JP2011522832A5 - - Google Patents
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- Publication number
- JP2011522832A5 JP2011522832A5 JP2011512700A JP2011512700A JP2011522832A5 JP 2011522832 A5 JP2011522832 A5 JP 2011522832A5 JP 2011512700 A JP2011512700 A JP 2011512700A JP 2011512700 A JP2011512700 A JP 2011512700A JP 2011522832 A5 JP2011522832 A5 JP 2011522832A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- fragment
- therapeutic agent
- dose
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5971108P | 2008-06-06 | 2008-06-06 | |
| US61/059,711 | 2008-06-06 | ||
| US9523208P | 2008-09-08 | 2008-09-08 | |
| US61/095,232 | 2008-09-08 | ||
| PCT/US2009/046441 WO2009149370A1 (en) | 2008-06-06 | 2009-06-05 | Methods for the treatment of rheumatoid arthritis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014173653A Division JP5809338B2 (ja) | 2008-06-06 | 2014-08-28 | 関節リウマチの治療のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011522832A JP2011522832A (ja) | 2011-08-04 |
| JP2011522832A5 true JP2011522832A5 (cg-RX-API-DMAC7.html) | 2014-04-10 |
| JP5607613B2 JP5607613B2 (ja) | 2014-10-15 |
Family
ID=40983388
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011512700A Expired - Fee Related JP5607613B2 (ja) | 2008-06-06 | 2009-06-05 | 関節リウマチの治療のための方法 |
| JP2014173653A Expired - Fee Related JP5809338B2 (ja) | 2008-06-06 | 2014-08-28 | 関節リウマチの治療のための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014173653A Expired - Fee Related JP5809338B2 (ja) | 2008-06-06 | 2014-08-28 | 関節リウマチの治療のための方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20110189172A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2293816B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5607613B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009256072B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2727171A1 (cg-RX-API-DMAC7.html) |
| CY (1) | CY1113640T1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2293816T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2398693T3 (cg-RX-API-DMAC7.html) |
| HR (1) | HRP20130042T1 (cg-RX-API-DMAC7.html) |
| PL (1) | PL2293816T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2293816E (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009149370A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8034014B2 (en) | 2007-03-06 | 2011-10-11 | Biomet Biologics, Llc | Angiogenesis initation and growth |
| US20080269762A1 (en) * | 2007-04-25 | 2008-10-30 | Biomet Manufacturing Corp. | Method and device for repair of cartilage defects |
| CA2710252C (en) | 2007-12-20 | 2017-03-28 | Xoma Technology Ltd. | Methods for the treatment of gout |
| US8753690B2 (en) | 2008-02-27 | 2014-06-17 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
| PL2259774T3 (pl) | 2008-02-27 | 2013-04-30 | Biomet Biologics Llc | Sposoby i kompozycje dla wprowadzania antagonisty receptora interleukiny-1 |
| US20110052561A1 (en) * | 2009-08-27 | 2011-03-03 | Biomet Biologics,LLC | Osteolysis treatment |
| CN102573790B (zh) | 2009-08-27 | 2017-03-22 | 拜欧米特生物制剂有限责任公司 | 用于产生白介素‑1受体拮抗剂的可植入装置 |
| AU2011296356B2 (en) | 2010-09-03 | 2015-07-09 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
| RU2013115927A (ru) | 2010-09-10 | 2014-10-20 | Апексиджен, Инк. | АНТИТЕЛА ПРОТИВ ИЛ-1β И СПОСОБЫ ПРИМЕНЕНИЯ |
| US9011846B2 (en) | 2011-05-02 | 2015-04-21 | Biomet Biologics, Llc | Thrombin isolated from blood and blood fractions |
