JP2011518837A - 再水和可能なチオール化多糖粒子およびスポンジ - Google Patents

再水和可能なチオール化多糖粒子およびスポンジ Download PDF

Info

Publication number
JP2011518837A
JP2011518837A JP2011506462A JP2011506462A JP2011518837A JP 2011518837 A JP2011518837 A JP 2011518837A JP 2011506462 A JP2011506462 A JP 2011506462A JP 2011506462 A JP2011506462 A JP 2011506462A JP 2011518837 A JP2011518837 A JP 2011518837A
Authority
JP
Japan
Prior art keywords
polysaccharide
thiolated
particles
sponge
gel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011506462A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011518837A5 (enExample
Inventor
ミンッティ，マシュー・エフ
オリヴァー，ダナ・エイ
ヴァッカロ，ブライアン・ジェイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Inc
Original Assignee
Medtronic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Inc filed Critical Medtronic Inc
Publication of JP2011518837A publication Critical patent/JP2011518837A/ja
Publication of JP2011518837A5 publication Critical patent/JP2011518837A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0036—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/08—Cellulose derivatives
    • C08L1/26—Cellulose ethers
    • C08L1/28—Alkyl ethers
    • C08L1/286—Alkyl ethers substituted with acid radicals, e.g. carboxymethyl cellulose [CMC]
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L3/00—Compositions of starch, amylose or amylopectin or of their derivatives or degradation products
    • C08L3/02—Starch; Degradation products thereof, e.g. dextrin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/02—Dextran; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/04—Alginic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/12—Agar or agar-agar, i.e. mixture of agarose and agaropectin; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2210/00—Compositions for preparing hydrogels

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2011506462A 2008-04-24 2009-04-23 再水和可能なチオール化多糖粒子およびスポンジ Pending JP2011518837A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4759808P 2008-04-24 2008-04-24
US61/047,598 2008-04-24
PCT/US2009/041588 WO2009132224A2 (en) 2008-04-24 2009-04-23 Rehydratable thiolated polysaccharide particles and sponge

Publications (2)

Publication Number Publication Date
JP2011518837A true JP2011518837A (ja) 2011-06-30
JP2011518837A5 JP2011518837A5 (enExample) 2012-06-14

Family

ID=40823262

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011506462A Pending JP2011518837A (ja) 2008-04-24 2009-04-23 再水和可能なチオール化多糖粒子およびスポンジ

Country Status (7)

Country Link
US (1) US9198997B2 (enExample)
EP (1) EP2291524A2 (enExample)
JP (1) JP2011518837A (enExample)
CN (1) CN102083476B (enExample)
AU (1) AU2009240509B2 (enExample)
CA (1) CA2722145A1 (enExample)
WO (1) WO2009132224A2 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8932560B2 (en) 2007-09-04 2015-01-13 University of Maryland, College Parke Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells
US8668899B2 (en) 2009-11-13 2014-03-11 University Of Maryland, College Park Advanced functional biocompatible foam used as a hemostatic agent for compressible and non-compressible acute wounds
US9486190B2 (en) * 2011-10-28 2016-11-08 Medtronic Xomed, Inc. Spray delivery system
WO2014160136A1 (en) 2013-03-13 2014-10-02 University Of Maryland, Office Of Technology Commercialization Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells
CN107750274A (zh) 2015-06-08 2018-03-02 康宁股份有限公司 用于水凝胶微载体的干燥制剂
ES2846848T3 (es) 2015-10-26 2021-07-29 Harvard College Polisacáridos reducidos y oxidados y métodos de uso de los mismos
EP3484450A4 (en) 2016-07-18 2020-04-01 Tissuegen, Inc. METHODS AND COMPOSITIONS FOR MAINTAINING THE CONFORMATION AND STRUCTURAL INTEGRITY OF BIOMOLECULES
US10786596B2 (en) * 2018-01-12 2020-09-29 Boston Scientific Scimed, Inc. Powder for achieving hemostasis
US12091471B2 (en) 2018-11-19 2024-09-17 Endomedix, Inc. Methods and compositions for achieving hemostasis and stable blood clot formation
US10517988B1 (en) 2018-11-19 2019-12-31 Endomedix, Inc. Methods and compositions for achieving hemostasis and stable blood clot formation
US11692161B2 (en) 2019-02-05 2023-07-04 Corning Incorporated Packed-bed bioreactor systems and methods of using the same
US11118151B2 (en) 2019-11-05 2021-09-14 Corning Incorporated Fixed bed bioreactor and methods of using the same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0625303A (ja) * 1992-04-17 1994-02-01 Kimberly Clark Corp 改善した吸収性を有する改質ポリサッカライド及びその製造方法
JP2005505644A (ja) * 2001-08-31 2005-02-24 ムコビオマー・ビオテヒノロギシェ・フォルシュングス−ウント・エントヴィックルングス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング キトサン−チオ−アミジン複合体ならびにその化粧的および薬学的使用
WO2008005671A2 (en) * 2006-07-05 2008-01-10 Medtronic Xomed, Inc. Flexible bioresorbable hemostatic packing and stent

