JP2011521979A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011521979A5 JP2011521979A5 JP2011511948A JP2011511948A JP2011521979A5 JP 2011521979 A5 JP2011521979 A5 JP 2011521979A5 JP 2011511948 A JP2011511948 A JP 2011511948A JP 2011511948 A JP2011511948 A JP 2011511948A JP 2011521979 A5 JP2011521979 A5 JP 2011521979A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridine
- hydroxymethyl
- methyl
- hydroxy
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13087408P | 2008-06-04 | 2008-06-04 | |
| US61/130,874 | 2008-06-06 | ||
| PCT/CA2009/000787 WO2009146555A1 (en) | 2008-06-04 | 2009-06-04 | Hiv integrase inhibitors from pyridoxine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011521979A JP2011521979A (ja) | 2011-07-28 |
| JP2011521979A5 true JP2011521979A5 (enExample) | 2012-01-05 |
| JP5514810B2 JP5514810B2 (ja) | 2014-06-04 |
Family
ID=41397686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011511948A Expired - Fee Related JP5514810B2 (ja) | 2008-06-04 | 2009-06-04 | ピリドキシンに由来するｈｉｖインテグラーゼ阻害剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8742123B2 (enExample) |
| EP (1) | EP2300433A4 (enExample) |
| JP (1) | JP5514810B2 (enExample) |
| CN (1) | CN102112447B (enExample) |
| AU (1) | AU2009253812A1 (enExample) |
| CA (1) | CA2726742A1 (enExample) |
| RU (1) | RU2010153656A (enExample) |
| WO (1) | WO2009146555A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8410300B2 (en) | 2006-09-21 | 2013-04-02 | Taimed Biologics, Inc. | Protease inhibitors |
| JP2010523476A (ja) | 2007-03-08 | 2010-07-15 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | ミトコンドリアアルデヒドデヒドロゲナーゼ−２モジュレーター及びその使用方法 |
| CN102209541B (zh) | 2008-09-08 | 2016-05-18 | 小利兰·斯坦福大学托管委员会 | 醛脱氢酶活性调节剂和其使用方法 |
| JP2012506856A (ja) | 2008-10-28 | 2012-03-22 | ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ | アルデヒドデヒドロゲナーゼのモジュレーターおよびその使用方法 |
| US8283366B2 (en) * | 2010-01-22 | 2012-10-09 | Ambrilia Biopharma, Inc. | Derivatives of pyridoxine for inhibiting HIV integrase |
| US10457659B2 (en) | 2011-04-29 | 2019-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
| WO2013102145A1 (en) | 2011-12-28 | 2013-07-04 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
| JP6242810B2 (ja) | 2011-12-28 | 2017-12-06 | グローバル・ブラッド・セラピューティクス・インコーポレイテッドＧｌｏｂａｌ Ｂｌｏｏｄ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 置換ベンズアルデヒド化合物および組織酸素化の増加におけるそれらの使用方法 |
| KR20150135332A (ko) * | 2013-03-14 | 2015-12-02 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 미토콘드리아 알데히드 탈수소효소-2 조절인자들 및 이들의 사용 방법 |
| SG11201507320QA (en) | 2013-03-15 | 2015-10-29 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
| US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| ES2993155T3 (en) | 2013-03-15 | 2024-12-23 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
| US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US10100043B2 (en) | 2013-03-15 | 2018-10-16 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
| US20140274961A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
| SG11201507453VA (en) | 2013-03-15 | 2015-10-29 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| PL3102208T5 (pl) | 2014-02-07 | 2024-10-14 | Global Blood Therapeutics, Inc. | Krystaliczny polimorf wolnej zasady 2-hydroksy-6-((2-(1-izopropylo-1h-pirazol-5-ilo)pirydyn-3-ylo)metoksy)benzaldehydu |
| MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
| ES3039236T3 (en) | 2015-12-04 | 2025-10-20 | Global Blood Therapeutics Inc | Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
| TW202246215A (zh) | 2015-12-18 | 2022-12-01 | 美商亞德利克斯公司 | 作為非全身ｔｇｒ５促效劑之經取代之４－苯基吡啶化合物 |
| US12084472B2 (en) | 2015-12-18 | 2024-09-10 | Ardelyx, Inc. | Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists |
| TWI752307B (zh) | 2016-05-12 | 2022-01-11 | 美商全球血液治療公司 | 新穎化合物及製造化合物之方法 |
| TW202332423A (zh) | 2016-10-12 | 2023-08-16 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
| CN108203439B (zh) * | 2016-12-20 | 2020-04-14 | 四川大学 | 苯乙烯吡啶类化合物、其制备方法和用途 |
| RU2641309C1 (ru) * | 2017-07-24 | 2018-01-17 | федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) | Антисептическое лекарственное средство |
