JP2011517937A - 体細胞性及び卵巣癌の診断のためのインビトロ診断方法 - Google Patents
体細胞性及び卵巣癌の診断のためのインビトロ診断方法 Download PDFInfo
- Publication number
- JP2011517937A JP2011517937A JP2011502373A JP2011502373A JP2011517937A JP 2011517937 A JP2011517937 A JP 2011517937A JP 2011502373 A JP2011502373 A JP 2011502373A JP 2011502373 A JP2011502373 A JP 2011502373A JP 2011517937 A JP2011517937 A JP 2011517937A
- Authority
- JP
- Japan
- Prior art keywords
- seq
- nucleic acid
- proteins
- acid molecules
- varies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000000392 somatic effect Effects 0.000 title claims abstract description 137
- 206010061535 Ovarian neoplasm Diseases 0.000 title claims abstract description 68
- 206010033128 Ovarian cancer Diseases 0.000 title claims abstract description 64
- 238000000338 in vitro Methods 0.000 title claims abstract description 42
- 238000003745 diagnosis Methods 0.000 title claims abstract description 35
- 238000002405 diagnostic procedure Methods 0.000 title description 3
- 150000007523 nucleic acids Chemical class 0.000 claims abstract description 475
- 102000039446 nucleic acids Human genes 0.000 claims abstract description 363
- 108020004707 nucleic acids Proteins 0.000 claims abstract description 363
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 231
- 201000011510 cancer Diseases 0.000 claims abstract description 164
- 239000012634 fragment Substances 0.000 claims abstract description 90
- 230000002159 abnormal effect Effects 0.000 claims abstract description 26
- 108090000623 proteins and genes Proteins 0.000 claims description 640
- 102000004169 proteins and genes Human genes 0.000 claims description 224
- 150000001413 amino acids Chemical class 0.000 claims description 113
- 239000000523 sample Substances 0.000 claims description 109
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 71
- 238000000034 method Methods 0.000 claims description 64
- 238000002493 microarray Methods 0.000 claims description 63
- 108020005187 Oligonucleotide Probes Proteins 0.000 claims description 59
- 239000002751 oligonucleotide probe Substances 0.000 claims description 59
- 239000012472 biological sample Substances 0.000 claims description 50
- 239000003795 chemical substances by application Substances 0.000 claims description 41
- 108091034117 Oligonucleotide Proteins 0.000 claims description 36
- 229920001184 polypeptide Polymers 0.000 claims description 25
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 25
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 25
- 239000002773 nucleotide Substances 0.000 claims description 24
- 125000003729 nucleotide group Chemical group 0.000 claims description 24
- 230000000295 complement effect Effects 0.000 claims description 23
- 238000012408 PCR amplification Methods 0.000 claims description 12
- 230000008859 change Effects 0.000 claims description 11
- 230000015572 biosynthetic process Effects 0.000 claims description 9
- 239000013642 negative control Substances 0.000 claims description 9
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims description 7
- 239000002299 complementary DNA Substances 0.000 claims description 7
- 208000019691 hematopoietic and lymphoid cell neoplasm Diseases 0.000 claims description 7
- 239000013641 positive control Substances 0.000 claims description 6
- 238000003365 immunocytochemistry Methods 0.000 claims description 5
- 238000010166 immunofluorescence Methods 0.000 claims description 5
- 238000003364 immunohistochemistry Methods 0.000 claims description 5
- 238000001114 immunoprecipitation Methods 0.000 claims description 5
- 238000010839 reverse transcription Methods 0.000 claims description 5
- 238000001262 western blot Methods 0.000 claims description 5
- 238000002965 ELISA Methods 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 230000001747 exhibiting effect Effects 0.000 claims description 3
- 238000002372 labelling Methods 0.000 claims description 3
- 238000003753 real-time PCR Methods 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 20