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3184385A (en) * 1961-10-16 1965-05-18 Eastman Kodak Co Dry, vitamin-active product and process for preparing same
US3678931A (en) * 1970-06-09 1972-07-25 Milton J Cohen Syringe
US3914214A (en) 1973-08-24 1975-10-21 Us Agriculture Thiolation of polysaccharides
US3989044A (en) * 1975-08-11 1976-11-02 Warner-Lambert Company Syringe
US4604384A (en) * 1982-06-24 1986-08-05 Smith Robert A Pharmaceutical gel composition
US4659700A (en) 1984-03-02 1987-04-21 Johnson & Johnson Products, Inc. Chitosan-glycerol-water gel
US4895724A (en) 1985-06-07 1990-01-23 Pfizer Inc. Chitosan compositions for controlled and prolonged release of macromolecules
US4960413A (en) 1985-11-09 1990-10-02 The Shirley Institute Wound dressing
JPS62123112A (ja) 1985-11-22 1987-06-04 Sunstar Inc 軟膏基剤
IT1219587B (it) * 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
JPH07116241B2 (ja) 1989-02-08 1995-12-13 サッポロビール株式会社 米糠由来生理活性多糖ｒｏｎの製造法
US5346703A (en) 1990-08-07 1994-09-13 Mediventures, Inc. Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels
GB9105995D0 (en) 1991-03-21 1991-05-08 Smith & Nephew Wound dressing
US5318780A (en) 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
US5308546A (en) 1991-12-09 1994-05-03 Glow-Tec Phosphorescent toy gel composition and methods of manufacture
US5550189A (en) * 1992-04-17 1996-08-27 Kimberly-Clark Corporation Modified polysaccharides having improved absorbent properties and process for the preparation thereof
US6197346B1 (en) 1992-04-24 2001-03-06 Brown Universtiy Research Foundation Bioadhesive microspheres and their use as drug delivery and imaging systems
US5312324A (en) 1992-09-15 1994-05-17 Walthour Charles D Nasal dressing system
GB2276819B (en) * 1993-03-23 1996-12-11 Johnson & Johnson Medical Aqueous wound treatment composition comprising a polysaccharide and hexylene glycol
US5709854A (en) 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5744155A (en) 1993-08-13 1998-04-28 Friedman; Doron Bioadhesive emulsion preparations for enhanced drug delivery
US5531716A (en) 1993-09-29 1996-07-02 Hercules Incorporated Medical devices subject to triggered disintegration
US5622834A (en) 1993-12-01 1997-04-22 Marine Polymer Technologies, Inc. Method of isolating poly-β-1-4-N-acetylglucosamine from microalgal culture
GB9416884D0 (en) 1994-08-20 1994-10-12 Danbiosyst Uk Drug delivery compositions
GB9422571D0 (en) * 1994-11-09 1995-01-04 Whitehall Lab Ltd Haemorrihoidal compositions and method of use
CN1090022C (zh) 1995-04-04 2002-09-04 俄克拉荷马创伤治疗所 通过光动力疗法与免疫佐剂联合应用治疗癌症
US5679658A (en) 1995-05-08 1997-10-21 Chitogenics, Inc. N,O-carbonxymethylchitosan for prevention of surgical adhesions
US6320029B1 (en) 1996-11-29 2001-11-20 The American National Red Cross Methods of production and use of liquid formulations of plasma proteins
EP1704878B1 (en) * 1995-12-18 2013-04-10 AngioDevice International GmbH Crosslinked polymer compositions and methods for their use
US6458889B1 (en) 1995-12-18 2002-10-01 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
US5985312A (en) 1996-01-26 1999-11-16 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers
IL118376A0 (en) * 1996-05-22 1996-09-12 Univ Ben Gurion Polysaccharide sponges for cell culture and transplantation
IN192791B (enExample) 1996-06-28 2004-05-22 Johnson & Johnson Medical
US6706690B2 (en) 1999-06-10 2004-03-16 Baxter Healthcare Corporation Hemoactive compositions and methods for their manufacture and use
CN1113672C (zh) 1996-11-05 2003-07-09 嘉年生化产品有限公司 用京尼平对生物医学材料进行化学改性
US6545042B2 (en) 1996-11-05 2003-04-08 Gp Medical Acellular biological material chemically treated with genipin
ATA7997A (de) 1997-01-21 1998-03-15 Bernkop Schnuerch Andreas Verfahren zur herstellung von chitosan-ethylendiamintetraacetat konjugaten
US6224893B1 (en) 1997-04-11 2001-05-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
US20050096282A1 (en) * 1997-04-21 2005-05-05 Lewin Alfred S. Adeno-associated virus-delivered ribozyme compositions and methods for the treatment of retinal diseases
US20030073663A1 (en) * 1997-06-25 2003-04-17 David M Wiseman Bioabsorbable medical devices from oxidized polysaccharides
ATE247990T1 (de) 1997-07-02 2003-09-15 Coloplast As Herstellungsmethode für ein faserfreies, poröses material
