JP2011518842A5 - - Google Patents
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- Publication number
- JP2011518842A5 JP2011518842A5 JP2011506485A JP2011506485A JP2011518842A5 JP 2011518842 A5 JP2011518842 A5 JP 2011518842A5 JP 2011506485 A JP2011506485 A JP 2011506485A JP 2011506485 A JP2011506485 A JP 2011506485A JP 2011518842 A5 JP2011518842 A5 JP 2011518842A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- galactomannan
- diol
- cis
- borate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000009472 formulation Methods 0.000 claims description 65
- 239000000203 mixture Substances 0.000 claims description 65
- OMDQUFIYNPYJFM-XKDAHURESA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4r,5s,6r)-4,5,6-trihydroxy-3-[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 claims description 20
- 229920000926 Galactomannan Polymers 0.000 claims description 20
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims description 16
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- 239000002202 Polyethylene glycol Substances 0.000 claims description 10
- 229920001223 polyethylene glycol Polymers 0.000 claims description 10
- 244000007835 Cyamopsis tetragonoloba Species 0.000 claims description 8
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 8
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 8
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
- 229930195725 Mannitol Natural products 0.000 claims description 8
- -1 hydroxypropyl Chemical group 0.000 claims description 8
- 239000000594 mannitol Substances 0.000 claims description 8
- 235000010355 mannitol Nutrition 0.000 claims description 8
- 239000000600 sorbitol Substances 0.000 claims description 8
- 150000001768 cations Chemical class 0.000 claims description 6
- 239000003974 emollient agent Substances 0.000 claims description 6
- 229920001451 polypropylene glycol Polymers 0.000 claims description 6
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 4
- 229920002125 Sokalan® Polymers 0.000 claims description 4
- 239000013543 active substance Substances 0.000 claims description 4
- 229920001400 block copolymer Polymers 0.000 claims description 4
- 235000011187 glycerol Nutrition 0.000 claims description 4
- 239000004584 polyacrylic acid Substances 0.000 claims description 4
- 229920001748 polybutylene Polymers 0.000 claims description 4
- 229920000573 polyethylene Polymers 0.000 claims description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 4
- 239000004327 boric acid Substances 0.000 claims description 2
- 125000005619 boric acid group Chemical group 0.000 claims description 2
- 238000004132 cross linking Methods 0.000 claims description 2
- 230000001050 lubricating effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 description 4
- 229940023490 ophthalmic product Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4817508P | 2008-04-26 | 2008-04-26 | |
| US61/048,175 | 2008-04-26 | ||
| PCT/US2009/041699 WO2009132294A1 (en) | 2008-04-26 | 2009-04-24 | Polymeric artificial tear system |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011518842A JP2011518842A (ja) | 2011-06-30 |
| JP2011518842A5 true JP2011518842A5 (https=) | 2013-03-14 |
| JP5659149B2 JP5659149B2 (ja) | 2015-01-28 |
Family
ID=40886688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011506485A Active JP5659149B2 (ja) | 2008-04-26 | 2009-04-24 | ポリマー性人工涙液系 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US20090270345A1 (https=) |
| EP (1) | EP2278954B1 (https=) |
| JP (1) | JP5659149B2 (https=) |
| KR (1) | KR101592872B1 (https=) |
| CN (1) | CN102046150B (https=) |
| AR (2) | AR071834A1 (https=) |
| AU (1) | AU2009240488B2 (https=) |
| BR (1) | BRPI0910717A2 (https=) |
| CA (1) | CA2722508C (https=) |
| CL (1) | CL2009000985A1 (https=) |
| ES (1) | ES2818619T3 (https=) |
| MX (1) | MX2010011736A (https=) |
| NZ (1) | NZ589323A (https=) |
| TW (1) | TWI526213B (https=) |
| UY (1) | UY31785A1 (https=) |
| WO (1) | WO2009132294A1 (https=) |
| ZA (1) | ZA201007644B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7220431B2 (en) * | 2002-11-27 | 2007-05-22 | Regents Of The University Of Minnesota | Methods and compositions for applying pharmacologic agents to the ear |
| US20050137166A1 (en) * | 2003-12-19 | 2005-06-23 | Alcon, Inc. | Use of cooling agents to relieve mild ocular irritation and enhance comfort |
| BRPI0910717A2 (pt) * | 2008-04-26 | 2015-09-29 | Alcon Res Ltd | sistema polimérico de lágrima artificial |
| TWI547522B (zh) | 2009-07-07 | 2016-09-01 | 愛爾康研究有限公司 | 環氧乙烷環氧丁烷嵌段共聚物組成物 |
| TWI478730B (zh) * | 2009-12-03 | 2015-04-01 | Alcon Res Ltd | 眼科乳劑 |