- 230000003321 amplification Effects 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 230000014509 gene expression Effects 0.000 abstract description 160
- 210000001550 testis Anatomy 0.000 description 189
- 210000002826 placenta Anatomy 0.000 description 144
- 210000001519 tissue Anatomy 0.000 description 98
- 210000004027 cell Anatomy 0.000 description 62
- 241000282414 Homo sapiens Species 0.000 description 33
- 230000001973 epigenetic effect Effects 0.000 description 30
- 238000013459 approach Methods 0.000 description 25
- 210000001082 somatic cell Anatomy 0.000 description 23
- 238000009396 hybridization Methods 0.000 description 19
- 210000004602 germ cell Anatomy 0.000 description 18
- 238000004458 analytical method Methods 0.000 description 17
- 101150070926 ct gene Proteins 0.000 description 15
- 210000004556 brain Anatomy 0.000 description 14
- 108091033319 polynucleotide Proteins 0.000 description 14
- 102000040430 polynucleotide Human genes 0.000 description 14
- 239000002157 polynucleotide Substances 0.000 description 14
- 230000002074 deregulated effect Effects 0.000 description 13
- 230000002381 testicular Effects 0.000 description 13
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 12
- 230000003211 malignant effect Effects 0.000 description 12
- 108010033040 Histones Proteins 0.000 description 11
- 230000003831 deregulation Effects 0.000 description 11
- 230000003169 placental effect Effects 0.000 description 11
- 108020004414 DNA Proteins 0.000 description 10
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 description 10
- 230000009368 gene silencing by RNA Effects 0.000 description 10
- 208000020816 lung neoplasm Diseases 0.000 description 9
- 230000007067 DNA methylation Effects 0.000 description 8
- 210000002950 fibroblast Anatomy 0.000 description 8
- 210000004072 lung Anatomy 0.000 description 8
- 230000011987 methylation Effects 0.000 description 8
- 238000007069 methylation reaction Methods 0.000 description 8
- 238000001514 detection method Methods 0.000 description 7
- 238000000126 in silico method Methods 0.000 description 7
- 108020004999 messenger RNA Proteins 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 108700039691 Genetic Promoter Regions Proteins 0.000 description 6
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 6
- 241000699666 Mus <mouse, genus> Species 0.000 description 6
- 230000028993 immune response Effects 0.000 description 6
- 201000005202 lung cancer Diseases 0.000 description 6
- 230000002018 overexpression Effects 0.000 description 6
- 238000011160 research Methods 0.000 description 6
- 102000006947 Histones Human genes 0.000 description 5
- 101150112897 TS gene Proteins 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 230000004048 modification Effects 0.000 description 5
- 238000012986 modification Methods 0.000 description 5
- 210000001672 ovary Anatomy 0.000 description 5
- 239000008194 pharmaceutical composition Substances 0.000 description 5
- 101150111062 C gene Proteins 0.000 description 4
- 206010009944 Colon cancer Diseases 0.000 description 4
- 108060003951 Immunoglobulin Proteins 0.000 description 4
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 4
- 108010029485 Protein Isoforms Proteins 0.000 description 4
- 102000001708 Protein Isoforms Human genes 0.000 description 4
- 239000013614 RNA sample Substances 0.000 description 4
- 108020004459 Small interfering RNA Proteins 0.000 description 4
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 4
- 230000001594 aberrant effect Effects 0.000 description 4
- 230000010307 cell transformation Effects 0.000 description 4
- 210000001072 colon Anatomy 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- 210000002308 embryonic cell Anatomy 0.000 description 4
- 108010051779 histone H3 trimethyl Lys4 Proteins 0.000 description 4
- 230000002163 immunogen Effects 0.000 description 4
- 102000018358 immunoglobulin Human genes 0.000 description 4
- 229940072221 immunoglobulins Drugs 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 208000037841 lung tumor Diseases 0.000 description 4