CA2212300A1 (en) 1997-08-04 1999-02-04 Abdellatif Chenite In vitro or in vivo gelfying chitosan and therapeutic uses thereof
AU751182B2 (en) 1997-12-02 2002-08-08 Archimedes Development Limited Compositions for nasal administration
US6514522B2 (en) 1998-04-08 2003-02-04 Chondros, Inc. Polymer constructs
CA2341732C (en) 1998-08-26 2008-08-19 Teijin Limited Powder composition for nasal administration
JP2000095678A (ja) * 1998-09-22 2000-04-04 Dai Ichi Kogyo Seiyaku Co Ltd パップ剤用基剤およびそれを含有するパップ剤
AT406054B (de) 1998-11-04 2000-02-25 Andreas Bernkop-Schnuerch Verfahren zur verbesserung der mucoadhäsion von polymeren sowie deren herstellung und verwendung
EP1152013B1 (en) 1998-11-10 2008-04-23 Netech Inc. Functional chitosan derivative
AU1908500A (en) * 1998-11-30 2000-06-19 Hercules Incorporated Controlled release carbohydrate embedded in a crosslinked polysaccharide
AU2707500A (en) 1998-12-04 2000-06-26 Incept Llc Biocompatible crosslinked polymers
BR0007296A (pt) 1999-01-04 2002-02-05 Biomm Inc Novas formulações poliméricas contendo compostos perfluorados para a engenharia de células e tecidos para transplantes que melhoram o metabolismo e a sobrevivência celular, e métodos para a sua produção
US6645947B1 (en) 1999-05-20 2003-11-11 Chitogenics, Inc. Adhesive N, O-carboxymethylchitosan coatings which inhibit attachment of substrate-dependent cells and proteins
JP2003503367A (ja) 1999-06-11 2003-01-28 シアウォーター・コーポレイション キトサンとポリ（エチレングリコール）または関連ポリマーから得られるヒドロゲル
AU782519B2 (en) 1999-11-09 2005-08-04 Denki Kagaku Kogyo Kabushiki Kaisha Use of soluble cellulose derivative having been made hardly soluble in water and process for producing the same
BR0109162A (pt) 2000-03-14 2005-01-11 Alcon Inc Viscoelásticos para uso na cirurgia do ouvido médio
WO2004087227A1 (en) 2003-04-04 2004-10-14 Tissuemed Limited Tissue-adhesive formulations
US6719987B2 (en) 2000-04-17 2004-04-13 Nucryst Pharmaceuticals Corp. Antimicrobial bioabsorbable materials
US6991652B2 (en) 2000-06-13 2006-01-31 Burg Karen J L Tissue engineering composite
DE10035799A1 (de) * 2000-07-22 2002-01-31 Kalle Nalo Gmbh & Co Kg Nach dem Aminoxidverfahren hergestellte Nahrungsmittelhüllen auf Cellulosebasis
GB0018527D0 (en) * 2000-07-27 2000-09-13 Photocure Asa Composition
US6989156B2 (en) 2001-04-23 2006-01-24 Nucryst Pharmaceuticals Corp. Therapeutic treatments using the direct application of antimicrobial metal compositions
US6417347B1 (en) * 2000-08-24 2002-07-09 Scimed Life Systems, Inc. High yield S-nitrosylation process
IT1317358B1 (it) 2000-08-31 2003-06-16 Fidia Advanced Biopolymers Srl Derivati cross-linkati dell'acido ialuronico.
US6989373B2 (en) 2000-11-15 2006-01-24 Bio Syntech Canada Inc. Method for restoring a fat-pad
AU2001298061A1 (en) 2000-12-13 2003-07-09 Purdue Research Foundation Microencapsulation of drugs by solvent exchange
JP3611534B2 (ja) 2001-04-26 2005-01-19 株式会社エス・エヌ・シー 高分子包接性化合物からなる有害物質除去のための繊維およびその製造方法ならびに使用
US20020193812A1 (en) * 2001-05-04 2002-12-19 Concentric Medical Hydrogel vaso-occlusive device
US20060004314A1 (en) * 2001-06-14 2006-01-05 Hemcon, Inc. Antimicrobial barriers, systems, and methods formed from hydrophilic polymer structures such as chistosan
DE10152407A1 (de) * 2001-10-24 2003-05-08 Aesculap Ag & Co Kg Zusammensetzung aus mindestens zwei biokompatiblen chemisch vernetzbaren Komponenten
WO2003042250A1 (en) 2001-11-15 2003-05-22 Biosyntech Canada Inc. Composition and method to homogeneously modify or cross-link chitosan under neutral conditions
US20030187381A1 (en) 2001-12-28 2003-10-02 Genzyme Corporation Bioresorbable foam packing device and use thereof
US6664301B1 (en) 2002-02-20 2003-12-16 Robert D. Kross Method for using glycol additives to texturally modify natural gum hydrogels
GB2386900B (en) * 2002-03-25 2006-11-01 Johnson & Johnson Medical Ltd Use in wound dressings of chemically modified polysaccharides
AU2003227447A1 (en) 2002-04-23 2003-11-10 Netech Inc. Medicinal compositions containing photocrosslinkable chitosan derivative
US20050176620A1 (en) 2002-06-21 2005-08-11 Prestwich Glenn D. Crosslinked compounds and methods of making and using thereof
US20050019404A1 (en) * 2003-06-30 2005-01-27 Hsing-Wen Sung Drug-eluting biodegradable stent
