CN101980711B - 芳族杂环稠合的吲哚并苯并二氮杂*hcv ns5b抑制剂 - Google Patents

芳族杂环稠合的吲哚并苯并二氮杂*hcv ns5b抑制剂 Download PDF

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Publication number
CN101980711B
CN101980711B CN2009801109761A CN200980110976A CN101980711B CN 101980711 B CN101980711 B CN 101980711B CN 2009801109761 A CN2009801109761 A CN 2009801109761A CN 200980110976 A CN200980110976 A CN 200980110976A CN 101980711 B CN101980711 B CN 101980711B
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CN
China
Prior art keywords
hcv
compound
hydrogen
alkyl
cyclohexyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2009801109761A
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English (en)
Chinese (zh)
Other versions
CN101980711A (zh
Inventor
约翰·A·本德
杨忠
约翰·F·卡多
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication date
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Publication of CN101980711A publication Critical patent/CN101980711A/zh
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
CN2009801109761A 2008-03-27 2009-03-24 芳族杂环稠合的吲哚并苯并二氮杂*hcv ns5b抑制剂 Expired - Fee Related CN101980711B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3996108P 2008-03-27 2008-03-27
US61/039,961 2008-03-27
PCT/US2009/038010 WO2009120650A1 (en) 2008-03-27 2009-03-24 Aromatic heterocyclic fused indolobenzadiazepine hcv ns5b inhibitors

Publications (2)

Publication Number Publication Date
CN101980711A CN101980711A (zh) 2011-02-23
CN101980711B true CN101980711B (zh) 2012-10-31

Family

ID=40810527

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801109761A Expired - Fee Related CN101980711B (zh) 2008-03-27 2009-03-24 芳族杂环稠合的吲哚并苯并二氮杂*hcv ns5b抑制剂

Country Status (10)

Country Link
US (1) US8431568B2 (enExample)
EP (1) EP2278977B1 (enExample)
JP (1) JP2011517673A (enExample)
KR (1) KR20100124848A (enExample)
CN (1) CN101980711B (enExample)
AT (1) ATE531373T1 (enExample)
AU (1) AU2009228451A1 (enExample)
ES (1) ES2374870T3 (enExample)
MX (1) MX2010010060A (enExample)
WO (1) WO2009120650A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103288828A (zh) * 2012-02-24 2013-09-11 中国科学院大连化学物理研究所 一种合成手性二氢-6H-吲哚并[2,1-c][1,4]-苯并二氮杂卓的方法
CN103539723A (zh) * 2013-10-29 2014-01-29 南方医科大学 一种3-氨基-2-芳甲酰基-1h-吲哚类衍生物的合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897392A (en) * 1989-07-03 1990-01-30 Hoechst-Roussel Pharmaceuticals, Inc. 4H-indolo(1,2-d)(1,2,4)triazolo(4,3-A)(1,4)benzodiazepines

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005013922D1 (de) * 2004-02-24 2009-05-28 Japan Tobacco Inc Kondensierte heterotetracyclische verbindungen und deren verwendung als hcv-polymerase-inhibitor
US7153848B2 (en) * 2004-08-09 2006-12-26 Bristol-Myers Squibb Company Inhibitors of HCV replication
US7348425B2 (en) 2004-08-09 2008-03-25 Bristol-Myers Squibb Company Inhibitors of HCV replication
AU2005298403A1 (en) 2004-10-26 2006-05-04 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Tetracyclic indole derivatives as antiviral agents
GB0518390D0 (en) * 2005-09-09 2005-10-19 Angeletti P Ist Richerche Bio Therapeutic compounds
US7399758B2 (en) 2005-09-12 2008-07-15 Meanwell Nicholas A Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
US7473688B2 (en) 2005-09-13 2009-01-06 Bristol-Myers Squibb Company Indolobenzazepine HCV NS5B inhibitors
US7456165B2 (en) 2006-02-08 2008-11-25 Bristol-Myers Squibb Company HCV NS5B inhibitors
GB0608928D0 (en) * 2006-05-08 2006-06-14 Angeletti P Ist Richerche Bio Therapeutic agents
US7521442B2 (en) 2006-05-25 2009-04-21 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
CN101490054B (zh) 2006-05-25 2012-05-16 百时美施贵宝公司 环丙基稠合的吲哚并苯并氮杂*hcv ns5b抑制剂
US7452876B2 (en) 2006-06-08 2008-11-18 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
KR20090029827A (ko) * 2006-07-20 2009-03-23 제네랩스 테크놀로지스, 인코포레이티드 폴리사이클릭 바이러스 억제제
US7642251B2 (en) 2007-08-09 2010-01-05 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US7652004B2 (en) 2007-08-09 2010-01-26 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US8143243B2 (en) 2007-08-09 2012-03-27 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US8138171B2 (en) 2008-03-27 2012-03-20 Bristol-Myers Squibb Company Dioxolane and dioxolanone fused indolobenzadiazepine HCV NS5B inhibitors
US8133884B2 (en) 2008-05-06 2012-03-13 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897392A (en) * 1989-07-03 1990-01-30 Hoechst-Roussel Pharmaceuticals, Inc. 4H-indolo(1,2-d)(1,2,4)triazolo(4,3-A)(1,4)benzodiazepines

Also Published As

Publication number Publication date
ES2374870T3 (es) 2012-02-22
MX2010010060A (es) 2010-09-30
WO2009120650A1 (en) 2009-10-01
KR20100124848A (ko) 2010-11-29
JP2011517673A (ja) 2011-06-16
AU2009228451A1 (en) 2009-10-01
EP2278977B1 (en) 2011-11-02
CN101980711A (zh) 2011-02-23
US20110014154A1 (en) 2011-01-20
EP2278977A1 (en) 2011-02-02
US8431568B2 (en) 2013-04-30
ATE531373T1 (de) 2011-11-15

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20121031

Termination date: 20150324

EXPY Termination of patent right or utility model