JP2011522795A5 - - Google Patents

Info

Publication number

JP2011522795A5

JP2011522795A5 JP2011508582A JP2011508582A JP2011522795A5 JP 2011522795 A5 JP2011522795 A5 JP 2011522795A5 JP 2011508582 A JP2011508582 A JP 2011508582A JP 2011508582 A JP2011508582 A JP 2011508582A JP 2011522795 A5 JP2011522795 A5 JP 2011522795A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

molecule

composition according

region

ctla4

Prior art date

2009-05-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000008194 pharmaceutical composition Substances 0.000 claims 15
• 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 8
• 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 8
• 108060003951 Immunoglobulin Proteins 0.000 claims 4
• 102000009786 Immunoglobulin Constant Regions Human genes 0.000 claims 4
• 108010009817 Immunoglobulin Constant Regions Proteins 0.000 claims 4
• 125000003275 alpha amino acid group Chemical group 0.000 claims 4
• 206010003246 arthritis Diseases 0.000 claims 4
• 102000018358 immunoglobulin Human genes 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• 210000000707 wrist Anatomy 0.000 claims 3
• 241000282693 Cercopithecidae Species 0.000 claims 2
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
• 239000004472 Lysine Substances 0.000 claims 2
• 235000004279 alanine Nutrition 0.000 claims 2
• 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 2
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
• 229930182817 methionine Natural products 0.000 claims 2
• 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims 2
• 208000024891 symptom Diseases 0.000 claims 2
• 208000006820 Arthralgia Diseases 0.000 claims 1
• 206010051763 Bone marrow oedema Diseases 0.000 claims 1
• 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 206010023232 Joint swelling Diseases 0.000 claims 1
• 208000002193 Pain Diseases 0.000 claims 1
• 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 1
• 235000003704 aspartic acid Nutrition 0.000 claims 1
• CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
• 230000037396 body weight Effects 0.000 claims 1
• 239000012636 effector Substances 0.000 claims 1
• 230000003628 erosive effect Effects 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 201000004595 synovitis Diseases 0.000 claims 1