US7070582B2 (en) 2002-08-09 2006-07-04 Boston Scientific Scimed, Inc. Injection devices that provide reduced outflow of therapeutic agents and methods of delivering therapeutic agents
GB2393120A (en) * 2002-09-18 2004-03-24 Johnson & Johnson Medical Ltd Compositions for wound treatment
US7862831B2 (en) 2002-10-09 2011-01-04 Synthasome, Inc. Method and material for enhanced tissue-biomaterial integration
US8673333B2 (en) 2002-09-25 2014-03-18 The Johns Hopkins University Cross-linked polymer matrices, and methods of making and using same
JP5102435B2 (ja) 2002-10-08 2012-12-19 株式会社リコム キトサン含有多糖、その製造方法及び用途
US20050069572A1 (en) 2002-10-09 2005-03-31 Jennifer Elisseeff Multi-layered polymerizing hydrogels for tissue regeneration
US7229966B2 (en) 2002-12-17 2007-06-12 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity
TWI251596B (en) 2002-12-31 2006-03-21 Ind Tech Res Inst Method for producing a double-crosslinked hyaluronate material
DE10318802A1 (de) * 2003-04-17 2004-11-04 Aesculap Ag & Co. Kg Selbsthaftendes resorbierbares Hämostyptikum
WO2005000374A1 (ja) * 2003-06-30 2005-01-06 Denki Kagaku Kogyo Kabushiki Kaisha 脊椎・脊髄手術用癒着防止材
US8124120B2 (en) * 2003-12-22 2012-02-28 Anika Therapeutics, Inc. Crosslinked hyaluronic acid compositions for tissue augmentation
US7901707B2 (en) 2004-03-15 2011-03-08 Christine Allen Biodegradable biocompatible implant and method of manufacturing same
WO2006008270A1 (de) 2004-07-22 2006-01-26 Thiomatrix Forschungs- Und Beratungs Gmbh Verwendung von thiolgruppen-hältigen verbindungen als efflux-pumpen-hemmer
US7282194B2 (en) * 2004-10-05 2007-10-16 Gp Medical, Inc. Nanoparticles for protein drug delivery
US8703659B2 (en) * 2005-01-24 2014-04-22 Halliburton Energy Services, Inc. Sealant composition comprising a gel system and a reduced amount of cement for a permeable zone downhole
US7834065B2 (en) * 2005-01-31 2010-11-16 Bmg Incorporated Medical-use two part reactive adhesive and medical-use resin having self-degradation property
US8679484B2 (en) * 2005-03-02 2014-03-25 Polyrizon Ltd. Method for removal of toxins from mucosal membranes
CN101137359B (zh) * 2005-03-10 2011-01-12 3M创新有限公司 治疗耳感染的方法
EP1880738A1 (en) 2005-05-13 2008-01-23 Netech Inc. Medical composition for promotion of skin regeneration
DE102005030011A1 (de) * 2005-06-17 2006-12-21 Aesculap Ag & Co. Kg Verfahren zur Herstellung von sterilen Polysaccharidlösungen
US20070031467A1 (en) * 2005-08-04 2007-02-08 Abrahams John M Composition and method for vascular embolization
FR2889449B1 (fr) 2005-08-05 2011-06-10 Khorionyx Preparations implantables
US20070087059A1 (en) 2005-10-17 2007-04-19 Frank Everaerts Bioactive delivery matrix compositions and methods
US20070110788A1 (en) 2005-11-14 2007-05-17 Hissong James B Injectable formulation capable of forming a drug-releasing device
WO2007084725A2 (en) 2006-01-19 2007-07-26 Osteotech, Inc. Injectable and moldable bone substitute materials
FR2897775B1 (fr) 2006-02-24 2013-05-03 Elisabeth Laugier Biomateriau, implant injectable le comprenant, son procede de preparation et ses utilisations
WO2007120818A2 (en) * 2006-04-12 2007-10-25 Massachusetts Institute Of Technology Compositions and methods for inhibiting adhesions
US20080075657A1 (en) 2006-04-18 2008-03-27 Abrahams John M Biopolymer system for tissue sealing
US20090010982A1 (en) 2006-04-18 2009-01-08 Endomedix, Inc. Biocompatible adherent sheet for tissue sealing
US7854923B2 (en) 2006-04-18 2010-12-21 Endomedix, Inc. Biopolymer system for tissue sealing
US20070243130A1 (en) 2006-04-18 2007-10-18 Weiliam Chen Biopolymer system for tissue sealing
US7959943B2 (en) 2006-05-10 2011-06-14 Medtronics Xomed, Inc. Solvating system and sealant for medical use in the middle or inner ear
CN100348272C (zh) 2006-06-23 2007-11-14 华南理工大学 可溶性纤维素止血海绵的制备方法
WO2008008857A2 (en) * 2006-07-11 2008-01-17 University Of Utah Research Foundation Thiolated macromolecules and methods of making and using thereof
JP2008247975A (ja) 2007-03-29 2008-10-16 Daicel Chem Ind Ltd 架橋ゲルおよびそれを用いた吸収体
JP2008285611A (ja) 2007-05-18 2008-11-27 Daicel Chem Ind Ltd 架橋ゲルの製造方法及びその架橋ゲル
JP2009040697A (ja) * 2007-08-07 2009-02-26 Asuka Corporation:Kk 化粧料組成物
US20090062233A1 (en) 2007-08-09 2009-03-05 Xin Ji Modified starch material of biocompatible hemostasis
CN101848739A (zh) 2007-08-28 2010-09-29 T·阿萨纳夏季斯 手术用水凝胶

