JP2011523637A5 - - Google Patents
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- Publication number
- JP2011523637A5 JP2011523637A5 JP2011508938A JP2011508938A JP2011523637A5 JP 2011523637 A5 JP2011523637 A5 JP 2011523637A5 JP 2011508938 A JP2011508938 A JP 2011508938A JP 2011508938 A JP2011508938 A JP 2011508938A JP 2011523637 A5 JP2011523637 A5 JP 2011523637A5
- Authority
- JP
- Japan
- Prior art keywords
- vivo imaging
- receptor
- gaba
- imaging method
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000011503 in vivo imaging Methods 0.000 claims 16
- 108020003175 receptors Proteins 0.000 claims 11
- 238000000034 method Methods 0.000 claims 10
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 8
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 8
- 102000005962 receptors Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 239000012216 imaging agent Substances 0.000 claims 4
- 210000005013 brain tissue Anatomy 0.000 claims 3
- 230000003371 gabaergic effect Effects 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 230000002285 radioactive effect Effects 0.000 claims 3
- 102000017707 GABRB3 Human genes 0.000 claims 2
- 102000016406 GABRR1 Human genes 0.000 claims 2
- 102100035924 Gamma-aminobutyric acid type B receptor subunit 2 Human genes 0.000 claims 2
- 101001073597 Homo sapiens Gamma-aminobutyric acid receptor subunit beta-3 Proteins 0.000 claims 2
- 101000822386 Homo sapiens Gamma-aminobutyric acid receptor subunit rho-1 Proteins 0.000 claims 2
- 101001000703 Homo sapiens Gamma-aminobutyric acid type B receptor subunit 2 Proteins 0.000 claims 2
- 230000001270 agonistic effect Effects 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 102000017693 GABRA4 Human genes 0.000 claims 1
- 102000017704 GABRG1 Human genes 0.000 claims 1
- 102000017703 GABRG2 Human genes 0.000 claims 1
- 101000893324 Homo sapiens Gamma-aminobutyric acid receptor subunit alpha-4 Proteins 0.000 claims 1
- 101001073577 Homo sapiens Gamma-aminobutyric acid receptor subunit gamma-1 Proteins 0.000 claims 1
- 101000926813 Homo sapiens Gamma-aminobutyric acid receptor subunit gamma-2 Proteins 0.000 claims 1
- 230000000994 depressogenic effect Effects 0.000 claims 1
- 210000004326 gyrus cinguli Anatomy 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 229910021645 metal ion Inorganic materials 0.000 claims 1
- 229910052755 nonmetal Inorganic materials 0.000 claims 1
- 210000001009 nucleus accumben Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0808832.0A GB0808832D0 (en) | 2008-05-15 | 2008-05-15 | Biomarkers for depression |
| GB0808832.0 | 2008-05-15 | ||
| PCT/EP2009/055944 WO2009138500A1 (en) | 2008-05-15 | 2009-05-15 | Gaba biomarkers for depression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011523637A JP2011523637A (ja) | 2011-08-18 |
| JP2011523637A5 true JP2011523637A5 (https=) | 2012-06-28 |
Family
ID=39571406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011508938A Pending JP2011523637A (ja) | 2008-05-15 | 2009-05-15 | うつ病に関するｇａｂａバイオマーカー |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8562950B2 (https=) |
| EP (1) | EP2281067A1 (https=) |
| JP (1) | JP2011523637A (https=) |
| CN (1) | CN102099489A (https=) |
| GB (1) | GB0808832D0 (https=) |
| WO (1) | WO2009138500A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0808834D0 (en) * | 2008-05-15 | 2008-06-18 | Ge Healthcare Ltd | Biomarkers for depression |
| GB0808833D0 (en) * | 2008-05-15 | 2008-06-18 | Ge Healthcare Ltd | Biomarkers for depression |
| US20130046093A1 (en) * | 2011-08-18 | 2013-02-21 | Korea Institute Of Science And Technology | Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same |
| AU2013329000A1 (en) * | 2012-10-12 | 2015-04-30 | Northwestern University | Methods of identifying compounds for treating depression and other related diseases |
| US20180348195A1 (en) * | 2015-11-12 | 2018-12-06 | Kyushu University, National University Corporation | Biomarker for diagnosing depression and use of said biomarker |
| JP7264384B2 (ja) | 2019-03-29 | 2023-04-25 | 日本たばこ産業株式会社 | うつ病の評価を補助するための方法及びうつ病の治療法の効果の評価を補助するための方法、並びにうつ病若しくはうつ病の治療法の効果を評価するためのデータを取得する方法 |
| CN111944835B (zh) * | 2019-05-14 | 2022-03-29 | 南通大学 | 一种突变型gabrg2转基因斑马鱼癫痫模型的构建方法及应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999040114A1 (en) | 1998-02-05 | 1999-08-12 | Merck & Co., Inc. | Novel gabab receptor dna sequences |
| US7247442B1 (en) * | 1998-05-12 | 2007-07-24 | Human Genome Sciences, Inc. | Antibodies to HHPEN62 polypeptide |
| JP2004508359A (ja) | 2000-09-06 | 2004-03-18 | ニューロゲン コーポレイション | アリール置換テトラヒドロインダゾール、及び、ｇａｂａ−ａ受容体に対するリガンドとしてのそれらの使用 |
| WO2004047727A2 (en) * | 2002-11-01 | 2004-06-10 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for diagnosing and treating mood disorders |
| US20050209181A1 (en) * | 2003-11-05 | 2005-09-22 | Huda Akil | Compositions and methods for diagnosing and treating mental disorders |
| DK1766077T3 (da) | 2004-06-21 | 2012-07-16 | Univ Leland Stanford Junior | Differentielt udtrykte gener og veje i bipolar forstyrrelse og/eller alvorlig depressiv forstyrrelse |
| WO2008020435A2 (en) | 2006-08-15 | 2008-02-21 | Quark Pharmaceuticals, Inc | Compositions and methods for treatment of mood disorders |
| GB0808834D0 (en) * | 2008-05-15 | 2008-06-18 | Ge Healthcare Ltd | Biomarkers for depression |
| GB0808833D0 (en) * | 2008-05-15 | 2008-06-18 | Ge Healthcare Ltd | Biomarkers for depression |
-
2008
- 2008-05-15 GB GBGB0808832.0A patent/GB0808832D0/en not_active Ceased
-
2009
- 2009-05-15 EP EP09745832A patent/EP2281067A1/en not_active Ceased
- 2009-05-15 JP JP2011508938A patent/JP2011523637A/ja active Pending
- 2009-05-15 CN CN200980128132XA patent/CN102099489A/zh active Pending
- 2009-05-15 WO PCT/EP2009/055944 patent/WO2009138500A1/en not_active Ceased
- 2009-05-15 US US12/991,925 patent/US8562950B2/en not_active Expired - Fee Related
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