JP2011523638A5 - - Google Patents
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- Publication number
- JP2011523638A5 JP2011523638A5 JP2011508939A JP2011508939A JP2011523638A5 JP 2011523638 A5 JP2011523638 A5 JP 2011523638A5 JP 2011508939 A JP2011508939 A JP 2011508939A JP 2011508939 A JP2011508939 A JP 2011508939A JP 2011523638 A5 JP2011523638 A5 JP 2011523638A5
- Authority
- JP
- Japan
- Prior art keywords
- vivo imaging
- glutamate receptor
- receptor
- imaging method
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000011503 in vivo imaging Methods 0.000 claims 16
- 238000000034 method Methods 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 108020003175 receptors Proteins 0.000 claims 5
- 102100030652 Glutamate receptor 1 Human genes 0.000 claims 4
- 101001010445 Homo sapiens Glutamate receptor 1 Proteins 0.000 claims 4
- 239000012216 imaging agent Substances 0.000 claims 4
- 102100035857 Glutamate decarboxylase 2 Human genes 0.000 claims 3
- 101001071437 Homo sapiens Metabotropic glutamate receptor 1 Proteins 0.000 claims 3
- 101001032848 Homo sapiens Metabotropic glutamate receptor 3 Proteins 0.000 claims 3
- 101001032837 Homo sapiens Metabotropic glutamate receptor 6 Proteins 0.000 claims 3
- 101001032841 Homo sapiens Metabotropic glutamate receptor 7 Proteins 0.000 claims 3
- 102000006541 Ionotropic Glutamate Receptors Human genes 0.000 claims 3
- 108010008812 Ionotropic Glutamate Receptors Proteins 0.000 claims 3
- 102100036834 Metabotropic glutamate receptor 1 Human genes 0.000 claims 3
- 102100038352 Metabotropic glutamate receptor 3 Human genes 0.000 claims 3
- 102100038300 Metabotropic glutamate receptor 6 Human genes 0.000 claims 3
- 102100038294 Metabotropic glutamate receptor 7 Human genes 0.000 claims 3
- 108010024780 glutamate decarboxylase 2 Proteins 0.000 claims 3
- 230000000848 glutamatergic effect Effects 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 230000002285 radioactive effect Effects 0.000 claims 3
- MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 claims 2
- 102100022758 Glutamate receptor ionotropic, kainate 2 Human genes 0.000 claims 2
- 101000903346 Homo sapiens Glutamate receptor ionotropic, kainate 2 Proteins 0.000 claims 2
- 101001032845 Homo sapiens Metabotropic glutamate receptor 5 Proteins 0.000 claims 2
- 102100038357 Metabotropic glutamate receptor 5 Human genes 0.000 claims 2
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 claims 2
- 210000005013 brain tissue Anatomy 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 230000000285 glutaminergic effect Effects 0.000 claims 2
- -1 GRIA4 Proteins 0.000 claims 1
- 102000018899 Glutamate Receptors Human genes 0.000 claims 1
- 108010027915 Glutamate Receptors Proteins 0.000 claims 1
- 230000000994 depressogenic effect Effects 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 239000002555 ionophore Substances 0.000 claims 1
- 230000000236 ionophoric effect Effects 0.000 claims 1
- 229910021645 metal ion Inorganic materials 0.000 claims 1
- 229910052755 nonmetal Inorganic materials 0.000 claims 1
- 210000001009 nucleus accumben Anatomy 0.000 claims 1
- 210000004129 prosencephalon Anatomy 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0808833.8 | 2008-05-15 | ||
| GBGB0808833.8A GB0808833D0 (en) | 2008-05-15 | 2008-05-15 | Biomarkers for depression |
| PCT/EP2009/055945 WO2009138501A1 (en) | 2008-05-15 | 2009-05-15 | Glutamine biomarkers for depression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011523638A JP2011523638A (ja) | 2011-08-18 |
| JP2011523638A5 true JP2011523638A5 (https=) | 2012-06-28 |
Family
ID=39571407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011508939A Pending JP2011523638A (ja) | 2008-05-15 | 2009-05-15 | うつ病に関するグルタミンバイオマーカー |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110064659A1 (https=) |
| EP (1) | EP2281068A1 (https=) |
| JP (1) | JP2011523638A (https=) |
| CN (1) | CN102099490A (https=) |
| GB (1) | GB0808833D0 (https=) |
| WO (1) | WO2009138501A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0808834D0 (en) * | 2008-05-15 | 2008-06-18 | Ge Healthcare Ltd | Biomarkers for depression |
| GB0808832D0 (en) * | 2008-05-15 | 2008-06-18 | Ge Healthcare Ltd | Biomarkers for depression |
| AU2012223364A1 (en) * | 2011-03-01 | 2013-09-19 | Ge Healthcare Limited | Radiolabelled Octreotate analogues as PET tracers |
| CN105759065B (zh) * | 2016-02-26 | 2017-10-13 | 天津桑尼匹克生物科技有限公司 | 血液代谢标记物的用途及抑郁症检测试剂盒 |
| JP7264384B2 (ja) | 2019-03-29 | 2023-04-25 | 日本たばこ産業株式会社 | うつ病の評価を補助するための方法及びうつ病の治療法の効果の評価を補助するための方法、並びにうつ病若しくはうつ病の治療法の効果を評価するためのデータを取得する方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7247442B1 (en) * | 1998-05-12 | 2007-07-24 | Human Genome Sciences, Inc. | Antibodies to HHPEN62 polypeptide |
| JP2006513996A (ja) * | 2002-10-24 | 2006-04-27 | メルク エンド カムパニー インコーポレーテッド | 代謝調節型グルタミン酸受容体結合用トレーサーとしてのアルキン誘導体 |
| WO2004047727A2 (en) * | 2002-11-01 | 2004-06-10 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for diagnosing and treating mood disorders |
| US20050209181A1 (en) * | 2003-11-05 | 2005-09-22 | Huda Akil | Compositions and methods for diagnosing and treating mental disorders |
| WO2008020435A2 (en) * | 2006-08-15 | 2008-02-21 | Quark Pharmaceuticals, Inc | Compositions and methods for treatment of mood disorders |
| GB0808834D0 (en) * | 2008-05-15 | 2008-06-18 | Ge Healthcare Ltd | Biomarkers for depression |
| GB0808832D0 (en) * | 2008-05-15 | 2008-06-18 | Ge Healthcare Ltd | Biomarkers for depression |
-
2008
- 2008-05-15 GB GBGB0808833.8A patent/GB0808833D0/en not_active Ceased
-
2009
- 2009-05-15 EP EP09745833A patent/EP2281068A1/en not_active Withdrawn
- 2009-05-15 WO PCT/EP2009/055945 patent/WO2009138501A1/en not_active Ceased
- 2009-05-15 US US12/991,943 patent/US20110064659A1/en not_active Abandoned
- 2009-05-15 CN CN2009801281847A patent/CN102099490A/zh active Pending
- 2009-05-15 JP JP2011508939A patent/JP2011523638A/ja active Pending
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