JP2011526482A5 - - Google Patents
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- Publication number
- JP2011526482A5 JP2011526482A5 JP2011515374A JP2011515374A JP2011526482A5 JP 2011526482 A5 JP2011526482 A5 JP 2011526482A5 JP 2011515374 A JP2011515374 A JP 2011515374A JP 2011515374 A JP2011515374 A JP 2011515374A JP 2011526482 A5 JP2011526482 A5 JP 2011526482A5
- Authority
- JP
- Japan
- Prior art keywords
- oligomer
- mtgpat1
- oligomer according
- nucleotide
- nucleotide sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000003729 nucleotide group Chemical group 0.000 claims 18
- 239000002773 nucleotide Substances 0.000 claims 13
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 8
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 6
- 208000004930 Fatty Liver Diseases 0.000 claims 4
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 4
- 108020004999 messenger RNA Proteins 0.000 claims 3
- 206010019708 Hepatic steatosis Diseases 0.000 claims 2
- 206010022489 Insulin Resistance Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 206010033307 Overweight Diseases 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 208000010706 fatty liver disease Diseases 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 231100000240 steatosis hepatitis Toxicity 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7794208P | 2008-07-03 | 2008-07-03 | |
| EP08104623 | 2008-07-03 | ||
| US61/077,942 | 2008-07-03 | ||
| EP08104623.7 | 2008-07-03 | ||
| PCT/EP2009/057907 WO2010000656A1 (en) | 2008-07-03 | 2009-06-24 | Rna antagonist compounds for the inhibition of expression of mitochondrial glycerol-3-phosphate acyltransferase 1 (mtgpat1) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011526482A JP2011526482A (ja) | 2011-10-13 |
| JP2011526482A5 true JP2011526482A5 (enExample) | 2012-05-24 |
Family
ID=41066150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011515374A Withdrawn JP2011526482A (ja) | 2008-07-03 | 2009-06-24 | ミトコンドリアグリセロール−３−リン酸アシルトランスフェラーゼ１（ｍｔｇｐａｔ１）の発現を阻害するためのｒｎａアンタゴニスト化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20120004276A1 (enExample) |
| EP (1) | EP2310504A1 (enExample) |
| JP (1) | JP2011526482A (enExample) |
| KR (1) | KR20110031368A (enExample) |
| CN (1) | CN102076854A (enExample) |
| AU (1) | AU2009265836A1 (enExample) |
| BR (1) | BRPI0915837A2 (enExample) |
| CA (1) | CA2729897A1 (enExample) |
| EA (1) | EA201170131A1 (enExample) |
| MX (1) | MX2010013552A (enExample) |
| WO (1) | WO2010000656A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6023705B2 (ja) * | 2010-06-23 | 2016-11-09 | カッパーアールエヌエー，インコーポレイテッド | ナトリウムチャネル、電位依存性、αサブユニット（ＳＣＮＡ）に対する天然アンチセンス転写物の阻害によるＳＣＮＡ関連疾患の治療 |
| DK2638163T3 (en) | 2010-11-12 | 2017-07-24 | Massachusetts Gen Hospital | POLYCOMB-ASSOCIATED NON-CODING RNAs |
| WO2012103520A1 (en) * | 2011-01-28 | 2012-08-02 | Board Of Regents Of The University Of Nebraska | Methods and compositions for modulating cyclophilin d |
| EA201492114A1 (ru) | 2012-05-16 | 2015-04-30 | Рана Терапьютикс, Инк. | Композиции и способы для модулирования экспрессии генов |
| SG11201503821YA (en) | 2012-11-15 | 2015-06-29 | Roche Innovation Ct Copenhagen As | Oligonucleotide conjugates |
| RU2649367C2 (ru) * | 2013-01-30 | 2018-04-02 | Ф. Хоффманн-Ля Рош Аг | Конъюгаты углевода и lna-олигонуклеотида |
| CN105039513B (zh) * | 2015-05-29 | 2018-12-28 | 广州市第一人民医院 | 用于非酒精性脂肪肝相关目的基因多态性检测方法及其引物，以及试剂盒 |
| CN104997768B (zh) * | 2015-07-23 | 2017-11-17 | 上海市第六人民医院 | 鱼藤酮在制备降血糖药物中的应用 |
| EP4649951A2 (en) | 2020-06-09 | 2025-11-19 | Alnylam Pharmaceuticals, Inc. | Sirna compositions and methods for silencing gpam (glycerol-3-phosphate acyltransferase 1, mitochondrial) expression |
| GB202015056D0 (en) * | 2020-09-23 | 2020-11-04 | Cambridge Entpr Ltd | Biomarkers |
| KR20230151996A (ko) | 2021-02-27 | 2023-11-02 | 리제너론 파마슈티칼스 인코포레이티드 | 미토콘드리아 글리세롤-3-인산염 아실전이효소 (gpam)억제제를 이용한 간 질환의 치료 |
| MX2024004913A (es) * | 2021-10-22 | 2024-05-06 | Amgen Inc | Constructos de arni para inhibir la expresion de gpam y metodos de uso de los mismos. |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003048316A2 (en) * | 2001-11-30 | 2003-06-12 | Bristol-Myers Squibb Company | Polynucleotides encoding novel human mitochondrial and microsomal glycerol-3-phosphate acyl-transferases and variants thereof |
| US20050053981A1 (en) * | 2003-09-09 | 2005-03-10 | Swayze Eric E. | Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini |
| US8178503B2 (en) * | 2006-03-03 | 2012-05-15 | International Business Machines Corporation | Ribonucleic acid interference molecules and binding sites derived by analyzing intergenic and intronic regions of genomes |
-
2009
- 2009-06-24 KR KR1020117002768A patent/KR20110031368A/ko not_active Withdrawn
- 2009-06-24 AU AU2009265836A patent/AU2009265836A1/en not_active Abandoned
- 2009-06-24 EA EA201170131A patent/EA201170131A1/ru unknown
- 2009-06-24 US US13/000,974 patent/US20120004276A1/en not_active Abandoned
- 2009-06-24 MX MX2010013552A patent/MX2010013552A/es not_active Application Discontinuation
- 2009-06-24 JP JP2011515374A patent/JP2011526482A/ja not_active Withdrawn
- 2009-06-24 BR BRPI0915837A patent/BRPI0915837A2/pt not_active Application Discontinuation
- 2009-06-24 CN CN200980124993.0A patent/CN102076854A/zh active Pending
- 2009-06-24 CA CA2729897A patent/CA2729897A1/en not_active Abandoned
- 2009-06-24 EP EP20090772356 patent/EP2310504A1/en not_active Withdrawn
- 2009-06-24 WO PCT/EP2009/057907 patent/WO2010000656A1/en not_active Ceased
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