JP2011523637A - うつ病に関するｇａｂａバイオマーカー - Google Patents

うつ病に関するｇａｂａバイオマーカー Download PDF

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Publication number
JP2011523637A
JP2011523637A JP2011508938A JP2011508938A JP2011523637A JP 2011523637 A JP2011523637 A JP 2011523637A JP 2011508938 A JP2011508938 A JP 2011508938A JP 2011508938 A JP2011508938 A JP 2011508938A JP 2011523637 A JP2011523637 A JP 2011523637A
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JP
Japan
Prior art keywords
vivo imaging
polypeptide
polynucleotide
gaba
receptor
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JP2011508938A
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English (en)
Japanese (ja)
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JP2011523637A5 (https=
Inventor
ハンソン，ピーター
ヒスコック，ダンカン
モリス，クリス
トーマス，アラン
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GE Healthcare Ltd
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GE Healthcare Ltd
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Publication of JP2011523637A publication Critical patent/JP2011523637A/ja
Publication of JP2011523637A5 publication Critical patent/JP2011523637A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2011508938A 2008-05-15 2009-05-15 うつ病に関するｇａｂａバイオマーカー Pending JP2011523637A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0808832.0A GB0808832D0 (en) 2008-05-15 2008-05-15 Biomarkers for depression
GB0808832.0 2008-05-15
PCT/EP2009/055944 WO2009138500A1 (en) 2008-05-15 2009-05-15 Gaba biomarkers for depression

Publications (2)

Publication Number Publication Date
JP2011523637A true JP2011523637A (ja) 2011-08-18
JP2011523637A5 JP2011523637A5 (https=) 2012-06-28

Family

ID=39571406

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011508938A Pending JP2011523637A (ja) 2008-05-15 2009-05-15 うつ病に関するｇａｂａバイオマーカー

Country Status (6)

Country Link
US (1) US8562950B2 (https=)
EP (1) EP2281067A1 (https=)
JP (1) JP2011523637A (https=)
CN (1) CN102099489A (https=)
GB (1) GB0808832D0 (https=)
WO (1) WO2009138500A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011523638A (ja) * 2008-05-15 2011-08-18 ジーイー・ヘルスケア・リミテッド うつ病に関するグルタミンバイオマーカー
JP2011523636A (ja) * 2008-05-15 2011-08-18 ジーイー・ヘルスケア・リミテッド うつ病に関するバイオマーカー
JP2016501514A (ja) * 2012-10-12 2016-01-21 ノースウェスタン ユニバーシティ うつ病および他の関連疾患を処置するための化合物を同定する方法
WO2017082103A1 (ja) * 2015-11-12 2017-05-18 国立大学法人九州大学 うつ病診断用バイオマーカー及びその使用
WO2020202923A1 (ja) 2019-03-29 2020-10-08 日本たばこ産業株式会社 うつ病の評価方法及びうつ病の治療法の効果の評価方法、並びにうつ病若しくはうつ病の治療法の効果を評価するためのデータ取得方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130046093A1 (en) * 2011-08-18 2013-02-21 Korea Institute Of Science And Technology Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same
CN111944835B (zh) * 2019-05-14 2022-03-29 南通大学 一种突变型gabrg2转基因斑马鱼癫痫模型的构建方法及应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004047727A2 (en) * 2002-11-01 2004-06-10 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for diagnosing and treating mood disorders
US20050209181A1 (en) * 2003-11-05 2005-09-22 Huda Akil Compositions and methods for diagnosing and treating mental disorders
US20070172830A1 (en) * 1998-05-12 2007-07-26 Human Genome Sciences, Inc. Antibodies to hhpen62 polypeptide
WO2008020435A2 (en) * 2006-08-15 2008-02-21 Quark Pharmaceuticals, Inc Compositions and methods for treatment of mood disorders
JP2011523636A (ja) * 2008-05-15 2011-08-18 ジーイー・ヘルスケア・リミテッド うつ病に関するバイオマーカー
JP2011523638A (ja) * 2008-05-15 2011-08-18 ジーイー・ヘルスケア・リミテッド うつ病に関するグルタミンバイオマーカー