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 4
- 238000010197 meta-analysis Methods 0.000 description 4
- 201000002528 pancreatic cancer Diseases 0.000 description 4
- 208000008443 pancreatic carcinoma Diseases 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000011002 quantification Methods 0.000 description 4
- 238000013518 transcription Methods 0.000 description 4
- 230000035897 transcription Effects 0.000 description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 3
- 102000053602 DNA Human genes 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- 206010025323 Lymphomas Diseases 0.000 description 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 3
- 239000004472 Lysine Substances 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 238000000636 Northern blotting Methods 0.000 description 3
- 101150072307 PS gene Proteins 0.000 description 3
- 206010039491 Sarcoma Diseases 0.000 description 3
- 208000024313 Testicular Neoplasms Diseases 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 210000003719 b-lymphocyte Anatomy 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000000481 breast Anatomy 0.000 description 3
- 208000035269 cancer or benign tumor Diseases 0.000 description 3
- 208000029742 colonic neoplasm Diseases 0.000 description 3
- 238000001962 electrophoresis Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 230000030279 gene silencing Effects 0.000 description 3
- 210000002980 germ line cell Anatomy 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 208000032839 leukemia Diseases 0.000 description 3
- 210000000496 pancreas Anatomy 0.000 description 3
- 210000002307 prostate Anatomy 0.000 description 3
- -1 rRNA Proteins 0.000 description 3
- 210000001995 reticulocyte Anatomy 0.000 description 3
- 239000004055 small Interfering RNA Substances 0.000 description 3
- 108700026220 vif Genes Proteins 0.000 description 3
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- 101150058734 A gene Proteins 0.000 description 2
- 101150076489 B gene Proteins 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 2
- 208000026310 Breast neoplasm Diseases 0.000 description 2
- 208000011691 Burkitt lymphomas Diseases 0.000 description 2
- 206010008342 Cervix carcinoma Diseases 0.000 description 2
- 108700024394 Exon Proteins 0.000 description 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 2
- 206010060862 Prostate cancer Diseases 0.000 description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 2
- 108091028664 Ribonucleotide Proteins 0.000 description 2
- 206010041067 Small cell lung cancer Diseases 0.000 description 2
- 108091027967 Small hairpin RNA Proteins 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 206010057644 Testis cancer Diseases 0.000 description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 2
- 208000009956 adenocarcinoma Diseases 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- 201000010881 cervical cancer Diseases 0.000 description 2
- 238000013075 data extraction Methods 0.000 description 2
- 238000007418 data mining Methods 0.000 description 2
- 238000013079 data visualisation Methods 0.000 description 2
- 238000012217 deletion Methods 0.000 description 2
- 230000037430 deletion Effects 0.000 description 2
- 239000005547 deoxyribonucleotide Substances 0.000 description 2
- 125000002637 deoxyribonucleotide group Chemical group 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000004049 epigenetic modification Effects 0.000 description 2
- 230000006718 epigenetic regulation Effects 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 238000010195 expression analysis Methods 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 210000005229 liver cell Anatomy 0.000 description 2
- 210000001165 lymph node Anatomy 0.000 description 2
- 210000003794 male germ cell Anatomy 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000021121 meiosis Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 239000002336 ribonucleotide Substances 0.000 description 2
