JP2011518875A5 - - Google Patents
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- JP2011518875A5 JP2011518875A5 JP2011506828A JP2011506828A JP2011518875A5 JP 2011518875 A5 JP2011518875 A5 JP 2011518875A5 JP 2011506828 A JP2011506828 A JP 2011506828A JP 2011506828 A JP2011506828 A JP 2011506828A JP 2011518875 A5 JP2011518875 A5 JP 2011518875A5
- Authority
- JP
- Japan
- Prior art keywords
- dominant
- recessive
- dystrophy
- retinal
- syndrome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000002780 macular degeneration Diseases 0.000 claims 17
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims 15
- 208000035719 Maculopathy Diseases 0.000 claims 13
- 208000011580 syndromic disease Diseases 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 239000000843 powder Substances 0.000 claims 8
- 206010003694 Atrophy Diseases 0.000 claims 7
- 208000017442 Retinal disease Diseases 0.000 claims 7
- 230000037444 atrophy Effects 0.000 claims 7
- 208000006992 Color Vision Defects Diseases 0.000 claims 5
- 230000002207 retinal effect Effects 0.000 claims 5
- OENHQHLEOONYIE-BVZAMQQESA-N 9-cis-beta-carotene Chemical group CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(\C)/C=C/C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-BVZAMQQESA-N 0.000 claims 4
- 241000195634 Dunaliella Species 0.000 claims 4
- 208000034461 Progressive cone dystrophy Diseases 0.000 claims 4
- 201000007737 Retinal degeneration Diseases 0.000 claims 4
- 201000007254 color blindness Diseases 0.000 claims 4
- 201000008615 cone dystrophy Diseases 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000000750 progressive effect Effects 0.000 claims 4
- 210000001525 retina Anatomy 0.000 claims 4
- 230000004258 retinal degeneration Effects 0.000 claims 4
- 208000036443 AIPL1-related retinopathy Diseases 0.000 claims 3
- 150000001579 beta-carotenes Chemical class 0.000 claims 3
- 201000006754 cone-rod dystrophy Diseases 0.000 claims 3
- 208000014674 injury Diseases 0.000 claims 3
- 206010007747 Cataract congenital Diseases 0.000 claims 2
- 208000033810 Choroidal dystrophy Diseases 0.000 claims 2
- 206010010356 Congenital anomaly Diseases 0.000 claims 2
- 241000550645 Danaea media Species 0.000 claims 2
- 241000856893 Dunaliella minuta Species 0.000 claims 2
- 241000738562 Dunaliella polymorpha Species 0.000 claims 2
- 208000032578 Inherited retinal disease Diseases 0.000 claims 2
- 208000036626 Mental retardation Diseases 0.000 claims 2
- 208000009795 Microphthalmos Diseases 0.000 claims 2
- 208000034247 Pattern dystrophy Diseases 0.000 claims 2
- 208000032430 Retinal dystrophy Diseases 0.000 claims 2
- 206010038910 Retinitis Diseases 0.000 claims 2
- 206010038923 Retinopathy Diseases 0.000 claims 2
- 208000027073 Stargardt disease Diseases 0.000 claims 2
- 206010047571 Visual impairment Diseases 0.000 claims 2
- 206010064930 age-related macular degeneration Diseases 0.000 claims 2
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims 2
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims 2
- 235000013734 beta-carotene Nutrition 0.000 claims 2
- 239000011648 beta-carotene Substances 0.000 claims 2
- 229960002747 betacarotene Drugs 0.000 claims 2
- 230000007850 degeneration Effects 0.000 claims 2
- 230000003176 fibrotic effect Effects 0.000 claims 2
- 201000006321 fundus dystrophy Diseases 0.000 claims 2
- 208000017532 inherited retinal dystrophy Diseases 0.000 claims 2
- 230000000366 juvenile effect Effects 0.000 claims 2
- 201000010478 microphthalmia Diseases 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 230000008733 trauma Effects 0.000 claims 2
- 230000004304 visual acuity Effects 0.000 claims 2
- 230000000007 visual effect Effects 0.000 claims 2
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims 2
- 201000004384 Alopecia Diseases 0.000 claims 1
- 206010003591 Ataxia Diseases 0.000 claims 1
- 208000037663 Best vitelliform macular dystrophy Diseases 0.000 claims 1
- 241000283690 Bos taurus Species 0.000 claims 1
- 208000016615 Central areolar choroidal dystrophy Diseases 0.000 claims 1
- 206010008025 Cerebellar ataxia Diseases 0.000 claims 1
- 206010010559 Congenital night blindness Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 206010011878 Deafness Diseases 0.000 claims 1
