CA2729897A1 - Rna antagonist compounds for the inhibition of expression of mitochondrial glycerol-3-phosphate acyltransferase 1 (mtgpat1) - Google Patents
Rna antagonist compounds for the inhibition of expression of mitochondrial glycerol-3-phosphate acyltransferase 1 (mtgpat1) Download PDFInfo
- Publication number
- CA2729897A1 CA2729897A1 CA2729897A CA2729897A CA2729897A1 CA 2729897 A1 CA2729897 A1 CA 2729897A1 CA 2729897 A CA2729897 A CA 2729897A CA 2729897 A CA2729897 A CA 2729897A CA 2729897 A1 CA2729897 A1 CA 2729897A1
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- Canada
- Prior art keywords
- sequence
- antisense sequence
- oligomer
- mtgpat1
- nucleotide
- Prior art date
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- Abandoned
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01015—Glycerol-3-phosphate O-acyltransferase (2.3.1.15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Diabetes (AREA)
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- Obesity (AREA)
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- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7794208P | 2008-07-03 | 2008-07-03 | |
| US61/077,942 | 2008-07-03 | ||
| EP08104623.7 | 2008-07-03 | ||
| EP08104623 | 2008-07-03 | ||
| PCT/EP2009/057907 WO2010000656A1 (en) | 2008-07-03 | 2009-06-24 | Rna antagonist compounds for the inhibition of expression of mitochondrial glycerol-3-phosphate acyltransferase 1 (mtgpat1) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2729897A1 true CA2729897A1 (en) | 2010-01-07 |
Family
ID=41066150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2729897A Abandoned CA2729897A1 (en) | 2008-07-03 | 2009-06-24 | Rna antagonist compounds for the inhibition of expression of mitochondrial glycerol-3-phosphate acyltransferase 1 (mtgpat1) |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20120004276A1 (enExample) |
| EP (1) | EP2310504A1 (enExample) |
| JP (1) | JP2011526482A (enExample) |
| KR (1) | KR20110031368A (enExample) |
| CN (1) | CN102076854A (enExample) |
| AU (1) | AU2009265836A1 (enExample) |
| BR (1) | BRPI0915837A2 (enExample) |
| CA (1) | CA2729897A1 (enExample) |
| EA (1) | EA201170131A1 (enExample) |
| MX (1) | MX2010013552A (enExample) |
| WO (1) | WO2010000656A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101914309B1 (ko) * | 2010-06-23 | 2018-11-02 | 큐알엔에이, 인크. | 전압 작동 나트륨 통로, 알파 소단위(scna)에 대한 자연 안티센스 전사체의 저해에 의한 전압 작동 나트륨 통로, 알파 소단위(scna) 관련된 질환의 치료 |
| EP2638163B1 (en) | 2010-11-12 | 2017-05-17 | The General Hospital Corporation | Polycomb-associated non-coding rnas |
| US20140050728A1 (en) * | 2011-01-28 | 2014-02-20 | Board Of Regents Of The University Of Nebraska | Methods and compositions for inhibiting cyclophilin d for the treatment and prevention of obesity and kidney indications |
| CN104583398A (zh) | 2012-05-16 | 2015-04-29 | Rana医疗有限公司 | 用于调节基因表达的组合物和方法 |
| CA2889044A1 (en) | 2012-11-15 | 2014-05-22 | Roche Innovation Center Copenhagen A/S | Anti apob antisense conjugate compounds |
| MX2015009056A (es) | 2013-01-30 | 2015-10-05 | Hoffmann La Roche | Conjugados de oligonucleotidos de acido nucleico bloqueado y carbohidratos. |
| CN105039513B (zh) * | 2015-05-29 | 2018-12-28 | 广州市第一人民医院 | 用于非酒精性脂肪肝相关目的基因多态性检测方法及其引物，以及试剂盒 |
| CN104997768B (zh) * | 2015-07-23 | 2017-11-17 | 上海市第六人民医院 | 鱼藤酮在制备降血糖药物中的应用 |
| CN116075592A (zh) * | 2020-06-09 | 2023-05-05 | 阿尔尼拉姆医药品有限公司 | 用于沉默gpam(线粒体甘油-3-磷酸酰基转移酶1)表达的sirna组合物和方法 |
| GB202015056D0 (en) * | 2020-09-23 | 2020-11-04 | Cambridge Entpr Ltd | Biomarkers |
| US12215322B2 (en) | 2021-02-27 | 2025-02-04 | Regeneron Pharmaceuticals, Inc. | Treatment of liver disease with mitochondrial glycerol-3-phosphate acyltransferase (GPAM) inhibitors |
| EP4419682A2 (en) * | 2021-10-22 | 2024-08-28 | Amgen Inc. | Rnai constructs for inhibiting gpam expression and methods of use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002364900A1 (en) * | 2001-11-30 | 2003-06-17 | Bristol-Myers Squibb Company | Polynucleotides encoding novel human mitochondrial and microsomal glycerol-3-phosphate acyl-transferases and variants thereof |
| US20050053981A1 (en) * | 2003-09-09 | 2005-03-10 | Swayze Eric E. | Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini |
| US8178503B2 (en) * | 2006-03-03 | 2012-05-15 | International Business Machines Corporation | Ribonucleic acid interference molecules and binding sites derived by analyzing intergenic and intronic regions of genomes |
-
2009
- 2009-06-24 US US13/000,974 patent/US20120004276A1/en not_active Abandoned
- 2009-06-24 KR KR1020117002768A patent/KR20110031368A/ko not_active Withdrawn
- 2009-06-24 CA CA2729897A patent/CA2729897A1/en not_active Abandoned
- 2009-06-24 EA EA201170131A patent/EA201170131A1/ru unknown
- 2009-06-24 EP EP20090772356 patent/EP2310504A1/en not_active Withdrawn
- 2009-06-24 WO PCT/EP2009/057907 patent/WO2010000656A1/en not_active Ceased
- 2009-06-24 AU AU2009265836A patent/AU2009265836A1/en not_active Abandoned
- 2009-06-24 JP JP2011515374A patent/JP2011526482A/ja not_active Withdrawn
- 2009-06-24 BR BRPI0915837A patent/BRPI0915837A2/pt not_active Application Discontinuation
- 2009-06-24 MX MX2010013552A patent/MX2010013552A/es not_active Application Discontinuation
- 2009-06-24 CN CN200980124993.0A patent/CN102076854A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2310504A1 (en) | 2011-04-20 |
| US20120004276A1 (en) | 2012-01-05 |
| JP2011526482A (ja) | 2011-10-13 |
| WO2010000656A1 (en) | 2010-01-07 |
| CN102076854A (zh) | 2011-05-25 |
| BRPI0915837A2 (pt) | 2015-11-03 |
| MX2010013552A (es) | 2011-03-24 |
| KR20110031368A (ko) | 2011-03-25 |
| EA201170131A1 (ru) | 2011-08-30 |
| AU2009265836A1 (en) | 2010-01-07 |
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| Date | Code | Title | Description |
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Effective date: 20130626 |