| US9573997B2 (en) * | 2012-03-19 | 2017-02-21 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Method for use in the treatment of aneurysm |
| EP3750917A1 (en) | 2012-11-05 | 2020-12-16 | Delenex Therapeutics AG | Binding members to il-1 beta |
| ES2895848T3 (es) | 2012-12-17 | 2022-02-22 | Cell Medica Inc | Anticuerpos contra IL-1 beta |
| US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
| US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
| US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
| US9758806B2 (en) | 2013-03-15 | 2017-09-12 | Biomet Biologics, Llc | Acellular compositions for treating inflammatory disorders |
| US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
| US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
| US9878011B2 (en) | 2013-03-15 | 2018-01-30 | Biomet Biologics, Llc | Treatment of inflammatory respiratory disease using biological solutions |
| WO2015081253A1 (en) | 2013-11-26 | 2015-06-04 | Biomet Biologics, Llc | Methods of mediating macrophage phenotypes |
| SG11201703458UA (en) | 2014-11-10 | 2017-05-30 | Hoffmann La Roche | Anti-ang2 antibodies and methods of use |
| KR20170080584A (ko) | 2014-11-10 | 2017-07-10 | 에프. 호프만-라 로슈 아게 | 이중특이적 항체 및 안과학에서 이의 사용 방법 |
| US10441635B2 (en) | 2014-11-10 | 2019-10-15 | Biomet Biologics, Llc | Methods of treating pain using protein solutions |
| US9763800B2 (en) | 2015-03-18 | 2017-09-19 | Biomet C. V. | Implant configured for hammertoe and small bone fixation |
| CN113444177A (zh) * | 2020-03-27 | 2021-09-28 | 中山康方生物医药有限公司 | 抗IL-1β的抗体、其药物组合物及其用途 |
| CN115281149A (zh) * | 2021-05-12 | 2022-11-04 | 四川大学华西医院 | 一种临床前类风湿关节炎(Pre-RA)小鼠模型 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5077219A (en) * | 1984-05-18 | 1991-12-31 | New England Medical Center Hospitals | Human IL-1 cDNA sequences encoding biologically-active human IL-1 proteins |
| EP0569687B1 (en) * | 1984-05-18 | 2002-08-21 | New England Medical Center Hospitals, Inc. | Human IL-1 cDNA sequences encoding biologically-active human IL-1 proteins |
| US4762914A (en) * | 1984-05-18 | 1988-08-09 | Auron Philip E | Truncated protein of interleukin-1 |
| US5484887A (en) * | 1984-06-19 | 1996-01-16 | Immunex Corporation | Homogeneous interleukin 1 |
| US5122459A (en) * | 1984-12-31 | 1992-06-16 | Immunex Corporation | Gene encoding biologically active human interleukin 1 |
| US4772685A (en) * | 1985-10-02 | 1988-09-20 | Merck & Co., Inc. | Immunogenic peptides of human interleukin-1 and the corresponding anti-peptide antibodies |
| US4935343A (en) * | 1986-08-08 | 1990-06-19 | Syntex (U.S.A.) Inc. | Monoclonal antibodies for interleukin-1β |
| US5474899A (en) * | 1987-05-13 | 1995-12-12 | Cistron Biotechnology, Inc. | Selective immunoassay for IL-1 β |
| DE68925935T2 (de) * | 1988-10-01 | 1996-08-14 | Otsuka Pharma Co Ltd | Antikörper gegen Interleukin-1-beta |
| ES2113856T3 (es) * | 1989-02-27 | 1998-05-16 | New England Medical Center Inc | Inhibidores de actividad biologica de il-1. |
| IE922437A1 (en) * | 1991-07-25 | 1993-01-27 | Idec Pharma Corp | Recombinant antibodies for human therapy |
| DE69233745D1 (de) * | 1991-12-02 | 2008-10-23 | Cambridge Antibody Tech | Herstellung von Autoantikörpern auf Phagenoberflächen ausgehend von Antikörpersegmentbibliotheken |