- 206010011891 Deafness neurosensory Diseases 0.000 claims 1
- 208000012239 Developmental disease Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 241001403474 Dunaliella primolecta Species 0.000 claims 1
- 241001231664 Dunaliella viridis Species 0.000 claims 1
- 206010058314 Dysplasia Diseases 0.000 claims 1
- 241001526948 Euchlora Species 0.000 claims 1
- 101000726148 Homo sapiens Protein crumbs homolog 1 Proteins 0.000 claims 1
- 108700000201 Hyaloideoretinal degeneration of Wagner Proteins 0.000 claims 1
- 201000008645 Joubert syndrome Diseases 0.000 claims 1
- 208000000743 Marshall syndrome Diseases 0.000 claims 1
- 108700000227 Marshall syndrome Proteins 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 208000021642 Muscular disease Diseases 0.000 claims 1
- 201000009623 Myopathy Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 241000286209 Phasianidae Species 0.000 claims 1
- 102100027331 Protein crumbs homolog 1 Human genes 0.000 claims 1
- 208000012322 Raynaud phenomenon Diseases 0.000 claims 1
- 201000007527 Retinal artery occlusion Diseases 0.000 claims 1
- 206010057430 Retinal injury Diseases 0.000 claims 1
- 101000825534 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 40S ribosomal protein S2 Proteins 0.000 claims 1
- 208000009966 Sensorineural Hearing Loss Diseases 0.000 claims 1
- 208000010112 Spinocerebellar Degenerations Diseases 0.000 claims 1
- 208000027077 Stickler syndrome Diseases 0.000 claims 1
- 206010044041 Tooth hypoplasia Diseases 0.000 claims 1
- 208000014769 Usher Syndromes Diseases 0.000 claims 1
- 208000010011 Vitamin A Deficiency Diseases 0.000 claims 1
- 208000022482 Wagner disease Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 208000028321 X-linked cone-rod dystrophy Diseases 0.000 claims 1
- 201000001408 X-linked juvenile retinoschisis 1 Diseases 0.000 claims 1
- 208000017441 X-linked retinoschisis Diseases 0.000 claims 1
- 208000004622 abetalipoproteinemia Diseases 0.000 claims 1
- 238000009825 accumulation Methods 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 230000006978 adaptation Effects 0.000 claims 1
- 231100000360 alopecia Toxicity 0.000 claims 1
- 210000002565 arteriole Anatomy 0.000 claims 1
- 230000003190 augmentative effect Effects 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 208000027129 choroid disease Diseases 0.000 claims 1
- 208000003571 choroideremia Diseases 0.000 claims 1
- 230000004456 color vision Effects 0.000 claims 1
- 230000036461 convulsion Effects 0.000 claims 1
- 210000004087 cornea Anatomy 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000006735 deficit Effects 0.000 claims 1
- 201000002268 dental enamel hypoplasia Diseases 0.000 claims 1
- 230000008021 deposition Effects 0.000 claims 1
- 238000002571 electroretinography Methods 0.000 claims 1
- 230000005221 enamel hypoplasia Effects 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 231100000888 hearing loss Toxicity 0.000 claims 1
- 230000010370 hearing loss Effects 0.000 claims 1
- 208000016354 hearing loss disease Diseases 0.000 claims 1
- 201000007500 hereditary night blindness Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000030194 mouth disease Diseases 0.000 claims 1
- 208000011045 mucopolysaccharidosis type 3 Diseases 0.000 claims 1
- 230000004297 night vision Effects 0.000 claims 1
- 239000000049 pigment Substances 0.000 claims 1
- 201000000757 red-green color blindness Diseases 0.000 claims 1
- 208000029941 retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations Diseases 0.000 claims 1
- 208000004644 retinal vein occlusion Diseases 0.000 claims 1
- 201000007714 retinoschisis Diseases 0.000 claims 1
- 231100000879 sensorineural hearing loss Toxicity 0.000 claims 1
- 208000023573 sensorineural hearing loss disease Diseases 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 230000004393 visual impairment Effects 0.000 claims 1
- 201000007790 vitelliform macular dystrophy Diseases 0.000 claims 1
- 208000020938 vitelliform macular dystrophy 2 Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7144708P | 2008-04-29 | 2008-04-29 | |
| US61/071,447 | 2008-04-29 | ||
| US20233609P | 2009-02-19 | 2009-02-19 | |
