JP2011517673A - 芳香族ヘテロ環縮合インドロベンザジアゼピンｈｃｖｎｓ５ｂ阻害剤 - Google Patents
芳香族ヘテロ環縮合インドロベンザジアゼピンｈｃｖｎｓ５ｂ阻害剤 Download PDFInfo
- Publication number
- JP2011517673A JP2011517673A JP2011501963A JP2011501963A JP2011517673A JP 2011517673 A JP2011517673 A JP 2011517673A JP 2011501963 A JP2011501963 A JP 2011501963A JP 2011501963 A JP2011501963 A JP 2011501963A JP 2011517673 A JP2011517673 A JP 2011517673A
- Authority
- JP
- Japan
- Prior art keywords
- hcv
- inhibitor
- hydrogen
- alkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- NPTSOXCPXHFGNY-UHFFFAOYSA-N CN(C)S(NC(c1ccc(c(C2CCCCC2)c-2[n]3Cc4ncc[n]4-c4c-2cccc4)c3c1)=O)(=O)=O Chemical compound CN(C)S(NC(c1ccc(c(C2CCCCC2)c-2[n]3Cc4ncc[n]4-c4c-2cccc4)c3c1)=O)(=O)=O NPTSOXCPXHFGNY-UHFFFAOYSA-N 0.000 description 1
- QOQJFUQDXVNLMK-UHFFFAOYSA-N COC(c1ccc(c(C2CCCCC2)c([nH]2)Br)c2c1)=O Chemical compound COC(c1ccc(c(C2CCCCC2)c([nH]2)Br)c2c1)=O QOQJFUQDXVNLMK-UHFFFAOYSA-N 0.000 description 1
- HCGFDRJRHDWEFA-UHFFFAOYSA-N COC(c1ccc(c(C2CCCCC2)c-2[n]3Cc4nnc[n]4-c4c-2cccc4)c3c1)=O Chemical compound COC(c1ccc(c(C2CCCCC2)c-2[n]3Cc4nnc[n]4-c4c-2cccc4)c3c1)=O HCGFDRJRHDWEFA-UHFFFAOYSA-N 0.000 description 1
- FKSBXSUNOSLZKF-UHFFFAOYSA-N OC(c1ccc(c(C2CCCCC2)c-2[n]3Cc4nnc[n]4-c4c-2cccc4)c3c1)=O Chemical compound OC(c1ccc(c(C2CCCCC2)c-2[n]3Cc4nnc[n]4-c4c-2cccc4)c3c1)=O FKSBXSUNOSLZKF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3996108P | 2008-03-27 | 2008-03-27 | |
| US61/039,961 | 2008-03-27 | ||
| PCT/US2009/038010 WO2009120650A1 (en) | 2008-03-27 | 2009-03-24 | Aromatic heterocyclic fused indolobenzadiazepine hcv ns5b inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011517673A true JP2011517673A (ja) | 2011-06-16 |
| JP2011517673A5 JP2011517673A5 (enExample) | 2012-05-10 |
Family
ID=40810527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501963A Pending JP2011517673A (ja) | 2008-03-27 | 2009-03-24 | 芳香族ヘテロ環縮合インドロベンザジアゼピンｈｃｖｎｓ５ｂ阻害剤 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8431568B2 (enExample) |
| EP (1) | EP2278977B1 (enExample) |
| JP (1) | JP2011517673A (enExample) |
| KR (1) | KR20100124848A (enExample) |
| CN (1) | CN101980711B (enExample) |
| AT (1) | ATE531373T1 (enExample) |
| AU (1) | AU2009228451A1 (enExample) |
| ES (1) | ES2374870T3 (enExample) |
| MX (1) | MX2010010060A (enExample) |
| WO (1) | WO2009120650A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103288828A (zh) * | 2012-02-24 | 2013-09-11 | 中国科学院大连化学物理研究所 | 一种合成手性二氢-6H-吲哚并[2,1-c][1,4]-苯并二氮杂卓的方法 |
| CN103539723A (zh) * | 2013-10-29 | 2014-01-29 | 南方医科大学 | 一种3-氨基-2-芳甲酰基-1h-吲哚类衍生物的合成方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0344392A (ja) * | 1989-07-03 | 1991-02-26 | Hoechst Roussel Pharmaceut Inc | ４Ｈ‐インドロ〔１，２‐ｄ〕〔１，２，４〕トリアゾロ〔４，３‐ａ〕〔１，４〕ベンゾジアゼピンおよびその製造法 |
| WO2007129119A1 (en) * | 2006-05-08 | 2007-11-15 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Pentacyclic indole derivatives as antiviral agents |
| JP2008509218A (ja) * | 2004-08-09 | 2008-03-27 | ブリストル−マイヤーズ スクイブ カンパニー | Ｈｃｖ複製の阻害剤 |
| JP2009544622A (ja) * | 2006-07-20 | 2009-12-17 | スミスクライン・ビーチャム・コーポレーション | 多環式ウイルス阻害剤 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602005013922D1 (de) * | 2004-02-24 | 2009-05-28 | Japan Tobacco Inc | Kondensierte heterotetracyclische verbindungen und deren verwendung als hcv-polymerase-inhibitor |
| US7348425B2 (en) | 2004-08-09 | 2008-03-25 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