- 125000002652 ribonucleotide group Chemical group 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 210000002863 seminiferous tubule Anatomy 0.000 description 2
- 208000000587 small cell lung carcinoma Diseases 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 238000011895 specific detection Methods 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 210000000130 stem cell Anatomy 0.000 description 2
- 230000000153 supplemental effect Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 230000009897 systematic effect Effects 0.000 description 2
- 201000003120 testicular cancer Diseases 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 201000002510 thyroid cancer Diseases 0.000 description 2
- 230000002103 transcriptional effect Effects 0.000 description 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 2
- 210000003932 urinary bladder Anatomy 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 1
- 208000036762 Acute promyelocytic leukaemia Diseases 0.000 description 1
- 208000009746 Adult T-Cell Leukemia-Lymphoma Diseases 0.000 description 1
- 206010001413 Adult T-cell lymphoma/leukaemia Diseases 0.000 description 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 1
- 239000010754 BS 2869 Class F Substances 0.000 description 1
- 239000010755 BS 2869 Class G Substances 0.000 description 1
- 206010004146 Basal cell carcinoma Diseases 0.000 description 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 208000003174 Brain Neoplasms Diseases 0.000 description 1
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 208000009458 Carcinoma in Situ Diseases 0.000 description 1
- 208000005243 Chondrosarcoma Diseases 0.000 description 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 206010052360 Colorectal adenocarcinoma Diseases 0.000 description 1
- 108020004635 Complementary DNA Proteins 0.000 description 1
- 108091029523 CpG island Proteins 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 230000004544 DNA amplification Effects 0.000 description 1
- 230000006820 DNA synthesis Effects 0.000 description 1
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 1
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 1
- 101100477411 Dictyostelium discoideum set1 gene Proteins 0.000 description 1
- 206010014733 Endometrial cancer Diseases 0.000 description 1
- 206010014759 Endometrial neoplasm Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 1
- 208000006168 Ewing Sarcoma Diseases 0.000 description 1
- 201000008808 Fibrosarcoma Diseases 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 208000021309 Germ cell tumor Diseases 0.000 description 1
- 208000032612 Glial tumor Diseases 0.000 description 1
- 206010018338 Glioma Diseases 0.000 description 1
- 208000017604 Hodgkin disease Diseases 0.000 description 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 description 1
- 208000007766 Kaposi sarcoma Diseases 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- 208000018142 Leiomyosarcoma Diseases 0.000 description 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 1
- 206010052178 Lymphocytic lymphoma Diseases 0.000 description 1
- 101150033052 MAS5 gene Proteins 0.000 description 1
- 206010025598 Malignant hydatidiform mole Diseases 0.000 description 1
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 description 1
- 208000000172 Medulloblastoma Diseases 0.000 description 1
- 208000003445 Mouth Neoplasms Diseases 0.000 description 1
- 208000034578 Multiple myelomas Diseases 0.000 description 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 1
- 108700019961 Neoplasm Genes Proteins 0.000 description 1
- 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 description 1
- 206010029260 Neuroblastoma Diseases 0.000 description 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 1
- 108700026244 Open Reading Frames Proteins 0.000 description 1
- 208000010191 Osteitis Deformans Diseases 0.000 description 1
- 208000027868 Paget disease Diseases 0.000 description 1
