CN102099489A - 抑郁症的gaba生物标记 - Google Patents

抑郁症的gaba生物标记 Download PDF

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Publication number
CN102099489A
CN102099489A CN200980128132XA CN200980128132A CN102099489A CN 102099489 A CN102099489 A CN 102099489A CN 200980128132X A CN200980128132X A CN 200980128132XA CN 200980128132 A CN200980128132 A CN 200980128132A CN 102099489 A CN102099489 A CN 102099489A
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CN
China
Prior art keywords
vivo imaging
polypeptide
receptor
polynucleotide
compound
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Pending
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CN200980128132XA
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English (en)
Chinese (zh)
Inventor
P·汉森
D·希斯科克
C·莫里斯
A·托马斯
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GE Healthcare Ltd
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GE Healthcare Ltd
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Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of CN102099489A publication Critical patent/CN102099489A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN200980128132XA 2008-05-15 2009-05-15 抑郁症的gaba生物标记 Pending CN102099489A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0808832.0A GB0808832D0 (en) 2008-05-15 2008-05-15 Biomarkers for depression
GB0808832.0 2008-05-15
PCT/EP2009/055944 WO2009138500A1 (en) 2008-05-15 2009-05-15 Gaba biomarkers for depression

Publications (1)

Publication Number Publication Date
CN102099489A true CN102099489A (zh) 2011-06-15

Family

ID=39571406

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980128132XA Pending CN102099489A (zh) 2008-05-15 2009-05-15 抑郁症的gaba生物标记

Country Status (6)

Country Link
US (1) US8562950B2 (https=)
EP (1) EP2281067A1 (https=)
JP (1) JP2011523637A (https=)
CN (1) CN102099489A (https=)
GB (1) GB0808832D0 (https=)
WO (1) WO2009138500A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020228305A1 (zh) * 2019-05-14 2020-11-19 南通大学 一种突变型gabrg2转基因斑马鱼癫痫模型的构建方法及应用

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0808834D0 (en) * 2008-05-15 2008-06-18 Ge Healthcare Ltd Biomarkers for depression
GB0808833D0 (en) * 2008-05-15 2008-06-18 Ge Healthcare Ltd Biomarkers for depression
US20130046093A1 (en) * 2011-08-18 2013-02-21 Korea Institute Of Science And Technology Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same
AU2013329000A1 (en) * 2012-10-12 2015-04-30 Northwestern University Methods of identifying compounds for treating depression and other related diseases
US20180348195A1 (en) * 2015-11-12 2018-12-06 Kyushu University, National University Corporation Biomarker for diagnosing depression and use of said biomarker
JP7264384B2 (ja) 2019-03-29 2023-04-25 日本たばこ産業株式会社 うつ病の評価を補助するための方法及びうつ病の治療法の効果の評価を補助するための方法、並びにうつ病若しくはうつ病の治療法の効果を評価するためのデータを取得する方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999040114A1 (en) 1998-02-05 1999-08-12 Merck & Co., Inc. Novel gabab receptor dna sequences
US7247442B1 (en) * 1998-05-12 2007-07-24 Human Genome Sciences, Inc. Antibodies to HHPEN62 polypeptide
JP2004508359A (ja) 2000-09-06 2004-03-18 ニューロゲン　コーポレイション アリール置換テトラヒドロインダゾール、及び、ｇａｂａ−ａ受容体に対するリガンドとしてのそれらの使用
WO2004047727A2 (en) * 2002-11-01 2004-06-10 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for diagnosing and treating mood disorders
US20050209181A1 (en) * 2003-11-05 2005-09-22 Huda Akil Compositions and methods for diagnosing and treating mental disorders
DK1766077T3 (da) 2004-06-21 2012-07-16 Univ Leland Stanford Junior Differentielt udtrykte gener og veje i bipolar forstyrrelse og/eller alvorlig depressiv forstyrrelse
WO2008020435A2 (en) 2006-08-15 2008-02-21 Quark Pharmaceuticals, Inc Compositions and methods for treatment of mood disorders
GB0808834D0 (en) * 2008-05-15 2008-06-18 Ge Healthcare Ltd Biomarkers for depression
GB0808833D0 (en) * 2008-05-15 2008-06-18 Ge Healthcare Ltd Biomarkers for depression

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020228305A1 (zh) * 2019-05-14 2020-11-19 南通大学 一种突变型gabrg2转基因斑马鱼癫痫模型的构建方法及应用

Also Published As

Publication number Publication date
GB0808832D0 (en) 2008-06-18
JP2011523637A (ja) 2011-08-18
EP2281067A1 (en) 2011-02-09
WO2009138500A1 (en) 2009-11-19
US8562950B2 (en) 2013-10-22
US20110091381A1 (en) 2011-04-21

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Application publication date: 20110615