JP2011524741A5 - - Google Patents
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- JP2011524741A5 JP2011524741A5 JP2011511785A JP2011511785A JP2011524741A5 JP 2011524741 A5 JP2011524741 A5 JP 2011524741A5 JP 2011511785 A JP2011511785 A JP 2011511785A JP 2011511785 A JP2011511785 A JP 2011511785A JP 2011524741 A5 JP2011524741 A5 JP 2011524741A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- partial sequence
- subsequence
- seq
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000004551 Interleukin-10 Receptors Human genes 0.000 claims 9
- 108010017550 Interleukin-10 Receptors Proteins 0.000 claims 9
- 230000006303 immediate early viral mRNA transcription Effects 0.000 claims 9
- 241000282414 Homo sapiens Species 0.000 claims 4
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 3
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 3
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 3
- 241000282553 Macaca Species 0.000 claims 2
- 241000282577 Pan troglodytes Species 0.000 claims 2
- 239000002158 endotoxin Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 229920006008 lipopolysaccharide Polymers 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 102000004495 STAT3 Transcription Factor Human genes 0.000 claims 1
- 108010017324 STAT3 Transcription Factor Proteins 0.000 claims 1
- 230000006229 amino acid addition Effects 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 210000000581 natural killer T-cell Anatomy 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 230000007781 signaling event Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5629908P | 2008-05-27 | 2008-05-27 | |
| US61/056,299 | 2008-05-27 | ||
| PCT/US2009/045322 WO2009154995A2 (en) | 2008-05-27 | 2009-05-27 | Interleukin 10 receptor (il-10r) antibodies and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011524741A JP2011524741A (ja) | 2011-09-08 |
| JP2011524741A5 true JP2011524741A5 (cg-RX-API-DMAC7.html) | 2012-06-28 |
Family
ID=41434638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011511785A Withdrawn JP2011524741A (ja) | 2008-05-27 | 2009-05-27 | インターロイキン１０受容体（ｉｌ−１０ｒ）抗体及び使用方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8420784B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2293667A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2011524741A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009154995A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2602971T3 (es) | 2010-03-02 | 2017-02-23 | Kyowa Hakko Kirin Co., Ltd. | Composición de anticuerpo modificado |
| WO2013086019A1 (en) * | 2011-12-06 | 2013-06-13 | Massachusetts Institute Of Technology | Use of humanized mice to determine toxicity |
| KR102276974B1 (ko) * | 2013-02-06 | 2021-07-13 | 인히브릭스, 인크. | 비-혈소판 및 비-적혈구 세포 격감성 cd47 항체 및 이를 이용하는 방법 |
| WO2016027697A1 (ja) * | 2014-08-22 | 2016-02-25 | 日東紡績株式会社 | ＴＲＡＣＰ－５ｂ（酒石酸抵抗性酸性フォスファターゼ５ｂ）に特異的なタンパク定量法 |
| GB201512215D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
| WO2018045273A2 (en) * | 2016-09-02 | 2018-03-08 | The Brigham And Women's Hospital, Inc. | Compositions and methods for treating neoplasias |
| CN110546168B (zh) | 2016-09-27 | 2024-03-15 | 埃皮辛特瑞柯斯公司 | 免疫调节性融合蛋白 |
| WO2018109667A1 (en) | 2016-12-15 | 2018-06-21 | Nestec Sa | Compositions and methods that modulate white blood cells or neutrophils in a companion animal |
| US10894833B2 (en) * | 2017-07-20 | 2021-01-19 | H. Lundbeck A/S | Agents, uses and methods for treatment |
| JP2020536518A (ja) * | 2017-09-27 | 2020-12-17 | エピセントアールエックス，インコーポレイテッド | 免疫調節融合タンパク質 |
| BR112021005464A2 (pt) * | 2018-08-15 | 2021-06-29 | The Regents Of The University Of California | inibição de il-10 para vacinas e imunoterapia |
| US20220144911A1 (en) * | 2019-02-01 | 2022-05-12 | Uab Research Foundation | Methods and compositions for il10 signaling antagonism |
| US20220307035A1 (en) * | 2019-06-12 | 2022-09-29 | Acurasysbio Co., Ltd. | Composition for preventing or treating cancer |
| WO2022032005A2 (en) | 2020-08-05 | 2022-02-10 | Synthekine, Inc. | Il10rb binding molecules and methods of use |
| JP7767391B2 (ja) * | 2020-08-05 | 2025-11-11 | シンセカイン インコーポレイテッド | ＩＬ１０Ｒａ結合分子および使用方法 |
| KR20240114801A (ko) * | 2023-01-17 | 2024-07-25 | 한양대학교 산학협력단 | Il-10 수용체에 특이적으로 결합하는 항체 및 이의 용도 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU772142B2 (en) | 1999-03-24 | 2004-04-08 | Government of The United States of America, as represented by The Secretary Department of Health & Human Services, The National Institutes of Health, The | Induction of antigen-specific unresponsiveness by glioblastoma culture supernatants (GCS) |
| US7288390B2 (en) * | 2000-08-07 | 2007-10-30 | Centocor, Inc. | Anti-dual integrin antibodies, compositions, methods and uses |
| UA81743C2 (uk) * | 2000-08-07 | 2008-02-11 | Центокор, Инк. | МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ |
| EP1439223A1 (en) | 2001-10-02 | 2004-07-21 | Mochida Pharmaceutical Co., Ltd. | Novel class ii cytokine receptor |
| GB0302167D0 (en) | 2003-01-30 | 2003-03-05 | Leuven K U Res & Dev | T cell phenotype |
| US7651855B2 (en) * | 2003-04-17 | 2010-01-26 | The Trustees Of The University Of Pennsylvania | Regulatory T cells and their use in immunotherapy and suppression of autoimmune responses |
| HN2004000285A (es) * | 2003-08-04 | 2006-04-27 | Pfizer Prod Inc | ANTICUERPOS DIRIGIDOS A c-MET |
| ES2533492T3 (es) * | 2004-02-06 | 2015-04-10 | University Of Massachusetts | Anticuerpos contra toxinas de Clostridium difficile y usos de los mismos |
-
2009
- 2009-05-27 US US12/994,789 patent/US8420784B2/en not_active Expired - Fee Related
- 2009-05-27 WO PCT/US2009/045322 patent/WO2009154995A2/en not_active Ceased
- 2009-05-27 JP JP2011511785A patent/JP2011524741A/ja not_active Withdrawn
- 2009-05-27 EP EP09767307A patent/EP2293667A4/en not_active Withdrawn
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