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999040114A1 (en) 1998-02-05 1999-08-12 Merck & Co., Inc. Novel gabab receptor dna sequences
JP2004508359A (ja) 2000-09-06 2004-03-18 ニューロゲン　コーポレイション アリール置換テトラヒドロインダゾール、及び、ｇａｂａ−ａ受容体に対するリガンドとしてのそれらの使用
DK1766077T3 (da) 2004-06-21 2012-07-16 Univ Leland Stanford Junior Differentielt udtrykte gener og veje i bipolar forstyrrelse og/eller alvorlig depressiv forstyrrelse

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070172830A1 (en) * 1998-05-12 2007-07-26 Human Genome Sciences, Inc. Antibodies to hhpen62 polypeptide
WO2004047727A2 (en) * 2002-11-01 2004-06-10 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for diagnosing and treating mood disorders
US20050209181A1 (en) * 2003-11-05 2005-09-22 Huda Akil Compositions and methods for diagnosing and treating mental disorders
WO2008020435A2 (en) * 2006-08-15 2008-02-21 Quark Pharmaceuticals, Inc Compositions and methods for treatment of mood disorders
JP2011523636A (ja) * 2008-05-15 2011-08-18 ジーイー・ヘルスケア・リミテッド うつ病に関するバイオマーカー
JP2011523638A (ja) * 2008-05-15 2011-08-18 ジーイー・ヘルスケア・リミテッド うつ病に関するグルタミンバイオマーカー

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6013044977; Ｓｈｅｌｉｎｅ　ｅｔ　ａｌ．: ''Ｄｅｃｒｅａｓｅｄ　ｈｉｐｐｏｃａｍｐａｌ　５-ＨＴ（２Ａ）　ｒｅｃｅｐｔｏｒ　ｂｉｎｄｉｎｇ　ｉｎ　ｏｌｄｅｒ　ｄｅｐｒｅｓｓｅｄ　ｐａｔｉｅｎｔｓ　ｕｓｉｎｇ　［１８Ｆ］ａｌｔａｎｓｅｒｉｎ　ｐ' Ｎｅｕｒｏｐｓｙｃｈｏｐｈａｒｍａｃｏｌｏｇｙ ２９（１２）, 2004, ｐｐ．２２３５-４１ *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011523638A (ja) * 2008-05-15 2011-08-18 ジーイー・ヘルスケア・リミテッド うつ病に関するグルタミンバイオマーカー
JP2011523636A (ja) * 2008-05-15 2011-08-18 ジーイー・ヘルスケア・リミテッド うつ病に関するバイオマーカー
JP2016501514A (ja) * 2012-10-12 2016-01-21 ノースウェスタン ユニバーシティ うつ病および他の関連疾患を処置するための化合物を同定する方法
WO2017082103A1 (ja) * 2015-11-12 2017-05-18 国立大学法人九州大学 うつ病診断用バイオマーカー及びその使用
JPWO2017082103A1 (ja) * 2015-11-12 2018-08-30 国立大学法人九州大学 うつ病診断用バイオマーカー及びその使用
WO2020202923A1 (ja) 2019-03-29 2020-10-08 日本たばこ産業株式会社 うつ病の評価方法及びうつ病の治療法の効果の評価方法、並びにうつ病若しくはうつ病の治療法の効果を評価するためのデータ取得方法

Also Published As

Publication number Publication date
GB0808832D0 (en) 2008-06-18
CN102099489A (zh) 2011-06-15
EP2281067A1 (en) 2011-02-09
WO2009138500A1 (en) 2009-11-19
US8562950B2 (en) 2013-10-22
US20110091381A1 (en) 2011-04-21

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