| AU2005298403A1 (en) | 2004-10-26 | 2006-05-04 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Tetracyclic indole derivatives as antiviral agents |
| GB0518390D0 (en) * | 2005-09-09 | 2005-10-19 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| US7399758B2 (en) | 2005-09-12 | 2008-07-15 | Meanwell Nicholas A | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
| US7473688B2 (en) | 2005-09-13 | 2009-01-06 | Bristol-Myers Squibb Company | Indolobenzazepine HCV NS5B inhibitors |
| US7456165B2 (en) | 2006-02-08 | 2008-11-25 | Bristol-Myers Squibb Company | HCV NS5B inhibitors |
| US7521442B2 (en) | 2006-05-25 | 2009-04-21 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
| CN101490054B (zh) | 2006-05-25 | 2012-05-16 | 百时美施贵宝公司 | 环丙基稠合的吲哚并苯并氮杂*hcv ns5b抑制剂 |
| US7452876B2 (en) | 2006-06-08 | 2008-11-18 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
| US7642251B2 (en) | 2007-08-09 | 2010-01-05 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| US7652004B2 (en) | 2007-08-09 | 2010-01-26 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| US8143243B2 (en) | 2007-08-09 | 2012-03-27 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| US8138171B2 (en) | 2008-03-27 | 2012-03-20 | Bristol-Myers Squibb Company | Dioxolane and dioxolanone fused indolobenzadiazepine HCV NS5B inhibitors |
| US8133884B2 (en) | 2008-05-06 | 2012-03-13 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
-
2009
- 2009-03-24 JP JP2011501963A patent/JP2011517673A/ja active Pending
- 2009-03-24 MX MX2010010060A patent/MX2010010060A/es active IP Right Grant
- 2009-03-24 CN CN2009801109761A patent/CN101980711B/zh not_active Expired - Fee Related
- 2009-03-24 KR KR1020107023917A patent/KR20100124848A/ko not_active Withdrawn
- 2009-03-24 AT AT09725965T patent/ATE531373T1/de active
- 2009-03-24 EP EP09725965A patent/EP2278977B1/en not_active Not-in-force
- 2009-03-24 US US12/922,801 patent/US8431568B2/en active Active
- 2009-03-24 AU AU2009228451A patent/AU2009228451A1/en not_active Abandoned
- 2009-03-24 WO PCT/US2009/038010 patent/WO2009120650A1/en not_active Ceased
- 2009-03-24 ES ES09725965T patent/ES2374870T3/es active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0344392A (ja) * | 1989-07-03 | 1991-02-26 | Hoechst Roussel Pharmaceut Inc | ４Ｈ‐インドロ〔１，２‐ｄ〕〔１，２，４〕トリアゾロ〔４，３‐ａ〕〔１，４〕ベンゾジアゼピンおよびその製造法 |
| JP2008509218A (ja) * | 2004-08-09 | 2008-03-27 | ブリストル−マイヤーズ スクイブ カンパニー | Ｈｃｖ複製の阻害剤 |
| WO2007129119A1 (en) * | 2006-05-08 | 2007-11-15 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Pentacyclic indole derivatives as antiviral agents |
| JP2009544622A (ja) * | 2006-07-20 | 2009-12-17 | スミスクライン・ビーチャム・コーポレーション | 多環式ウイルス阻害剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2374870T3 (es) | 2012-02-22 |
| MX2010010060A (es) | 2010-09-30 |
| WO2009120650A1 (en) | 2009-10-01 |
| KR20100124848A (ko) | 2010-11-29 |
| AU2009228451A1 (en) | 2009-10-01 |
| EP2278977B1 (en) | 2011-11-02 |
| CN101980711A (zh) | 2011-02-23 |
| US20110014154A1 (en) | 2011-01-20 |
| CN101980711B (zh) | 2012-10-31 |
| EP2278977A1 (en) | 2011-02-02 |
| US8431568B2 (en) | 2013-04-30 |
| ATE531373T1 (de) | 2011-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120316 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20120316 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130917 |
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| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20140507 |