JP2011522892A - パーキンソン病緩和のためのラサギリン - Google Patents
パーキンソン病緩和のためのラサギリン Download PDFInfo
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- JP2011522892A JP2011522892A JP2011513503A JP2011513503A JP2011522892A JP 2011522892 A JP2011522892 A JP 2011522892A JP 2011513503 A JP2011513503 A JP 2011513503A JP 2011513503 A JP2011513503 A JP 2011513503A JP 2011522892 A JP2011522892 A JP 2011522892A
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- Prior art keywords
- rasagiline
- parkinson
- disease
- patient
- pharmaceutically acceptable
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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| JP2014508758A (ja) * | 2011-02-23 | 2014-04-10 | ユニバルシテ ラバル | パーキンソン病を治療するためのシスタミン類似体 |
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| EP1991214B1 (en) * | 2006-02-21 | 2015-08-05 | Teva Pharmaceutical Industries, Ltd. | Use of rasagiline for the treatment of multiple system atrophy |
| EP2007369A4 (en) * | 2006-04-03 | 2009-07-01 | Teva Pharma | USE OF RASAGILINE FOR THE TREATMENT OF LEG SYNDROME WITHOUT REST |
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| WO2009032273A1 (en) * | 2007-09-05 | 2009-03-12 | Teva Pharmaceutical Industries, Ltd. | Method of treating glaucoma using rasagiline |
| US8188149B2 (en) * | 2007-09-17 | 2012-05-29 | Teva Pharmaceutical Industries, Ltd. | Use of R(+)-N-propargy1-1-aminoindan to treat or prevent hearing loss |
| WO2009089049A1 (en) * | 2008-01-11 | 2009-07-16 | Teva Pharmaceutical Industries, Ltd. | Rasagiline formulations, their preparation and use |
| US20100008983A1 (en) * | 2008-06-10 | 2010-01-14 | Muhammad Safadi | Rasagiline soft gelatin capsules |
| CA2727021A1 (en) * | 2008-06-19 | 2009-12-23 | Teva Pharmaceutical Industries Ltd. | Process for purifying rasagiline base |
| BRPI0909997A2 (pt) | 2008-06-19 | 2015-10-27 | Teva Pharma | r(+)-n-propargil-1-aminoindano cristalino, composição farmacêutica, processo de secagem de r(+)-n-propargil-1-aminoindano sólido, processo de preparação de uma composição farmacêutica, processo de produção de um lote validado de um produto de farmaco que contém r(+)-n-propargil-1-aminoindano cristalino e pelo menos um veículo farmaceuticamente aceitável para distribuição e processo de prudução de r(+)-n-propargil-1-aminoindano cristalino |
| US20100189791A1 (en) * | 2009-01-23 | 2010-07-29 | Teva Pharmaceutical Industries, Ltd. | Delayed release rasagiline malate formulation |
| DK2451771T3 (da) | 2009-07-09 | 2014-09-08 | Ratiopharm Gmbh | Salte af rasagilin og farmaceutiske fremstillingsmåder heraf |
| EP2515891A4 (en) * | 2009-12-22 | 2013-06-05 | Teva Pharma | 3-keto-N-propargyl-1-aminoindan |
| WO2012015946A1 (en) * | 2010-07-27 | 2012-02-02 | Teva Pharmaceutical Industries Ltd. | Dispersion of rasagiline citrate |
| RU2587330C2 (ru) | 2010-07-27 | 2016-06-20 | Тева Фармасьютикал Индастриз Лтд. | Применение разагилина для лечения обонятельной дисфункции |