- 206010033645 Pancreatitis Diseases 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 241001085205 Prenanthella exigua Species 0.000 description 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
- 238000001190 Q-PCR Methods 0.000 description 1
- 102000009572 RNA Polymerase II Human genes 0.000 description 1
- 108010009460 RNA Polymerase II Proteins 0.000 description 1
- 208000015634 Rectal Neoplasms Diseases 0.000 description 1
- 206010038389 Renal cancer Diseases 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 101100344462 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) YDJ1 gene Proteins 0.000 description 1
- 238000002105 Southern blotting Methods 0.000 description 1
- 208000024770 Thyroid neoplasm Diseases 0.000 description 1
- 108700025716 Tumor Suppressor Genes Proteins 0.000 description 1
- 102000044209 Tumor Suppressor Genes Human genes 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 208000008383 Wilms tumor Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000012197 amplification kit Methods 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 208000003373 basosquamous carcinoma Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 201000009036 biliary tract cancer Diseases 0.000 description 1
- 208000020790 biliary tract neoplasm Diseases 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 201000000053 blastoma Diseases 0.000 description 1
- 210000002937 blood-testis barrier Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000133 brain stem Anatomy 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000011748 cell maturation Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 201000010989 colorectal carcinoma Diseases 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000017858 demethylation Effects 0.000 description 1
- 238000010520 demethylation reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 201000008184 embryoma Diseases 0.000 description 1
- 230000007608 epigenetic mechanism Effects 0.000 description 1
- 201000004101 esophageal cancer Diseases 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 108091008053 gene clusters Proteins 0.000 description 1
- 208000005017 glioblastoma Diseases 0.000 description 1
- 210000002149 gonad Anatomy 0.000 description 1
- 230000003394 haemopoietic effect Effects 0.000 description 1
- 201000010536 head and neck cancer Diseases 0.000 description 1
- 208000014829 head and neck neoplasm Diseases 0.000 description 1
- 201000005787 hematologic cancer Diseases 0.000 description 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 230000006607 hypermethylation Effects 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000002390 hyperplastic effect Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 description 1
- 206010024627 liposarcoma Diseases 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 208000003747 lymphoid leukemia Diseases 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 208000027202 mammary Paget disease Diseases 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 108091070501 miRNA Proteins 0.000 description 1
- 239000002679 microRNA Substances 0.000 description 1
- 238000005065 mining Methods 0.000 description 1
- 201000008026 nephroblastoma Diseases 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 208000029974 neurofibrosarcoma Diseases 0.000 description 1
- 238000007899 nucleic acid hybridization Methods 0.000 description 1
- 210000004940 nucleus Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 201000008968 osteosarcoma Diseases 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 101150074154 pe gene Proteins 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 201000008814 placenta cancer Diseases 0.000 description 1
- 201000008824 placental choriocarcinoma Diseases 0.000 description 1
- 208000023958 prostate neoplasm Diseases 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 206010038038 rectal cancer Diseases 0.000 description 1
- 201000001275 rectum cancer Diseases 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000001718 repressive effect Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 description 1
