2011527677A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7886708P 2008-07-08 2008-07-08
US61/078,867 2008-07-08
PCT/US2009/048394 WO2010005783A1 (en) 2008-07-08 2009-06-24 Pyrrolidinyl and piperidinyl compounds useful as nhe-1 inhibitors

Publications (2)

Publication Number Publication Date
JP2011527677A JP2011527677A (ja) 2011-11-04
JP2011527677A5 true JP2011527677A5 (enExample) 2012-08-09

Family

ID=41090284

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011517461A Pending JP2011527677A (ja) 2008-07-08 2009-06-24 Ｎｈｅ−１阻害剤として有用なピロリジニル及びピペリジニル化合物

Country Status (5)

Country Link
US (1) US20110118262A1 (enExample)
EP (1) EP2321274A1 (enExample)
JP (1) JP2011527677A (enExample)
CA (1) CA2730116A1 (enExample)
WO (1) WO2010005783A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0916576A2 (pt) 2008-08-04 2017-06-27 Chdi Inc pelo menos uma entidade química, composição farmacêutica, e, método para tratar uma condição ou distúrbio.
NZ601547A (en) 2010-01-25 2014-04-30 Chdi Foundation Inc Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
WO2011103126A1 (en) * 2010-02-17 2011-08-25 Ampla Pharmaceuticals Inc. Treatment of metabolic syndrome with piperidine amides
WO2013033068A1 (en) 2011-08-30 2013-03-07 Stephen Martin Courtney Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
SG2014012926A (en) 2011-08-30 2014-06-27 Chdi Foundation Inc Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
CN104662018B (zh) 2012-04-20 2017-10-24 阿迪维纳斯治疗有限公司 取代的杂双环化合物、组合物及其医疗应用
FR3000065A1 (fr) 2012-12-21 2014-06-27 Univ Lille Ii Droit & Sante Composes bicycliques ayant une activite potentialisatrice de l'activite d'un antibiotique actif contre les mycobacteries-composition et produit pharmaceutiques comprenant de tels composes
CN104098483A (zh) * 2013-04-12 2014-10-15 江苏英力科技发展有限公司 一种4-甲氧基-n,n-二甲基-1-萘甲酰胺制备方法
CA2934251C (en) 2013-12-20 2024-01-02 3-V Biosciences, Inc. A combination of heterocyclic modulators of lipid synthesis and chemotherapeutic drugs in treatment of cancer
MX372995B (es) 2014-07-17 2020-04-13 Chdi Foundation Inc Metodos y composiciones para el tratamiento de trastornos relacionados con vih.
CN107108581B (zh) 2014-08-21 2020-06-23 百时美施贵宝公司 作为强效rock抑制剂的回接苯甲酰胺衍生物
JP6710273B2 (ja) * 2016-05-09 2020-06-17 日本曹達株式会社 環状アミン化合物および有害生物防除剤
CN106905191B (zh) * 2017-03-05 2019-03-29 北京化工大学 一种含有羟肟酸基团的氮芥类化合物及其制备方法和用途
EP3762379A1 (en) 2018-03-07 2021-01-13 Bayer Aktiengesellschaft Identification and use of erk5 inhibitors
WO2020191208A1 (en) 2019-03-20 2020-09-24 Emory University Prostaglandin receptor ep2 antagonists, derivatives, and uses related thereto
CN113968804B (zh) * 2020-07-22 2022-12-02 中国农业大学 莫奈太尔砜的半抗原、人工抗原及其制备方法与应用
EP4577202A1 (en) 2022-08-26 2025-07-02 Mitodicure GmbH Use of a therapeutic agent with sodium-hydrogen antiporter 1 inhibitory activity for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance
WO2026132258A1 (en) * 2024-12-20 2026-06-25 Basf Se Heterocyclic compounds for combating invertebrate pests

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0589336B1 (de) * 1992-09-22 1997-01-08 Hoechst Aktiengesellschaft Benzoylguanidine, Verfahren zu ihrer Herstellung, sowie ihre Verwendung als Antiarrhythmika
US5665739A (en) * 1992-12-15 1997-09-09 Hoechst Aktiengesellschaft Substituted benzoylguanidines, process and their preparation, their use as pharmaceutical or diagnostic, and pharmaceutical containing them
DE4430861A1 (de) * 1994-08-31 1996-03-07 Merck Patent Gmbh Heterocyclyl-benzoylguanidine
DE19601303A1 (de) * 1996-01-16 1997-07-17 Boehringer Ingelheim Kg Neuartige Benzoylguanidin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln
DE19621482A1 (de) * 1996-05-29 1997-12-04 Hoechst Ag Substituierte 1-Naphthoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19843489B4 (de) * 1998-09-22 2006-12-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Benzoylguanidin-Abkömmlinge mit vorteilhaften Eigenschaften, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln, sowie diese enthaltende pharmazeutische Zubereitung
US6323207B1 (en) * 1998-09-22 2001-11-27 Boehringer Ingelheim Pharma Kg Benzoylguanidine derivatives
IL149544A0 (en) * 1999-11-10 2002-11-10 Aventis Pharma Gmbh N-ACYLPYRROLIDIN-2-YLALKYLBENZAMIDINE DERIVATIVES AS INHIBITORS OF FACTOR Xa
US20020045613A1 (en) * 2000-04-27 2002-04-18 Heinz Pauls 1-aroyl-piperidinyl benzamidines
US6730678B2 (en) * 2001-02-15 2004-05-04 Boehringer Ingelheim Pharma Kg Benzoylguanidine salt and hydrates thereof
DE10106970A1 (de) * 2001-02-15 2002-08-29 Boehringer Ingelheim Pharma Neues Benzoylguanidinsalz
US20040097583A1 (en) * 2002-02-14 2004-05-20 Hans-Jochen Lang Use of inhibitors of the sodium/hydrogen exchanger for the treatment of thrombotic and inflammatory disorders
US20030220383A1 (en) * 2002-02-14 2003-11-27 Aventis Pharma Deutschland Gmbh Use of inhibitors of the sodium-dependent chloride/bicarbonate exchanger for the treatment of thrombotic and inflammatory disorders
DE10353204A1 (de) * 2003-11-13 2005-06-16 Aventis Pharma Deutschland Gmbh Verfahren zur Herstellung von 4-Pentafluorsulfanyl-benzoylguanidinen
JP2007526324A (ja) * 2004-03-02 2007-09-13 スミスクライン・ビーチャム・コーポレイション Ａｋｔ活性のある阻害剤
DE102004054847A1 (de) * 2004-11-13 2006-05-24 Sanofi-Aventis Deutschland Gmbh Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
AU2006214378A1 (en) * 2005-02-16 2006-08-24 Pharmacopeia, Inc. Pyridyl and phenyl substituted piperazine-piperidines with CXCR3 antagonist activity
EP1937666B1 (en) * 2005-10-11 2012-02-22 Schering Corporation Substituted heterocyclic compounds with cxcr3 antagonist activity

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