| PH12012501111A1 (en) * | 2009-12-03 | 2016-09-09 | Novartis Ag | Carboxyvinyl polymer-containing nanoparticles suspensions |
| CA2798069C (en) * | 2010-05-05 | 2016-07-05 | Howard Allen Ketelson | Stabilized ophthalmic galactomannan formulations |
| UA113434C2 (uk) * | 2012-05-04 | 2017-01-25 | Алкон Рісерч, Лтд. | Офтальмологічна композиція з поліпшеним захистом від зневоднювання й утриманням |
| US20130344619A1 (en) | 2012-06-21 | 2013-12-26 | Lightship Medical Limited | Glucose sensor |
| TWI884130B (zh) * | 2018-02-21 | 2025-05-21 | 瑞士商愛爾康公司 | 基於脂質的眼用乳劑 |
| US11730699B2 (en) | 2018-02-21 | 2023-08-22 | Alcon Inc. | Lipid-based ophthalmic emulsion |
| JP6705495B1 (ja) * | 2018-12-26 | 2020-06-03 | 株式会社Ｊｖｃケンウッド | 車両用記録制御装置、車両用記録装置、車両用記録制御方法およびプログラム |
| WO2020177714A1 (zh) * | 2019-03-04 | 2020-09-10 | 中山大学中山眼科中心 | 一种羊毛甾醇前药化合物的组合物及其制备方法和应用 |
| TWI757773B (zh) * | 2019-06-28 | 2022-03-11 | 瑞士商愛爾康公司 | 眼用組成物 |
| JP7419499B2 (ja) | 2019-09-18 | 2024-01-22 | アルコン インク． | 湿式充填のソフトヒドロゲル眼用インサート |
| CN114191378A (zh) * | 2021-11-23 | 2022-03-18 | 温州医科大学附属眼视光医院 | 一种地夸磷索缓释凝胶及其制备方法与应用 |
| WO2025186703A1 (en) | 2024-03-04 | 2025-09-12 | Alcon Inc. | Carbamoylphenylboronic acid-containing acrylic monomers and uses thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4136173A (en) * | 1977-01-31 | 1979-01-23 | American Home Products Corp. | Mixed xanthan gum and locust beam gum therapeutic compositions |
| GB1593954A (en) * | 1977-01-31 | 1981-07-22 | American Home Prod | Xanthan gum or locust bean gum topical therapeutic compositions |
| US5505953A (en) * | 1992-05-06 | 1996-04-09 | Alcon Laboratories, Inc. | Use of borate-polyol complexes in ophthalmic compositions |
| AU8570498A (en) * | 1997-07-29 | 1999-02-22 | Alcon Laboratories, Inc. | Switchable viscoelastic systems containing galactomannan polymers and borate |
| DE69839355T2 (de) * | 1997-07-29 | 2009-06-04 | Alcon Laboratories, Inc., Fort Worth | Ophthalmische Zusammensetzungen enthaltend Galaktomannanpolymere und Borat |
| IT1298758B1 (it) * | 1998-03-19 | 2000-02-02 | Angelini Ricerche Spa | Soluzione umettante e lubrificante per uso oftalmico |
| TWI336257B (en) * | 2003-06-13 | 2011-01-21 | Alcon Inc | Ophthalmic compositions containing a synergistic combination of three polymers |
| EP1696878A1 (en) * | 2003-12-11 | 2006-09-06 | Alcon, Inc. | Ophthalmic compositions containing a polysaccharide/borate gelling system |
| DE102006031500A1 (de) | 2006-07-06 | 2008-04-17 | Henkel Kgaa | O/W-Emulsion |
| US20100021561A1 (en) * | 2006-09-21 | 2010-01-28 | Chowhan Masood A | Self-preserved aqueous pharmaceutical compositions |
| US9096819B2 (en) * | 2008-01-31 | 2015-08-04 | Bausch & Lomb Incorporated | Ophthalmic compositions with an amphoteric surfactant and an anionic biopolymer |
| US8119112B2 (en) * | 2008-01-31 | 2012-02-21 | Bausch & Lomb Incorporated | Ophthalmic compositions with an amphoteric surfactant and hyaluronic acid |
| BRPI0910717A2 (pt) * | 2008-04-26 | 2015-09-29 | Alcon Res Ltd | sistema polimérico de lágrima artificial |
| CA2798069C (en) * | 2010-05-05 | 2016-07-05 | Howard Allen Ketelson | Stabilized ophthalmic galactomannan formulations |
-
2009
- 2009-04-24 BR BRPI0910717A patent/BRPI0910717A2/pt not_active Application Discontinuation
- 2009-04-24 CN CN2009801189624A patent/CN102046150B/zh active Active
- 2009-04-24 UY UY31785A patent/UY31785A1/es not_active Application Discontinuation
- 2009-04-24 WO PCT/US2009/041699 patent/WO2009132294A1/en not_active Ceased
- 2009-04-24 EP EP09734932.8A patent/EP2278954B1/en active Active
- 2009-04-24 CA CA2722508A patent/CA2722508C/en active Active
- 2009-04-24 KR KR1020107026488A patent/KR101592872B1/ko active Active
- 2009-04-24 JP JP2011506485A patent/JP5659149B2/ja active Active
- 2009-04-24 US US12/429,942 patent/US20090270345A1/en not_active Abandoned
- 2009-04-24 AU AU2009240488A patent/AU2009240488B2/en active Active
- 2009-04-24 AR ARP090101464A patent/AR071834A1/es not_active Application Discontinuation
- 2009-04-24 MX MX2010011736A patent/MX2010011736A/es active IP Right Grant
- 2009-04-24 CL CL2009000985A patent/CL2009000985A1/es unknown
- 2009-04-24 TW TW098113635A patent/TWI526213B/zh active
- 2009-04-24 ES ES09734932T patent/ES2818619T3/es active Active
- 2009-04-24 NZ NZ589323A patent/NZ589323A/en not_active IP Right Cessation
-
2010
- 2010-10-26 ZA ZA2010/07644A patent/ZA201007644B/en unknown
-
2011
- 2011-11-22 US US13/302,439 patent/US8685945B2/en active Active
-
2014
- 2014-02-14 US US14/180,396 patent/US9259472B2/en active Active
-
2018
- 2018-07-26 AR ARP180102103 patent/AR112286A2/es unknown
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