JP2011522553A5 - - Google Patents

Info

Publication number

JP2011522553A5

JP2011522553A5 JP2011512983A JP2011512983A JP2011522553A5 JP 2011522553 A5 JP2011522553 A5 JP 2011522553A5 JP 2011512983 A JP2011512983 A JP 2011512983A JP 2011512983 A JP2011512983 A JP 2011512983A JP 2011522553 A5 JP2011522553 A5 JP 2011522553A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

composition according

growth factor

interleukin

range

Prior art date

2009-06-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 10
• 102000003745 Hepatocyte Growth Factor Human genes 0.000 claims 6
• 108090000100 Hepatocyte Growth Factor Proteins 0.000 claims 6
• 102000004889 Interleukin-6 Human genes 0.000 claims 6
• 108090001005 Interleukin-6 Proteins 0.000 claims 6
• 102000004890 Interleukin-8 Human genes 0.000 claims 6
• 108090001007 Interleukin-8 Proteins 0.000 claims 6
• 229940100601 interleukin-6 Drugs 0.000 claims 6
• 229940096397 interleukin-8 Drugs 0.000 claims 6
• XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims 6
• 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 4
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 4
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 4
• 210000004027 cell Anatomy 0.000 claims 4
• 238000012258 culturing Methods 0.000 claims 4
• 102000049853 macrophage stimulating protein Human genes 0.000 claims 4
• 108010053292 macrophage stimulating protein Proteins 0.000 claims 4
• 239000003636 conditioned culture medium Substances 0.000 claims 3
• 239000001963 growth medium Substances 0.000 claims 3
• 210000003494 hepatocyte Anatomy 0.000 claims 3
• 210000004185 liver Anatomy 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 239000000203 mixture Substances 0.000 claims 3
• 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 2
• 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 2
• 101500025419 Homo sapiens Epidermal growth factor Proteins 0.000 claims 2
• 239000006143 cell culture medium Substances 0.000 claims 2
• 210000003237 epithelioid cell Anatomy 0.000 claims 2
• 229940116978 human epidermal growth factor Drugs 0.000 claims 2
• GVUGOAYIVIDWIO-UFWWTJHBSA-N nepidermin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C(C)C)C(C)C)C1=CC=C(O)C=C1 GVUGOAYIVIDWIO-UFWWTJHBSA-N 0.000 claims 2
• 210000002966 serum Anatomy 0.000 claims 2
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
• 102000008100 Human Serum Albumin Human genes 0.000 claims 1
• 108091006905 Human Serum Albumin Proteins 0.000 claims 1
• 206010053159 Organ failure Diseases 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 239000002577 cryoprotective agent Substances 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000008103 glucose Substances 0.000 claims 1
• 210000003734 kidney Anatomy 0.000 claims 1
• 210000004962 mammalian cell Anatomy 0.000 claims 1
• 210000000056 organ Anatomy 0.000 claims 1
• 230000008816 organ damage Effects 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 210000000130 stem cell Anatomy 0.000 claims 1
• 238000010257 thawing Methods 0.000 claims 1
• 239000011782 vitamin Substances 0.000 claims 1
• 229940088594 vitamin Drugs 0.000 claims 1
• 229930003231 vitamin Natural products 0.000 claims 1
• 235000013343 vitamin Nutrition 0.000 claims 1