| MX2013004598A (es) * | 2010-10-26 | 2013-07-17 | Teva Pharma | Rasagilina enriquesida con deuterio. |
| HK1200315A1 (en) | 2011-10-10 | 2015-08-07 | Teva Pharmaceutical Industries Ltd. | R(+)-n-formyl-propargyl-aminoindan |
| JP2014534195A (ja) * | 2011-10-10 | 2014-12-18 | テバ ファーマシューティカル インダストリーズ リミティド | ラサギリンシトルアミド |
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| US9308182B2 (en) | 2012-08-17 | 2016-04-12 | Teva Pharmaceutical Industries, Ltd. | Parenteral formulations of rasagiline |
| JP2017517481A (ja) * | 2014-04-01 | 2017-06-29 | テバ ファーマシューティカル インダストリーズ リミティド | ラサギリンに対する応答を予測するために有用な一塩基多型の決定 |
| US10292947B2 (en) * | 2016-03-26 | 2019-05-21 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical compositions for N-propargylamine derivative |
| CA3058818A1 (en) * | 2017-04-05 | 2018-10-11 | Crestovo Holdings Llc | Compositions and methods for treating parkinson's disease (pd) and related disorders |
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| US9066903B2 (en) * | 2006-02-28 | 2015-06-30 | The United States Of America As Represented By The Department Of Veterans Affairs | Pharmacological treatment of Parkinson's disease |
| CN101032474B (zh) * | 2006-03-06 | 2011-02-16 | 重庆医药工业研究院有限责任公司 | 一种治疗或预防神经系统疾病的雷沙吉兰透皮贴片及其制备方法 |
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| EP1892233A1 (de) * | 2006-08-18 | 2008-02-27 | Ratiopharm GmbH | Neue Salze des Wirkstoffs Rasagilin |
| RS52183B (sr) | 2006-12-14 | 2012-10-31 | Teva Pharmaceutical Industries, Ltd. | Kristalna čvrsta baza razagilina |
| BRPI0718339A2 (pt) * | 2006-12-14 | 2014-02-18 | Teva Pharma | Composto, composição, composição farmacêutica e processo de fabricação de tanato de rasagilina |
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| WO2009032273A1 (en) * | 2007-09-05 | 2009-03-12 | Teva Pharmaceutical Industries, Ltd. | Method of treating glaucoma using rasagiline |
| US8188149B2 (en) * | 2007-09-17 | 2012-05-29 | Teva Pharmaceutical Industries, Ltd. | Use of R(+)-N-propargy1-1-aminoindan to treat or prevent hearing loss |
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| US20100008983A1 (en) * | 2008-06-10 | 2010-01-14 | Muhammad Safadi | Rasagiline soft gelatin capsules |
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| DE102008064061A1 (de) * | 2008-12-19 | 2010-06-24 | Ratiopharm Gmbh | Feste Zusammensetzung mit dem Wirkstoff Rasagilin |
| US20100189791A1 (en) * | 2009-01-23 | 2010-07-29 | Teva Pharmaceutical Industries, Ltd. | Delayed release rasagiline malate formulation |
| AU2010304755A1 (en) * | 2009-10-09 | 2012-05-24 | Teva Pharmaceutical Industries, Ltd. | Use of rasagiline for the treatment of Progressive Supranuclear Palsy |
| EP2515891A4 (en) * | 2009-12-22 | 2013-06-05 | Teva Pharma | 3-keto-N-propargyl-1-aminoindan |
-
2009
- 2009-06-12 BR BRPI0909894-1A patent/BRPI0909894A2/pt not_active IP Right Cessation