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0625303A (ja) * 1992-04-17 1994-02-01 Kimberly Clark Corp 改善した吸収性を有する改質ポリサッカライド及びその製造方法
JP2005505644A (ja) * 2001-08-31 2005-02-24 ムコビオマー・ビオテヒノロギシェ・フォルシュングス−ウント・エントヴィックルングス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング キトサン−チオ−アミジン複合体ならびにその化粧的および薬学的使用
WO2008005671A2 (en) * 2006-07-05 2008-01-10 Medtronic Xomed, Inc. Flexible bioresorbable hemostatic packing and stent

Also Published As

Publication number Publication date
AU2009240509B2 (en) 2014-08-21
EP2291524A2 (en) 2011-03-09
CN102083476B (zh) 2016-08-31
US9198997B2 (en) 2015-12-01
WO2009132224A3 (en) 2009-12-17
US20090285897A1 (en) 2009-11-19
AU2009240509A1 (en) 2009-10-29
CA2722145A1 (en) 2009-10-29
WO2009132224A2 (en) 2009-10-29
CN102083476A (zh) 2011-06-01

Similar Documents

Publication Publication Date Title
JP5738753B2 (ja) 再水和可能な多糖粒子およびスポンジ
JP5757861B2 (ja) キトサン−含有保護用組成物
JP2011518837A (ja) 再水和可能なチオール化多糖粒子およびスポンジ
JP5833919B2 (ja) キトサンと酸化多糖とに基づく保護用ゲル
JP5711113B2 (ja) チオール化キトサンゲル
JP6962919B2 (ja) 溶解可能な鼻洞スポンジ

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120423

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20120423

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20131025

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140127

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140203

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140225

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140304

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140325

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140401

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140425

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20140604