| US61/202,336 | 2009-02-19 | ||
| PCT/IL2009/000448 WO2009133552A2 (en) | 2008-04-29 | 2009-04-27 | Methods of treating ophthalmic disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011518875A JP2011518875A (ja) | 2011-06-30 |
| JP2011518875A5 true JP2011518875A5 (https=) | 2011-11-04 |
| JP5443470B2 JP5443470B2 (ja) | 2014-03-19 |
Family
ID=40904160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011506828A Active JP5443470B2 (ja) | 2008-04-29 | 2009-04-27 | 眼障害の治療方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US8529907B2 (https=) |
| EP (1) | EP2296682B8 (https=) |
| JP (1) | JP5443470B2 (https=) |
| WO (1) | WO2009133552A2 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009133552A2 (en) | 2008-04-29 | 2009-11-05 | Nikken Sohonsha Corporation | Methods of treating ophthalmic disorders |
| EP2509611B1 (en) | 2009-12-10 | 2016-03-02 | Nikken Sohonsha Corporation | Crude dunaliella powder for use in treating psoriasis |
| CN102973745A (zh) * | 2012-11-30 | 2013-03-20 | 邢强强 | 用于治疗中心性视网膜炎的中药组合物及其制备方法 |
| CN112153990A (zh) * | 2018-03-23 | 2020-12-29 | 纽约市哥伦比亚大学理事会 | 用于常染色体显性疾病的基因编辑 |
| CN108342323B (zh) * | 2018-04-02 | 2021-11-19 | 大连理工大学 | 一种利用碳酸氢钠作为碳源的杜氏藻培养基及其应用 |
| JP7773374B2 (ja) * | 2019-04-01 | 2025-11-19 | シェバ インパクト リミテッド | 神経変性疾患、タンパク質ミスフォールディングに関連する障害及び認知機能低下の予防及び／又は治療のためのドナリエラ藻類製剤 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI920646A0 (fi) | 1989-08-17 | 1992-02-14 | Cortecs Ltd | Farmaceutiska preparat. |
| IL119224A (en) * | 1996-09-09 | 2002-11-10 | Hadasit Med Res Service | Medicament for protection from effects of irradiation |
| EP3326623A1 (en) * | 2003-03-14 | 2018-05-30 | University of Washington | Retinoid replacements and opsin agonists and methods for the use thereof |
| US7264813B2 (en) * | 2003-09-24 | 2007-09-04 | Nikken Sohonsha Corporation | Therapeutic uses of Dunaliella powder |
| NZ587006A (en) | 2004-06-18 | 2011-12-22 | Univ Washington | 11-cis-Retinal derivatives and methods for the use thereof for the treatment of visual disorders |
| BRPI0515104A (pt) | 2004-09-09 | 2008-07-08 | Univ Washington | método para produzir todo-trans-(13,14)-diidrorretinol, polipeptìdeo isolado, polinucleotìdeo isolado, construção de expressão, célula procariótica ou eucariótica cultivada, vetor, célula hospedeira isolada, método para produzir um polipeptìdeo retsat, anticorpo, método para identificar agonistas ou antagonistas de um polipeptìdeo retsat eucariótico, composição farmacêutica, e, métodos para tratar uma doença neoplásica em um indivìduo mamìfero, para tratar doença retinal ou cegueira em um indivìduo mamìfero, para tratar um estado de doença retinal ou cegueira em um indivìduo mamìfero, para tratar doença auto imune em um indivìduo mamìfero e para tratar uma condição ou distúrbio de pele em um indivìduo mamìfero |
| EP1861078A2 (en) * | 2005-02-11 | 2007-12-05 | Kalamazoo Holdings, Inc. | A capsicum variety exhibiting a hyper-accumulation of zeaxanthin and products derived therefrom |
| WO2006091796A2 (en) | 2005-02-22 | 2006-08-31 | Acucela, Inc. | Compositions and methods for diagnosing and treating retinal diseases |
| WO2006091761A1 (en) | 2005-02-24 | 2006-08-31 | University Of Washington | Methods for treatment of retinal degenerative disease |
| JP2007153842A (ja) | 2005-12-07 | 2007-06-21 | Hideki Aoki | ビタミンアパタイト複合体 |
| CA2644423A1 (en) * | 2006-03-24 | 2007-10-04 | Ian Simon Tracton | Stable packaged dosage form and process therefor |
| WO2008063768A2 (en) | 2006-10-12 | 2008-05-29 | Case Western Reserve University | Compositions and methods for treating metabolic diseases |
| WO2009133552A2 (en) | 2008-04-29 | 2009-11-05 | Nikken Sohonsha Corporation | Methods of treating ophthalmic disorders |
| JP6063615B2 (ja) * | 2008-04-29 | 2017-01-18 | 株式会社日健総本社 | 眼の医学的症状の治療用組成物 |
-
2009
- 2009-04-27 WO PCT/IL2009/000448 patent/WO2009133552A2/en not_active Ceased
- 2009-04-27 EP EP09738565.2A patent/EP2296682B8/en active Active
- 2009-04-27 US US12/989,817 patent/US8529907B2/en active Active
- 2009-04-27 JP JP2011506828A patent/JP5443470B2/ja active Active
-
2013
- 2013-07-18 US US13/945,366 patent/US8961993B2/en active Active
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