| US5869619A (en) * | 1991-12-13 | 1999-02-09 | Xoma Corporation | Modified antibody variable domains |
| EP1291360A1 (en) * | 1991-12-13 | 2003-03-12 | Xoma Corporation | Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof |
| WO1994000470A1 (en) * | 1992-06-30 | 1994-01-06 | The Wistar Institute Of Anatomy And Biology | DEVELOPMENTAL EMBRYONIC MOUSE cDNA LIBRARIES |
| US5959085A (en) * | 1993-11-23 | 1999-09-28 | Schering Corporation | Human monoclonal antibodies against human cytokines and methods of making and using such antibodies |
| US5817476A (en) * | 1995-06-07 | 1998-10-06 | Genetics Institute, Inc. | Polynucleotides encoding interleukin-1 receptor intracellular ligand proteins |
| GB0001448D0 (en) * | 2000-01-21 | 2000-03-08 | Novartis Ag | Organic compounds |
| AU2001259758A1 (en) * | 2000-05-12 | 2001-11-26 | Immunex Corporation | Interleukin-1 inhibitors in the treatment of diseases |
| GB0020685D0 (en) * | 2000-08-22 | 2000-10-11 | Novartis Ag | Organic compounds |
| US20030026806A1 (en) * | 2000-10-27 | 2003-02-06 | Amgen Inc. | Antibodies and other selective IL-1 binding agents that allow binding to IL-1 receptor but not activation thereof |
| US20030166069A1 (en) * | 2000-11-28 | 2003-09-04 | Amgen, Inc. | Interleukin-1 receptor antagonist-like molecules and uses thereof |
| US6727234B2 (en) * | 2001-04-03 | 2004-04-27 | University Of Iowa Research Foundation | Isoprenoid analog compounds and methods of making and use thereof |
| EP1423432A4 (en) * | 2001-07-26 | 2006-01-11 | Lilly Co Eli | ANTIBODIES TO INTERLEUKIN 1 BETA (IL-1BETA) |
| US20050152850A1 (en) * | 2004-01-09 | 2005-07-14 | Engebretson Steven P. | Methods and compositions for facilitating metabolic control |
| US7732478B2 (en) * | 2004-01-09 | 2010-06-08 | The Trustees Of Columbia University In The City Of New York | Methods for facilitating metabolic control |
| US8618054B2 (en) * | 2004-05-05 | 2013-12-31 | Valorisation-Rechereche Société en Commandite | Interleukin-1 receptor antagonists, compositions, and methods of treatment |
| ES2335232T3 (es) * | 2005-06-21 | 2010-03-23 | Xoma Technology Ltd. | Anticuerpos y fragmentos de los mismos que se unen a la il-1 beta. |
| WO2007050607A2 (en) * | 2005-10-26 | 2007-05-03 | Novartis Ag | Novel use of il-1beta compounds |
| JP5645409B2 (ja) * | 2006-12-20 | 2014-12-24 | ゾーマ （ユーエス） リミテッド ライアビリティ カンパニー | ＩＬ−１β関連疾患の治療方法 |
| CA2710252C (en) * | 2007-12-20 | 2017-03-28 | Xoma Technology Ltd. | Methods for the treatment of gout |
-
2009
- 2009-06-05 CA CA2727171A patent/CA2727171A1/en not_active Abandoned
- 2009-06-05 AU AU2009256072A patent/AU2009256072B2/en not_active Ceased
- 2009-06-05 JP JP2011512700A patent/JP5607613B2/ja not_active Expired - Fee Related
- 2009-06-05 US US12/996,516 patent/US20110189172A1/en not_active Abandoned
- 2009-06-05 HR HRP20130042AT patent/HRP20130042T1/hr unknown
- 2009-06-05 WO PCT/US2009/046441 patent/WO2009149370A1/en not_active Ceased
- 2009-06-05 PT PT97595284T patent/PT2293816E/pt unknown
- 2009-06-05 DK DK09759528.4T patent/DK2293816T3/da active
- 2009-06-05 PL PL09759528T patent/PL2293816T3/pl unknown
- 2009-06-05 ES ES09759528T patent/ES2398693T3/es active Active
- 2009-06-05 EP EP09759528A patent/EP2293816B1/en active Active
-
2013
- 2013-02-05 CY CY20131100102T patent/CY1113640T1/el unknown
-
2014
- 2014-08-28 JP JP2014173653A patent/JP5809338B2/ja not_active Expired - Fee Related