- 108020004418 ribosomal RNA Proteins 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000010187 selection method Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 210000000717 sertoli cell Anatomy 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 230000021595 spermatogenesis Effects 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- 210000002536 stromal cell Anatomy 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 206010042863 synovial sarcoma Diseases 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 208000030829 thyroid gland adenocarcinoma Diseases 0.000 description 1
- 208000030901 thyroid gland follicular carcinoma Diseases 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 210000002993 trophoblast Anatomy 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Hospice & Palliative Care (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08290307.1 | 2008-03-31 | ||
| EP20080290307 EP2107127A1 (en) | 2008-03-31 | 2008-03-31 | In vitro diagnostic method for the diagnosis of somatic and ovarian cancers |
| PCT/EP2009/053809 WO2009121878A2 (en) | 2008-03-31 | 2009-03-31 | In vitro diagnostic method for the diagnosis of somatic and ovarian cancers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011517937A true JP2011517937A (ja) | 2011-06-23 |
| JP2011517937A5 JP2011517937A5 (enExample) | 2012-04-12 |
Family
ID=39789414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011502373A Pending JP2011517937A (ja) | 2008-03-31 | 2009-03-31 | 体細胞性及び卵巣癌の診断のためのインビトロ診断方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20110059856A1 (enExample) |
| EP (2) | EP2107127A1 (enExample) |
| JP (1) | JP2011517937A (enExample) |
| AU (1) | AU2009231511B2 (enExample) |
| WO (1) | WO2009121878A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011107456A1 (en) | 2010-03-02 | 2011-09-09 | Technische Universität Dresden | Novel protein with structural homology to proteins with il-8-like chemokine fold and uses thereof |
| EP2444504A1 (en) * | 2010-10-20 | 2012-04-25 | Université Joseph Fourier | Use of specific genes or their encoded proteins for a prognosis method of classified lung cancer |
| EP2444503B1 (en) * | 2010-10-20 | 2016-03-02 | Université Joseph Fourier | Use of specific genes for the prognosis of lung cancer and the corresponding progonosis method |
| US9568486B2 (en) * | 2011-02-15 | 2017-02-14 | The Wistar Institute Of Anatomy And Biology | Methods and compositions for diagnosis of ectopic pregnancy |
| EP2620772A1 (en) * | 2012-01-25 | 2013-07-31 | APP Latvijas Biomedicinas petijumu un studiju centrs | Gastric cancer biomarkers and methods of use thereof |
| US9903870B2 (en) | 2012-10-04 | 2018-02-27 | The Wistar Institute Of Anatomy And Biology | Methods and compositions for the diagnosis of ovarian cancer |
| WO2015187612A1 (en) * | 2014-06-02 | 2015-12-10 | Valley Health System | Method and systems for lung cancer diagnosis |
| US20220177891A1 (en) * | 2019-02-19 | 2022-06-09 | Board Of Regents, The University Of Texas System | Hipk inhibitors and methods of use thereof |
| CN110577991B (zh) * | 2019-09-23 | 2022-05-27 | 中国人民解放军陆军军医大学 | 一种用于非阻塞性无精症的诊断盒 |
| JP2024501482A (ja) * | 2020-12-14 | 2024-01-12 | ビオンテック ユーエス インコーポレイテッド | がん免疫療法のための組織特異的抗原 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002085071A (ja) * | 2000-09-08 | 2002-03-26 | Japan Science & Technology Corp | 新規ヒト癌・精巣抗原及びその遺伝子 |
| WO2006029176A2 (en) * | 2004-09-08 | 2006-03-16 | Ludwig Institute For Cancer Research | Cancer-testis antigens |
| EP1795596A1 (en) * | 2005-12-08 | 2007-06-13 | Ganymed Pharmaceuticals AG | Composition and methods for therapy and diagnosis of cancer |
| WO2007112330A2 (en) * | 2006-03-24 | 2007-10-04 | Diadexus, Inc. | Compositions and methods for detection, prognosis and treatment of colon cancer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1308459A3 (en) * | 2001-11-05 | 2003-07-09 | Research Association for Biotechnology | Full-length cDNA sequences |
| US20070099251A1 (en) * | 2005-10-17 | 2007-05-03 | Institute For Systems Biology | Tissue-and serum-derived glycoproteins and methods of their use |