- 2009-06-12 NZ NZ589445A patent/NZ589445A/xx unknown
- 2009-06-12 CA CA2727022A patent/CA2727022A1/en not_active Abandoned
- 2009-06-12 EP EP09762921A patent/EP2296462A4/en not_active Withdrawn
- 2009-06-12 CN CN201310714021.5A patent/CN103893160A/zh active Pending
- 2009-06-12 EA EA201170018A patent/EA201170018A1/ru unknown
- 2009-06-12 WO PCT/US2009/003528 patent/WO2009151625A1/en not_active Ceased
- 2009-06-12 JP JP2011513503A patent/JP2011522892A/ja active Pending
- 2009-06-12 MX MX2010013766A patent/MX2010013766A/es not_active Application Discontinuation
- 2009-06-12 CN CN2009801230031A patent/CN102065687A/zh active Pending
- 2009-06-12 AU AU2009258151A patent/AU2009258151A1/en not_active Abandoned
- 2009-06-12 EP EP20130176166 patent/EP2666356A1/en not_active Withdrawn
- 2009-06-12 US US12/456,166 patent/US20090312436A1/en not_active Abandoned
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2010
- 2010-11-04 IL IL209131A patent/IL209131A0/en unknown
- 2010-11-25 ZA ZA2010/08484A patent/ZA201008484B/en unknown
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2013
- 2013-11-27 US US14/092,526 patent/US20140243418A1/en not_active Abandoned
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2014
- 2014-12-17 JP JP2014255148A patent/JP2015096532A/ja active Pending
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2016
- 2016-11-15 AU AU2016259315A patent/AU2016259315A1/en not_active Abandoned
- 2016-12-02 JP JP2016234976A patent/JP2017081938A/ja not_active Withdrawn
Non-Patent Citations (4)
| Title |
|---|
| JPN6013056741; 永井将弘ら: '今後出てくる新しい治療法' Ｐｈａｒｍａ Ｍｅｄｉｃａ Ｖｏｌ．２４、Ｎｏ．９, 2006, ｐ．５７-６０ * |
| JPN6013056744; 長谷川一子: 'パーキンソン病では、薬物治療を早期に始めるほうが、病状進行を遅くすることができるのか？' 治療 Ｖｏｌ．８８、増刊号, 2006, ｐ．１１０７-１１１１ * |
| JPN6013056747; Ｐａｒｋｉｎｓｏｎ Ｓｔｕｄｙ Ｇｒｏｕｐ: 'Ａ Ｃｏｎｔｒｏｌｌｅｄ， Ｒａｎｄｏｍｉｚｅｄ， Ｄｅｌａｙｅｄ-Ｓｔａｒｔ Ｓｔｕｄｙ ｏｆ Ｒａｓａｇｉｌｉｎｅ ｉｎ Ｅａｒｌｙ Ｐａｒｋｉｎｓｏｎ Ｄｉｓｅａｓｅ' Ａｒｃｈ Ｎｅｕｒｏｌ Ｖｏｌ．６１, 2004, ｐ．５６１-５６６ * |
| JPN6013056751; Ｖ．Ｏｌｄｆｉｅｌｄ ｅｔ．ａｌ．: 'Ｒａｓａｇｉｌｉｎｅ' Ｄｒｕｇｓ Ｖｏｌ．６７, 2007, ｐ．１７２５-１７４７ * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014508758A (ja) * | 2011-02-23 | 2014-04-10 | ユニバルシテ ラバル | パーキンソン病を治療するためのシスタミン類似体 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2296462A1 (en) | 2011-03-23 |
| CN102065687A (zh) | 2011-05-18 |
| MX2010013766A (es) | 2011-03-15 |
| IL209131A0 (en) | 2011-01-31 |
| WO2009151625A1 (en) | 2009-12-17 |
| JP2017081938A (ja) | 2017-05-18 |
| JP2015096532A (ja) | 2015-05-21 |
| AU2009258151A1 (en) | 2009-12-17 |
| BRPI0909894A2 (pt) | 2015-07-28 |
| CN103893160A (zh) | 2014-07-02 |
| AU2016259315A1 (en) | 2016-12-01 |
| EP2296462A4 (en) | 2011-06-15 |
| NZ589445A (en) | 2013-06-28 |
| US20090312436A1 (en) | 2009-12-17 |
| EA201170018A1 (ru) | 2011-08-30 |
| ZA201008484B (en) | 2012-05-30 |
| US20140243418A1 (en) | 2014-08-28 |
| EP2666356A1 (en) | 2013-11-27 |
| CA2727022A1 (en) | 2009-12-17 |
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