JP2011522879A5 - - Google Patents

Info

Publication number

JP2011522879A5

JP2011522879A5 JP2011513112A JP2011513112A JP2011522879A5 JP 2011522879 A5 JP2011522879 A5 JP 2011522879A5 JP 2011513112 A JP2011513112 A JP 2011513112A JP 2011513112 A JP2011513112 A JP 2011513112A JP 2011522879 A5 JP2011522879 A5 JP 2011522879A5

Authority

JP

Japan

Prior art keywords

chitosan

composition

highly

composition according

deacetylated

Prior art date

2009-06-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 229920001661 Chitosan Polymers 0.000 claims 36
• 239000000203 mixture Substances 0.000 claims 30
• 150000004676 glycans Polymers 0.000 claims 8
• 229920001282 polysaccharide Polymers 0.000 claims 8
• 239000005017 polysaccharide Substances 0.000 claims 8
• 150000004804 polysaccharides Polymers 0.000 claims 8
• 238000006640 acetylation reaction Methods 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 4
• 210000004027 cells Anatomy 0.000 claims 3
• WKPUACLQLIIVJJ-RHKLHVFKSA-M (2S,3R,4R,5S,6R)-4-hydroxy-3-methoxy-6-[(2S,3R,4S,5S,6R)-6-methoxy-4-oxido-5-(sulfooxyamino)-2-(sulfooxymethyl)oxan-3-yl]oxy-5-sulfooxyoxane-2-carboxylate Chemical compound [O-][C@H]1[C@H](NOS(O)(=O)=O)[C@H](OC)O[C@@H](COS(O)(=O)=O)[C@@H]1O[C@H]1[C@@H](OS(O)(=O)=O)[C@H](O)[C@@H](OC)[C@@H](C([O-])=O)O1 WKPUACLQLIIVJJ-RHKLHVFKSA-M 0.000 claims 2
• 229920001287 Chondroitin sulfate Polymers 0.000 claims 2
• KXKPYJOVDUMHGS-OSRGNVMNSA-N Chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 claims 2
• 229960000633 Dextran Sulfate Drugs 0.000 claims 2
• 229920002971 Heparan sulfate Polymers 0.000 claims 2
• ZFGMDIBRIDKWMY-PASTXAENSA-N Heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 claims 2
• 229960002897 Heparin Drugs 0.000 claims 2
• KXCLCNHUUKTANI-RBIYJLQWSA-N Keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 claims 2
• 229920000288 Keratan sulfate Polymers 0.000 claims 2
• 229940067631 Phospholipids Drugs 0.000 claims 2
• 210000004102 animal cell Anatomy 0.000 claims 2
• 229940059329 chondroitin sulfate Drugs 0.000 claims 2
• -1 dextran sulfate Chemical compound 0.000 claims 2
• 229940079593 drugs Drugs 0.000 claims 2
• 229920000669 heparin Polymers 0.000 claims 2
• 229920002674 hyaluronan Polymers 0.000 claims 2
• 229960003160 hyaluronic acid Drugs 0.000 claims 2
• 150000003904 phospholipids Chemical class 0.000 claims 2
• 229920001184 polypeptide Polymers 0.000 claims 2
• MAKUBRYLFHZREJ-JWBQXVCJSA-M sodium;(2S,3S,4R,5R,6R)-3-[(2S,3R,5S,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylate Chemical compound [Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@H](O)[C@H]1O MAKUBRYLFHZREJ-JWBQXVCJSA-M 0.000 claims 2
• 239000000126 substance Substances 0.000 claims 2
• QAOWNCQODCNURD-UHFFFAOYSA-L sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 2
• 206010059837 Adhesion Diseases 0.000 claims 1
• 229940102223 Injectable Solution Drugs 0.000 claims 1
• 208000004412 Rotator Cuff Injury Diseases 0.000 claims 1
• 206010039227 Rotator cuff syndrome Diseases 0.000 claims 1
• 238000003381 deacetylation reaction Methods 0.000 claims 1
• 239000000017 hydrogel Substances 0.000 claims 1
• 230000001264 neutralization Effects 0.000 claims 1
• 201000008482 osteoarthritis Diseases 0.000 claims 1
• 238000002360 preparation method Methods 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 230000017423 tissue regeneration Effects 0.000 claims 1
• 210000001519 tissues Anatomy 0.000 claims 1
• 230000029663 wound healing Effects 0.000 claims 1