| EP3687538B1 (en) * | 2017-10-30 | 2024-04-17 | Montreal Heart Institute | Methods of treating elevated plasma cholesterol |
| US11014884B2 (en) | 2018-10-01 | 2021-05-25 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin |
| US12404260B2 (en) * | 2019-04-11 | 2025-09-02 | Janssen Pharmaceutica Nv | Pyridine rings containing derivatives as MALT1 inhibitors |
| WO2020237374A1 (en) * | 2019-05-28 | 2020-12-03 | Montreal Heart Institute | Picolinic acid derivatives and use thereof for treating diseases associated with elevated cholesterol |
| CN113116890B (zh) * | 2021-04-25 | 2022-06-03 | 西南大学 | 5-Pyridoxolactone用于制备抑制家蚕核型多角体病毒的药物中的应用 |
| CN117343006B (zh) * | 2023-10-08 | 2024-07-09 | 河南科技大学 | 一种arb-272572的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6107291A (en) | 1997-12-19 | 2000-08-22 | Amgen Inc. | Azepine or larger medium ring derivatives and methods of use |
| ATE260255T1 (de) * | 1998-11-05 | 2004-03-15 | Pfizer Prod Inc | 5-oxo-pyrrolidine-2-carbonsäure- hydroxamidderivate |
| PA8586801A1 (es) | 2002-10-31 | 2005-02-04 | Pfizer | Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso |
| EP1656348B1 (en) * | 2003-08-20 | 2007-02-07 | Axys Pharmaceuticals, Inc. | Acetylene derivatives as inhibitors of histone deacetylase |
| CA2564356A1 (en) * | 2004-04-26 | 2005-11-03 | Pfizer Inc. | Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors |
| US8114886B2 (en) * | 2005-04-08 | 2012-02-14 | Daiichi Sankyo Company, Limited | Pyridylmethylsulfone derivative |
-
2009
- 2009-06-04 WO PCT/CA2009/000787 patent/WO2009146555A1/en not_active Ceased
- 2009-06-04 CN CN2009801304571A patent/CN102112447B/zh not_active Expired - Fee Related
- 2009-06-04 AU AU2009253812A patent/AU2009253812A1/en not_active Abandoned
- 2009-06-04 RU RU2010153656/04A patent/RU2010153656A/ru unknown
- 2009-06-04 CA CA2726742A patent/CA2726742A1/en not_active Abandoned
- 2009-06-04 JP JP2011511948A patent/JP5514810B2/ja not_active Expired - Fee Related
- 2009-06-04 EP EP09757017A patent/EP2300433A4/en not_active Withdrawn
- 2009-06-04 US US12/995,890 patent/US8742123B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011521979A5 (enExample) | ||
| RU2010153656A (ru) | Ингибиторы интегразы вич из пиридоксина | |
| US9790183B2 (en) | Pyridyl inhibitors of hedgehog signalling | |
| JP4818798B2 (ja) | Ｃｃｒ９インヒビターおよびその使用方法 | |
| US6835731B2 (en) | Chemokine receptor binding heterocyclic compounds | |
| US20020193377A1 (en) | Quinazolines as MMP-13 inhibitors | |
| ES2344347T3 (es) | Derivados de cianopiridina novedosos utiles en el tratamiento de cancer y otros trastornos. | |
| AU694465B2 (en) | Anthranilic acid derivative | |
| US9096527B2 (en) | TRPM8 antagonists and their use in treatments | |
| US20070155744A1 (en) | N-benzyl-3,4-dihyroxypyridine-2-carboxamide and n-benzyl-2,3-dihydroxypyridine-4- carboxamide compounds useful as hiv integrase inhibitors | |
| US20050267119A1 (en) | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions | |
| SK9612000A3 (en) | Inhibition of raf kinase using symmetrical and unsymmetrical substituted diphenyl ureas | |
| US20170015627A1 (en) | Pyridyl inhibitors of hedgehog signalling | |
| US9060515B2 (en) | Heterocyclic urea compounds | |
| IE41838L (en) | 4-(n-heterocyclic)-quinazolines; cardiac stimulants | |
| CA2437409A1 (en) | Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators | |
| JPH1029979A (ja) | 新規ピリジン誘導体 | |
| US20220143020A1 (en) | 2-aminoquinazolinone derivative | |
| JP7510520B2 (ja) | 新規なリンカーで結合された少なくとも２種のアリール又はヘテロアリールを含むカルボノヒドラゾノイルジシアニド化合物及びその用途 | |
| US20080293696A1 (en) | 2-Aminoarylcarboxamides Useful as Cancer Chemotherapeutic Agents | |
| CN119585255A (zh) | 杂芳基衍生化合物及其用途 | |
| AU2007209981A1 (en) | Potassium channel inhibitors | |
| US6720315B2 (en) | Dihydrostilbene alkanoic acid derivatives | |
| MX2014001052A (es) | Compuesto novedoso que tiene actividad inhibidora de angiogénesis, metodo para preparar del mismo, y composicion farmaceutica que comprende el mismo. | |
| JP2003502423A (ja) | チオフェン−エチル−チオウレア化合物およびｈｉｖの治療におけるその使用 |