| WO2007067500A2 (en) * | 2005-12-05 | 2007-06-14 | Genomic Health, Inc. | Predictors of patient response to treatment with egfr inhibitors |
| CA2643225A1 (en) * | 2006-02-28 | 2007-09-07 | Pfizer Products Inc. | Gene predictors of response to metastatic colorectal chemotherapy |
| US7635753B2 (en) * | 2007-02-19 | 2009-12-22 | Wisconsin Alumni Research Foundation | Prostate cancer and melanoma antigens |
-
2008
- 2008-03-31 EP EP20080290307 patent/EP2107127A1/en not_active Withdrawn
-
2009
- 2009-03-31 EP EP09726587.0A patent/EP2640845B1/en not_active Not-in-force
- 2009-03-31 US US12/935,768 patent/US20110059856A1/en not_active Abandoned
- 2009-03-31 JP JP2011502373A patent/JP2011517937A/ja active Pending
- 2009-03-31 WO PCT/EP2009/053809 patent/WO2009121878A2/en not_active Ceased
- 2009-03-31 AU AU2009231511A patent/AU2009231511B2/en not_active Ceased
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002085071A (ja) * | 2000-09-08 | 2002-03-26 | Japan Science & Technology Corp | 新規ヒト癌・精巣抗原及びその遺伝子 |
| WO2006029176A2 (en) * | 2004-09-08 | 2006-03-16 | Ludwig Institute For Cancer Research | Cancer-testis antigens |
| EP1795596A1 (en) * | 2005-12-08 | 2007-06-13 | Ganymed Pharmaceuticals AG | Composition and methods for therapy and diagnosis of cancer |
| WO2007112330A2 (en) * | 2006-03-24 | 2007-10-04 | Diadexus, Inc. | Compositions and methods for detection, prognosis and treatment of colon cancer |
Non-Patent Citations (5)
| Title |
|---|
| JPN5007015808; ＣＨＥＮ Ｙ-Ｔ: ＴＨＥ ＣＡＮＣＥＲ ＪＯＵＲＮＡＬ ＦＲＯＭ ＳＣＩＥＮＴＩＦＩＣ ＡＭＥＲＩＣＡＮ Ｖ５ Ｎ１, 1999, Ｐ１６-１７, ＳＣＩＥＮＴＩＦＩＣ ＡＭＥＲＩＣＡＮ，ＩＮＣ． * |
| JPN5007015811; ＳＩＭＰＳＯＮ ＡＮＤＲＥＷ Ｊ Ｇ: ＮＡＴＵＲＥ ＲＥＶＩＥＷＳ ＣＡＮＣＥＲ Ｖ５ Ｎ８, 200508, Ｐ６１５-６２５ * |
| JPN6013057607; Ｐｒｏｃ． Ｎａｔｌ． Ａｃａｄ． Ｓｃｉ． ＵＳＡ．， ２００５， １０２（２２）， ｐｐ．７９４０-７９４５ * |
| JPN6013057608; Ｃａｎｃｅｒ Ｒｅｓ．， ２００２， ６２（１４）， ｐｐ．３９７１-３９７９ * |
| JPN6013057610; Ｐｒｏｃ． Ｎａｔｌ． Ａｃａｄ． Ｓｃｉ． ＵＳＡ．， ２００６， １０３（４８）， ｐｐ．１８０６６-１８０７１ * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2107127A1 (en) | 2009-10-07 |
| WO2009121878A2 (en) | 2009-10-08 |
| EP2640845B1 (en) | 2017-09-13 |
| US20110059856A1 (en) | 2011-03-10 |
| EP2640845A2 (en) | 2013-09-25 |
| AU2009231511B2 (en) | 2014-07-03 |
| AU2009231511A1 (en) | 2009-10-08 |
| WO2009121878A3 (en) | 2010-01-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8492096B2 (en) | TGFBR1 expression modifies risk for colorectal cancer | |
| JP2011517937A (ja) | 体細胞性及び卵巣癌の診断のためのインビトロ診断方法 | |
| CN103026227B (zh) | 新的卵巢癌生物标志物和靶 | |
| JP6603232B2 (ja) | 膀胱がんの監視、診断、およびスクリーニング方法 | |
| CA2712505C (en) | Biomarkers for the diagnosis and treatment of pancreatic cancer | |
| BR112012001469B1 (pt) | Método diagnóstico in vitro para diagnose de câncer endometrial | |
| WO2014036387A2 (en) | Methods for diagnosis and treatment of cancer | |
| CN104583422A (zh) | 标志物在诊断和治疗前列腺癌中的用途 | |
| US20210395834A1 (en) | Abca1 downregulation in prostate cancer | |
| WO2011111820A1 (ja) | 肺癌または子宮頸癌の診断マーカー | |
| JP6949315B2 (ja) | 肺扁平上皮癌と肺腺癌の鑑別評価方法 | |
| EP2550534A1 (en) | Prognosis of oesophageal and gastro-oesophageal junctional cancer | |
| WO2015105190A1 (ja) | 子宮体がんのリンパ節転移能の評価方法 | |
| JP2006518031A (ja) | ガンの予測および予後、ならびにガン治療を監視するための方法 | |
| US9988687B2 (en) | Companion diagnostics for cancer and screening methods to identify companion diagnostics for cancer based on splicing variants | |
| WO2015105191A1 (ja) | リンパ節腫脹病変の評価方法 | |
| US20160138116A1 (en) | Methods for monitoring treatment response and relapse in breast cancer | |
| EP2510113A1 (en) | Egfr and pten gene alterations predicts survival in patients with brain tumors | |
| JPWO2015115545A1 (ja) | 乳がんの転移又は再発リスクの評価方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120221 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20120221 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20131126 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20140226 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20140305 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140523 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20141202 |